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        • KCI등재

          한국에서의 도시 및 농촌아동의 신체상의 비교연구

          정희연 大韓神經精神醫學會 1976 신경정신의학 Vol.15 No.1

          '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

          For the purpose of comparative study of the body image between urban and rural children in Korea, the author administered Machover's draw-a-person test to 100 cases of urban children and 100 cases of rural children. As a scoring system the author adopted Ootomo's system of problem indices and symbolic factor analysis. The result obtained were as follows: 1. The age distribution of these two groups were similar and the average age of the urban children was 9.2 years and the rural children 8.6 years. Among the urban group first and last born children were more than among rural group and the rural one have more family members than the urban. The urban children supposed to have the opportunities of having more civilized facilities than the rural children. 2. Results of the analysis of the portraits which were drawn by the two groups are as follow; On the age of their drawn portraits the rural one designated 9 to 10 years. As to the impression of the portraits which they drawn almost of the rural children sad, "I don't like it.". To the question of the portraits future career the answer of the urban one were teacher or scientist, on the other hand, the rural one farmer or worker. 3. The analysis of the drawing place revealed that most of the rural children drew on the left side of the upper part. Comparing the size of the portrait, the urban children drew bigger than the rural children, and the majority of the rural children drew in profile. 4. As to the characteristics of the bodily parts of their portraits, the urban children's portraits showed emphasized hair, emphasized pupil, omitted nose, omitted eyebrow, figures being omitted leg and foot, elaborated clothes and figure with necktie. The rural children's portraits showed omitted pupil, emphasized nostril, large mouth and mouth with showing teeth, square body, thin arm and finger without hand, figure with navel, poor discrimination of sexes, hardly distinguishable line of clothes. 5. From these results the differences of personality characteristics between rural children and urban children supposed to be as follows; The rural children exhibit more oral aggressiveness, tendency of striving for physical strength, poor sexual identity, more dependent need and self centric tendency. Instead the urban children exhibited the tendency of striving intellectual power, alertness and interests toward his environment, more active attitude but insecurity of their sense of belongingness.

        • KCI등재

          백서 해마에서 카이닌산에 의한 조기유전자의 발현과 p42, p44 MAPK 및 Elk-1 인산화의 발달 단계에 따른 변화

          정희연,김수진,김종흔,정선주,박주배,김용식,조수철 대한신경정신의학회 1999 신경정신의학 Vol.38 No.4

          '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

          연구목적: 어린 백서에게 카이닌산(kainic acid, KA)을 주사하여 발작을 일으킨 후, 해마에서 조기유전자 -c-fos, junB, 및 TIS1의 발현 유도 양상을 발달 단계별로 조사하여 전기경련충격(electroconvulsive shock, ECS) 에서의 결과와 비교함으로써 백서 뇌 신호전달계의 성숙과정을 파악하고자 하였다. 그리고 KA 주사후 p42, p44 mitogen activated protein kinase(MAPK)의 인산화 및 그에 의해 활성화되는 것으로 알려진 전사인 자 Elk-1의 인산화를 관찰하여, KA 주사후 MAPK 신호전달계를 통한 c-fos의 발현 경로를 발달 단계별 로 밝히고자 하였다. 방 법: 생후 7, 14 21일 된 수컷 백서에서 KA를 복강내 주사한 후, 백서 해마에서 조기유전자의 발현 양상은 northern blot analysis로, p42, p44 MAPK와 Elk-1의 인산화는 immunoblotting으로 관찰하였다. 결 론: 생후 7일된 백서의 해마에서는 ECS와는 달리, KA에 의한 세 가지 조기유전자의 발현이 관찰되지 않았다. 그 러나 생후 14일부터 이들 조기유전자의 뚜렷한 발현을 관찰할 수 있었고 생후 21일에는 성숙한 백서와 같은 수준의 발현 양상을 볼 수 있었다. 세 가지 유전자 모두 백서의 연령과 KA 주사 후 시간에 따른 발현 유도 양상은 비슷하였다. p42, p44 MAPK는 생후 7일부터 상당한 수준의 기저치 인산화가 관찰되었으나, KA에 의 한 인산화 증가는 생후 14일부터 관찰되었다. Elk-1의 인산화 역시 생후 7일부터 높은 수준으로 관찰되었 으나 KA 주사 후 시간에 따른 Elk-1 인산화의 변화는 관찰할 수 없었다. 결 론: ECS와 KA가 조기유전자 발현 양상에 차이를 보이는 것은 이들 유전자의 발현과 관련되어 활성화되는 신 호전달경로의 차이 때문으로 생각된다. 백서 해마에서 KA에 의한 MAPK 활성화에 관여하는 신호전달 기구 는 연령이 높아짐에 따라 점차 성숙하고, MAPK의 활성화로 전달된 신호는 Elk-1 이외의 다른 경로를 통 해 c-fos 발현을 조절하는 것으로 추측된다 Objectives:In order to investigate the maturational process of intracellular signal transduction system in rat brain, we studied the induction of the immediate early genes(IEGs)-c-fos, junB, and TIS1 in each developmental stage after kainic acid(KA)-induced seizure in young rat hippocampus and then compared these with the results after electroconvulsive shock(ECS). And to elucidate the induction mechanism of c-fos via mitogen-activated protein kinase(MAPK) by KA in each developmental stage, we investigated the phosphorylation of p42, p44 MAPK and Elk-1 after KA treatment in young rat hippocampus. Methods:We examined the induction patterns of IEGs by northern blot analysis, and the phosphorylation of p42, p44 MAPK and Elk-1 by immunoblotting in rat hippocampus at post-natal day 7, 14, and 21(P7, P14 & P21), respectively after intraperitoneal injection of KA. Results:Unlike ECS, KA did not induce c-fos, junB, and TIS1 in P7 hippocampus. But these genes were apparently induced at P14 and to an adult level at P21. These three IEGs showed similar temporal patterns of induction in each developmental stage. Although the basal level of phosphorylated 42p, 44p MAPK was considerable in P7 rat hippocampus, the increase of phosphorylation after KA treatment was observed at P14 . While the phosphorylation of Elk-1 was detected with high basal level in P7 rat, the amount of phosphorylated Elk-1 was not changed after KA treatment. Conclusion:Our results suggest that the differences in IEGs induction patterns between KA and ECS may be due to the differences in the activated signal transduction pathways. And our results also implicate that the signal transduction system involved in MAPK phosphorylation after KA treatment mature with aging and c-fos induction via MAPK activation may be regulated through some pathways other than Elk-1 in rat hippocampus

