지하 무선 CDMA 망의 전파 측정 및 Micro BTS의 성능 분석

안호중,노재성,조성언,조성준 한국항공대학교 1998 論文集 Vol.36 No.-

지하 무선망에서 CDMA(Code Division Multiple Access)시스템의 용량과 품질은 다중 사용자 간섭과 임펄스성 간섭의 영향을 받는다. 그러므로 CDMA 시스템에서는 간섭을 최소화하려는 연구가 필요하다. 최근에는 서비스 영역을 확대하기 위한 방법으로 지하 공간 또는 음영 지역에서 LCX(Leakage Coaxial Cable)가 이용되고 있다. 본 논문에서는 지하 무선 CDMA 망의 전파의 세기를 측정하였다. 그리고 측정된 결과를 이용하여 이론적인 Micro BTS의 성능을 분석하였다. 이론적인 BER 해석을 위하여 지하 무선 CDMA 망의 임펄스성 간섭 모델을 제안하고, 측정된 파라미터 값을 이용하여 Micro BTS의 BER 성능을 구하였다. 측정 결과, 지하철이 없을 경우보다 지하철이 운행함에 따라서 임펄스성 간섭이 중대됨을 알 수 있었으며, 단방향 운행보다 양방향 운행에서 임펄스성 간섭이 더욱 증가하였다. 수치 계산을 통하여 임펄스성 간섭의 발생 시간율과 다중 사용자 수에 따라 Micro BTS의 BER 성능이 주로 열화됨을 알 수 있었다. The capacity and quality of CDMA(Code Division Multiple Access) system are affected by multi user interference and impulsive interference in the underground wireless network. Therefore, it is essential to minimize the interference in CDMA system. Recently, LCX (Leaxial Cable) is used to expand service area in the underground area or shadow region. In this paper, the propagation of underground wireless CDMA network is measured. And then, using the measured data the theoretical performance of Micro BTS(Base Transmitter Station) is analyzed. For theoretical BER analysis, the impulsive interference model in the underground wireless CDMA network is proposed and the BER performance of Micro BTS is obtained by using the measured data. From the measurement results, it is found that the impulsive interference increases in the presence of passing train than the absence of passing train. Also, it is known that more interference appears in the presence of crossing two way train than in the presence of passing one way directional train. From the numerical results, the BER performance of Micro BTS is to be mainly degraded by the occurrence rate of impulsive interference and the number of multiple users.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

40세 이하 관상동맥 질환자에서 장기적 임상 관찰

이승욱,정명호,박종철,박형욱,조상희,김원,김계훈,이상현,강경태,조장현,김남호,김건형,안영근,조정관,박종춘,강정채 全南大醫大 2001 전남의대학술지 Vol.37 No.2

역행적 골수정 삽입술을 이용한 대퇴골 과상부 골절의 치료

권진우,신승호,조원호,성기호,김기환,손경태,이상훈,박세원,배종문,권태우 대한골절학회 2003 대한골절학회지 Vol.16 No.4

종 분포 모형을 이용한 구상나무림의 지속 및 쇠퇴에 관한 연구 - 전라남도 광양시 백운산을 중심으로 -

조선희 ( Seon Hee Cho ),박종영 ( Jong Young Park ),박정호 ( Jeong Ho Park ),이양근 ( Yang Geun Lee ),문이만 ( Lee Man Mun ),강상호 ( Sang Ho Kang ),김광현 ( Gwang Hyun Kim ),윤종국 ( Jong Guk Yun ) 한국산림과학회 2015 한국산림과학회지 Vol.104 No.3

