정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

RFID/USN 기반 지능형버스정보시스템

손병락,정유정,김중규 대구대학교 2005 대구대학교 학술논문집 Vol.1 No.1

Integration of RFID, capable of electronic authentication and data collection, and ITS (Intelligent Transportation System) can be an intelligent and efficient data collection and authentication system If RFID based ITS apply to a traffic information system, a good quality of traffic information can be given to the users in real-time. While a big amount of money is required to establish an ITS, a highly efficient RFID based ITS can be established with smaller amount of money. In this paper, we propose IBIS (Intelligent Bus Information System) using RFIDs. Current BIS (Bus Information System) that is mainly for the operator, and it has much geographical restrictions. The IBIS offers real-time traffic information to the operator and user of the public transportation. This system collects the real-time traffic information using REID based USN along with beacon and GPS for the information of location. This IBIS system is linked with RFID authentication technology and traffic-money card system, and it achieves the improvement of the deferred payment system of the traffic card. The ITS system can reduce the unnecessary communication traffic and observe real-time environmental pollution data through the USN based environmental surveillance system. 지능적인 전자인증과 정보 수집을 할 수 있는 RFID와 교통정보시스템(ITS, Intelligent Transportation System)의 통합은 지금까지 응용한 어떠한 서비스 모델보다 효율적으로 작용할 수 있다고 판단된다. 만약 ITS가 RFID 기반으로 응용한다면 질적으로 향상된 교통정보를 사용자들에게 실시간 제공할 수 있다. 그리고 설치측면에서도 기존 ITS를 설치할 경우 막대한 자본이 투입되는 반면에 RFID를 응용한 ITS는 저자본, 고효율적으로 적용될 수 있다. 본 논문에서는 RFID 기반 지능형 버스 정보 시스템을 제안한다. 현재 운용되고 있는 버스정보시스템은 운행자 위주의 시스템이다. 그리고 지리적 제약사항이 많이 따른다. 하지만 제시하는 지능형대중교통시스템은 운행자에게 정보를 제공할 뿐만 아니라 대중교통사용자에게 또한 실시간 교통정보를 제공한다. 위치 식별을 위한 비콘과 GPS와 더불어 RFID을 적극 활용하여 교통정보를 실시간 제공할 수 있다. 더 나아가 RFID의 인증기술과 현 교통카드 및 후불제 교통카드와 연동함으로써 결재 시스템에서 향상된 효과를 볼 수 있다. USN을 이용하여 지능적으로 교통흐름을 감지하여 불필요한 통신량을 줄일 수 있고, 환경감시를 통하여 실시간 공해를 감시할 수 있다.

Silaethene CL₂Si=CHCH₂?Bu의 엔반응 : Unsaturated Compounds of 14Group Elements(Ⅸ)

김정균,박은미,구미영,박경래,손병영 東亞大學校 大學院 1992 大學院論文集 Vol.17 No.-

Silaethene Cl₂Si=CHCH₂?Bu 1, generated as a reaction intermediate by the thermal elimination of LiX from Cl₃SiCHLiCH₂?Bu 2, combines with ene-component containing compounds(propene, 2-methylpropene, DMB) to give 40∼90% yield ene-products. They can be isolated and spectroscopic identified.

실라에텐 Cl_2Si=CHCH_2^tBu의 생성과 반응성 : Unsaturated Compounds of 14 group Elements(IX)^1

金貞均,朴恩美,具美英,朴慶來,孫炳榮 충남대학교 약학대학 의약품개발연구소 1993 藥學論文集 Vol.9 No.-

Lithiated 화합물인 Cl_3SiCHLiCH_2′Bu로부터 LiCl의 제거반응에 의해 생성된 준안정 반응중간체인 silaethene, Cl_2Si=CHCH_2′Bu은 propene, 2-methylpropene, 1,3-butadiene, 2,3-dimethyl-1,3-butadiene, anthracene과 반응하여 엔반응 생성물, 2+2-, 2+4-고리화부가 생성물을 생성한다. 이들을 분별진공증류법에 의해 분리하였고 분광학적으로 확인하였다. Silaethene Cl_2Si=CHLiCH_2′Bu, generated as a metastable reaction intermediate by the thermal eliminatio of LiCl from lithiated compound Cl_3SiCHCH_2′Bu, react with propene, 2-methylpropene, 1,3-butadiene, 2,3-dimethyl-1,3-butadiene, and anthracene to give ene-reaction product, 2+2-, and 2+4-cycloadducts. They are isolated by vacuum fractional distillation method and spectroscopically identified.

