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          Alcoholism과 우울

          우행원 大韓神經精神醫學會 1986 신경정신의학 Vol.25 No.1

          '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

          Alcoholism and depression are major psychiatric problems and any evidence pointing toward a shared etioloical factors should have great impact on the practice of psychiatry, the burden of cost, and suffering born by society, patients, and their families. Then the author intented to evaluate the correlation between those researches on alcoholism and depression. With a thorough review of the literatures, the author reached the following results. Before looking at research findings, we must be careful about the meaning of terms. The word "depression" used in broad scale: a sad or dysphoric mood, insomnia, anorexia, loss of concentration or psychomotor retardation. Alcohol dependence syndrome used in broad scale also: alcoholism, alcoholics and alcohol intoxication. Other definition of the word will must be specified. Symptom that are similar to some of those of depressive illness are common in both the drinking and withdrawal alcoholic. These however, are not typical of serious endogenous illness. They are marked by dysphoria and mixed with the anxiety. Response to medication aften used in the treatment of depression(antidepressants, neuroleptics and lithium) is seen but is not yet demonstrably specific. Among those alcoholic patients who do suffer from serious depressive illness and a high rare of suicidal behavior, a family background of serious depressive illness is more common than expected. Furthermore, a subset of families in whom alcoholism is prevalent tends to have a large numbers of family members especially female, who suffer from depression alone and not alcoholism. This depression is essentially, indistinguishable from that seen in a typical endogenous depression. Some unstable personality characteristics and a chaotic social life tend to characterize these patients. Bipolar affective disease has yet to be linked with alcohlism conclusively.

        • 과거 10년간 이화대학병원 정신과 외래 소아환자에 대한 임상적 고찰

          우행원 梨花女子大學校 醫科大學 醫科學硏究所 1978 EMJ (Ewha medical journal) Vol.1 No.4

          In view of the absence of any systematic study of the psychiatric disorders among the children (16 years and younger) in this country, the author reviewed 325 child psychiatric patients seen at the department of neuropsychiatry, Ewha Womans University Hospital during 10 years(from 1968~1977). In this paper the study group of 325 child psychiatric patients were studied with special emphasis on diagnostic distribution, age sex distribution, family back ground, sibiling order and course and purpose of visiting hospital. The results are as follows: 1) 325(8.7%) new child patients visited to neuropsychiatric department among the total 3,736 new patients from 1968 to 1977. 2) The number of the new child patients had increased year after year. 3) Most frequent diagnosis was neurosis followed by epilepsy, schizophrenia and special symptoms in that order. 4) 163 cases (50.1%) were male and 162 cases were female. Most prevalent age distribution was 12~16 year group(53.8%) 5) 16 patients (4.9%) had the history of paternal loss. 6) In sibling order, most prevalent was middle sibilings(18.6%). followed by last(17%), and first(16.6%). 7) Most patients were referes via O.P.D. 8) Purposes of visiting hospital were symptom treatment(55.1%), and psychiatric evaluation(44.9%).

        • 정신과 입원 환자의 혈청 칼슘농도에 관한 연구

          우행원,임원정 梨花女子大學校 韓國生活科學硏究院 1992 韓國生活科學硏究院 論叢 Vol.50 No.-

          Serum calcium levels have been estimated in 273 successively admitted inpatient who met DSM-ⅢR diagnosis of Schizophrenia, Bipolar disorder, manic episode, Bipolar disorder, depressive episode, Major depression, DSM Ⅱ Diagnosis of Neurosis at Department of Neuropsychiatry, Ewha Womans University hospital. The mean serum clacium value was 9.28±0.6㎎/㎗. In regard to the relation between calcium level and psychiatric diagnosis, biolar disorder, depressive episode had the lowest serum calcium level(8.73±0.73㎎/㎗) and bipolar disorder, manic episode had the highest level (9.35±0.44㎎/㎗). The difference was significant(P<0.01). The patient with abnormally low serum calcium value were 6 cases(2.2%), consisting of 3 bipolar disorder, depressive episode, 1 Schizophrenia, 1 neurosis and 1 major depression. Certainly serum calcium level is associated with different psychiatric diagnosis. And this kind of relationship between serum calcium level and psychiatric diagnosis is prominent in mood disorder.