        • KCI등재

          정신분열병 환자에 있어서 가족력과 임상유형(Type I, Type II)에 따른 안구추적운동의 차이

          정희연,임두원,권영준,주경수,서미경,김동수,Jeong, Hee Yeon,Rheem, Doo Won,Kwon, Young Joon,Joo, Gyung Soo,Seo, Mi Kyoung,Kim, Dong Soo 대한생물정신의학회 1995 생물정신의학 Vol.2 No.2

          Smooth pursuit eye movement, one of the reliable biological markers of schizophrenia, is not always abnormal in schizophrenic patients. Therefore the authors studied it in schizophrenic patients and normal controls and compared the results according to the presence or abscence of family history of psychosis and types (type I and type II). The results are as follows: 1) In the 18 normal control group (8 mole, 10 female), there was no sex difference in the responses of smooth pursuit eye movement. 2) In th 44 schizophrenic group (28 male, 16 female), there also was no sex difference in the responses of smooth pursuit eye movement. 3) In comparison of 44 schizophrenic group to 18 normal control group, there was significantly increased abnormal response in smooth pursuit eye movement in schizophrenic group (P < 0.005). 4) In schizophrenic group, there was no difference in the responses of smooth pursuit eye movement between type I and type II schizophrenia. 5) The presence or abscence of family history of psychosis made no difference in the responses of smooth pursuit eye movement in schizophrenic group. 6) Subdivision of type I or type II in each case of presence or abscence of family history made no difference in the responses of smooth pursuit eye movement in schizophrenic group.

        • KCI등재

          한국어 온라인 동영상 수업에 대한 학습자 인식 조사 연구

          정희연,윤지원 사단법인 아시아문화학술원 2020 인문사회 21 Vol.11 No.3

          This study aims to verify the problem of online video lectures which had carried out amid the Covid-19 pandemic situation of the Korean language institute and to propose the solution through the student’s perception by the student survey. It presents the online video lecture case of the Korean Language Institute of P University in Daejeon, the analysis of student’s perception, and the satisfaction of online video lectures. 125 students responded to the survey, by the result of the survey, it showed that the preferred subject was the grammar and listening, whereas reading and speaking lecture was not preferred. It had identified the positive and negative opinion on online video lecture through the written responses. The meaning of this study is that its result will be contributed as the foundation for the development of online content and the online video lecture in Korean Education because student opinion came after they had experienced online video lectures for 7 to 8 weeks. 본 연구는 코로나바이러스19로 인해 온라인 동영상으로 이루어진 한국어 수업에 대한 학습자 인식을 통해 온라인 한국어 수업의 문제점을 확인하고 해결 방안을 제안하는 데 목적이 있다. 이를 위해 대전 소재 P대학교 한국어교육원의 온라인 동영상 수업 사례를 소개하고, 이에 대한 학습자 인식 및 만족도를 조사한 결과를 분석하여 제시하였다. 총 125명의 학생이 응답하였으며, 연구결과를 보면 온라인 동영상 수업으로 문법과 듣기 수업을 선호하고 있었다. 읽기와 말하기 수업에 대한 선호도는 낮은 것으로 나타났다. 또한 주관식 응답을 통해 원격수업에 대한 학습자들의 긍정적 의견과 부정적 의견을 확인하였다. 본 연구에서 확인한 학생들의 의견은 7주, 8주간의 원격수업을 직접 경험한 후에 작성한 것으로 한국어교육에서 진행되는 원격수업과 온라인 콘텐츠 개발 및 발전에 도움이 되는 기초자료로서 의의를 가진다.

