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Objectives: The purpose of this study is to collect and analyze the KCD codes applied to the treatment of 27 postpartum women who had been treated with Korean traditional medicine in a Korean medicine hospital, so that this study may be used as a basic data for setting the direction of postpartum Korean medical treatment research. Methods: It was approved by the Institutional Review Board (IRB) of ⃝⃝ University medical center (IRB approval number : WSOH IRB H1708-02-01). Twenty-seven postpartum women who had been treated at ⃝⃝ University medical center were received outpatient treatment for two weeks (from September 27, 2017 to January 5, 2018), and the KCD codes applied to the mothers were collected after obtaining the consent. On the day of registration of the study, the fertility, obstetric history and high-risk pregnancies were identified through an interview. Results: 1. The mean age of the 27 subjects was 33.33±3.99 years old. Among the subjects, 17 mothers (63.0%) were high-risk pregnancy and 10 mothers (37.0%) were normal. 2. Among the 22 major disease categories, 8 categories were used. M code (musculoskeletal system) was used 243 times (70.85%), followed by R code (unclassified symptom) of 51 times (14.87%) and U code (special purpose code) of 23 times (6.71%). 3. The most commonly used code among the ten frequently used codes was M25.57 (joint pain, ankle and foot), a total of 47 times. Of the remaining nine codes, except for R60.1 (systemic edema) and U68.4 (The deficiency of yang in Bi), all codes were M codes (musculoskeletal system). 4. The M code (musculoskeletal system) was the most used major disease category in high-risk group, a total of 159 times. But in specific categories, the most commonly used code was R60.1 (systemic edema), a total of 28 times. 5. In normal group, the M code (musculoskeletal system) was the most used major disease category, a total of 84 times. Also, in specific categories, the most commonly used code was M25.57 (joint pain, ankle and foot), total 29 times. 6. The U code, corresponding to 'the diagnosis of childbirth and other obstetrical medical use', was used 23 times (6.71%), O code three times (0.87%) and Z code two times (0.58%), which was less than 10% of the total number of codes used. Conclusion: When analyzing KCD codes related to Korean medicine treatment for postpartum diseases, it is important to select the KCD codes that reflect the actual clinical state. 목적 : 일개 한방병원에서 한의치료를 받은 산욕초기 27명의 산모를 대상으로 치료 시 적용된 KCD 코드를 수집, 분석하여 산후의 한의진료 자료구축 연구에 대한 방향 설정의 기초자료로 활용하고자 하였다. 방법 : OO대학교기관생명윤리위원회(Institutional Review Board, 이하 IRB)의 승인을 받아 실시하였다(IRB 승인 번호 (WSOH IRB H1708-02-01). 2017년 9월 18일부터 2018년 1월 5일까지 OO대학교 부속한방병원 한방부인과에서 한의치료를 받은 초기 산욕기 산모 27명의 동의를 얻어 2주간 외래를 방문하여 한의치료를 받을 때마다 적용된 KCD코드를 수집하였다. 연구등록당일에는 문진을 통하여 출산력, 산과력 및 고위험산모 여부를 확인하였다. 결과 : 1. 대상자 27명의 평균 연령은 33.33±3.99세였으며, 고위험 산모가 17명(63.0 %), 일반 산모가 10명(37.0 %)이었다. 2. 전체 22개의 질병 대분류 8개의 분류가 사용되었으며, M코드(근골격계통)가 243회(70.85%), R코드(달리 분류되지 않은 증상)가 51회(14.87%), U코드(특수목적 코드)가 23회(6.71%) 순이었다. 3. 다빈도 상위 10개 세분류 상병코드 중 가장 많이 사용 된 코드는 총 47회로 M25.57(관절통, 발목 및 발)이었고, 나머지 9개의 코드 중 R60.1(전신부종), U68.4(비양허증)을 제외하면, 7개의 코드가 모두 M코드(근골격계통)였다. 4. 고위험군의 질병대분류 또한 M코드(근골격계) 가 159회로 가장 높았으나, 세분류 상병코드 중 가장 많이 사용된 것은 총28회로 R60.1(전신부종)이었다. 5. 일반군의 질병대분류 또한 M코드(근골격계) 가 84회로 가장 높았으며, 세분류 상병코드 중 가장 많이 사용된 것은 총29회로 M25.57(관절통, 발목 및 발)이었다. 6. ‘분만 및 기타 산과 의료이용 진단코드’에 해당하는 U코드가 23회(6.71%), O코드가 3회(0.87%), Z코드가 2회(0.58%)사용되어, 전체 사용된 코드 건수의 10% 미만이었다. 결론 : 출산 후의 한방의료 이용질환에 관한 상병코드 분석 시, 실제 임상현장을 반영한 상병코드의 선정이 중요함을 알 수 있다.
