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Effectiveness of Mini-Implant for the Reduction of Mandibular Fracture
김남호,허정욱,박준섭 대한치의학회 2013 Journal of korean dental science Vol.6 No.1
Purpose: This study sought to verify the usefulness of mini-implant and surgical steel wire in the treatment of mandibular fracture through the objective identifi cation of the change of bone structure and bone density before and after reduction by evaluating radiological change through fractal analysis when mandibular fracture is treated using mini-implant and surgical wire. Materials and Methods: This study looked at 45 patients (males: 38, female: 7) diagnosed with mandibular fracture in the oral and maxillofacial surgery division of Chung-Ang University Dental Hospital and who received open reduction and intra-osseous fi xation. Result: The average fracture dimension values were higher for the group of the patients who had mini-implants and surgical wire treatment. Conclusion: Based on the results of the study on the usefulness of the reduction technique using mini-implant and surgical steel wire in the treatment of mandibular fracture through the fractal analysis method, the reduction technique using mini-implant and surgical steel wire is regarded as an effective method of minimizing the gap between mandibular fracture fragments.
김남호,김승혁,홍재승,전성호,허성오 한국분자세포생물학회 2014 Molecules and cells Vol.37 No.7
Lysophosphatidic acid (LPA) is a lipid growth factor that exerts diverse biological effects through its cognate recep-tors (LPA1-LPA6). LPA1, which is predominantly expressed in the brain, plays a pivotal role in brain development. However, the role of LPA1 in neuronal migration has not yet been fully elucidated. Here, we delivered LPA1 to mouse cerebral cortex using in utero electroporation. We demonstrated that neuronal migration in the cerebral cortex was not affected by the overexpression of LPA1. Moreover, these results can be applied to the identification of the localization of LPA1. The subcellular localization of LPA1 was endogenously present in the perinuclear area, and overexpressed LPA1 was located in the plasma mem-brane. Furthermore, LPA1 in developing mouse cerebral cortex was mainly expressed in the ventricular zone and the cortical plate. In summary, the overexpression of LPA1 did not affect neuronal migration, and the protein expres-sion of LPA1 was mainly located in the ventricular zone and cortical plate within the developing mouse cerebral cortex. These studies have provided information on the role of LPA1 in brain development and on the technical advantages of in utero electroporation.
김남호,Ali Sadra,박희영,오성민,Jerold Chun,윤정교,허성오 한국분자세포생물학회 2019 Molecules and cells Vol.42 No.2
Lysophosphatidic acid (LPA) is an endogenous lysophospholipid with signaling properties outside of the cell and it signals through specific G protein-coupled receptors, known as LPA1–6. For one of its receptors, LPA1 (gene name Lpar1), details on the cis-acting elements for transcriptional control have not been defined. Using 5′RACE analysis, we report the identification of an alternative transcription start site of mouse Lpar1 and characterize approximately 3,500 bp of non-coding flanking sequence 5′ of mouse Lpar1 gene for promoter activity. Transient transfection of cells derived from mouse neocortical neuroblasts with constructs from the 5′ regions of mouse Lpar1 gene revealed the region between −248 to +225 serving as the basal promoter for Lpar1. This region also lacks a TATA box. For the region between −761 to −248, a negative regulatory element affected the basal expression of Lpar1. This region has three E-box sequences and mutagenesis of these E-boxes, followed by transient expression, demonstrated that two of the E-boxes act as negative modulators of Lpar1. One of these E-box sequences bound the HeLa E-box binding protein (HEB), and modulation of HEB levels in the transfected cells regulated the transcription of the reporter gene. Based on our data, we propose that HEB may be required for a proper regulation of Lpar1 expression in the embryonic neocortical neuroblast cells and to affect its function in both normal brain development and disease settings.
사물인터넷 기반의 해양 적·녹조 실시간 모니터링 시스템 설계
김남호,Kim, Nam Ho 한국스마트미디어학회 2016 스마트미디어저널 Vol.5 No.1
본 논문에서 제안하는 실시간 해양 이상조류 모니터링 시스템은 직접적으로 적 녹조의 주원인인 플랑크톤을 감지하는 것이 아니라 적조의 동물성 플랑크톤 특성인 수중 내의 산소 감소를 체크하고, 녹조의 식물성 플랑크톤 특성인 수중 내의 질소 감소를 측정한다. 각각의 특성 체크 및 간접적 요소인 수중 내외의 온도, 조도 센서를 이용하여 실시간 감시하는 모듈을 만들고 모듈은 특정 주기에 맞게 신호를 서버로 전송하여 데이터베이스를 형성하고, 이렇게 수집된 데이터는 해양수산청 적 녹조 기준 데이터와 비교 하여 분석하여 알맞은 형태의 정보로 가공한 뒤 사용자에게 정보를 시각화 하여 제공한다. 기존의 광역적 감지 및 감시 시스템이 아닌 지역적 특성을 갖게 되는, 어업을 하지 않는 시간에도 빠르게 대처 가능한 개인사업 맞춤형 양식장 적 녹조 감시 시스템을 제안하였다. In this paper, the real time monitoring system for the abnormal state of marine algae does not detect the plankton which may directly cause the red tide or the water bloom. But checks both oxygen reduction and nitrogen reduction in water, which indicates the characteristics of zooplankton and phytoplankton respectively, and this system makes a module that monitors in real time the temperature and the illumination of the water, which are indirect factors, with sensors placed in and outside the water, and this module transmits signals periodically at specific intervals to a sever that builds up data base, and the data collected in these ways will be analyzed and compared with the standard data from Ministry of Oceans and Fisheries, and then these data will be made the adequate form of information to be provided to the users as visual information, thus, this system intends to make a red tide and water bloom monitoring system tailored for individual fish farm businesses that has local characteristics and can quickly operate outside working hours, which differs from the existing wide area detecting and monitoring systems.
김남호,Kim, Nam-Ho 사단법인 한국당뇨협회 2006 당뇨 Vol.204 No.-
당뇨병은 피 속에 포도당이 높아져 이에 따른 각종 합병증으로 심각한 상황을 초래할 수 있는 질환이다. 이 중에서 신장 합병증은 중요한 당뇨병성 합병증 가운데 하나인데, 당뇨병환자가 점차 늘어가면서 최근에는 인공 신장 치료 환자의 가장 큰 원인으로 당뇨병을 꼽고 있는 실정이다. 따라서 당뇨병환자는 모든 합병증과 더불어 신장 합병증에도 큰 주위를 기울여야 한다.