정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

HBsAg양성 원발성간암에 있어서 HBV-DNA표지자의 PCR성적

이원길,김재식,김정철,서장수,강은자,이중원,김기연,송경은,양정선 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.2

목적 : HBV-DNA를 정성적 그리고 정량적으로 검출함으로써 강한 전염성과 높은 유병율로 인해 사회적으로 문제가 되는 B형 간염과 원발성간암의 연관성을 알아보고자 하였다. 대상 및 방법 : B형 간염 표면항원(HBsAg)이 양성을 보이는 원발성간암 환자 38명을 대상으로 하였으며 HBV-DNA 중합효소연쇄반응법을 이용하여 정성적 검출 그리고 luminometry법을 이용하여 정량적 검출을 하였다. 결과 : HBV-DNA 중합효소연쇄반응법과 luminometry법의 양성율은 각각 57.9%, 39.5%를 보였다. 그리고 HBsAg과 HBeAg가 동시에 양성을 보인 11명에서는 HBV-DNA 양성율이 81.8%를 보였다. 결론: HBV-DNA 중합효소연쇄반응법의 양성율이 luminometry법에 의한 양성율보다 높은 결과를 보였고 HBV-DNA 검사는 B형 간염을 조기 발견하고 치료하여 만성간질환으로의 진행을 예방하고 특히 원발성간암의 병율을 낮추는데 많이 기여할 것으로 사료되었다. Background : Primary hepatocellular carcinoma(PHCC) is the most common malignant neoplasm in most countries of Asia and Africa. Hepatitis B virus is known to be strongly related to the pathogenesis of PHCC. HBV-DNA PCR and HBV-DNA quantitation assay were attempted to apply to 38 cases of HBsAg positive PHCC. Methods : The ordinary HBV markers(HBsAg, anti-HBs, anti-HBc(Ig-G and -M), HBeAg and anti-HBe) were examined with ELISA. Qualitative screening of HBV-DNA PCR and HBV-DNA quantitation-luminometric measurement were performed. Results : Among 38 cases of HBsAg positive PHCC, positive rates for HBV DNA-PCR and HBV DNA-quantitation were 57.9% and 39.5%, respectively. And 11 cases which were positive for both HBsAg and HBeAg showed 81.8% positive rate in HBV-DNA PCR. Conclusion : For 38 cases of HBsAg positive PHCC, the positive rate for HBV DNA-PCR was higher than HBV-DNA quantitation-luminometry. In HBV-DNA PCR, both HBsAg and HBeAg positive cases showed high positive rate.

株當本數에 따른 油菜의 生育, 靑刈收量 및 組成分 變化

趙南棋,劉哲受,姜榮吉,宋昌吉,趙英一 濟州大學校 亞熱帶農業硏究所 1999 亞熱帶農業硏究 Vol.16 No.-

ABSTRCT Four rape cultivars were grown at 1 to 5 plants per hill to investigate the effects of the number of plants per hill on major agronomic characters of forage rape in Cheju volcanic soil. Days to flowering of Sparta was 191 days, those of Ramon and Youngsanyuchae were 189 and 188 days, respectively. And that of Hallayuchae was 180.3 days. Days to flowering decreased as number of plants per hill was increased. Sparta was tallest (153.6cm), while Hallayuchae was shortest (131.8cm). Plant height with three plants per hill( 155.3cm) was longest, while with 5 plants per hill(131.8cm) was shortest. The number of branches, stem diameter, leaf length and leaf width gradually decreased as the number of plants per hill were increased. Sparta had the greatest fresh and dry matter, total digestible nutrient (TDN) and crude protein yields, while Hallayuchae had the least. Fresh yield were greatest (7,544 kg) at the three plants per hill. Dry matter TDN, and crude protein yields were also greatest (7,544 kg) at the three plants per hill. Ramon had the greatist SPAD reading (44.7) while Youngsanyuchae had the lowest (40.7). SPAD reading were highest (44,1) in the one plant per hill plot but decreased as the number of plants per plant was increased. Sparta had greater contents of crude fiber and crude ash, but Hallayuchae and Youngsanyuchae had lower contents. The content of crude protein, crude fat, nitrogen free extract(NFE) and TDN were increased as number of plant per hill were increased. But the contents of crude fiber and crude ash were decreased as the number of plants per hill was increased.

