정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

소화성궤양 환자에 대한 Omeprazole(Losec^(�))의 임상 효과

이종선,이기천,허승식,안정기,윤세진,정현용,이헌영,김영건 최신의학사 1990 最新醫學 Vol.33 No.9

간세포암의 고주파 열치료 후 천자침 경로를 통한 전이 1례

조영완,박석주,진한영,김준영,이재익,강명주,박정하,윤정희,박성재,지삼룡,이연재,이상혁,설상영 인제대학교 2006 仁濟醫學 Vol.27 No.-

Radiofrequency ablation(RFA), as a form of minimally invasive therapy for hepatocellular carcinoma, has become an important treatment modality. Because of limitation of surgery, RFA has become standard therapy for hepatocellular carcinoma in some situations. But there are some complications of RFA such as bleeding, infection, hematoma, adjacent organ thermal damage including intestinal perforation, needle track seeding, and so on. There are few reports in the literature that systematically evaluate the incidence of needle tract seeding and its associated risk factors. And only 2 cases of needle tract seeding of hepatocellular carcinoma after RFA were reported in Korea. We report a case of needle tract seeding of hepatocellular carcinoma after RFA.

승화전사날염의 수공예적 기법 적용에 관한 硏究

이연순,정은영 영남대학교 지역발전연구소 1997 새마을지역개발연구 Vol.21 No.-

The purpose of this study is to investigate the possibility of heat transfer printing on cotton fabrics by disperse dyes. In order to know the effect of the temperature and time of transfer on the transfer printing, cotton fabrics were pretreated with resin finishing agents printed with disperse dyes, and then the colorfastness of printing fabrics were investigated. The results of this study were as follows: 1. The effect of transfer printing was increased according to the temperature till 210 ℃, but the effects were decreased in temperature 210 ℃ above. 2. The effect of transfer printing was increased linearly with transfer time, above a certain critical point. The optimum time for printing was, in this researcher opinion, 60 seconds. 3. According to the manual handicrafts made by trasfer printing, the works were made freely and easily and the variable pattern designs were able to print.

조기 발병한 정신증적 장애에서 자기공명영상을 이용한 측뇌실에 대한 구조적인 예비연구

이윤희,강민희,김철응,이정섭,배재남,홍강의 대한소아청소년정신의학회 2001 소아청소년정신의학 Vol.12 No.2

연구목적:측뇌실의 확장은 성인기의 정신분열병에서 잘 확립되는 소견이지만, 조기에 발병한 정신증적 장애에서는 아직 논란이 있다. 본 연구에서는 자기공명영상을 이용한 후향적인 방법을 통하여 지금까지 비교적 연구가 많이 시행되지 않았던 조기발병한 정신분열증·양극성 장애 환아들을 대상으로 측뇌실의 구조적인 이상을 연구하여, 이러한 뇌의 구조적 이상이 병의 초기부터 시작되어 정상과는 다른 경과로 진행되는 것인가를 알아보고자 하였다 방법:정신분열병과 양극성 장애의 DSM-Ⅲ-R 진단 기준에 부합하는 14명의 환아(평균 연령 14.0세,표준편차 2.1)와 26명의 두통 대조군에서 뇌자기공명 영상상을 후향적으로 모집하였다. 분석을 위하여 측뇌실이 가장 잘 보이는 축 영상(axial image)를 선택하였다. 뇌자기공명영상상은 평판형 스캐너로 읽어들여서 NIH IMAGE 프로그램을 통하여 분석하였다. 결과:환자군에서는 측뇌실 크기, 측뇌실확장지수가 연령의 증가에 따라 함께 증가하는 상관관계를 나타내었으나, 대조군에서는 연령과 측뇌실 크기, 측뇌실확장지수 등이 유의한 상관관계를 보이지 않았다. 환자군에서는 정상군에서 보이는 좌우 측뇌실 비대칭성이 소실된 결과를 보였다. 그리고 통계적으로 유의한 정도는 아니었으나 환자군이 대조군에 비해 측뇌실과 측뇌실확장지수가 큰 경향을 보였다. 결론:정신증적 환자에서의 뇌의 구조적 이상은 병의 비교적 초기 경과에서부터 시작되며, 정상과는 다소 다른 경과를 취하여 진행한다는 것을 시사하는 결과라 할 수 있다. Objective : The enlargement of the lateral ventricle is well established finding in adult-onset schizophrenia, but in the patients with early-onset psychotic disorder(EOPD) is still controversal. To identify structural abnormalities of the lateral ventricle in patients with EOPD and difference of the brain developmental course in EOPD group, planimetrical assessment of the lateral ventricle was conducted by means of retrospective quantitative neuroimaging. Methods : The brain MR images of 14 patients with EOPD(mean age 14.0±2.1 years) who met the DSM-Ⅲ-R diagnostic criteria for schizophrenia and bipolar disorder and 24 control subjects with simple headache(mean age 10.0±2.1 years) were collected. Single best view for the lateral ventricle, one axial slice was selected for analysis. MR images were redigitalized with flatbed scanner and data were analyzed with NIH IMAGE software. Results : In the patients with EOPD, there were significant correlations between aging and lateral ventricular sizes and between aging and ventricular brain ratio(VBR). The statistical significance of normal asymmetry of the lateral ventricle was not observer for the EOPD group. The EOPD group had larger lateral ventricular sizes and VBR than control group, but these results were not statistically significant. Conclusion : These findings suggest that the brain abnormalities in patients with EOPD progress from the earlier course of the disorders and the course of brain development in EOPD group is different from control group.