Objectives: This study was aimed to investigate the weight change of the high-risk group and the general maternal group and weight-relating factors in the early postpartum period. Methods: We retrospectively reviewed the medical records of those who received postpartum care from January 1, 2020, to December 31, 2020, in the postpartum care center affiliated with one Korean Medicine hospital. A total of 257 postpartum women's medical charts were included and divided into the high-risk group and the general maternal group. We investigated the weight changes and Body mass index (BMI) of the postpartum women and compared the difference between the two groups after taking the postpartum care. Finally, we used a Pearson correlation analysis to identify the weight-relating factors in the early postpartum period. Results: All the postpartum women showed the following results; 33.81±4.03 years old as the mean age; 22.23±3.28 as pre-pregnancy BMI; 58.21±9.18 kg of pre-pregnancy weight increased into 70.75±9.70 kg in the last month of pregnancy. Of the total 257 patients, 149 (58.0%) of high-risk pregnancy experience and 108 (42.0%) of general pregnancy were included. The edema index right after childbirth was significantly higher in the high-risk group than in the general maternal group (p<0.001), but there was no significant difference in BMI. After treatment with Korean medicine treatments, body weight, BMI, and edema index decreased significantly in both groups (p<0.01). As a result of correlation analysis, weight gain during pregnancy had a significant negative correlation with pre-pregnancy weight and pre-pregnancy BMI and a significant positive correlation with weight and BMI of the last month of pregnancy. In particular, pre-pregnancy BMI and body weight showed a significant negative correlation only in the high-risk group. Postpartum weight loss was significantly positively correlated with pre-pregnancy weight, pre-pregnancy BMI, weight & BMI of the pregnancy last month, weight gain during pregnancy, and decrease in edema (p<0.01) Conclusions: The weight during pregnancy of the high-risk group increased in inverse proportion to the pre-pregnancy BMI. The level of edema right after childbirth was significantly higher than that of the general maternal group, but showed a significant decrease after 2 weeks of Korean medicine treatments. Although it implicates the need for active Korean medicine treatments in the early postpartum period, further studies with controlled groups are needed. 목적 : 본 연구는 산후 초기에 고위험군과 일반 모성 군의 체중 변화와 체중 관련 요인을 조사하고자 하였다. 방법: 2020년 1월 1일부터 2020년 12월 31일까지 일개 한방병원 산후조리원에서 산후조리를 받은 사람들의 의무기록을 후향적으로 조사하였다. 총 257명의 대상자들이 선정되었고, 고위험군과 일반산모군의 두그룹으로 나누어 산후 여성의 체중 변화와 체질량지수(BMI)를 조사하고 두 그룹의 차이를 비교하였다. 마지막으로 Pearson 상관 분석을 사용하여 산욕초기의 체중 회복 관련 요인을 살펴보았다. 결과: 대상자의 평균 연령은 33.81±4.03세, 임신 전 BMI는 22.23±3.28, 임신 전 체중 58.21±9.18kg이 임신 마지막 달에 70.75±9.70kg으로 증가했다. 총 257명의 환자 중 고위험 임신 경험 149명(58.0%)과 일반 임신 108명(42.0%)이 포함되었다. 산후 부종지수는 고위험군이 일반 산모군보다 유의하게 높았으나(p<0.001), 체질량지수(BMI)에서는 유의한 차이가 없었다. 한방치료 후 체중, BMI, 부종지수는 두 군에서 유의하게 감소하였다(p<0.01). 상관 관계 분석 결과, 임신 중 체중 증가는 임신 전 체중 및 임신 전 BMI와 유의 한 음의 상관 관계를 보였으며, 임신 말기 체중 및 BMI와 유의 한 양의 상관 관계를 보였다. 특히 임신 전 BMI와 체중은 고위험군에서만 유의한 음의 상관관계를 보였다. 산후 체중 감소는 임신 전 체중, 임신 전 BMI, 지난달 임신의 체중 및 BMI, 임신 중 체중 증가, 부종 감소와 유의하게 양의 상관관계가 있었다(p<0.01). 결론 : 고위험군의 임신 중 체중은 임신 전 체질량 지수에 반비례하여 증가했습니다. 산후 부종의 정도는 일반 산모군에 비해 유의하게 높았으나 한방치료 2주 후에는 유의하게 감소하였다. 산후 초기에 적극적인 한방 치료에 대한 근거로 활용할수 있다 판단된다.