        • 만성 가장성 신체장애, Munchansen 증후군 : Munchausen Syndrome

          우행원 梨花女子大學校 醫科大學 醫科學硏究所 1983 EMJ (Ewha medical journal) Vol.6 No.4

          Chronic factitious disorder with physical symptoms is an appropriate diagnosis in patients who consciously distort their medical history and produce misleading physical finding and laboratory results through self-inflicted lesions. By simulating patterns of physical diseases, these patients may subject themselves to painful and dangerous diagnostic and treatment procedures. Munchausen syndrome represents a special pattern within the group of chronic factitious disorder with physical symptoms. The typical patient presents at a hospital as an acute emergency and usually has a lurid yet plausible medical and social history, which is laterfound to be entirely false and fabricated. After several fruitless investications with or without surgical operations, a diagnosis cannot be made and the patient eventually discharges himself and goes to another hospital where the process is repeated. It is importent to diagnose these patients early to avoid unnecessary medical and surgical interventions and to introduce psychiatric treatment. A typical case of Munchausen syndrome is reported with a brief review of literatures. This is believed to be the first reported case of Munchausen syndrome in Koera.

        • Tranquilizer를 투여한 백서 간 뇌조직의 3-Hydroxy-3-Methylglutaryl-Co A 및 Cholesterol 및 생합성에 대하여

          우행원 梨花女子大學校 醫科大學 醫科學硏究所 1981 EMJ (Ewha medical journal) Vol.4 No.3

          The incidence of mental illness in the modern society has been increasing and the use of the tranquilizer for the treatment of these illnesses has been increasing also. The side effects of the tranquilizer are reportedly, minimal and the long term use of the medicine is widely practised in this field. But the question of its effect on cardiovascular system has been discussed previously and the level of cholesterol and triglyceride was found to increase in patients who have been on the tranquilizer for a long period of time. The current study was undertaken to find out the effect of tranquilizer(chlorpromazine, thioridazine, perphenazine, haloperidol, and pimozide) given to the animals for 4 weeks. And the results are summarized as follow: 1) In the animal group given chlorpromazine, thioridazine, and perphenazine, the level of total serum cholesterol was increased and the activity of microsomal HMG-Co A reductase was also increased. However, in the group given haloperidol and pimozide, there was no increase of cholesterol level or activity of microsomal HMG-Co A reductase. 2) The correlation of serum total cholesterol level and the activity of HMG-Co A reductase in the liver and brain was significant. From the Above results, it could be concluded that the effect of the long term use of tranquilizer on the cadiovascular systerm should be reevaluated.

        • 흡연이 정신분열병 환자의 임상 증상 및 혈청 Prolactin에 미치는 영향

          우행원,임원정,연규월,Woo, Haing-Won,Lim, Weon-Jeong,Yun, Kyu-Wol 한국정신신체의학회 1997 정신신체의학 Vol.5 No.2

