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          • 약학대학에서 문제중심학습법의 효과 분석 : 충남대학교 약학대학 사례를 중심으로

            윤휘열,김정태,유영훈,백현문,송병정,권광일 충남대학교 약학대학 의약품개발연구소 2016 藥學論文集 Vol.31 No.-

            After exchanging pharmacy edcuation system from 4th years to 6th years at 2011, Problem Based Learning (PBL), expecially fields of pharmacotherapy, is considered as alternative teaching implements to enhance student’s skills about solving-problem, critical thinking, clinical reasoning and self-motivated learning. The purpose of this study is to analyze the effectiveness about PBL class in clinical pharmacy students, and provide the evidence of its application. Four groups consisted of 10~12 students on each (Total number of students were 54) had PBL class with 4 pharmacists who were pre-educated about PBL class as tutors. After PBL class, all of students took part in the paper-based survey about effect of PBL class in clinical pharmacy education. In results of survey, the effectiveness of PBL was superior in comparisons with traditional teaching method and student’s attitudes for class such as satisfaction and participation were also improvements. In conclusions, PBL methods had a lots of benefits about improvement of academic performance and professional knowledges in clinical pharmacy teaching, therefore PBL class should be suggested more frequently in clinical pharmacy.

          • 후박의 품질평가

            배기환,김영호,원도희,이준성,강종성 충남대학교 약학대학 의약품개발연구소 1997 藥學論文集 Vol.13 No.-

            Magnolol and honokiol, the main components of Magnoliae Cortex, were isolated and used as the standard substances for the analysis. In order to determine the contents of magnolol and honokiol in Magnoliae Cortex originated from Korea. China and Japan, both HPLC and HPTLC methods are applied and compared with each other. The components were separated on C8 column with acetonitrile-water-acetic acid (50:50:1) in HPLC and detected at UV 294㎚. The components separated on HPTLC precoated silica gel plate with chloroform-methanol (9:1) were detected directly on the plate at 254㎚. The contents of magnolo and honokiol in Magnoliae Cortex were in the wide range of 0.01~2.8% and 0.005~0.8%, respectively, according to their purchase places. It is also applicable to the quality control of various preparation from Magnoliae Cortex.

          • Pipemidic Argininate 및 Pipemidic Acid β-Cyclodextrin Inclusion Complex의 장관흡수실험

            智雄吉,羅成範 충남대학교 약학대학 의약품개발연구소 1986 藥學論文集 Vol.2 No.-

            Pipemidic argininate and pipemidic acid β-cyclodextrin inclusion complex was examined for the absorption by rat intestin in situ recirculation. The absorption rate constant was pipemidic acid 0.096hr^-1, pipemidic argininate 0.276hr^-1 and pipemidic acid β-cyclodextrin inclusion complex 0.221hr^-1. The absorption rat of pipemidic argininate and it's complex turned out to be greater than that of pipemidic acid. And the absorption mechanism of pipemidic argininate was examined by everted sac of rat intestin, 0.1mM drug buffer solution was incubated in serosal and mucosal for 30 minutes, and the result showed that drug concentration of serosal was 0.144mM, concentration of mucosal was 0.0897mM. Through this study it is infered that the absorption mechanism was a special transport.

          • 인삼사포닌의 마우스 비장 임파구에 대한 면역활성

            정경수,이대우,양희정,이순철,김길현 충남대학교 약학대학 의약품개발연구소 1994 藥學論文集 Vol.10 No.-

            To ellucidate immunologic activities of ginseng saponin, the splenic leukocytes of BALB/c mice were incubated in RPMI medium for 48hr with or without ginseng total saponin(GTS), and then analyzed flow cytometrically. Upto the concentration of 100㎍/㎖, GTS exherted stimulatory effect on the immune cells most prominently on B cells: the percentage of the surface Immunoglobulin (sIg) -positive cells (B cells) of the control was 47.l%, while that of GTS treated was 58.9%. The percentages of monoclonal antibody(mAb) J1j-reactive cells (T cells) were 28.8% and 3l.3%, those of mAb Gkl.5-reactive cells (CD4' T cells) were l8.5% and l9.l%, and those of mAb M1/70-reactive cells (mostly macrophages) were 4.4 and 5.0% at the concentration of 0 and 100㎍/㎖, respectively. However, at the concentration of 300㎍/㎖ or higher, GTS was found to be toxic to the immune cells especially to B cells in that the flow rate of the cells (gated viable cells) significantly decreased and the percentage of B cells droped from 58.9% to 31.2% and 25.4% at l00, 300, and 1000㎍/㎖, respectivelly. These data strongly suggests that GTS would exhert B-cell mitogen-like activity at physiological concentrations of 100㎍/㎖ or lower.