The present study investigated the habitats of Korean fir trees (Abies koreana E. H. Wilson) on Mt. Baekwun (Baekwun-san), determined the current distribution, quantified the contribution of biological and nonbiological environmental factors affecting the distribution, derived actual and potential habitats, presented a plan for the establishment of protected areas, applied RCP 8.5 climate change scenario to analyze the effects of climate change on the future distribution of Korean fir trees, and predicted future potential habitats. According to the results of the study, 3,325 Korean fir trees (DBH >= 2.5 cm) inhabited Mt. Baekwun, and their distribution area was approximately 150 ha. Populations of Korean fir trees were confirmed to exist at an altitude of 900 m above sea level and were distributed up to 1,200 m. Based on potential distribution, areas appropriate for habitation by Korean fir trees were analyzed to be 450 ha, three times the current distribution area, with a focus on Sang Peak (Sang-bong), Eokbul Peak (Eokbul-bong), Ddari Peak (Ddari-bong), and Dosol Peak (Dosol-bong). The forest stands near Sang Peak, the main peak, were evaluated as those with the most appropriate potential for the habitation of Korean fir trees, and populations of the trees tended to prefer the northern slope rather than the southern slope. When climate change scenario RCP 8.5 was applied and future potential distribution was analyzed, the habitats were expected to decrease in area to 20 ha by 2050, with a focus on Sang Peak, and areas appropriate for habitation were predicted not to exist by 2080. Judging from such results, as global warming accelerates, the habitats of Korean fir trees are clearly expected to move from lowlands to highlands.

Adenovirus-mediated heme oxygenase-1 gene transfer to neonatal porcine islet-like cluster cells: the effects on gene expression and protection from cell stress

염혜정,Han Ro,Sol Ji Park,Ju Ho Hong,Bumrae Cho,김화정,Sung Joo Kim,황종익,이병천,안규리,양재석 한국바이오칩학회 2012 BioChip Journal Vol.6 No.1

Porcine islet xenotransplantation is a promising strategy for the treatment of diabetes that overcomes donor shortages. However, islet xenografts are susceptible to oxidative stress and apoptosis. Heme oxygenase-1 (HO-1) has been shown to protect cells from oxidative stress, apoptosis and inflammation. Here, we investigated whether introduction of human HO-1 (hHO-1) into neonatal porcine islet-like cell clusters (NPCCs) can induce beneficial transcriptional changes in NPCCs against cellular stress. NPCCs were transduced with either adenovirus-HO-1 (Ad-HO-1) or control adenovirus-GFP (Ad-GFP). After treatment with hydrogen peroxide (H2O2) for 24 hours, nitrite oxide (NO) production assays were performed to detect oxidative stress. Microarray analysis was performed using a pig oligonucleotide 44 K gene chip. We profiled transcriptional changes to apoptosis, oxidant and inflammatory genes, and real-time PCR analysis was also performed to confirm the microarray results. Survival of NPCCs after treatment with H2O2 was significantly higher in the Ad-HO-1 group (p⁄0.001), and NO production also decreased in the Ad-HO-1 group (p⁄0.01). The microarray results showed that the expression of pro-apoptosis genes such as CASP3, CASP7, CASP10, CIDE-B and CIDE-C was significantly decreased in the Ad-HO-1 virus group (CASP10; p⁄0.05, CASP3, CIDE-C; p⁄0.01, CASP7, CIDE-B; p⁄0.001). We also found that the expression of oxidative stresses genes including COX1, COX2, CYB5A, SDHD and NOS2 was decreased, and that the anti-oxidant genes Gpx1 and SOD2 were increased in the Ad-HO-1 group (NOS2; p⁄0.05, COXI, COX2, CYB5A, SDHD, SOD2, GPX1; p⁄0.001). However, inflammatory gene expression was not significantly changed. Realtime PCR analysis confirmed the results of the microarray analysis. These results shed light on the underlying mechanisms of the protective effects of hHO-1 on porcine islets from cellular stresses and suggest that hHO-1 could be a promising target gene for the production of transgenic pigs that confer improved islet xenograft survival.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