          본 연구는 정신분열병 환자의 흡연성향 및 흡연이 임상양상이나 증상, 혈청 prolactin에 미치는 영향을 조사해 보고자 하였다. 연구결과는 다음과 같다. 1) 흡연군과 비흡연군의 연령, 발병연령, 이환기간, 복용하는 항정신병 약물 및 항파킨슨 약물의 용량은 유의한 차이가 없었으나, 기호 식품인 커피를 매일 한잔이상 마신다고 답한 경우가 흡연군에서 유의하게 많았다(p<0.05). 2) 흡연 이유는 긴장 완화(85.7%), 권태로움을 피하고 싶어서(45.2%), 습관(38.1%), 친구들과 어울리고 싶어서나 또는 친구를 모방(23.8%)하여 담배를 피운다고 응답했다. 80.1%가 금연을 시도했었으나, 94%에서 craving때문에 금연에 실패하였다. 금단증상으로 불안감(52.9%), 정신과적 증상의 악화(23.5%), 환청의 악화(8.8%), 약물부작용의 악화(14.7%), 졸리움의 증가(47.1%)등이 있었다. 3) BPRS 총점수는 흡연군과 비흡연군에서 유의한 차이가 없었으나, 불안척도가 흡연군에서 유의하게 낮았다(p<0.05). HAM-D에 의한 우울증상 및 SCL-90-R의 대인관계 민감도 항목과 공포증 항목이 흡연군에서 유의하게 낮았다(p<0.05). PANSS. AIMS는 두군에서 유의한 차이를 보이지 않았다. 4) 흡연군에서는 혈청 prolactin이 비흡연군에 비해 유의하게 낮았고(p<0.01) 공변량분석결과 흡연이 혈청 prolactin에 의미 있는 영향을 미치는 것으로 나타났다.(p<0.05). 5) 정신 분열병 환자에서 금연 유도시 적절한 항불안 약물이나 항우울 약물의 일시적인 병합치료로서 금단증상을 최소화 시켜야 하며, 환자들의 낮은 자존심 및 높은 의존심을 충족시키는 정신치료가 병행되어야 될 것으로 사료된다.hromatography를 반복(反復)하여 stilbene 계열(系列)의 화합물(化合物)인 Rhapontigenin (Compound 1)과 Rhaponticin (Compound 2)을 얻었다. S. aureus SG 511에 대(對)해 Rhapontigenin은 50 mg/ml 이상(以上) 농도(濃度)에서 항균(抗菌) 효과(效果)를 나타내었고, Rhaponticin은 $200\;mg/m{\ell}$ 농도(濃度)에서 미약(微弱)하게 유효(有效)한 항균(抗菌) 효과(效果)를 나타내었으며, B. subtilis ATCC 6633에 대(對)해 Rhapontigenin은 50 mg/ml 이상(以上) 농도(濃度)에서 항균(抗菌) 효과(效果)를 나타내었고, Rhaponticin은 200 mg/ml 농도(濃度)에서 우수(優秀)한 항균(抗菌) 효과(效果)를 나타내었으며, 100 mg/ml 농도(濃度)에서 미약(微弱)하게 유효(有效)한 항균(抗菌) 효과(效果)를 나타내었다. 또한 E. coli 055에 대(對)해서는 Rhapontigenin과 Rhaponticin 모두 200 mg/ml 농도(濃度)에서 미약(微弱)하게 유효(有效)한 항균(抗菌) 효과(效果)를 나타내었다. 이상(以上)의 결과(結果)로 보아 선방활명음(仙方活命飮)의 항균(抗菌) 효능(效能)은 군약(君藥)인 대황(大黃)의 성분(成分) 중(中)의 하나인 stilbene 계열(系列)의 화합물(化合物)인 Rhapontigenin과 Rhaponticin의 작용(作用)에 의(依)한 것이며, 이는 한의학(韓醫學) 방제(方劑) 원리(原理)인 군신좌사(君臣佐使) 이론(理論)에서 군약(君藥)이 주증(主症)에 주(主)로 작용(作用)하는 약물(藥物)이라는 것을 밝혀주는 것이라고 사료(思料)된다. This study was performed to evaluate the characteristics of smoking behavior and the effects of smoking on clinical symptoms and level of serum prolactin in schizophrenic patients. Methods : 76 male schizophrenic patients answered the questionnaire about the characteristics of smoking patterns. And patients were assessed by brief psychiatric rating scale(BPRS), positive and negative syndrome scle(PANSS), Hamilton rating scale for depression(HAM-D), assessment for involuntary movement scale(AIMS) and symptom checklist 90 R(SCL-90-R). Serum prolactin levels were measured by enzymeimmunoassay. Results: 1) The frequences of drinking coffee were significantly higher in smokers. The reasons for smoking were to relieve tension, to avoid boredom, due to habit and to do with friends. 80.1% of smokers tried quitting, but smoking was relapsed due to craving and withdrawal symptoms. 2) No significant difference was seen in mean neuropeltic doses, scores of PANSS and AIMS. But as for BPRS, scores of anxiety/depression subscale were significanly lower in smokers. Scores of HAM-D and scores of interpersonal sensitivity and phobia among SCL-90-R were significantly lower. 3) Levels of serum prolactin were significanlty lower in smokers. Conclusion : These findings suggest that in schisophrenia smoking relieves anxiety and depression subjectively But decreased prolactin levels may suggest that the possibility of increased dopamine in CNS.

        • KCI등재

          자매에서 본 Alopecia totalis 의 정신역동학적 고찰

          우행원,박수훈 대한신경정신의학회 1974 신경정신의학 Vol.13 No.-

          '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        • KCI등재

          정신장애자의 역학적 조사에 관한 문헌적 고찰

          우행원 대한신경정신의학회 1975 신경정신의학 Vol.14 No.1

          '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

          The Revaluation of the Epidemiological Studies on Mental Disorders The Author intended to reValuate of the 6pidemilogical studies on mental disorder, who have been many difficulties for the collection of materials. The contents were analysed in terms of diagnostic classifications, age and sex, social class, marrige, occupations and education, parental deprivation,duration of hospital life, readmission, and discharge, & treatment, eid. After an extensive review oi the literatures, the author reached the following conclusion. The most of studies were carried out separately and sporadically, and no reliable consistency in interpreting the conclusion besides that there is a lack of corelation of various factors.

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