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이정균 大韓神經精神醫學會 1973 신경정신의학 Vol.12 No.2
1. Nine schizophrenia patients were treated with thiothixene(Navane ?) for the study of new neuroleptics. 2. The patient's clinical symptoms were evaluated with Gorham's Brief Psychiatric Rating Scale. 3. The symptoms of emotional withdrawal, motor retardation, blunted affect were improved by thiothixene treatment. 4. Four of nine patients showed moderate to severe extrapyramidal effects, but not serious. 5. The major clinical improvement was noted after 30 days of treatment.
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抗精神病藥物이 血淸 Dopamine-β-Hydroxylase 活性度에 미치는 影響 : 慢性 精神分裂病患者를 中心으로
薛玹旭,禹鍾仁,李定均 大韓神經精神醫學會 1983 신경정신의학 Vol.22 No.2
To investigate the effect of antipsychotic drugs directly, the serum dopamine-beta-hydroxylase activty was measured before and after three weeks' washout period in chronic schizophrenics. Total number of subjects were eighty-two chronic schizophrenics, consisting of forty-eight male and thirty-four female patients. The diagnostic criteria was based on DSM-Ⅲ and duplicated assay was applied by modified Udenfriend method. The results were as follows; 1. After three weeks' washout period, the serum dopamine-beta-hydroxylase activity was 13.50±2.12 in male, 11.72±2.12 in total patients. Serum dopamine-beta-hydroxylase activity of female patients were significantly lower than in male patients.(p<0.001) 2. The range of serum dopamine-beta-hydroxylase in total patients was from 8.45 to 18.45㎛ol/min/1, which is relatively small compared with previous reports in the literature. 3. During the three weeks' washout period, the percent change was -8.81±17.35% in male (p<0.01), 1.94±20.92% in female(N.S), and -4.35±19.64%(p<0.05) in total patients compare to the serum dopamine-beta-hydroxylase activity of three weeks' washout period. The difference between male and female(p<0.02) is not clear. 4. During the three weeks' washout period, the absolute value of percent change was 16.48±10.36% in male, 17.71±13.93% in female, and 16.57±11.40% in total patients. (all, p<0.001) 5. The percent change of serum dopamine-beta-hydroxylase activity did not seem to be related to the type of drugs, dose of drugs, age, hospital duration, duration of illness, and the presence of active symptom. 6. In summary, the current findings suggest that the interpretation of data indicating low serum dopamine-beta-hydroxylase activity in medicated schizophrenics should be made with caution.
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Realization of specific illuminance distributions of OLED lightings using inverted microlens films
이정균,박준희,고재현 한국정보디스플레이학회 2018 Journal of information display Vol.19 No.3
The illuminance distribution of flat organic-light-emitting diode (OLED) lightings combined with inverted microlens arrays was investigated through both an experiment and simulation. Two inverted prism films on the OLED surface produced a fourfold symmetry in the illuminance distribution caused by the refraction at the lower and the upper interfaces with air. A simple simulation model could reliably reproduce the experimental distribution. Other specific illuminance distributions, such as the ring-shaped one, were formed in terms of inverted ellipsoidal and pyramid microlens arrays. These results suggest that specific illuminance distributions can be realized by combining inverted microlens arrays with flat OLED lightings, which may be useful for special lightings such as decoration or exhibition lightings.
