고요산혈증의 위험인자 : 아산시 지역 주민을 대상으로

김용배,장원기,황보영,김화성,안규동,이병국,이용진,이종은,이준숙,이찬구,이한정,이성수 순천향대학교 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

Objective : Serum uric acid has now been identified as a marker for a number of metabolic and hemodynamic abnormalities. The aim of this study is to evaluate risk factors which influence hyperuricemia in the citizens of Asan. Method : The study design was cross-sectional and research subjects were 1086 citizens of Asan. General characteristics, cigarette smoking, alcohol consumption, and past history were obtained by interview using a structural questionnaire. Also, we measured height, weight and blood pressure, and serum uric acid of the subjects. Results : The mean serum uric acid level was 5.27 ㎎/㎗ in men and 4.01 ㎎/㎗, in women, In the multiple logistic regression analysis, statically significant risk factors of hyperuhcemia were gender, body mass index, blood lead concentration, and serum creatinine. Conclusion : Our results suggest that gender, body mass index, blood lead concentration, and serum creatinine might be the most important risk factors of hyperurcemia. Education program as well as routine check-up for serum uric acid was highly recommended for the effective prevention of hyperuricemia.

연작업자들의 신기능 평가에서 요중 δ-aminolevulinic acid 측정의 의의

이병국,이숙,김용배,리갑수,김화성,황규윤,장봉기,이성수,안규동 순천향대학교 산업의학연구소 1999 순천향산업의학 Vol.5 No.1

To clarify the effect of occupational lead exposure on renal function 241 lead workers working and 56 non lead workers were studied in 5 lead acid battery industries. Study variables for renal effect were urinary N-acetyl-β-D-glucosaminidase(NAG), urinary total protein(U-TP), blood urea nitrogen(BUN), serum creatinine(S-Cr), and serum uric acid(S-Ua). On the other hand, blood lead(PbB), zinc protoporphyrin in whole blood(ZPP), and delta-aminolevulinic acid in urine(δ-ALA) were selected for the variables of lead exposure. Information on age, work duration, smoking and drinking history were also obtained. The results obtained were as follows. While the mean values of lead exposure indicators of lead workers were significantly different from non-exposed ones, the mean values of BUN, U-TP and S-Cr of renal function indicators of exposed were also different from non-exposed. BUN, U-TP and NAG showed statistically significant correlation with PbB and ZPP, and NAG revealed also statistically strongly significant correlation with δ-ALA. On multiple regression using renal fuction indicators as a dependent variable and δ-ALA, age, work duration,lead exposure,smoking and drinking as independent variables, only δ-ALA contributed to NAG.

2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

김치유래 젖산균의 균체지방산 분석을 이용한 분류학적 연구

이정숙,정민철,김우식,이근철,김홍중,박찬선,이헌주,주윤정,이근종,안종석,박완,박용하,민태익 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.2

표준균주를 포함한 230여개의 김치유래 젖산균에 대한 균체지방산(FAMEs)을 분석하였다. FAMEs profiles는 Euclidian Distance 17.5에 의해 7개의 Major Cluster와 1개의 Single Cluster로 나뉘어졌다. 이중 A, B, C 및 Cluster는 Leuconostoc속으로 분석되어졌고, F는 Lactobacillus속으로 분석되어졌다. 그리고 E와 G cluster는 두개의 Genus가 혼재되어 나타났으며 보충적인 연구가 필요하다. 앞으로 김치유래 젖산균의 균체지방산 분석결과를 기반으로 한 데이타베이스에 95가지 탄소원을 이용하는 수치분류학적 접근방법 및 Pyrolysis Mass Spectrometry 등의 화학적 분석 방법과 분자친화적 연구를 통한 종합적 분류정보 체계가 갖추어지면 젖산균의 신속, 정확한 동정 및 연구에 활발히 이용되어질 것이다. Two hundreds and thirty lactic acid bacteria, mostly isolated from Kimchi, including type strains were sued for analysis of cellular fatty acids. The 230 test strains were recoverd in 7 major and 1 single clusters defined a Euclidian distance of 17.5. These aggregate taxa were equivalent to the genus Leuconostoc (aggregate group A, B, C and D), and the genera Leuconostoc and Lactobacillus (aggregate group G). It is concluded as evident that FAMEs (Fatty Acid Methyl Esters) profile of cell can be used as a criterion in classification of lactic acid bacterial from kimchi. Additional comparative taxonomic studies need to be carried out on well chosen representative strains to determine the most appropriate methods of value.

