천포창 혈청의 자가항체 검색법 비교 및 자가항체 형별에 관한 연구

전재홍,이창우 한양대학교 의과대학 1999 한양의대 학술지 Vol.19 No.2

Immunological assays are required for the accurate diagnosis of autoimmune bullous dermatoses. Pemphigus is an autoimmune bullous disease with circulating anti-desmosome autonatibodies of IgG type. In the detection of circulating autoantibodies to desmosomal components of pemphigus antigen, the method-priority remains debatable between indirect immunofluorescence(IIF) and immunoblot(IB) assay. Besides the pathogenic IgG, in the direct IF study in pemphigus with perilesional tissue IgA autoantibodies can also be seen although the intensity is weaker than IgG. We have examined the sera of patients with pemphigus for the comparative sensitivity between the IIF and IB assay in the detection of pemphigus autoantibodies, and also for the presence/frequency of IgA autoantibodies in addition to IgG using the two detection methods. For the comparative sensitivity, eight patients' sera of pemphigus(pemphigus vulgaris, PV 4; pemphigus foliaceus, PF 4) with serum IgG titers of 1:80 were examined by IIF and by IB assays to figure out the end-titers in each case. For the presence/frequency of IgA autoantibodies, the IIF and IB assays were also carried out with 30 IgG-positive sera of pemphigus(PV 15, PF 15) to identify if there is some Ag-specific IgA autoantibodies. The degree of sensitivity in detecting the serum autoantibodies of IgG, IB assay was more efficient since the end-point titers of detection were 2-5 folds higher than the IIF study in every individual case(p=0.0017, Mann-Whitney U test). For the frequency of IgA autoantibodies in pemphigus, we observed IgA in 11 cases(PV 5, PF 6) among the total 30 cases examined, in constrast to the IIF which showed only 6 case-positivity. The results further revealed that IB assay demonstrates higher sensitivity and specificity in the detection of circulating autoantibodies in pemphigus. In patients with pemphigus, IB assay is more efficient for the detection of serum autoantibodies and about 37% of cases have serum IgA-type autoantibodies as well as IgG, specific to the pemphigus antigens(Desmoglein 1/3). However, pathogenic roles of the IgA autoantibodies in pemphigus are still unclear at this time.

黃芩 抽出物이 DNCB로 誘導된 생쥐의 Allergy性 接觸皮膚炎에 미치는 影響

全宰弘,姜允皓 동국대학교 한의학연구소 1998 東國韓醫學硏究所論文集 Vol.7 No.1

본 실험은 황금이 Allergy性 접촉피부염의 면역과민반응 및 염증반응에 미치는 영향을 조사하기 위해서 시행되었다. 실험을 위해 BALB/C계 생쥐를 DNCB 처리군과 DNCB 처리 후 황금추출액을 경구 투여한 황금추출물투여군(HGET군)으로 나누어 2,4-dinitrochlorobenzene(DNCB)를 도포하여 Allergy性 접촉피부염을 유발한 뒤, 시간의 경과에 따라 contact hypersensitivity assay, 피부의 일반적인 구조 혈관생성, 림프구를 비롯한 염증세포, sulfated acid mucosubstance, 비만세포, IL-2 R, ICAM-1 그리고 CD11b의 변화를 관찰하였다. Contact hypersensitivity assay에서 HEGT군은 DNCB처리군에 비해 有意性있는 ear swelling의 감소를 보였다. 피부표피의 변화에서 HEGT군에서 DNCB처리군에 비해 감소된 것으로 나타났다. 또한 혈관생성, 림프구의 침투 및 표피 기저층과 가시층 세포치 손상은 HEGT군에서 DNCB처리군에 비해 감소된 것으로 나타났다. 또한 혈관생성, 림프구를 비롯한 염증세포, sulfated acid mucosubstance와 비만세포, IL-2 R 양성반응세포, ICAM-1 양성반응세포 그리고 CD11b 양성반응은 Allergy性 접촉피부염의 면역과민반응억제와 항염증작용에 효과가 있는 것으로 사료된다. This study was performed to investigated the effects of an immunosuppression and a mitigation of inflammation of Scutellaria baicalensis GEORGI on Allergic contact dermatitis. In order to study, after oral administration of Scutellaria baicalensis GEORGI extract, contact hypersensitivity assay, general morphologic change of skin, suIfated acid mucosubstance, mast cell, lL-2R, ICAM-1 and CD11b were observed in BALB/C mouse induced allergic contact dermatitis by the contact sensitizing DNCB. Ear swelling in contact hypersensitivity assay was decreased in the Scutellaria baicalensis GEORGI extracts administered(HEGT) group, compared with DNCB painted group. In the general morphologic change of skin, hyperplasia of keratinocytes, increase of lymphocytes and inflammatory cell, increase of vasculogenesis and epidermal lymphocytes infiltration, increase of cell damage in epidermal basal layer and prickle layer were decreased in the HEGT group, compared with DNCB painted group. Increase of sulfated acid mucosubstance, mast cell, lL-2R positive cell, ICAM-1 positive cell, CD11b positive cell were decreased in the HEGT group, compared with DNCB painted group.

