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        • 위 유문동 평활근 세포에서 Caffeine에 의해 활성화되는 이온 전류에 관한 연구

          정인원,이무열,방효원,엄대용,이상돈 중앙대학교 의과대학 의과학연구소 1992 中央醫大誌 Vol.17 No.3

          In order to clarify the existence of the non-selective cationic channel of CI^- -channel in gastric antral smooth muscle cells which suggested to play a critical role in generation and maintenance of depolarization and exitability, the whole cell mode of patch-clamp experiment was conducted. Following results were obtained ; 1. Puff injection of caffeine induced the increase of inward currents in the hyperpolarized holding potential ranges, and the increase of outward currents in the hypopolarized range. 2. In the case of blocking of all known currents, these current components were observed. 3. These current components were disappeared when known as a Cl^- -channel blocking agent was treated and intracellular EGTA concentration was increased. The above results could be concluded that these current components strongly suggested as a Ca^2+ -dependent Cl^- current in the gastric antral smooth muscle cells.

        • KCI등재

          알코올 의존 환자에서의 Aldehyde Dehydrogenase II와 CYP2E1 유전자 다형성과 임상적 특성간의 연관성

          정인원,김영랑,지경환,김헌,Chung, In-Won,Kim, Yeoung-Rang,Chi, Kyung-Hwan,Kim, Heon 대한생물정신의학회 2002 생물정신의학 Vol.9 No.1

          Objective:This study was to explore the relation of genetic polymorphisms of ALDH2 and CYP2E1 to clinical characteristics of alcoholic patients and alcohol induced liver damage. Methods:The genotype and allele frequencies of 128 male hospitalized patients who met DSM-IV criteria for alcohol dependence were compared with 128 healthy male control subjects. The genetic informations of ALDH2 and CYP2E1 were identified with the technique of polymerase chain reaction and restriction fragment length polymorphism. The clinical characteristics of the alcoholic patients were assessed and analyzed in relation to the family history of alcoholism. For the relation of CYP2E1 genetic polymorphism to the liver damage, the blood levels of various liver function indicators such as ALT, AST, and protein were checked out. Results:1) The alcoholic patients with the family history of alcoholism had the earlier onset of age (p=0.001), the longer duration of illness(p=0.045), and higher NCA scores(p=0.018) than those without the family history of alcoholism. 2) Most alcoholic patients were homozygous for $ALDH2^*1$, compared to control subjects.(p=0.000) 3) There was no difference of CYP2E1 distribution between alcoholic patients and control subjects. However, alcoholic patients having mutant c2 allele showed higher alcoholism severity scores(p=0.004) and more hospitalizations(p=0.014) than those having c1 allele. 4) There was no relationship between CYP2E1 genotype and the functional abnormalities of the liver. Conclusion:This study suggests that $ALDH2^*1$ is highly related with alcohol dependence. Also mutant c2 allele of CYP2E1 is correlated with the severity of alcoholism and the number of hospitalization. But genetic polymorphim of CYP2E1 seems to have no relation to liver damages.

        • KCI등재

          폭력과 자살의 병리와 치료에서 세로토닌의 역할

          정인원,Chung, In-Won 대한생물정신의학회 1997 생물정신의학 Vol.4 No.2

          Along with psychosocial factors of suicide, biological backgrounds of suicide are explored by extensive works mostly on biological markers, neurobiological models, genetic bases, and relationships with aggression and violence. The biology of suicide confers on neurotransmitters in central nervous system exploring metabolites, receptor binding affinities, neuroendocrine challenge tests in brain, cerebrospinal fluid, blood and etc. The major concerns with suicide are focused mainly on serotonin system : low CSF 5-HIAA concentration, higher $5-HT_2$ receptor binding, and blunt prolactin response to fenfluramine. Postmortem study, in vivo study, genetic contributions, and some other issues such as suicidal methods, serum cholesterol, alcohol, and selective serotonin reuptake inhibitors are reviewed and discussed.