테니스 라켓 스트링 장력의 차이에 따른 근전도 분석

이훈식,서국웅,윤양진,정미라,김용재,서국은,이중숙 한국운동역학회 2000 한국운동역학회지 Vol.9 No.2

The purpose of this paper is to select 7 male athletes and female athletes of high school, and to compare their active potential differences of upper arm muscles according to characteristic of a racket. the results obtained are as follows: 1. In the accumulative distribution rate of racket string tension, 65Ibs is higher in all muscle active potentials except male flexor carpi radialis muscle than 55Ibs or 60Ibs, and this result shows that 65Ibs gives lower efficiency to athletes. 2. In the muscle load rate of racket string tension, 55Ibs shows the lowest active muscle potential and is thought to be better in its efficiency, but 66Ibs shows a little high active potential and is thought not to be good in its efficiency.

열경화성수지를 사용한 화학제품의 열안정성에 관한 연구

이용숙,박근호 국립7개대학공동논문집간행위원회 2005 공업기술연구 Vol.5 No.-

We are investigated to thermal stability of various thermosetting resin products. The degree of thermal decomposition of thermosetting resin and resin products measured to the heat flow using differential scanning calorimeter (DSC). The other characteristics were tested using infrared spectra(FT-IR) and thermogravimetric analysis(TGA). As a result, DSC curve of the urea resin product appeared on a large endothermic peak at about 305℃, and the thermal decomposition of phenol resin product showed most excellent thermal stability at high temperature in this study.

韓國産 高酸價 米糠油의 脫色에 關한 硏究

李容億,金恩卿,盧長淑 명지대학교 1983 明大論文集 Vol.14 No.-

The rice bran produced in the process of rice milling is only ingredient of edible oil and fat in Korea. If and when the rice bran is left negligently for a long time, a good quality of edible oil cannot be obtained. It is not only because the loss of the rice bran is resulted in the process of refining from starch degeneration, discoloration, and generation of free fatty acid or unsaponifiable matter but because the decolorization processing becomes much more difficult. In this connection, the experiment on the decolorization of the high acid value rice bran oil was made with clay. Although remarkable results were not yielded, continuous research is needed. If successful, it will contribute to the development of domestic medical ingredients with consequent extraction and refining of orizanol or inositol etc.