차량 및 항공분야의 RAMSIS를 이용한 인체공학 설계의 적용

전재홍 대한인간공학회 2006 대한인간공학회 학술대회논문집 Vol.- No.-

공학의 발전과 더불어 차량 및 항공기 등의 많은 목적에 부합하는 기계들이 등장하여 왔다. 그러나 그 기계들의 근본 목적은 인간 생활의 편리를 위해서임은 너무도 당연한 사실이다. 또한 그 기계들을 운용함에 있어서의 주체는 인간이다. 따라서 인간을 위한 도구를 인간의 본질을 파악하고 적용하여 인간이 편리하게 사용할 수 있도록 설계하는 것은 도구를 제작함에 있어서의 기본이라 할 수 있다. 이에 차량 내부 및 항공기의 조종실 설계에 있어서 인간공학의 개념을 도입하여 설계에 적용, 인간이 자동차나 항공기를 운용함에 있어 쾌적성과 안정성을 가지고 장기간 편안히 운행 할 수 있어야 한다. 그러나 현재까지의 차량 및 항공기 제작에 있어서 인체공학의 개념을 체계적으로 도입하고 System 화하여 설계에 적용할 수 있는 CAD Solution 의 적용은 불가능하였고 단지 설계자의 경험에 의존하는 방식이었다. RAMSIS 는 자동차 및 항공기 내부설계에 가장 광범위한 인체공학 Design 을 위한 CAD Tool 이다. 자동차 및 항공기 등 내부 설계시 실제 사람과 꼭 같은 사이즈의 마네킹을 적용하여 설계를 함으로써 사람이 느끼는 안락함과 불편함을 미리 예측하여 설계에 적용하는 Software 이다. 예를 들어, 자동차 운전자의 안전벨트 설계 시 가장 안전한 위치를 찾아 설계할 수 있는 것 등이다. 따라서 여기에서는 RAMSIS 를 이용하여 인간 공학의 개념을 설계에 적용, 제품개발과정의 초기단계에서 폭 넓은 인체공학 분석(ergonomic analysis)을 수행하게 함으로써 차량 및 항공기 내부설계의 개선된 방향을 제시하려고 한다.

