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오병훈,박재형,유동길,임경택,이정미 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-
Extracellular vesicle(EV) has highlighted as a therapeutic nanomedicine to intractable diseases because it plays an essential role in cell-to-cell communications. However, their poor circulation properties limit the therapeutic potential of EVs. To overcome this issue, we developed surface-engineered EVs(S-EVs) based on the modification of EV-donor cell surfaces. The S-EVs were prepared by ultracentrifugation and characterized by nanoparticle tracking analysis, flow cytometry, and transmission electron microscopy. Notably, they showed enhanced targeting efficiency for tumor and rheumatoid arthritis mice models compared to control EVs owe to not only a passive- but also an active-targeting process. These results suggest the methodology to engineered exosome surface as a powerful tool for targeting intractable diseases.
정상인,정신분열증 및 우울증환자에서 한글의 시각적인식과 관련된 대뇌반구의 비대칭성
오병훈,민성길,장환일 대한신경정신의학회 1990 신경정신의학 Vol.29 No.4
Hemispheric asymmetry in recognition of Hangul words was investigated in 33 normal subjects and 33 schizophrenic and 33 depressive patients who were physically healthy. Using a computer program and a computer monitor with very short decay time, Hangul words were presented to the right or left visual field at 3° from the central fixation point for 150 msec. Each subject was instructed to respond with his right or left hand respectively immediately upon the recognition of the tachistoscopically presented word as either the same as or different from the word presented just later the middle of visual field. Each subject had 48 practices and 48 examined trials. The procedures were randomized and counterbalanced. The reaction time and the rates of correct response were measured. The means of medial value of reaction time and the means of correct response in each of 4 units of 2 visual field conditions x 2 association value conditions were statistically compared. 1) the reaction time was significantly faster in the normal group than in the schizophrenic and depressive group. There as no difference between the two visual fields but there was a tendency of slower reaction time in the right visual field in the schizophrenic group and in the left visual field in the depressive group. The reaction time in the right ipsilateral conditionOeft hemisphere) was significantly slower in the schizophrenic group, and in the left ipsilateral condition(right hemisphere), it was significantly slower in the depressive group. 2) The correct response rate was significantly higher in the normal group than in the schizophrenic and depressive group. There was a significantly interaction between the two visual fields; higher rate was observed in the right visual field. There was a strong tendency of right visual field superiority in the normal group but right visual field inferiority in the schizophrenic group. In conclusion, the results suggest that the left hemisphere was superior to right hemisphere in recognition of Hangul words and that schizophrenia is related with dysfunction of the left hemisphere and depression is related with dysfunction of the right hemisphere
Neurocognitive Function Assessment of Traumatic Brain Injury
오병훈,Oh, Byoung Hoon The Korean Society of Biological Psychiatry 1995 생물정신의학 Vol.2 No.2
외상후 뇌손상은 대표적이며, 가장 중요한 신경정신계 질환의 하나이다. 더욱이 외상후 뇌손상 환자들은 각종의 사고 및 산업재해 등으로 인해 그 수가 급증하고 있으며, 특히 인지기능의 장애로 인한 다양한 기질성 정신장애로 고통을 겪게 된다. 따라서 외상후 뇌손상은 손상의 시점에서부터 정확하고 올바른 평가는 물론 손상후의 경과 및 치료대책의 수립에 있어서 체계적이며 종합적인 신경인지기능의 평가는 필수적이다. 왜냐하면 신경인지기능평가는 뇌의 손상부위와 이와 관련된 기능장애 및 행동의 변화에 대한 객관적인 자료를 제시해 주기 때문이다. 신경인지기능 평가의 영역은 지각, 운동기능은 물론 주요인지기능인 기억, 언어, 실행 및 감정조절능력에 이르기까지 다양하며, 외상후 뇌손상환자들은 손상부위 및 정도에 따라 신경인지기능의 장애를 초래하게 된다. 대표적인 신경인지기능평가 도구로는 KWIS, Halstead-Reitan, Luria-Nebraska batteries, 특히 전두엽기능검사인 Wisconsin Card Sorting Test (WCST)를 비롯하여, 현재는 PC/S Vienna Test System 및 Stim등의 각종 전산화 인지기능검사가 개발되어 임상에서 활발히 사용되고 있다. 즉 외상후 뇌손상환자를 위한 신경인지기능평가의 목적은 뇌손상과 관련된 신경인지기능장애를 정확히 평가하여, 환자 개개인에 적합한 인지재활치료 계획을 수립하는데 있다. 물론 여기에는 신경정신상태검사(neuropsychiatric mental status examination)를 통하여 외상 후 뇌손상의 경과 및 예후에 결정적인 영향을 미칠 수 있는 나이, 의식소실 및 외상후 기억 손상 시간의 정확한 측정은 물론 심리 사회 문화적인 상태와 두부외상전 환자의 지적수준 및 사회 적용기능이 함께 평가되어야 할 것이다.