화살나무 추출물에 의한 Doxorubicin-유도 조직손상의 억제

이정호,신숙정,문용,이동근 大韓免疫學會 1996 大韓免疫學會誌 Vol.18 No.2

Doxorubicin(DR), a potent antineoplastic drug, is effective in adult and childhood solid tumors and hematologic cancer. However, it has minor(mucositis, nausea, vomiting and alopecia) and major(myelosuppression, cumulative dose-related cardiomyopathy, and skin and subcutaneous ulcers) clinical toxic effects. Accidental subcutaneous DR-extravasation may provoke a prolonged and severe cutaneous inflammatory reaction for which there is currently no simple and effective treatment method. Because of this, apart from measures to prevent paravenous extravasation, many methods of preventing these ulcers have been tried clinically or experimentally, but the efficacy is uncertain. The present study was undertaken to exploit Euonymus alatus extract(EA) as an antidote for DR-induced skin ulceration, using animal model, and to evaluate the effects of EA on the pharmacological activity of DR. Sprague-Dawley rats and ICR mice were intradermally injected DR(0.5 mg/rat and 0.2 mg/ mouse) with or without EA(10 mg/rat and 5 mg/mouse). In rat model, intradermal injection of DR alone produced predictable uniform skin necrosis and ulceration involving the deep dermis. These ulcers developed within 3-7 days, remained stable for 2-4 weeks, and all rats died in 55 days of observation. However, intradermal injection of DR plus EA into rat developed only minor transient edema, erythema and mild inflammation involving the superficial dermis, which healed quickly, and all rats survived throughout the experimental periods. In mouse model, intradermal injection of DR alone produced an ulcer approximately 15.2 mm2 at 5 days. This ulcer was progressively aggravated in size until 15 days, and regressed and healed after that. But, when mice were intradermally injected DR plus EA, the ulcers were reduced in size and healed quickly. These results suggest significant efficacy for EA as a DR-extravasation antidote. B16 cells, 3LL cells and human tonsillar lymphocytes were cultured in the presence of DR with or without EA, and the proliferation responses of these cells were evaluated. DR alone de-creased remarkably the proliferation of malignant cells as well as normal cells, in a dose-dependent fashion. On the other hand, the EA itself reduced weakly the responses of tumor cells but increased those of normal cells. And EA also slightly enhanced the DR- induced inhibition of the tumor cell-proliferation, but it restored the DR-derived decrease of the lymphocyte-prol-iferation. These results suggest that EA itself has no side effects, and also suggest that EA may possibly diminish the systemic toxic effects of DR-administration. Taken together, the present study reveals that EA has an antidotic activity against DR-ex-travasations and systemic DR. And these results suggest the possibility that EA could be developed and used in a form of DR-annex as an antidotic and reinforcing agent of DR.

佛語作文 指導를 위한 새로운 敎授法 試圖와 그 分析

李容淑 이화여자대학교 한국문화연구원 1978 韓國文化硏究院 論叢 Vol.31 No.-

Dans l'enseignement du francais en Coree, les cours de composition et de theme sont souvent consideres comme identiques. Et aux cours de composition francaise, on fait traduire les phrases coreennes qui se succedent sans aucun lien interne. Les etudiants qui doivent faire ces exercices de traduction sont encore incapables de s'exprimer correctement en francais fondamental, et leurs connaissances theoriques de la grammaire francaise sont donc les seuls supports dans ce travail de dechiffrage. Il en resulte alors que le contenu du cours est communique dans un etat de desequilibre enorme entre ce qui est enseigne et ce qui est acquis pas les etudiants. D'apres la nouvelle conception de l'enseignement de langue vivante, la communication ecrite, comme la communication orale, doit s'apprendre "sans passer par le stade de la traduction ou du dechiffrage". Le but de l'enseignment aux cours de composition francaise doit etre desormais l'expression libre et personnelle des etudiants, ecrite en francais correct. Par consequent, le contenu et la methodologie doivent etre aussi modifies. En ce qui concerne le contenu, il faudrait que la presentation successive des sujets de redaction puisse toujours eveiller la curiosite intellectuelle et le besoin d'ecrire de la part des etudiants. Quant a la methodologie, on peut concevoir 3 differents procedes de cours selon le contenu. D'abord, on devra chercher a utilser les situations de la vie courante pour que les etudiants puissant s'entrainer en style quotiden. On peut utiliser efficacement la bande dessinee qui permet la mobilisation et l'emploi des moyens d'expression don't les etudiants disposent. Deuxiemement, le travail sera fait a partir d'un texte litteraire et les etudiants s'y habitueront au style litteraire. Le niveau reel des etudiants et leur interet psychologique dovient etre les premieres conditions a observer dans le choix de ces textes. D'apres les classes experimentales, faites avec les etudiantes de 3 annee de la Section Francaise (Faculte de pedagogie, Universite d'Ewha), les texts en Francais Facile sont bien appropries au debut, car les difficultes linguistiques des oeuvres authentiques peuvent nuire au travail indiciduel des etudiants. Apres la comprehension exacte du texte par l'analyse des elements linguistiques, il faudra les faire expoiter dans les devoirs des etudiants. Troisiemement, une seance doit etre reserve aux exercices de reemploi des elements deja appris mais qui n'ont pas ete fixes , et aux apprentissages de differents devoirs a rediger d'apres les subjects donnes a la fin de chaque cours, et ils devront essayer d'y employer tous les elements linguistiques acuis dans la semaine. Le professeur devra faire la correction de ces devoirs sur deux plans: d'abord sur le plan individual dans les cahiers des etudiants, puis en claees, sur le plan collectif, insistant sur les points communs des fautes qui se trouvent dans ces devoirs. Dans les devoirs des etudiantes de nos classes experimentales, on a pu releve deux groupes de fautes: les fautes de grammaire dont la theorie a ete seulement apprise sans etre suffisament exploitee, et les fautes de construction, commise par l'habitude de traduction et par le manque de conception exacte des structures. On ne pourrait pas arriver a une exprestion convenable apr?s in ou deux cours semestriels. Ce qui importe ici, c'est de faire comprendre aux etudiants que la capacite d'expression est beaucoup plus importante que celle de comprehensiom dams l'apprentissage d'une langue vivante, de leur donner l'gabitude d'exploiter et de reempoyer dans les phrases personnelles tous les elements appris.