栽植密度에 따른 油菜의 生育, 靑刈收量 및 粗成分 變化

趙南棋,劉哲受,姜榮吉,宋昌吉,趙榮一 濟州大學校 亞熱帶農業硏究所 1999 亞熱帶農業硏究 Vol.16 No.-

ABSTRACT Four cultivars of rape were grown at 5 planting densities in Cheju volcanic soil to investigate the effects of planting density on major agronomic characters of forage rape. Hallayuchae flowered earliest (180 days) while Sparta latest(191 days). Days to flowering was reduced as planting density was decreased. The average plant height of Sparta was 162.2cm and that of Ramon and Youngsanyuchae was 158.4 and 138.6cm, respectively. In 10 X 10cm planting density plot, plant height was 152.5cm and it was gradually decreased as planting density was decreased. The number of branches, stem diameter, leaf length and leaf width of Ramon was greatest, while those of Hallayuchae were least. These variables were increased as planting density was decreased. Fresh forage yield (5,719kg/10a) and dry matter yield (1,229kg/10a) for lOxlOcm planting density plot, were greatest, but those were gradually decreased as planting density was decreased and those for 30 X 30cm planting density plot were 4,232kg/10a and 906kg/10a respectively. Crude protein yield and total digestable nutrient (TDN) per lOa was positively correlated with fresh forage yield and dry matter yield. Sparta produced the greatest fresh forage, and Hallayuchae produced the smallest. Sparta had the highest SPAD reading value, and Hallayuchae had the lowest. SPAD reading was reduced in proportion to increased planting density. Sparta had greater crude protein yield, and crude fat, nitrogen free extract (NFE) and TDN contents and Youngsanyuchae and Hallayuchae had lower contents while Youngsanyuchae and Hallayuchae had greater crude fiber and crude ash contents and Sparta had lower contents. Crude protein yield, and crude fat. NFE and TDN contents were decreased as planting density was decreased, while crude fiber and crude ash contents were increased as planting density was decreased.

범법 정신 장애자와 일반 정신 장애자의 약물 사용 양상에 관한 비교 분석

이길홍,박두병,나철,이재광,기백석,이재우,유영식,이영식,이헌재 중앙대부설한국의과학연구소 1991 한국의과학 Vol.23 No.1

동국제강에서 배출되는 대기오염물질이 인접지역 환경에 미치는 영향

朴淸吉,李起浩,李濟根,許喆九 釜山水産大學校 1989 釜山水産大學 硏究報告 Vol.29 No.1-2

The environmental effect of air pollutants emitted from Dong-Kuk Steel Company on neighboring area was assessed by measuring air pollutants and using the computer simulation model. Some results from this study were summarized as follows; The concentration of sulfur dioxide in winter was mostly exceeded the Air Quality Criteria(0.05ppm) but its annual average concentration was far below the Criteria. However, the annual average concentration of total suspended particulates(TSP) in the atmosphere(170㎍/㎥) was largely exceeded the Criteria(150㎍/㎥) and the fluctuation of its concentration between months was very great. The results calculated from the computer simulation by TEM-8 Model showed that the air quality in this region was fairly good in view of the concentration of sulfur dioxide with the range from 0.01 to 0.03ppm. However, it was assessed by simulation that when the wind blew from the ESE direction the maximum concentration of sulfur dioxide might be reached up to 0.078ppm and then could be largely exceeded the Criteria. Fortunately, according to the data from in situ measuruement, those undesirable wether condition was little occurred during the term of research.

범법정신장애자의 정신의학적 특성분석

이길홍,이재광,박두병,나철,기백석,이재우,유영식,이영식,이헌재 중앙대부설한국의과학연구소 1991 한국의과학 Vol.23 No.1

신경인성방광에서 요역동학적 고찰

노준,전상준,정치영,이기봉,이길용,소영석,김철성,장대수 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and objectives : A disparity between clinical and urodynamic findings is commonly found and its application to the clinical management of neurogenic bladder is pratically as well embrassing as it reading. We investigated urodynamic study for the diagnosis and management of neurogenic bladder. Materials and methods : From July 1997 to June 2001, total of 83 patients of neurogenic bladder were evaluated by urodynamic study. Results : urodynamically, there were 20 cases(24%) showing detrusor hyperreflexia with detrusor external sphincter dyssynergia(DESD), 12 cases(15%) detrusor areflexia with low compliance. A disparity between the clinical and urodynamic assessment was noted in 26 cases(31%), clinically severe symptom with complication was particularily common in detrusor hyperreflexia with DESD, detrusor areflexia with low compliance and catheter indwelling patients. Conclusion : In neurogenic bladder, clinically symptom with complication was particularly common in detrusor hyperreflexia with DESD, detrusor areflexia with low compliance and catheter indwelling patients.