수직 진동형 Rheometer를 이용한 복합레진의 유변학적 성질의 측정

이인복,조병훈,손호현,이상탁,엄정문 大韓齒科保存學會 2004 Restorative Dentistry & Endodontics Vol.29 No.6

Objective: The purpose of this study was to investigate the viscoelastic properties related to handling characteristics of composite resins. Methods: A custom designed vertical oscillation rheometer (VOR) was used for rheological measurements of composites. The VOR consists of three parts: (1) a measuring unit, (2) a deformation induction unit and (3) a force detecting unit. Two medium viscous composites, Z100 and Z250 and two packable composites, P60 and SureFil were tested. The viscoelastic material function, including complex modulus E* and phase angle δ, were measured. A dynamic oscillatory test was used to evaluate the storage modulus (E′), loss modulus (E″) and loss tangent (tanδ) of the composites as a function of frequency (ω) from 0.1 to 20 ㎐ at 23℃. Results: The E′and E″ increased with increasing frequency and showed differences in magnitude between brands. The E*s of composites at ω= 2 ㎐, normalized to that of Z100, were 2.16 (Z250), 4.80 (P60) and 25.21 (SureFil). The magnitudes and patterns of the change of tanδof composites with increasing frequency were significantly different between brands. The relationships between the complex modulus E*, the phase angle δ and the frequency ωwere represented by frequency domain phasor form, E* (ω) = E*e^(iδ)= E*∠δ. Conclusions: The viscoelasticity of composites that influences handling characteristics is significant different between brands. The VOR is a relatively simple device for dynamic, mechanical analysis of high viscous dental composites. The locus of frequency domain phasor plots in a complex plane is a valuable method of representing the viscoelastic properties of composites.

단량체 및 무기질 filler 조성 변화에 따른 복합레진의 유변학적 특성

이인복,이종혁,조병훈,손호현,이상탁,엄정문 大韓齒科保存學會 2004 Restorative Dentistry & Endodontics Vol.29 No.6

Objectives. The aim of this study was to investigate the effect of monomer and filler compositions on the rheological properties related to the handling characteristics of resin composites. Methods. Resin matrices that Bis-GMA as base monomer was blended with TEGDMA as diluent at various ratio were mixed with the Barium glass (0.7 um and 1.0 um), 0.04 um fumed silica and 0.5 um round silica. All used fillers were silane treated. In order to vary the viscosity of experimental composites, the type and content of incorporated fillers were changed. Using a rheometer, a steady shear test and a dynamic oscillatory shear test were used to evaluate the viscosity (η) of resin matrix, and the storage shear modulus (G′), the loss shear modulus (G″), the loss tangent (tanδ) and the complex viscosity (η*) of the composites as a function of frequency ω= 0.1-100 rad/s. To investigate the effect of temperature on the viscosity of composites, a temperature sweep test was also undertaken. Results. Resin matrices were Newtonian fluid regardless of diluent concentration and all experimental composites exhibited pseudoplastic behavior with increasing shear rate. The viscosity of composites was exponentially increased with increasing filler volume%. In the same filler volume, the smaller the fillers were used, the higher the viscosities were. The effect of filler size on the viscosity was increased with increasing filler content. Increasing filler content reduced tanδby increasing the G′further than the G″. The viscosity of composites was decreased exponentially with increasing temperature.

오차드그래스(Dactylis glomerata L.)의 품종에 따른 종자유래의 캘러스 형성률과, 캘러스 크기 및 식물체 재분화 효율의 비교

배은경,이인애,김기용,이병현,손대영,이효신,정민섭,조진기 Plant molecular biology and biotechnology research 2002 Plant molecular biology and biotechnology research Vol.2002 No.-