Objectives: The purpose of this study is to assess the quality of case reports from the Journal of Obstetrics and Gynecology of Korean Medicine. Methods: Case reports were selected from the Obstetrics and Gynecology of Korean Medicine from January 2015 to March 2019, by utilizing Oriental Medicine Advanced Searching Integrated System (OASIS). The quality of the reports were reviewed based on the Consensus-based Clinical Case Reporting Guideline Development (CARE) guideline. Results: Total of 41 case reports were finally selected for the assessment. 69.23% of the case reports included necessary information based on the CARE guideline but the rest of the reports did not. More than 50% of the reports were missing data regarding ‘Diagnostic challenges', ‘Intervention adherence and tolerability', ‘Adverse and unanticipated events', or ‘Patient perspective or experience', and ‘Informed consent'. Also, the reports did not include ‘Key word', ‘timeline’. Conclusions: Case reports from the Journal of Obstetrics and Gynecology of Korean Medicine have important role in women. Efforts are needed to improve the quality of the case reports as well as to develop reporting guidelines for the Journal of Obstetrics and Gynecology of Korean Medicine. Objectives: The purpose of this study is to assess the quality of case reports from the Journal of Obstetrics and Gynecology of Korean Medicine. Methods: Case reports were selected from the Obstetrics and Gynecology of Korean Medicine from January 2015 to March 2019, by utilizing Oriental Medicine Advanced Searching Integrated System (OASIS). The quality of the reports were reviewed based on the Consensus-based Clinical Case Reporting Guideline Development (CARE) guideline. Results: Total of 41 case reports were finally selected for the assessment. 69.23% of the case reports included necessary information based on the CARE guideline but the rest of the reports did not. More than 50% of the reports were missing data regarding ‘Diagnostic challenges', ‘Intervention adherence and tolerability', ‘Adverse and unanticipated events', or ‘Patient perspective or experience', and ‘Informed consent'. Also, the reports did not include ‘Key word', ‘timeline’. Conclusions: Case reports from the Journal of Obstetrics and Gynecology of Korean Medicine have important role in women. Efforts are needed to improve the quality of the case reports as well as to develop reporting guidelines for the Journal of Obstetrics and Gynecology of Korean Medicine.