Silicoater technique을 이용한 veneered stainless steel crown 수복의 임상적 평가

이상호,이창섭,김왕근,정연화 大韓小兒齒科學會 1999 大韓小兒齒科學會誌 Vol.26 No.1

광법위한 치질파괴가 있는 상악유전치를 갖는 소아에서 silicoater technique에 의한 veneered stainless steel crown으로 수복 후 3∼12개월 동안 주기적 검사와 수복물의 평가 결과, 다음과 같은 결론을 얻었다. 1. 행동조절이 어려운 소아에서 chair time을 감소시킴으로써 행동조절에 도움을 주었다. 2. 유지력,내구성,심미성이 우수하였으므로 유전치부의 광법위한 치질손상시 유용한 수복방법이다. Restoration of severly carious, malformed or traumatically fractured primary incisors is one of the most difficult challenges in restorative dental care for preschloers. In restoring primary anterior teeth, four types of complete coverage crowns have been attempted over the years. Stainless steel crowns, open-faced stainless steel crowns, acid-etched crowns(strip crowns), and preformed polycarbonate crowns have been the choeces. While these restorations have beem accepatable for many patients, they all have very distinct limitations. The ideal full coronal restoration for a primary incisor requires durability, retention, and esthetics. This paper reported veneered stainless steel crown restoration of primary anterior teeth by silicoacter technique. Veneered stainless steel crown restoration by silicoater technique is considered to be a durable, retentive, and esthetic restoration.

편심보강평판의 좌굴해석

이정윤 三陟大學校 1998 論文集 Vol.31 No.1

In this study, the rigidities of stiffened plates was compared with theory and experimental results. The rigidities obtained from the natural frequency experiment were used in computing the buckling load. The static buckling load was increased with the amount of eccentricity stiffeners. The result of between the static buckling loads obtained from the vibration experiment and the buckling experiment for the eccentricaly stiffened plates agreed with 4~9 percents. In case of isotropic plates, static buckling load was agreed with 7 percents.

전하 제어법을 이용한 압전 액추에이터의 이력저감

정순종,이대수,송재성,홍원표,강은구,최원종 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

This paper presents a method to reduce hysteresis in multilayer ceramic actuator by connecting the actuator with a capacitor in a series circuit. The change in hysteresis with respect to the capacitor was examined. 0.2Pb(Mg_(1/3)Nb_(2/3))O₃-0.8Pb(Zr_(0.475)Ti_(0.525)) O₃ ceramic material was used as a piezoelectric material for the actuator. Displacement of the actuator was measured in a capacitive gap sensor measuring system. In case of inserting a capacitor in a total circuit, hysteresis became dramatically decreased, and then finally the hysteresis value can be reduced below 0.2%. It was found in this present study that reducing the hysteresis in the actuator is dependent upon the characteristics of the capacitor in total circuit and also operating frequency

팝아트의 꼴라주 기법을 이용한 패션일러스트레이션

이혜영,서윤정 대전대학교 생활과학연구소 2000 생활과학연구 Vol.6 No.-

The objective of this paper was to identify the relationship between Pop art and fashion illustration in relation to its techniques of fashion illustration, particularly collage. As the result of this study, it was found the followings. Pop art was characterized as popular, mass production, mass media, photograph, youth and modern. Also 60's fashion illustration expressed the image of Pop art. Collage techniques is used one of several fashion illustration expression. It was distinguishable according to object, various materials of collage and how to express is fashion illustration, which is flat object or not. Hamilton, Wahol, Antonio, Bill Donovan, Mat Gustavson, Zoltan showed fashion illustration using by collage techniques of Pop art or development of collage techniques, that is Graffito, Assemblage, photographic Montage

여자고등학생의 가정생활에 대한 가치의식과 가사수행능력

이정우,윤현희 숙명여자대학교 건강ㆍ생활과학연구소 1997 生活科學硏究誌 Vol.12 No.1

This study is to investigate general tendency of high school girl's consciousness of values in the family and household abilities, to identify their related variables, and to find the main variables affecting household abilities. Data was collected for 569 students. Through a structured questionnaire, data was analyzed by frequency distribution, percentage, mean, Duncan's multiple range test, and Stepwise Regression. Major findings are as follows : 1) The consciousness of values in the family of high school girls showed a modern tendency in general. 2) Most subjects showed medium level of household abilities(52.6 point out of a possible 100), proving to be relatively lower. 3) Household abilities of high school girls were influenced by the consciousness of values in the time management, household, and life satisfaction about family.