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알코올중독 환자의 예후 예측에 관한 연구(Ⅱ) : 가족력 및 DRD₂와의 관계를 중심으로
성상경,차성조,이규항,이정균 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.6
알코올중독 환자의 예후인자를 알아보기 위해 나이와 성별을 통제하여 음주군과 단주군 남자환자 각각 30명을 대상으로 비교 연구하였다. 양군간의 인구통계학적 특성, 음주력, 가족력, 자아강도 등의 차이 및 도파민 D2수용체 유전자 분포를 비교하였으며, 질병경과, 가족력 및 도파민 D2수용체 유전자와의 관련성을 알아보았다. 그 결과는 다음과 같다. 1) 단주군은 음주군에 비해 기혼율이 높았으며, 높은 경제상태, 높은 학력 등이 중요한 요소였으나 직업의 종류 및 종교에 있어서는 차이가 없었다. 2) 단주군은 음주군에 비해 과거 음주력상 최대 단주기간이 길었으나 평균 음주량이 더 많았다. 또한 음주군은 단주군에 비해 사회경제적 스트레스 및 정신적 불안정이 주된 음주 이유인 경우가 많았으나 음주기간, 음주양상, 음주시기, 음주시작 연령, 술의 종류에 있어서는 차이가 없었다. 3) 알코올중독의 가족력에 따른 비교에서 단주군과 음주군 사이에 유의한 차이는 없었다. 4) 단주군은 음주군에 비해 자아강도의 평균점수가 더 높았다. 5) 도파민 D2수용체 유전자의 A1 대립유전자 비교에서 단주군에서 A1 대립유전자의 이환율은 70%, 음주군에서는 60%였다. A1 대립유전자의 빈도는 각각 0.38과 0.42로 양군간에 차이는 없었다. 6) 알코올중독 가족력에 따른 도파민 D2 수용체 유전자분포 비교에서 가족력이 있는 군에 A1 대립유전자의 이환율은 70%, 빈도는 0.43이었고, 가족력이 없는 군에서는 이환율이 61%, 빈도는 0.38로 양군간에 유의한 차이는 없었다. 가족력이 있는 경우에 음주시작의 연령이 더 낮았으며 문제음주도 보다 일찍 나타났다. 그러나 평균 음주기간은 가족력이 없는 경우에 더 길었으며, 평균 음주량, 최고 단주기간 및 NAST 비교에서는 차이가 없었다. 결론적으로 알코올중독 환자의 긍정적 예후인자로 기혼, 높은 학력 및 경제상태, 과거 음주력상 보다 긴 단주 기간 및 강한 자아강도를 들 수 있었다. 반면에 직업, 종교, 알코올중독 가족력 유무, 음주기간, 음주양상, 음주시작 연령, 술의 종류 및 도파민 D2수용체 유전자 A1 대립유전자 분포 등에서는 알코올중독의 예후의 의미 있는 상관관계가 없었다. Objectives : The purpose of the study was to identify the prognosis-predicting indicators is alcoholics by the correlation between prognosis and demographic characteristics, ego strength, family history and distribution of dopamine D2 receptor gene A1 allele. Methods : The subjects were composed of 60 alcoholics including 30 psychiatric inpatients(drinking group) and 30 alcoholics abstinent for 6 months or more after discharge(abstinent group). They were investigated with interview, questionnaire, blood sample and review of their charts. Results : The results were as follows ; 1) The abstinent group had higher rate of married state, higher economic status and longer education years than the drinking group. There were no differences in occupation and religion between the two groups. 2) There were no differences between the abstinent group and drinking group according to alcoholic family history. 3) The abstinent group had higher mean score in ego strength scale than the drinking group. 4) In comparision of dopamine D2 receptor gene A1 allele, the prevalence of A1 allele was seventy percent and the frequency was 0.38 in the abstinent group. The prevalence of A1 allele was sixty percent and the frequency was 0.42 in the drinking group. Both groups were not significantly different in A1 allele prevalence and frequency. 5) In comparision of dopamine D2 receptor gene A1 allele according to alcoholic family history, the prevalence of A1 allele was seventy percent and the frequency was 0.43 in the family history positive group. The prevalence of A1 allele was sixty-one percent and the frequency was 0.38 in the family history negative group. Both groups were not significantly different in A1 allele prevalence and frequency. Conclusions : With the above results, the authors think that successful prognostic indicators of alcoholics are married state, higher economic status, longer education years, longer abstinenence period in past history, and strong ego strength. But family history and distribution of dopamine D2 receptor A1 allele were not significantly related to the prognositc indicators of alcoholics.
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