精神分裂病의 5年 追跡調査 : 後向性 硏究 Retrospective Study

李定均,金容植,崔珍淑 大韓神經精神醫學會 1987 신경정신의학 Vol.26 No.4

To explore the possible factors affecting the course of schizophrenia and to clarify some questions on the nature of schizophrenia, a structured retrospective study was carried out to 142 patients (male 74, female 68) discharged from psychiatric department of Seoul National University Hospital during July, 1st 1981 - June, 30th 1982. The study group consisted of 97 patients diagnosed as schizophrenia according to DSM-Ⅲ and 45 controls, who met the following screening criterias, i.e., ⅰ) between the ages of 16 and 65, ⅱ) no evidence of organic, drug related or alcoholdisorder, iii) psychotic symptoms not due to any other mental disorders, such as manic episode, or atypical psychosis, or factitious disorder, etc. The data at index discharge were obtained from clinical records and filled up by one of researchers. Five year follow-up assessment was performed by 4 trained medical students, blind to clinical records, from Jan, 20th through Feb, 28th 1987. Among them 78 patients (male 40, female 38) were able to be traced and successfully interviewed. The average duration of follow-up was 62.2±7.2months(mean±S.D.). To investigate the prognostic significance and specific relations between predictors and outcome variables, 49 predictor variables were chosen from clinical records and 18 outcome variables were selected and grouped by 5-outcome dimensions. Outcome variables were length of rehospitalization during follow-up period, rehospitalization during the last one year, quality of social contact during the last one year, deterioration of work performance during the last one year, severity of psychopathology during the last one year. Results demonstrated some differences between schizophrenia and control groups in clinical records and follow-up assessments. Schizophrenia group definitely showed poorer outcomes than control group. Correlations of individual predictor variables with outcome were calculated, although significant statistically (P<0.05) were modest in their magnitude. Multiple regression analysis of the presenting predictor variables to the outcome dimensions showed correlation .29 -.77, thus explaining statistically about 8-59% of the outcome variance in schziophrenia group. Among them some predictor variables, i.e, work performance during the last one year, social contacts during the last one year, etc, presented high correlations with these outcome variables. Intercorrelations among the 5 outcome dimensions for schizophrenia group were calculated, dimensions correlated each other to a minimal or moderate degrees. Among them social contact correlated highly with individual outcome dimensions.