무의촌 봉사 활동 이대로 좋은가?

한양대학교 의과대학 학생회 한양대학교 의과대학 학생회 1981 杏堂醫烽 Vol.- No.2

간 흡충증에 관한 조사; 한양대학병원에서 진단된 환자를 중심으로

任敬一,安明姬 한양대학교 의과대학 1985 한양의대 학술지 Vol.5 No.1

1983년 한해동안 한양대학병원에 내원한 환자의 총 대변검사 8,561례중에서 187례의 간흡충환자를 찾을 수 있었다. 연령별로는 40대, 50대가 51.3%로써 가장 많았으며 성별비는 5.7 : 1로 남자가 월등히 많았다. 경 또는 중등도 감염이 전체 간흡충증 환자의 87.5%로 대부분이었고 감염정도와 말초혈액의 호산구증다간에는 상관성이 있었다. 입원환자의 주된 동반 질병은 소화기질환이었으며 간흡충증환자에 대한 치료시행이나 치료후 추적연구가 불충분하였다. Total 187 cases of Clonorchiasis were detected out of 8,561 samples which were examined by the formalin-ether concentration method and Stoll's egg counting method, among the patients visiting Hanyang University hospital, from January to December, 1983 in Seoul. This study was undertaken to reveal the change of clinical pattern of Clonorchiasis, comparing with the previous reports. 1. The highest prevalence of Clonorchiasis was found in the 40 - 49 years group. And sex ratio of male vs female was 5.7:1. 2. Light and moderate infection cases, less than 9,999 in E.P.G., were detected 87.1% out of total cases tested. 3. There was a good correlation between the degree of peripheral blood eosinophilia and E.P.G. (coefficient 0.65) 4. Among the associated diseases of inpatients, gastrointestinal diseases were frequently involved. 5. Follow-up study after anthelminthic treatment was carried out unsatisfactorily.

大學文化에 關한 小考

오창석 한양대학교 의과대학 학생회 1983 杏堂醫烽 Vol.- No.3

신증후군, 단클론성 감마병증 및 다발성 골용해 병변으로 발현한 소형 림프구성 림프종 1예

유준호,안명주,김호중,이웅수,박용욱,박문향 한양대학교 의과대학 1999 한양의대 학술지 Vol.19 No.2

We reported here a 70-year-old woman with small lymphocytic lymphoma who was initially presented with recurrent nephrotic syndrome and later developed multiple bone lytic lesions and monoclonal gammopathy, mimicking plasma cell dyscrasia and only involving bone marrow without lymphadenopathy or hepatosplenomegaly. She responded to combination chemotherapy, including cyclophosphamide and prednisone with proteinuria disappearing. The unusual features of this case includes : (1) nephrotic syndrome of minimal change lesion as the initial manifestion in lymphocytic lymphoma, (2) only bone marrow involvement of lymphoma without organomegaly or lymphadenopathy, (3) the presence of multiple bone lytic lesions in conjunction with monoclonal gammopathy in a patient with lymphoma rather than multiple myeloma.

폐이식의 실험적 쥐모델

정원상 한양대학교 의과대학 1998 한양의대 학술지 Vol.18 No.2

In studies concerning lung transplantation, the dog has been used as the main experimental animals, chiefly historical reasons, but also because lung transplantation in smaller animals is technically more difficult. But as above mention, organ transplantation in the rats was made possible by development of microsurgery and anesthesia in the last two decade, pioneered by Dr Lee. And also was due to the availability of very thin suture materials(8-0, 9-0, 10-0 ethicon or nylon suture etc). But, the intensive training needed for microsurgical training is illustrated by steadily improving perioperative survival in the course of our experiment.