          • 꽃송이버섯 열수 추출물을 포함하는 조합물들의 항암면역활성

            정경수,이우찬 충남대학교 약학대학 의약품개발연구소 2005 藥學論文集 Vol.20 No.-

            In order to develope a new composite to be used as immunopotentiating health food, the composites including extracts of Sparassis crispa, Grifola frondosa, Phellinus linteus, red ginseng, and Oxya japonica were prepared and tested for their antitumor immunoactivities. Of these, the composite G3, which contained the extracts of S. crispa (20%), G. frondosa (55%), P. linteus (5%), red ginseng (10%), and O. japonica (10%), showed marked lymphoblastogenic activity on the in vitro cultured BALB/c mouse splenic lymphocytes and successfully suppressed the growth of sarcoma 180 cells implanted into the peritoneum of ICR mice. Moreover, the composite G3 exerted antitumor activity against sarcoma 180 tumor cells subcutaneously implanted into the left groin of ICR mice with the tumor inhibition ratio of 46.2%.

          • 은행잎 플라보놀배당체에 대한 셀루라제류의 영향

            배기환,민병선,백흠영,안병준 충남대학교 약학대학 의약품개발연구소 1991 藥學論文集 Vol.7 No.-

            The extractability and stability of ginkgoflavonolglycosides under presence of several cellulase preparations were investigated. The enzymes used were macerosin, cellulase C and cellulase NC. The content variation of the glycosides was measured with HPLC method, using caffeic acid as an internal standard. The methanol extract of ginkgo leaf, containing the total flavonolglycosides of 4.46%, was used for the content comparison. By extraction with the enzymes, each or mixed, the peak levels of all the glycosides began to decrease after 1 or 2 hours. After 24 hour extraction, most of the glycosides were degraded to minor components. The flavonolglycosides in ginkgo leaf were also hydrolysed simply by the water extraction. After 24 hour extraction with water at 40℃, the peak levels of major glycosides were distinctly decreased. Rutin was hydrolysed by enzyme treatment or by ginkgo leaf itself. As a result, it was concluded that the commercially available cellulases and the ginkgo leaf itself contain the activities of β-glycosidase and α-rhamnosidase. Kaempferol-3-O-(6'"-O-p-coumaroylglucosyl)-rhamnoside and four other ginkgo flavonolglycosides were not hydrolysed under the same condition.

          • 오메프라졸과 γ-시클로덱스트린과의 복합체 형성 및 제제학적 특성

            이계주,김은영 충남대학교 약학대학 의약품개발연구소 1995 藥學論文集 Vol.11 No.-

            The interaction of omeprazole(OMP)with γ-cyclodextrin(γ-CyD) was investigated by solubility study and the complexation was confirmed by means of UV/VIS spectrophotometer, circular dichroism, differential scanning calorimeter, and ^1H nuclear magnetic resonance spectra. The stability, dissolution rate, and partition coefficient of the complex were measured. The results present that the benzimidazole moiety and a part of pyridine ring containing sulfur atom of OMP might be included into the cavity of γ-CyD and the formation type of inclusion complex appeared to be B_s. The stoichiometric ratio of OMP to γ-CyD in the complex was found to be 1:1 and the stability constant of the complex found to be 97.1 M^-1. And the dissolution rate of OMP was markedly increased by inclusion complex formation with γ-CyD, and so it was above 90% in 5min. from solid complex. Oil to water partition coefficient of OMP-γ-CyD complex was 60, which is significantly higher than that of OMP itself, 36.4. The degradation rate constant of OMP were greater than OMP-γ-CyD complex in aqueous solutions of various pHs, and the half lives of OMP and OMP-γ-CyD at pH 9 were 279.2 and 509.9 days, respectively, showing that the complex was more stable than OMP, therefore it was thought that OMP was stabilized by inclusion formation with γ-CyD.