단백질흡착을 막는 소프트콘택트렌즈에 관한 연구

조종수,정영일,나재운,김성호 朝鮮大學校 1997 藥學硏究誌 Vol.18 No.2

양말단에 이크릴레이트를 갖는 폴리에틸렌글리콜 미크로마(PEG macromer)와 또한 PEG macromer와 폴리하이드록시에칠메타아크릴레이트[P(HEMA)] 혹은 폴리(하이드록시에칠메타아크릴레이트-하이드록시프로메타아크릴레이트-비닐피롤리돈)[P(HEMA-co-HPMA-co-NVP)]와 상호침투된 망상구조의 시료가 소프트콘텍트렌즈의 알부민의 흡착을 막기위하여 제조되었다. PEG macromer의 중합으로 macromer의 다관능성기로 인하여 가교된 겔이 형성되었다. P(HEMA-co-HPMA-co-NVP)/PEG IPN계 콘텍트렌즈에서 PEG분자량이 중가할수록 알부민의 흡착량은 감소되었다. 또한 IPN제조시의 PEG의 농도가 짙을수록 알부민의 흡착량은 감소되었다. PEG macromer와 IPN하기전의 P(HEMA)계 및 P(HEMA-co-HPMA-co-NVP)계의 콘텍트렌즈에 비하여 PEG macromer와 IPN함으로서 렌즈의 착용감이 훨씬 상승되었다. Poly(ethylene glycol)(PEG) macromers terminated with diacrylate groups and interpenetrating polymer networks(IPN) composed of poly(hydrowyethyl methacrylate)(PHEMA) or poly(hydrowyethyl methacrylate-co-hydroxypropyl methacrylate-co-N-vinyl pyrrolidone)[P(HEMA-co-HPMA-co-NVP)]and PEG macromer were synthesized with the aim of abtaining protein adsorption resistant soft contact lens. Polymerization of PEG macromer. Crosslinked p(HEMA)or P(HEMA-co-HPMA-co-NVP) chains were interpenetrated into the cross-linked three-dimensional networks of PEG. It was found that albumin adsorption onto the contact lens prepared by P(HEMA-co-HPMA-co-NVP)/PEG IPN decreases with an increase of molecular weight of PEG. Also, it was found that albumin adsorption onto the both contact lens decreases with an increase of concentration of PEG macromer in the IPN preparation. There are also more adequate in the biointerness for the contact lens by P(HEMA)/PEG IPN or P(HEMA-co-HPMA-co-NVP)/PEG IPN than that by P(HEMA) or P(HEMA-co-HPMA-co-NVP).

다운홀 시험결과의 신뢰도 향상을 위한 자료해석법

조명진,장대우,조성호 中央大學校 建設環境硏究所 2002 環境科學硏究 Vol.13 No.1

파의 부정확한 도달시점에 의해 전단파의 속도가 결정된다면, 동적 탄성계수 또한 부정확하게 된다. 반면, 전단파의 도달시점을 정확히 결정하여 전단파 속도 측정의 정확성을 향상할 수 있다면, 상대적으로 신뢰성이 작지만, 경제적이고 효율적인 다운홀 실험의 적용성을 극대화시킬 수 있다. 따라서, 본 연구에서는 다운홀 시험에서 전단파 속도를 가장 정확하게 결정하는 방법을 결정하기 위해서 현재 적용가능한 도해법, 최대곡률법, 상호교차법, 상호상관법, 위상속도법 등을 비교검토하였다. 또한, 각 깊이에서의 전단파 전파시간으로부터 전단파 속도 주상도를 결정하기 위한 다운홀 해석법인 직접법, 수정 간접법, 역산 해석법 등과 신뢰도가 높은 SASW실험결과를 비교하였다. 그 결과 전달파 전파시간의 결정은 최대곡률법과 교차상관법이 적합한 것으로 판단되었고, 다운홀 해석 법으로는 Snell 법칙을 이용하는 역산해석 법이 신뢰도가 높은 것으로 판단되었다. In case of visual measurement of velocity, there is a potential error for the arrival point of shear wave. Consequently, the error causes incorrect results in the evaluation of dynamic modulus. The disadvantage of downhole test can be improved, if the velocity of shear wave is exactly chosen by arrival point of the wave. Thus, in this study, visual method, cross-over method, cross-correlation method and phase of cross spectrum method were used to find the most reliable procedure for the determination of the S-wave velocity Also, to provide the reliable interpretation procedure to evaluate the S-wave velocity profile from travel times at depths, the results of the direct method, the modified interval method, arid the inversion method were compared with the results of SASW measurments. As a result, the modified interval method and the inversion method based on Snell's method turned out to be the reliable procedures to determine the S-wave velocity profile from the travel times of the S-wave at depths.