정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

췌장 선방세포암 1예

이화정,지준호,박승찬,박정철,최은정,서혜진,이원식,이정림,배병조,손경락,이경희 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Acinar cell carcinoma is a rare tumor that represents 1~2% of al1 pancreatic cancers. Clinical and radiologic findings are inconclusive in this disease Acinar cell carcinoma is characterized by rapid progression and early metastasis, which lead to its poor prognosis. A 41-year-o1d man was admitted to our hospital for abdominal pain. Abdominal computed tomography (CT) and positron emission tomography-computed tomography (PET-CT) showed a splenic mass, which was being invaded by a pancreatic tail mass and which had increased ^(18)F-fluorodeoxyglucose (FDG) uptake Primary radical distal pancreatectomy and splenectomy were performed. Pathologic findings revealed an acinar cell carcinoma of the Pancreas The patient underwent a total gastrectomy three months later because of gastric recurrence Four months later, multiple hepatic metastases were discovered, and the patient underwent a left hepatectomy During treatment with capecitabine, there was no evidence of tumor progression for 14 months. We report a case of metastatic pancreatic acinar cell carcinoma, which did not progress for an extended period while the patient was being treated with capecitabme.

원발성 후복막 점액낭샘암종 1예

지준호,이화정,박승찬,박정철,최은정,서혜진,이원식,이정림,배병조,손경락,이경희 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Primary retroperitoneal mucinous cystadenocarcinoma is a very rare malignancy, and little is known concerning its Pathogenesis, optimal treatment, and prognosis. A 29-year-o1d pregnant woman (21 weeks) Presented with abdominal discomfort CA 19-9, CA 125, and CEA were normal Abdominal CT scanning revealed a 19x15x13 cm retropentoneal tumor Exploratory laparotomy and tumor excision were performed. Mucinous retropentoneal implants were removed as completely as possible Histologically, the tumor showed focal areas of capsular invasion, but free resection margins The uterus and both ovaries were normal in appearance No adjuvant therapy was pursued. Six months later, Peritoneal and bilateral ovarian metastases were discovered. Hence, we report the details of this case of primary retroperitoneal mucinous Cystadeno-carcinoma and present a review of the literature.

데이터 마이닝 접근방법에 의한 기업 도산 예측

정병화,지원철 弘益大學校 科學技術硏究所 2000 科學技術硏究論文集 Vol.11 No.-

Bankruptcy Prediction is a noble application of data mining. We attempt to analyze korean companies which were bankrupted or in financial insolvency after IMF is introduced, using Frailty Model. Frailty model has the advantage that it can consider multiple observations over some periods, while neither MDA nor Logit analysis can. Firstly, we build the model according to frailty analysis, and remodel the prediction model to estimate the parameters using hierarchical generalized linear model. The model select the ratio of interest over sales volume as a most influential factor in predicting bankruptcy.

장기간 수영운동에 참가한 중년여성의 신체구성과 건강체력 특성에 대한 연구

전종귀,성민철,이창규,현광석,조병준 충남대학교 체육과학연구소 2000 體育科學硏究誌 Vol.18 No.1

The purpose of this study was to identify the effects of swimming exercise career on the middle-aged women. The number of sujects were 44 postmenopausal women(45-60 age group). The number of exercise group were 27(3 years average career) and that of control group were 17, Percent body fat physical development score, back strength, grip strength, trunk flexion, endurance were measured. The results were as followings; 1. The percent body fat, physical development score, back strength, grip strength, endurance of swimming exercise group was higher than that of control group. The difference showed the statistical significance. The trunk flexion and grip strength of swimming exercise group were lower than that of control group. The difference didn't showed the statistical significance. 2. The back strength, muscle endurance, endurance of swimming exercise 7 years average career group was higher than that of 3 years average career group. The difference showed the statistical significance. As the above, the regular participation of swimming exercise help the middle-aged women to promote their health-related fitness. Also the exercise prevent obesity, back pain.

분자선 Epitaxy법에 의해 MgO(100) 및 MgO/Si(111) 기판위에 증착된 YBa_2Cu_3O_7-x 박막의 초전도 및 결정특성(Ⅰ)