실내 스모그 챔버의 설계 및 성능평가

배귀남,김민철,이승복,송기범,진현철,문길주 한국대기환경학회 2003 한국대기환경학회지 Vol.19 No.4

A multi-functional indoor smog chamber was designed and evaluated lo investigate photochenical or water vapor reaction mechanisms of air pollutants. Various smog chamber experiments could be conducted using ambient air or purified air in this smog chamber. The smog chamber consisted of a housing, a Teflon bag, blacklights, injection ports, sampling ports, and utility facilities. The characteristics of light source, the wall losses of air pollutants, and the quality of purified air were experimentally investigated. The maximum NO₂ photolysis rate was 1.10min^(-1). In a 2.5-m³ Teflon bag, the wall losses of ambient O₃, NO, and NO₂were 1.2~2.4×10^(-3)min^(-1), 0.7~2.0×10^(-3)min^(-1), and 0.4-2.0×10^(-3)min^(-1), respectively. The wall loss of ambient particles ranging 0.05 to 0.2㎛ was 1.8~5.4×10^(-3)min^(-1), which was slightly higher than those of ambient gaseous species. The purified air supply system provided high quality of air with NO₂, < 1 ppb, and total hydrocarbons <5 ppb.

융모막성에 따른 쌍태아 체중 불일치의 주산기 예후

길기철 ( Ki Chul Kil ),이귀세라 ( Gui Se Ra Lee ),강영화 ( Young Hwa Kang ),김연희 ( Yeon Hee Kim ),김사진 ( Sa Jin Kim ),신종철 ( Jong Chul Shin ) 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.11

목적: 본 연구는 융모막성에 따라 쌍태아간 체중불일치와 주산기 예후와의 관련성을 알아보고자 하였다. 방법: 2000~2007년 동안 가톨릭대학교 성빈센트병원에서 분만한 쌍태아를 대상으로 후향적 연구를 시행하였다. 체중불일치는 체중이 큰 신생아를 기준으로 20% 이상 차이가 있는 경우이며 체중일치는 20% 이하의 차이가 있는 경우로 정의하여 단일융 모막성 및 이중융모막성 쌍태아에서 체중불일치군과 체중일치군 간의 주산기 결과를 비교 분석하였다. 결과: 38명의 단일융모막성 쌍태아에서 34.2%는 체중불일치였고 66.8%는 체중일치를 보였으며 144명의 이중융모막성 쌍태아에서 9.9%의 체중불일치와 91.9%의 체중일치를 보였다. 단일융모막성 쌍태아의 체중불일치군과 체중일치군을 비교한 결과 자궁내태아사망, 쌍태아간 수혈증후군, 자궁내발육저하 및 신생아 저혈당증의 발생이 통계학적으로 유의하게 증가하였으며 이중융모막성 쌍태아에서는 자궁내발육저하와 저혈당증의 발생이 체중불일치군에서 증가하였다. 기타 주산기 결과는 두 융모막성쌍태아의 각각 군간에 통계적으로 유의한 차이를 보이지 않았다. 결론: 단일융모막성 쌍태아의 체중불일치는 태아 사망, 쌍태아간수혈증후군, 자궁내태아발육부전 및 신생아 저혈당의 발생의 가능성이 높으며 이중융모막성 쌍태아의 체중 불일치는 자궁내태아발육부전 및 신생아 저혈당의 발생 가능성이 높지만, 불량한 주산기 결과를 단정적으로 예측하기에는 미흡한 요인이라고 생각된다. Objective: The purpose of this study was to examine the association between intrapair birth weight discordance and perinatal outcomes according to the chorionicity. Methods: Twin births in St. Vincent`s Hospital of Catholic University of Korea for the period 2000~2007 were retrospectively studied. Discordance was defined as an intertwin birth weight difference ≥20% and concordance was defined as weight difference <20% calculated from the larger newborn. Perinatal outcomes were compared between discordant and concordant pairs in monochorio-diamnionic and dichorionic twins. Results: Among 38 monochorionic twin births, 34.2% was discordant and 66.8% was concordant. Among 144 dichorionic twin birth, 9.9% was discordant and 91.9% was concordant. The incidences of intrauterine fetal death (FDIU), twin-to-twin transfusion syndrome (TTTS), intrauterine growth restriction (IUGR) and neonatal hypoglycemia of discordant group of monochorionic twins were statistically increased compared with concordant group of monochorionic twins. The incidences of IUGR and neonatal hypoglycemia were statistically increased in the discordant group of dichorionic twins compared with concordant group of dichorionic twins. The others were not shown statistically significant between two groups in the both chorionic twins. Conclusions: Birth weight discordance in monochorionicity seems to predict fetal death, TTTS, IUGR and newborn hypoglycemia. Birth weight discordance in dichorionicity does not seem to be good predictor of adverse perinatal outcomes except IUGR and neonatal hypoglycemia.