The purpose of this study was to investigate the effects of Gardeniae Fructus Water Extract (GF) on the production of inflammatory mediators in RAW264.7 cell treated with lipopolysaccharide (LPS). Methods: Gradeniae Fructus was extracted with distilled water (2, 000 ml) for 2hours. In order to evaluate cytotoxicity of GF, 3 - (4, 5-dimethylthiazol-2-yl) - 2, 5- diphenyltetrazolium bromide (MTT) assay was performed. To investigate anti-inflammatory effects, the concentration of nitric oxide (NO) was measured with No assay, calcium (Ca) was measured with Fluo-4 Ca assay, and cytokine was measured by Bio-Plex cytokine assay in RAW 264.7 cell. And when p-value is below 0.05, itis judged to have the significant difference statistically. Results:1. GF did not show any cytotoxicity. 2. GF suppressed the production of NO and Ca at the concentration of 25, 50, 100 and 200 μg/ml. 3. GF suppressed the production of interleukin (IL)-1β, IL-10, IL-12p40, macrophage-colony stimulating factor (M-CSF), macrophage inflammatory protein (MIP)-1β andkeratinocyte chemoattractant(KC) at the concentration of 25, 50, 100 and 200 μg/ml. 4. GF suppressed the production of vascular endothelial growth factor (VEGF), granulocyte-colony stimulating factor (G-CSF) and monocyte cheomattractant protein(MCP)-1 at the concentration of 25, 50 and 100 μg/ml. 5. GF suppressed the production of granulocyte macrophage-colony stimulating factor (GM-CSF) and regulated on activation, normal T cell expressed and secreted(RANTES) at the concentration of 25 and 50 μg/ml. 6. GF suppressed the production of MIP-2 at the concentration of 50 and 100μg/ml, and tumor necrosis factor (TNF)-α at the concentration of 50 and 200 μg/ml. Conclusions: These results suggest that GF has anti-inflammatory effect and immuno-modulating activity.
This study was conducted to evaluate the inhibitory effect of polygoni cuspidati radix (PCR) extract on osteoclast differentiation. Methods: MTT-assay was performed to estimate cytotoxicity of PCR extractin BMMs stimulated with RANKL. Tartrate resistant acid phosphatase (TRAP)staining, TRAP activity and RT-PCR were performed to know the inhibitory effecton osteoclast differentiation. actin ring formation were analysed to observe the effect of PCR extract. Results: PCR decreased the number of TRAP positive cells and TRAP activitiesin BMMs stimulated with RANKL and M-CSF. PCR restrained the formation ofactin ring. PCR down regulated the induction of NFATc1, c-Fos, TRAP and OSCARby RANKL. PCR inhibited NF-κB activity by inducing degradation of IκBα. Conclusions: We suggest that PCR Extracts can be an effective therapeutic agenton osteoclast differentiation caused by diseases such as osteoporosis.
The purpose of this study is to evaluate the effects of Gyejigabuja-tang on a menopausal female patient complained of excessive sweating after bilateral salpingo-oophorectomy (BSO). Methods: We studied one menopausal female patient complained of excessive sweating who visited OO University Hospital from 10th July 2013 to 23th July 2013. We only treated her with Gyejigabuja-tang. The climacteric symptoms of the patient had been estimated with Numeric Rating Scale (NRS) and Menopause Rating Scale (MRS). Results: After treatment, climacteric symptoms were improved and the score of MRS was reduced from 20 to 10 during 12days. NRS score of sweating was reduced from 10 to 2. NRS scores of fatigue, hot flush, thirst, anorexia, dyspepsia,back pain and cramp of calves also reduced after treatment. Conclusions: This study suggests that Gyejigabuja-tang significantly reduced the climacteric symptoms of patient.
This review is to figure out evidence that suggest effectiveness of Korean Medicine treatments against cervical dysplasia. Methods: Studies on cervical cancer and cervical dysplasia were searched through 6 databases: Korean Studies Information Service System(KISS), National Discovery for Science Leaders (NDSL), Korea Institute of Science and Technology Information (Korean TK), Oriental Medicine Advanced Searching Integrated System (OASIS),the Journal of Korean Medicine, and the Journal of Korean Obstetrics & Gynecology. After that, the articles were extracted with reference point of Korean Traditional Medicine. Results: 37 articles were included lastly according to selection criteria. 3 of them were case reports on cervical dysplasia, and 34 were in-vitro studies on Human Papilloma Virus (HPV) positive cancer cell. In case reports, acupuncture,moxibustion, medical herbs and pharmacoacupuncture were used for treatments of cervical dysplasia with about 3 months. Experimental studies on cervical cancer cell showed that several herbs function with clear heat, eliminate stasis (淸熱解毒, 化瘀消腫) have anti-cancer effects inducing apoptosis. Conclusions: The results of articles are not enough to use in practice. Therefore,we indicates more advanced research methodology as follows: development of Korean Medicine treatment protocol with oral and external, in-vivo experimental study, and evaluation immunity index.