        • KCI등재후보

          향정신성 약물의 입체이성질체

          정인원 대한정신약물학회 2003 대한정신약물학회지 Vol.14 No.1

          Many psychotropic drugs are marketed and prescribed as a racemate form in a mixture of the stereoisomers. A chiral center or a center of unsaturation of carbon atoms in the chemical structures creates various stereoisomers of the psychotropic drugs, including antidepressants such as fluoxetine and venlafaxine, etc. The stereochemical significances of enantiomers on the pharmacokinetics and pharmacodynamics of several psychotropic drugs and their relationships with pharmacogenetic polymorphisms were reviewed. The single enantiomer drugs will be increasing more in the market shares replacing the racemic drugs by chiral switching, which is driven by the development of the analytical and preparative resolution techniques and will be of much benefit to the treatment from low dosages, simple dose-response curve, few adverse reactions, and so on.

        • KCI등재후보

          향정신성 약물의 맞춤형 약물치료

          정인원,이규영 대한정신약물학회 2002 대한정신약물학회지 Vol.13 No.3

          The pharmacotherapeutic responses such as clinical efficacy and adverse events exhibit wide variabilities in individuals and even in different races and populations. The human genetic diversity has been known as the one of the main factors in the variations of drug responses expressed in the area of pharmacokinetics and pharmacodynamics. Polygenetic implications have been suggested in the pathophysiology of psychiatric disorders. The risks in psychiatric disorders could be explored by combining the polymorphisms of multiple candidate genes. This suggests that drug therapy should be tailored to the genetic make-up of the individual. The emerging field of pharmacogenomics could be a landmark for the development of more effective clinical efficacy and less adverse events by individually tailored drugs.

        • 항정신병약물이 정신분열병 증상에 미치는 영향 : 리스페리돈과 할로페리돌의 임상적 효과 비교

          정인원 충북대학교 의과대학 충북대학교 의학연구소 1999 忠北醫大學術誌 Vol.9 No.2

          연구목적: 비정형 항정신병약물과 정형 항정신병약물을 비교하기 위해서 risperidone과 haloperidol의 임상효과와 부작용에 대한 후향성 개방 연구를 수행하였다. 대상 및 방법: 20명의 정신분열병환자를 대상으로 나이와 성별을 일치시켜 두 치료집단을 나누어 4주간 정신 증상을 측정하였다. 환자의 정신 증상은 정신분열병의 양성 음성 증후군 척도(PANSS), 단기 정신증 척도(BPRS), 해밀턴 우울 척도(HAMD), 해밀턴 불안 척도(HAMA), 전반적 공격성 척도(OAS), 예일-브라운 강박 척도(YBOCS)등을 사용하였다. 약물의 부작용은 추체외로 증상 평가 척도(ESRS)와 비정상적 불수의 운동 척도(AIMS)로 측정하였다. 결과: 두 치료 집단 모두에서 임상 증상의 호전을 보였다. 그러나 집단간에 증상 호전의 차이는 보이지 않았다. 그 외 추체외로 증상 및 부작용도 차이를 보이지 않았다. 결론: 비정형성 항정신병약물인 risperidone은 정신분열병환자의 치료에서 적어도 4주간의 치료 초기에는 정형 항정신병약물인 haloperidol에 비하여 우월한 임상 효과를 보이지 않았다. Purpose: A retrospective open clinical study was conducted to evaluate the clinical efficacy and the side effect of atypical antipsychotics in comparison with conventional antipsychotics. Materials and Methods: Twenty schizophrenic patients were divided to two groups and assessed the psychopathology once a week for four weeks. The symptoms were assessed by means of the Positive and Negative Syndrome Scale for Schizophrenia (PANSS), the Brief Psychotic Rating Scale (BPRS), the Hamilton Depression Rating Scale (HAM-D), the Hamilton Anxiety Rating Scale (HAM-A), the Overt Aggression Scale (OAS) and the Yale-Brown Obsessive Compulsive Scale (YBOCS). The side effects were assessed by the Extrapyramidal Symptom Rating Scale (ESRS) and the Abnormal Involuntary Movement Scale (AIMS). Results: The results indicated that two antipsychotics, risperidone and haloperidol showed improvements of clinical symptoms for four weeks of treatment. And any differences between two groups were not found. Conclusion: This study suggests that the superiority of risperidone over haloperidol is not apparent during the initial period of antipsychotic treatment.

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