        • KCI등재

          산조인이 백서 뇌에 미치는 영향 - 세로토닌, 수면시간, 수면뇌파, 자동운동을 중심으로 -

          정희연,권영준,박인준,권준택,한병훈,이성필,Jeong, Hee-Yeon,Kwon, Young-Joon,Park, In-Joon,Kwon, Joon-Taek,Han, Byung-Hoon,Lee, Sung-Pil 대한생물정신의학회 1997 생물정신의학 Vol.4 No.1

          Objects : Sanjoin, the seeds of Zizyphus vulgaris var. spinosus has been used as the most important hypnotic agent in chinese medicine to treat insomnia. This research was performed in order to examine the effect of betulinic acid and sanjoinine-A which are components of Sanjoin. Method : Sleeping time, sleep recordings of EEG, EMG, serum serotonin level, and locomotor activity were measured in rats which received betulinic acid and sanjoinine-A as sleep induction material extracted from Sanjoin. Results : 1) Groups received betulinic acid, sanjoinine-A, and lorazepam showed increased sleep time than control group with saline. 2) Groups with betulinic acid, sanjoinine-A, lorazepam and saline recorded ${\beta}$-wave in sleep recordings of EEG. In EMG, there was no significant difference among all groups. 3) No significant difference in serum serotonin level among all groups was found. 4) In autonomic activity testing, groups of betulinic acid, sanjoinine-A, and lorazepam showed significantly more decreased in activity than saline group. In comparison of groups of betulinic acid and sanjoinine-A with a group of lorazepam, there was no significant difference. Conclusion : These results suggest that betulinic acid and sanjoinine-A have the sedative effect like lorazepam rather than sleep effect.

        • KCI등재

          주정의존 환자에서 초발연령에 따른 ${\beta}$-Endorphin의 반응

          정희연,박인준,김진만,진혁희,Jeong, Hee-Yeon,Park, In-Joon,Kim, In-Man,Jin, Hyuk-Hee 대한생물정신의학회 1998 생물정신의학 Vol.5 No.1

          정상대조군 29명 및 남자 주정의존 환자 48명을 발병연령에 따라 분류하여 입원 7일 후 오전 9시에 알코올 0.75gm/kg을 투여하기 전후의 혈중 ${\beta}$-endorphin농도, alcohol농도, cortisol농도, 그리고 혈당을 측정하여 비교한 결과는 다음과 같다. 1) 25세 이전과 25세 이후에 발병한 환자군의 비율은 약 2 : 3이었다. 2) 25세 이전과 25세 이후에 발병한 두 환자군간에 입원 당시의 연령은 차이가 없었다. 3) 25세 이전과 25세 이후에 발병한 두 환자군과 정상대조군에서 알코올 투여 후 혈중 알코올의 농도변화는 세 군간에 차이가 없었다. 4) 25세 이전과 25세 이후에 발병한 두 환자군과 정상대조군에서 알코올 투여 후 혈중 ${\beta}$-endorphin의 농도변화는 세 군간에 차이가 없었다. 5) 25세 이전과 25세 이후에 발병한 두 환자군과 정상대조군에서 알코올 투여 후 혈중 cortisol의 농도변화는 세 군간에 차이가 없었다. 6) 25세 이전과 25세 이후에 발병한 두 환자군에서 알코올 투여 후 혈당변화는 양군간에 차이가 없었다. Objectives : To evaluate the relation of onset-age and plasma level of ${\beta}$-endorphin, Ethanol, ${\beta}$-endorphin, cortisol and blood glucose were compared in 48 male alcoholics and 29 normal controls Methods : Alcoholics are divided into two groups by onset-age of alcoholism. Blood samples were obtained before and after 0.75gm/kg of ethanol consumption at the 7th admission day. Results : 1) The ratio of onset-age before 25 years to after 25 years of the patient group was 2 to 3. 2) There was no significant difference in age at admission between two patient groups. 3) There was no significant difference in change of plasma ethanol levels among three groups. 4) There was no significant difference in change of plasma ${\beta}$-endorphin levels among three groups. 5) There was no significant difference in change of plasma cortisol level among three groups. 6) There was no significant difference in change of fasting blood sugar level among two patient groups.

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