알레르기성 비염환자에서 레이저 하비갑개 소작술의 증상개선효과에 관한 연구

김경래,이형석,박철원,이승환,박준수 한양대학교 의과대학 2000 한양의대 학술지 Vol.20 No.1

Allergic rhinitis is conventionally treated with anti-histamine or immunotherapy, although in many cases the results are unsatisfactory. Using a CO_2 laser we have succeeded in relieving the symptom of rhinitis by thermocoagulating only the inferior turbinate, making this a quick and effective form of treatment. The subjects were 82 patients with house-dust induced allergic rhinitis presented to the out-patient clinic of the otolaryngology department of Hanyang University Hospital. There were 37 men and 45 women ranging in age from 16 to 47 years. Patients were irradiated at an output of 7-9 W of CO_2 laser. Prior to the procedure, surface anesthesia was applied using 10% lidocaine. The irradiation was completed in three time. The effects of this therapy were evaluated using 4 points to express the degree of subjective symptoms and intranasal findings. From one week before surgery the patients was asked to record symptoms (sneezing, rhinorrhea and obstruction). After surgery, the effects were evaluated by adding up the total scores for sneezing, rhinorrhea and obstruction at one week intervals. Full effect including disapprearance of symptoms, was obtained in 80%, good effect in 10%, fair effects in 5% and no effect in 5%.

선상 태선과 편평 태선의 면역조직화학적 소견에 대한 비교 연구

노영석,권상진 한양대학교 의과대학 2000 한양의대 학술지 Vol.20 No.1

Lichen striatus(LS) is an uncommon linear eruption characterized by discrete, flat-topped lichenoid papules resembling lichen planus(LP). The histologic picture of LS is nonspecific and shows so many remarkable variations that it can be easily misinterpreted. In the present study, we have evaluated the immunohistochemical aspects of 10 cases of LS and 4 cases of LP using paraffin-embedded section to evaluate if they are useful when differentiating LS from LP is difficult in clinically and histopathologically. There was no significant difference of CD4 and CD8 expression between LS and LP. In all cases focal reactivity for HLA-DR was confined to keratinocytes adjacent to the HLA-DR+ dermal lymphoid infiltrates except one case of LS in which HLA-DR was expressed on the surface of keratinocytes in diffuse pattern. There was a marked increase in S-100^- epidermal Langerhans cell in LP rather than LS.

세포막 Capacitance 측정을 이용한 단일 백서 췌장 β 세포의 분비기전 연구

박용수,이창범,김동선,최웅환,안유헌,김태화 한양대학교 의과대학 2000 한양의대 학술지 Vol.20 No.1

The relationship between depolarization-induced exocytosis and inward Ca^2+ current (I_ca) in single isolated rat pancreatic β cells was investigated in perforated patch recordings. I_ca was elicited by depolarization and change in cell membrane capacitance (C_m) was monitored as an indicator of resultant exocytosis. Although there was significant variety of change in C_m and Ca^2+ influx, the increase in C_m had positive correlation with Ca^2+ influx and also with duration of depolarization. Removal of extracellular Ca^2+ or inclusion of extracellular Cd^2+ (100uM) completely eliminated both I_ca and increase in C_m following depolarization. Dihydropyridine(DHP), Ca^2+ channel blocker (5uM) partly and in parallel suppressed depolarization-induced peak I_ca, Ca^2+ influx, and change in C_m. These data suggest that rat pancreatic β cell expresses at least two types of Ca^2+ channels; Ca^2+ entry through these DHP-sensitive, presumably L-type, and DHP-insensitive channels trigger exocytosis with similar efficacy.

