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      • KCI등재
      • KCI등재

        Etiology and therapeutic outcomes of children with gonadotropin-independent precocious puberty

        강은구,조자향,최진호,유한욱 대한소아내분비학회 2016 Annals of Pediatirc Endocrinology & Metabolism Vol.21 No.3

        Purpose: This study was performed to investigate the etiology, clinical features, and outcomes of patients with gonadotropin-independent precocious puberty (GIPP). Methods: The study included 16 patients (14 female and 2 male patients) who manifested secondary sexual characteristics, elevated sex hormones, or adrenal androgens with prepubertal luteinizing hormone levels after gonadotropin releasing hormone stimulation diagnosed between May 1994 and December 2015. Patients with congenital adrenal hyperplasia were excluded. Clinical features, laboratory findings, treatment modalities, and outcomes were retrospectively reviewed. Results: The median age at diagnosis was 2.6 years (range, 0.7–7.9 years) and median follow-up duration was 4.6 years (range, 1 month–9.8 years). Patients with McCune-Albright syndrome (n=5) and functional ovarian cysts (n=4) presented with vaginal bleeding and elevated estradiol levels (23.3±17.5 pg/mL); adrenocortical tumors (n=4) with premature pubarche and elevated dehydroepiandrosterone sulfate levels (87.2–6,530 μg/dL); and human chorionic gonadotropin (hCG)- producing tumor (n=1) with premature pubarche and elevated β-human chorionic gonadotropin levels (47.4 mIU/mL). Two patients were idiopathic. Six patients transited to gonadotropin-dependent precocious puberty median 3.3 years (range, 0.3–5.1 years) after the onset of GIPP. Initial and follow-up height standard deviation scores (0.99±0.84 vs. 1.10±1.10, P=0.44) and bone age advancement (1.49±1.77 years vs. 2.02±1.95 years, P=0.06) were not significantly different. Conclusion: The etiologies of GIPP are heterogeneous, and treatment and prognosis is quite different according to the etiology. Efficacy of treatment with aromatase inhibitors needs to be evaluated after long-term follow-up.

      • KCI등재후보

        온도안진검사상 정상 소견을 보이는 선택적 하전정신경염 1예

        강은구,황규린,이종대,성기범 대한평형의학회 2009 Research in Vestibular Science Vol.8 No.1

        Vestibular neuritis is commonly diagnosed by demonstrating of peripheral vestibular failure as a unilateral loss of the caloric response. It is a sudden, spontaneous, unilateral loss of vestibular function without simultaneous hearing loss or brainstem signs. In most patients with vestibular neuritis, the process is thought to involve the superior vestibular nerve. Very rarely, vestibular neuritis involves only the inferior vestibular nerve. We experienced a 56-year-old male with inferior vestibular neuritis. The patient had vertigo and spontaneous nystagmus, but a normal caloric test. Brain magnetic resonance imaging was normal, while vestibular evoked myogenic potentials had absent amplitudes on the lesion side. The patient was thought to suffer from pure inferior nerve vestibular neuritis. Vestibular neuritis is commonly diagnosed by demonstrating of peripheral vestibular failure as a unilateral loss of the caloric response. It is a sudden, spontaneous, unilateral loss of vestibular function without simultaneous hearing loss or brainstem signs. In most patients with vestibular neuritis, the process is thought to involve the superior vestibular nerve. Very rarely, vestibular neuritis involves only the inferior vestibular nerve. We experienced a 56-year-old male with inferior vestibular neuritis. The patient had vertigo and spontaneous nystagmus, but a normal caloric test. Brain magnetic resonance imaging was normal, while vestibular evoked myogenic potentials had absent amplitudes on the lesion side. The patient was thought to suffer from pure inferior nerve vestibular neuritis.

      • KCI등재

        Emission Characteristics of High-Voltage Plasma Diode Cathode for Metal Surface Modification

        강은구,김진석,이석우,민병권,이상조 한국정밀공학회 2015 International Journal of Precision Engineering and Vol. No.