장호정,김병철 단국대학교 신소재기술연구소 1993 신소재 Vol.3 No.-

분자선 Epitaxy법에 의해 MgO(100) 및 MgO/Si(111) 기판위에 기판온도 590℃, chamber압력 9.5×10^-5 Torr의 증착조건에서 YBA_2Cu_3O_7-x (YBCO)박막을 제작하여 초전도 및 결정특성을 조사하였다. MgO(100) 단결정 기판위에 증착된 YBCO박막은 초전도 전이온도 Tc_zero 86K의 표면이 거칠은 단결정 박막을 재현성있게 얻을 수 있었다. 또한 MgO/Si(111)기판위에 증착된 박막시료의 경우 Tc_zero 75K의 다결정의 결정특성을 나타내었다. XRD분석결과 양쪽시료 모두 기판위에 수직한 c축 배향구조를 나타내었고, rocking curve의 FWHM(Full width at half maximum) 값은 MgO(100)기판위에 증착된 박막이 0.65°로써 더 작은 값을 나타내어 c축 배향성이 개선되었음을 알 수 있었다. SEM에 의해 표면조직을 관찰한 결과 박막표면에 과성장 핵(outgrowth nuclei)이 관찰되었으며, 이는 증착중 a, b축과 c축의 결정성장 속도의 차이에 기인하는 것으로 사려 되었다. MgO(100) 기판위에 증착된 Tc_zero 83K의 YBCO박막시료의 임계전류밀도(Jc)값은 온도 4.2K 1 Tesla 자장하에서 5.1×10^6A/㎠이었다. The YBa_2Cu_3O_u-x(YNCO) thin films were grown on MgO(100) and MgO/Si(111) substrate at the substrate temperature of 590℃ and the chamber pressure of 9.5×10^-5 Torr by a molecular beam epitaxy method. The superconductivity and crystalline quality were investigated. The YBCO film on MgO(10)substrate showed Tc zero 86K with single crystal phase in RHEED observation. Whereas, the YBCO film deposited on the MgO/Si(111) substrate was Tc zero 75K with polycrystalline nature under the same deposition condition. The X-ray diffraction (XRD) analysis for the both samples showed preferentially c-axis oriented superconducting phases perpendicular to the film surface. The FWHM (Full Width at Half Maximum) of (005) rocking curve for the YBCO film on MgO(100) substrate was 0.65° and was increased to 1.72° when the YBCO film was deposited on MgO/Si(111) substrate. This large value of FWHM means that the degree of preferred orientation was lowered. The critical current density (Jc) for the films deposited on MgO(100) substrate was found to be 5.1×10^6 A/㎠ at 4.2K and 1 Tesla in applied magnetic field.

24시간 혈압 감시를 통한 만성 뇌졸중 환자에서의 야간 혈압 강하 현상의 연구

정산,이병철,유경호,정승철,김성민,권기한,황성희 대한신경과학회 1996 대한신경과학회지 Vol.14 No.4

고분자 복합재료를 위한 액정중합체(I)

조철형,조성휴,조병욱,김정규,김숭평,권중근 조선대학교 생산기술연구소 1983 生産技術硏究 Vol.1983 No.-

Copolyesters containing oxybenzoate as a rigid rod molecule and methylene group and dimethyl tetramethyl disiloxane as flexible spacers were prepared by room temperature solution polymerization for the purpose of the developement of polymeric composite materials. The thermal properties and the characteristics of the polymers were investigated by DSC and a polarizing microscope. The polymers may be formed nematic liquid crystal phase, and the thermodynamic characteristics of their mesophase to isotropic phase transition could be explained on the basis of its structural features.

전기로 분진에서 납의 휘발반응에 대한 속도론적 연구

김병수,유재민,이재천,남철우,윤정모 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.4

"he removal of lead from electric arc furnace (EAF) dust is important in the process for recovering zinc by a reduction-volatilization method. In this study, experiments on kinetics of the volatilization reaction of lead by chlorine components as NaCl and KCl contained in the EAF dust were carried out in the temperature range of 973 to 1223 K under an air atmosphere using a weight-loss technique. As a result, the volatilization ratio of lead was about 99.0% at the temperature of 1223 K and the reaction time of 180 min. Jander equation was found to fit well the volatilization reaction rate over the entire temperature range. The volatilization reaction of lead is rate controlled by solid-solid diffusion. An activation energy of 175 kJ/mol(41.8 kcal/mol) was obtained. (Received January 8, 2004)

불안정성 흉요추체 방출형 골절 환자에서 기구를 이용한 고정술의 결과

안병조,이정청,김재은,김형일,김철진,최하영 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.9

Fifty six patients with unstable thoracolumbar bursting fractures were treated using variable internal fixation devices such as the Kaneda Anterior Fixation System(Kaneda device), the Z-Plate-ATL^(TM) Anterior Fixation System(Z-Plate ATL^(TM)device), the Harrington device. Cotrel-Dudousset(CD) or Compact Cotrel Dubousset(CCD) device of Steffee Transpedicular System with or without decompression. Suchy internal fixation devices were grouped into anterior and posterior internal fixation devices and compared with each other in the aspect of the degree of neurological improvement, the changes of the vertebral height and the kyphotic angle, the duration of admission, and postoperative complications. In conclusion, the anterior internal fixation device appears to be of more benefit in the management of patients with unstable thoracolumbar bursting fracture