          • Berberine glycyrrhizinate가 흰쥐 대뇌 Na^+, K^+ -ATPase활성도에 미치는 영향

            金泰眞,柳柄泰 충남대학교 약학대학 의약품개발연구소 1985 藥學論文集 Vol.1 No.-

            Effect of several forms of berberine glycyrrhizinate on the Na^+, K^+-ATPase activity were compared with those of the mixture of berberine and glycyrrhizine. Berberine and glycyrrhizine solution (5×10 exp(2)M) was mixed at the same molar ratio and the pH of mixed solution was adjusted to 3.0, 3.5, 4.0, 4,7, and 5.0, respectively. After centrifugation, the berberine glycyrrhizinate was identified by TLC, UV, IR and M.P., and then the molar ratio was determined by UV spectrophotometer at 251nm and 350nm was examined. When incubated in Tris-buffer (pH7.4) at 37℃, the ATPase activity was improved by the berberine glycyrrhizinate (1.95:1), in case of the incubation time was less than 30 minutes. But incubated more than 30min, the enzyme activity was inhibited. Whereas, the enzyme activity was inhibited by berberine, glycyrrhizine and their mixture (1.95:1) throughout the incubation time up to 40 minutes.

          • 케토프로펜을 함유하는 고형 지질 나노파티클의 제조 및 평가

            백명기,이상영,지웅길 충남대학교 약학대학 의약품개발연구소 1996 藥學論文集 Vol.12 No.-

            Solid lipid nanopaticles (SLN) have been developed as a new drug delivery system. Although many particulate drug carriers, such as microsphere, liposome, niosome, emulsion, etc have been introduced, they have some disadvantage: low efficiency of incorporation and stability, lack of reproducibility, and so on. Meanwhile, SLN as a new drug delivery system are known to entrap drugs with a high efficiency and a good reproducibility. Moreover, small size SLN can circulate in blood for a prolonged time. Although many preparation methods were introduced microfluidization method is recommended to be the most useful. This study was attempted to prepare and evaluate ketoprofen-incorporatd SLNs (keto-SLN), which were prepared by two methods, ultrasonication and microfluidization. Keto SLN was evaluated by measurement of particle size and zeta potential, efficacy of entrapment, sedimentation volume, in virto release pattern. The mean particle size was about 0.1 ㎛, and the size was dependent on the type and the amount of emulsifier. Zeta potential was negative. -9~-13㎷ and entrapment efficacy was very high and stability was good for at least 60 days in the respect of particle size and sedimentation volume ratio. Analgesic effect was also determined as well as pharmacokinetic parameters. The former was comparable to that of that of ketoprofen loaded suspension (keto-sus) and the latter revealed that consistent with the delayed release of keto-SLN T_max was longer than keto-sus. Therefore keto-SLN was favourable dosage forms in the field of drug delivery system such as anti-cancer. analgesics and anti-inflammatory agents.

          • α-Glucosidase Inhibitors from Commelina communis

            Kim, Hang Sub,Kim, Young Ho,Hong, Young Soo,Paek, Nam Soo,Lee, Hong Sub,Kim, Tae Han,Kim, Kee Won,Lee, Jung Joon 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-

            A methanolic extract of Commelina communis showed potent inhibitory activity against α-glucosidase. One pyrrolidine alkaloid, 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine(DMDP, 1) and four piperidine alkaloids, 1-deoxymannojirimycin (2), 1-deoxynojirimycin (3), α-homonojirimycin (4) and 7-O-β-D-glucopyranosyl α-homonojirimycin (5) were isolated by bioasgay-directed fractionation and separation. These compounds have been identified for the first time from Commelina communis, supporting the pharmacological basis of this plant that has been used as a traditional herbal medicine for the treatment of diabetes.

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