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RISS 활용도 분석
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일본/중국/유럽자료
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최신/인기 학술자료
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RISS 인기검색어
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- 저자 : 윤세진 (검색결과 329 건)
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윤세진,김영건 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2
We reported a case of 51-year old female who was diagnosed primary leiomyosarcoma in duodenum confirmed by post-operation pathologic diagnosis. She complained of melena and general weakness. The endoscopy revealed mass with central necrosis in third portion of duodenum. The endoscopic biopsy showed nonspecific inflammation and ulcer. The case was performed segmental resection and end-to-side duodeno-jejunostmy. Final postoperative diagnosis is low grade leiomyosarcoma in duodenum second and third portion.
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윤세진,정형민,차광렬,김남형,이경아 한국발생생물학회 2004 발생과 생식 Vol.8 No.1
미성숙의 Germinal Vesicle(GV 단계에서 성숙한 Metaphase II(MII) 단계가 되는 난자성숙 과정은 핵과 세포질의 성숙을 통해 이루어지며, 이를 통해 수정과 배 발달을 할 수 있는 능력을 갖게 된다. GV 난자는 prophase I 단계에 arrest 되어 있다가 meiosis 과정을 거쳐 성숙한 MII로 되는데 이를 조절하는 기작에 대해서는 거의 알려져 있지 않다. 따라서 본 연구는 미성숙 난자와 성숙 난자간의 유전자 발현의 차이 Oocyte maturation refers to the process that prophase I arrested germinal vesicle(GV) drives the progression of meiosis to metaphase II(MII) to have the capacity for fertilization and embryo development. To better understand the molecular mechanism(s) involved in oocyte maturation, we identified differentially expressed genes(DEGs) between GV and MII mouse oocytes using a new innovative annealing control primer (ACP) technology. Using 20 ACPs, we successfully cloned 32 DEGs between GV and Mll oocytes, and 26 out of these 32 DEGs were functionally known genes. Four genes including Pscd2 were GV-specific, 10 genes including PKD2 and CSN3 were highly expressed in GV oocytes(GV-selective), and 12 genes including Diva were highly expressed in MII oocytes (MII-selective). Ail of the genes identified in this study were first reported in the oocyte expression using ACP system and especially, we could characterize the existence of PKD-CSW signaling pathwayin the mouse oocytes. Results of the present study would provide insight for studying molecular mechanisms regulating oocyte maturation.
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