BIM 기반 에너지성능분석을 통한 공동주택의 주동 설계 전략개발

전재홍,박혜진,이권형,추승연 대한건축학회 2018 대한건축학회논문집 Vol.34 No.2

Korea has achieved a rapid economic development and with the increase in population and national income and the expansion of social andeconomic activities, energy consumption has rapidly increased too. Energy consumption per head has constantly increased and currently, powerconsumption per head is 7.5 times bigger than in 1985. Buildings occupy 25% of total energy consumption and especially, 50% of totalenergy is consumed for heating and cooling. In this situation, multi-family housing, which has constantly been increased, has an energysaving rate of 1.9%, which is the lowest level and this makes the government’s energy policy for sustainable energy system developmentuseless. Besides, energy consumption leads to secondary problems, such as air, water and marine pollution and heat pollution andwastewater/drainage and the increased use of fossil fuel is a fundamental reason for ozone layer destruction and global warming. Therefore,efficient energy consumption plans are required. This study aims to analyze energy performance in each block type of high-rise anddiversified multi-family housing that accounts for 60% of all the housing forms, depending on the variations in stories through BIM-basedenergy simulation. For this study, four representative block types were selected, based on the multi-family floor plan, which is certified forenergy performance evaluation and they were applied to the floor plan of a multi-family house that is scheduled to be built. Then BIMmodeling was conducted from the fifth story to the 40th story at an intervals of 5 stories and based on the finding, energy characteristics ofeach block type and energy performance depending on the variations in stories were analyzed. It is considered that this would serve asobjective data for block type and block story decision of energy performance-based multi-family housing. 본 논문에서는 전체주택의 60%를 차지하고 있으며 점점 더 고층화, 다양화 되어가는 공동주택의 주동형태별 에너지 성능 및 층수 변화에 따른 에너지 성능을 BIM 기반의 에너지 시뮬레이션을 통하여 분석하고자 하였다. 에너지성능평가의 본 인증을 취득한 공동주택 평면도를 기초로 선정된 4가지 대표 주동형태를 실제 준공 예정인 공동주택의 평면도에 대입하여 5층 단위로, 5층에서 40층까지 BIM 모델링을 실시하고 그 결과 값을 통하여 주동형태별 에너지 특성과 층수변화에 대한 에너지 성능 변화를 분석하였다.

오(吳) 사기(師機)의 외치법(外治法)에 대한 연구(硏究) - ${\ll}$이륜병문(理淪騈文)${\gg}$ 중 <속증약언(續增略言)> 을 중심(中心)으로 -

전재홍,최인화,Jeon, Jae-Hong,Choi, In-Hwa 대한한방안이비인후피부과학회 2005 한방안이비인후피부과학회지 Vol.18 No.1

Objectives : In order to comprehend and utilize external therapy, we considered that we needed to research Wu Shi-Ji who was a medical specialist of external therapy. We looked at the special study on external therapy in his book, ${\ll}li-yao-pian-wen{\gg}$, especially <xu-zeng-lue-yun> ; in this part his generai approach to external therapy was well-detaiied. Methods : We translated and analyzed <xu-zeng-lue-yun>. Results : In <xu-zeng-lue-yun>, he gives a supplementary explanation about the insufficient attention paid to external therapy, 膏(gao) - (ti) 坐(zuo) (yu) 抹(mo) 纏法(chan fa), through San Jiao(三焦). And he insisted on his conception of external therapy: ointment(膏) and the moth of sneezing, sitting on herbs(坐), steaming or attaching herbs patients's navel, rubbing(抹) and binding(縛), based on ${\ll}nei-jing{\gg}$ and ${\ll}shang-han-lun{\gg}$. He put forward the general rules of external therapy using those methods. And through <xu-zeng-lue-yun>, he explained that the efficacy of his external therapy was basically the same as internal therapy and medicine, the only difference was in the method. In addition, this external therapy has some merits when compared with internal medicine. First, it's easier to diagnose a disease and treat patients compared to internal medicine. For instance, when a patient has a problem with his abdomen, we just have to diagnose a disease of the abdomen and treat using one method of external therapy on the abdomenal area. Second, external therapy has fewer side effects. And third, we can utilize the meridian theory when we use external therapy. Conclusions : Through <xu-zeng-lue-yun>, we basically understood his conception of external therapy. Although more research is needed, we suggest that we need to enlarge our usage of external therapy, not just confine ourselves to smaller areas of focus. His point of view suggests that external therapy is not merely an adjunct to internal therapy, but an interdependent course of study and action in its own right.

