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Histone Deacetylases and Their Regulatory MicroRNAs in Hepatocarcinogenesis
김형석,Qingyu Shen,남석우 대한의학회 2015 Journal of Korean medical science Vol.30 No.10
A growing body of evidence suggests that epigenetic modifications are promising potential mechanisms in cancer research. Among the molecules that mediate epigenetic mechanisms, histone deacetylases (HDACs) are critical regulators of gene expression that promote formation of heterochromatin by deacetylating histone and non-histone proteins. Aberrant regulation of HDACs contributes to malignant transformation and progression in a wide variety of human cancers, including hepatocellular carcinoma (HCC), gastric cancer, lung cancer, and other cancers. Thus, the roles of HDACs have been extensively studied because of their potential as therapeutic targets. However, the underlying mechanism leading to deregulation of individual HDACs remains largely unknown. Some reports have suggested that functional microRNAs (miRNAs) modulate epigenetic effector molecules including HDACs. Here, we describe the oncogenic or tumor suppressive functions of HDAC families and their regulatory miRNAs governing HDAC expression in hepatocarcinogenesis.
김형석,허춘웅,김달수,목진호,김인수,김세환 대한뇌혈관외과학회 2014 Journal of Cerebrovascular and Endovascular Neuros Vol.16 No.3
Vertebral artery hypoplasia (VAH) can be easily overlooked if the contralateralside vertebral artery is intact, because of compensation by thecontralateral artery or cerebral collateral network. The clinical relevanceand hemodynamic impact of VAH is still controversial. However, VAH hasrecently been considered a risk factor for posterior circulation ischemia. Ischemic stroke is seldom caused by free floating thrombi (FFT) in theartery. Pathophysiology of FFT has not yet been clarified. The state of reducedblood flow such as a vertebral artery origin stenosis may causeFFT. Their instability may make them sources of recurrent artery to arteryembolism. Patients with FFT will require appropriate medical and endovasculartreatment. The current case illustrates a short-term angiographic change of spontaneousthrombolysis of VAH and multiple thrombi at the distal region ofthe stenosed lesion after stent-assisted angioplasty for a vertebral arteryorigin stenosis.
김형석,이종명,고은정,최하영 대한뇌혈관외과학회 2014 Journal of Cerebrovascular and Endovascular Neuros Vol.16 No.3
Coil migration into the parent artery during endovascular coil embolizationis a rare, but life-threatening complication, which can induce thromboembolismand result in poor outcome. A 63-year-old man was referredto Chonbuk National University Hospital emergency center due to migrationof a coil for a left middle cerebral artery bifurcation unrupturedaneurysm. We performed an emergency craniectomy to remove the coilmigrated to the distal M2 branch and thrombus, and aneurysmal neckclipping for his aneurysm. Fortunately, at the six month follow-up, the patientdid not show any noticeable neurological sequela. In case of parentartery occlusion due to coil migration an immediate recanalization shouldbe performed by a neurovascular specialist who can provide both surgicaltreatment and endovascular management in order to prevent severesequela or even death.
Intradiploic Encephalocele of the Left Parietal Bone: A Case Report
김형석,허춘웅,김달수,목진호,김인수,양근석 대한영상의학회 2015 대한영상의학회지 Vol.72 No.6
Encephaloceles are generally regarded as midline abnormalities. A 50-year-old man presented with a parietal intradiploic encephalocele manifesting as intermittent headache for the past 6 months. Computed tomography (CT) showed bone destruction associated with a left parietal lesion. Magnetic resonance imaging (MRI) demonstrated brain herniation within the intradiploic space. Cerebral angiographic imaging showed a normal cerebral vessel pattern within the herniated brain lesion. In this case, surgical treatment may not be necessary in the absence of concurrent symptoms and neurologic deficit. We report the CT, MRI, and angiographic findings of an extremely rare case of parietal intradiploic encephalocele in adulthood.