2시간 및 6시간 허혈시킨 흰쥐의 가자미근에서 재관류 시간경과에 따라 나타나는 SOD 활성변동에 대한 연구

황규성,안동춘,서윤경,백두진,정호삼,노원재,이문구 한양대학교 의과대학 2000 한양의대 학술지 Vol.20 No.1

It has been well known that ischemia reperfusion injury to skeletal muscle following an acute arterial occulusion causes significant morbidity and mortality. The skeletal muscle, which contains high energy phosphate compounds, has ischemic tolerance. During the ischemia, the ATP is catalyzed to hypoxanthine anaerobically and hypoxanthine dehydrogenase is converted to xanthine oxidase. During reperfusion, the hypoxanthine is catalyzed to xanthine by xanthine oxidase undr O_2 presence and that results in production of cytotoxic oxygen free radicals. So, the damage of skeletal muscle occrus during reperfusion. The permeability of the capillary, one of the major phenomenon in injured muscle, is increased by reactive oxygen released from the neutrophils and the arachidonate metabolites, which are catalyzed from the lipid component of the membrane structures by lipooxygenase during reperfusion. The reversible changes in the muscle occur after 2hours of ischemia and reperfusion and recover within 24 hours. The irreversible damage, which is necrosis of muscle, occurs after 6 hours of ischemia and reperfusion. The reactivity of superoxide dismutase(SOD), one of the antioxidant enzymes is increased against the formation of superoxide radical during the reperfusion. The SOD metabolizes the superoxide radical to H_2O_2 and O_2. There are two types of SOD in the cell. The one of them is Cu,Zn-SOD in the cytoplasm and the other is Mn-SOD in the mitochondria. The author performes the present study to investigate the changes of SOD immunoreactivities in the soleus muscle of the rat after 2 hours or 6 hours of ischemia and timely reperfusion. A total of 88 healthy Sprague-Dawley rats weighing from 200 gm to 250 gm were used as experimental animals. Under urethane(3.0g/kg., i.p.) anesthesia, lower abdominal incision was made and left common iliac artery were ligated by using vascular clamp for 2 hours. Soleus muscles were obtained at 0 hour, 1 hour, 2 hours, 24 hours 48hours after the removal of vascular clamp. The specimens were sectioned in 14㎛ thickness with cryostat. The immunoreactivities of SOD by use of anti human Cu,Zn- and Mn-SOD antibodies were observed. The results were as follows. 1. The immunoreactivities of SOD around sarcolemma were stronger than those in the sarcoplasm. 2. The immunoreactivities of SOD in the soleus muscles decreased a little after 2 hours of ischemia and increased markedly after 6 hours of ischemia. 3. The immunoreactivities of Cu,Zn-SOD in the soleus muscle increased after 2 hours or 6 hours of ischemia and timely reperfusion. The immunoreactivities of Cu,Zn-SOD in the 6 hours of reperfused group were highest after 2 hours of ischemia. Those in the 2 hours of reperfused group were highest after 6 hours of ischemia. At 48 hours of reperfusion, immunoreactivities of Cu,Zn-SOD recovered after 2 hours of ischemia and those kept higher reactivities after 6 hours of ischemia. 4. The immunoreactivities of Mn-SOD in the soleus muscles increased after 2 hours or 6 hours of ischemia and timely reperfusion. At 48 hours of reperfusion, immunoreactivities of Mn-SOD recovered after 2 hours of ischemia and those were increased markedly after 6 hours of ischemia. These results suggest that the immunoreactivities of SOD increased after 2 hours or 6 hours of ischemia and timely reperfusion. At 48 hours of reperfusion the immunoreactivities of SOD recover after 2 hours of ischemia and keep higher reactivities after 6 hours of ischemia.

만성 바이러스성 간염의 치료

이민호 한양대학교 의과대학 1998 한양의대 학술지 Vol.18 No.1

Chronic viral hepatitis is the principal cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma. In Korea, of the known hepatits viruses, two can chronic hepatitis: the hepatits B virus(HBV) and the hepatits C virus(HCV). In chronic hepatitis B, a 4-6 month course of interferon alfa is effective in inducing clearlance of HBV DNA and HBeAg from serum and an improvement in serum transaminase concentration. New approaches to theraphy for hepatitis B include lamivudine and famiciclovir. In chronic hepatitis C, characterized by an indolent course, but with the potential for development of serious consequences. At present, the only approved agent is interferon alfa, with a sustained biochemical response rate of 10-22%. New approach to therapy for hepatitis C include combination theraphy with interferon alfa and ribavirin. In this article, strategies for treatment development of chronic B hepatitis and chronic C hepatitis are reviewed.