Heinrich Heine 詩論 : 特히 "Neue Gedichte"를 中心으로

轉在弘 釜山大學校 師範大學 1978 교사교육연구 Vol.5 No.1

Welch ein Lied! "Eine gewaltige Lust ergreift mich! Wa˝hrend ich sitze, und schreibe, erklingt Musik unter meinem Fenster, und an dem elegischen Grimm der lang-gezogenen Melodie, erkenne ich jene Marseiller Hymne, womit der scho˝ne Barbaroux und seine Gefa˝hrten die. Stadt Paris begru˝Bten, jener Kuhreigen der Freiheit, bei dessen To˝nen die Schweizer in den Tuilerien das Heimweh bekamen, jener triumphierende Todesgesang der Gironde, das alte su˝Be Wiegenlied-Es durehschauert mich mit Feuer und Freude, und entzU˝ndet in mir die glU˝henden Sterne der Begeisterung und die Raketen des Spottes. Ja, diese sollen nicht fehlen, bei dem groBen Feuerwerk der Zeit. Klingende Frammenstro˝me des Gesanges sollen sich ergieBen von der Ho˝he der Freiheitslust, in ku˝hnen Kaskaden, wie sich der Ganges herabstU˝rzt vom Himalaya! Und du, holde Satyra, Tochter der gerechten Themis und des bocksfu˝Bigen Pan, leih mir deine Hu˝lfe, Du bist ja mu˝tterlicher Seite dem Titanengeschlechte entsprossen, und hassest gleich mir die Feinde deiner Sippschaft, die schwa˝chlichen Usurpatoren des Olymps. Leih mir das Schwert deiner Mutter. damit ich sie richte, die verhaBte Brut, und gib mir die Picke-lflo˝te deines Vaters, damit ich sie zu Tode pfeife-">>schrieb Heinrich Heine die Spa˝tere Nachschrift der'〉Reisebilder'<<schon im November 1830. Nachdem Heine den Reisestoff auf die beschriebene Weise aufgearbeitet hatte, war er in politischer Hinsicht fu˝r ihn abgeschlossen. Heines Bedu˝rfnis nach Variation lieB eine einfache Wiederholung nicht zu. So arbeitete er mit neuem Stil das>'Neuer Fru˝hling'<1828/31von der Neuen Gedichte in Hamburg auf. Die Chance fu˝r eine. Realisierung ist hier gro˝Ber. In dieser Phase ist ihm die politisch-gesellschaftliche Aufgabe wichtiger als die dichterische. Denn Heine mo˝chte als politischer Befreier in die Geschichte eingehen. Auch an seinen Werk Neuer Fru˝hling<' wendet sich das Technische von Metrik, Sprache und Form.

리기다소나무림 유역에서 강수 시 계류수의 탁도 변화

전재홍,김경하,최형태,유재윤,정용호 한국임학회 2006 한국임학회 학술발표논문집 Vol.2006 No.-

吳 師機의 外治法에 대한 硏究중 〈續增略言〉을 中心으로

전재홍,최인화 대한한방안이비인후피부과학회 2005 한방안이비인후피부과학회지 Vol.18 No.1

吳師機의 外治法 思想에 대한 硏究 -<理倫騈文> 中 <略言>을 中心으로

전재홍,김현아,Cheon, Jae-Hong,Kim, Hyun-a 대한한방안이비인후피부과학회 1999 한방안이비인후피부과학회지 Vol.12 No.1

External therapy is a very useful method in today. But a study of theoretical basis of external therapy is very poor in Korea. So I carried out to investigate of 《Li Yue Pian Wen, 理淪騈文》. And I translated and analyzed to <Lue Yan, 略言> , firstly. Wu Shi Ji (吳師機) was one of the physician in qing(淸) dynasty (AD). He wrote the 《Li Yue Pian Wen, 理淪騈文》 which is the first special book on the external therapy(外治法). This is composed of 5 parts. In these parts, <Lue Yan, 略言) is an introduction and general remarks of this book, in which his medical thought is described well. In this part, he explained theoretical basis of external therapy and basic usage of external therapy. He insisted that external therapy had the same theoretical basis(理) as internal therapy(內治法) and the only difference was method of therapy(法). This point of view is most important theme of his medical thought. Therefore he also explained prescription(方) and medicinal herb(藥) in this point of view. And he said that external therapy had a merit - in an economic point of view, had a fewer side effects then internal therapy, could be used when it is impossible to use internal therapy. As a conclusion, he insisted that because external and internal therapy were interdependence, physician had to be well acquainted with both therapy.

Hollow Fiber 한외여과막을 이용한 Colloidal Silicon 폐수의 투과 특성

전재홍,이석기,함용규,최호상,도갑수 한국폐기물자원순환학회 1997 한국폐기물자원순환학회지 Vol.14 No.7