        Electron beam cathodes have been used in various fields such as microscopy, X-ray tubes, welding, and surface modification. Generally, cathodes use metals with lower work function, higher thermal resistance, lower poisoning effects of gases, etc. LaB6,tungsten, and tantalum have normally been used as cathode materials with special materials coated if required. This study investigatedthe high-voltage plasma diode cathode for surface modifications of metal products such as polishing, hardening and heat treatment. The most fascinating features of this cathode are the high voltage and current that can be obtained at a low vacuum of a few mTorr. However, it is difficult to control the emission current to attain a steady state and to obtain higher brightness than that achieved usinga thermal cathode. We studied the emission characteristics in terms of cathode and anode design parameters such as anode distanceand cathode shape. Additionally, changes of emission characteristics are discussed in terms of the type of gas, pressure parameter,etc. using the emission resistance, effective breakdown voltage, and brightness. Finally, by measuring the change in surface roughnessusing the emitted electron beams, we found that the surface roughness values before the process were Ra=0.8 μm and Rz=5.4 μm,whereas those after the process were Ra=0.25 μm and Rz=2.3 μm. The electron beam polishing technology is eco-friendly and canminimize the emission of many harmful materials that arise when existing mechanical or electrochemical polishing technologies areused.

      • KCI등재

        경구개에 발생한 말초성 T세포 림프종 1예

        강은구,이용만,박계훈,백병준 대한이비인후과학회 2009 대한이비인후과학회지 두경부외과학 Vol.52 No.6

        Peripheral T cell neoplasms (PTCNs) comprise a group of uncommon and heterogenous lymphoid malignancies. They are more difficult to diagnose and treat and have a worse prognosis than B cell lymphomas. NK/T cell lymphoma is the most common histologic subtype in the head and neck. Unspecified type is the most common subtype of PTCNs but is not reportedin oral cavity or nasal cavity. We report a case of a perforating palatal ulceras a rare presentation of peripheral T cell lymphoma with a review of literature.

      • KCI등재

        칼만 필터와 차량 특징 정보를 이용한 중첩된 다중 차량 추적에 관한 연구

        강은구,김성동,최기호 한국통신학회 2001 韓國通信學會論文誌 Vol.26 No.4

        본 논문은 고정된 카메라를 통해 들어오는 도로연상에서 추적되는 다중 차량들의 겹침(occlusion)발생시 칼만 필터와 차량의 특징정보를 이용하여 개별 차량을 분할하고 추적 가능한 시스템을 제안하고 구현하였다. 다중 차량을 추적할 시 가장 큰 문제점이 되고 있는 차량 겹침을 해결하기 위해 카메라와의 거리를 이용하여 해결하는 방법 3D 모델을 이용하여 해결하는 방법, 겹침 추론 등 차량 겹침을 해결하기 위한 여러 가지 방법들이 제시되고 있다. 그러나 영상에 연속적으로 나타나는 다중 차량의 겹침을 단일 차량으로 인식할 수 는 단점이 있다. 따라서 칼만 필터와 차량의 특징 정보로서 차량의 높이와 넓이의 비, 추적에 사용되는 박스에서 차량과 여백의 비를 이용함으로서 연속적으로 나타날 수 있는 차량 겹침을 분할하고 추적 가능하게 하는 시스템을 구현하고 실험하였다. 본 시스템에서는 256X 256의 크기로 15 frames/sec로 저장된 AVI 파일 형식의 동영상을 사용하여 실험에 이용하였으며, 시내 도로에서의 차량들의 실험 결과 기존의 방법 보다 차량 특징 정보를 이용한 방법이 연속적 겹침에 대한 처리에 우수함을 보였다.

      • KCI등재

        Plasma Diode Electron Beam Heat Treatment of Cast Iron: Effect of Direct Preheating

        강은구,최헌종,민병권,이상조 한국정밀공학회 2017 International Journal of Precision Engineering and Vol.18 No.10

        Cast iron is relatively cheap and highly machinable and is thus used for various mechanical parts. However, cast iron (H2 grade) is a high-carbon steel that shows cracks or craters owing to the martensitic transformation during conventional surface heat treatments. In this study, we investigated electron-beam (e-beam)-based direct preheating for preventing the formation of craters and cracks during the heat treatment of cast iron using a plasma diode e-beam. Scanning electron microscopy, X-ray diffraction analysis, energy-dispersive X-ray spectroscopy, and hardness measurements were performed to elucidate the crater and crack formation mechanism. Craters were formed within the graphite phase, owing to the low-melting-point elements and compounds. It was also observed that crack and crater formation was correlated to the distortion of the primary gamma phase, based on a significant decrease in the d-spacings. The direct preheating process resulted in a lower degree of distortion of the gamma phase. As a result, we could achieve a hardness as high as 800 HV without cracks or craters in cast iron, which is a cheap material. Moreover, the results of potentiodynamic polarization tests showed that the corrosion resistance increased after the surface treatment, owing to the removal of the low-melting-point impurities and grain refinement.

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