Comparison results of callus formation ratio from seed explants, callus sizes, regeneration ratios from callus and regeneration efficiency [calculated by following formular; callus formation ratio(%) × regeneration ratio(%)/100]for 27 ochardgrass (Dactylis glomerata L.)varieties imported and Hapsung 2 developed in Korea are as follows; 1. Among ochardgrass varieties showing more than 50% callus formation ratios, the descending order of callus formation ratio after bedding the seed explants for 4 weeks was 93>Sparta>Pizza>Condor>Lidaglo>Glorus>Hapsung2>Frode. 2. The callus sizes after bedding for 4 weeks were in the range of φ 0.43cm~4.2cm in which there was 10 times size difference between the largest one and the smallest one but most of them were between φ2.5cm~4cm. 3. The regeneration ratio from callus among varieties were in the range of 0~36% and descending order of the upper 6 varieties was Plano>Akimidori>Justus>Lidacta>Currie>Hall mark. 4. The regeneration efficiency which is calculated by the ratios of regeneration from seed explant numbers was between 0 to 17.4% among which Justus showed the highest value in the 4-week treatment. 5. The correlation between callus formation ratios and the callus sizes, callus formation ratios and regeneration efficiency, and callus sizes and regeneration efficiency were r=0.5765, r=0.6365 and r=0.6246, respectively in 4-week callus and all the correlations were significant on the 1% level. 6. In 6-week callus, the descending order callus formation ratios from seed sxplants for the best 6 varieties was Condor>Sparta>93M>Justus>Potomac>Lidaglo>Frode. 7. The callus sizes formed were between φ1.5~5.7cm in which Sparta, the largest one of φ5.7cm was five times larger than the smallest one. The callus size of the control variety. Hapsung 2 was φ3.8cm, which belonged to larger size. 8. Regeneration ratio showed a great deviation among varieties from 6-week old calli by showing from 0% to 100% in which all the calli were regenerated in Plano while no callus was regenerated in Juno, 9. The range of regeneration effciency was between 0~28% among varieties in which the values from 6-week callus treatment were larger than those from 4-week callus treatment. Especially, the value of Potomac in 6-week was 3 times larger than that in 4-week. 10. The correlation between callus formation ratios and the callus sizes, callus formation ratios and regeneration efficiency, and callus sizes and regeneration effciency were r=0.8369, r=0.6683 and r=0.5937, respectively in 6-week callus, and all the correlations were significant on the 1% level.

백서 간재생중 H2B Histone 유전자 발현에 대한 Octamer Binding Transcription Factor의 역할

임규,방재웅,최두식,손미영,이영철,박청,김태동,김영래,박종일,윤완희,박승길,황병두 한국노화학회 2001 한국노화학회지 Vol.11 No.1

임신부의 인플루엔자 백신 접종률 및 관련요인

김미정,이승연,이광수,김아름,손동욱,정문현,박신구,박지현,이병익,이진수 대한감염학회 2009 감염과 화학요법 Vol.41 No.6

Background : During seasonal influenza epidemics and previous pandemics, pregnant women have been at increased risk for complications related to influenza infection. Although influenza vaccination has been widely recommended to pregnant women and immunocompromised hosts, the vaccination rate is presumed to be low in pregnant women. This study was aimed to evaluate the vaccination rate and factors associated with Influenza vaccination among pregnant women, who are at high risk for developing complications from the influenza. Materials and Methods : This study was carried out by telephone survey from April, 2007 to August, 2007. Women who were in their second trimester of pregnancy or above,- during October, 2006 and February, 2007, the recommended vaccination period, and had given birth at Inha University Hospital were selected as the study population. Immunization status, general understanding, and factors associated with vaccination were evaluated. Results : Among a total of 506 eligible pregnant women, 227 (44.8%) responded to the questionnaires. The influenza vaccination rate among the pregnant women was only 4% (9/227). Major reasons for not receiving vaccination were first, not awaring the necessity of immunization during pregnancy (48.5%, 110/227) and second, misunderstanding that it is prohibited during pregnancy (36.1%, 82/227). The major factors that influenced the compliance of vaccination were correct understanding and doctor's recommendation on the influenza immunization during pregnancy. Conclusions : The influenza vaccine coverage on pregnant women was very low and the awareness of influenza vaccination during pregnancy in general was inaccurate. Shift in perception is required and this can be achieved by educating the pregnant women on the safety and efficacy of vaccination. In addition, doctors' active encouragement to vaccination is highly recommended.

뇌척수액에서 당감소를 보인 대상포진 수막뇌염 1례

최병철,정원희,김정환,정근호,조필자,강훈,손숙자 대한신경과학회 1997 대한신경과학회지 Vol.15 No.5