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ADH1B와 NQO2 유전자 다형성이 알코올 의존의 발병연령과 금단증상에 미치는 영향
이영식,한덕현,윤성구,최삼욱,조근호,서정석 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.3
Objectives : We hypothesized that polymorphisms of ADH1B and NQO2 could have an effect on the onset of alcohol de-pendence and withdrawal symptoms. Methods : PCR (polymerase chain reaction) and RFLP (restriction fragment length polymorphism) were used to analyzegenetic polymorphisms of ADH1B and NQO2 in 194 male patients with alcohol dependence (AD) and 152 healthy Compari-sons. The AD were classified into the early and late onset groups with the onset age of 25. Alcohol withdrawal symptoms were measured by Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA-Ar). Results : 1) Alcohol dehydrogenase 1B gene : There was no difference in genotype distribution between the patients group and the control group. However, the frequency of ADH1B*2 allele in late-onset alcohol dependence was higher compared to the early-onset group. 2) NRH-quinone oxidoreductase 2 (NQO2) : The patients group had higher Sequency of D allele than the healthy comparisons, In patients grouP, the frequency of the D allele in the late-onset group was higher than the early-onset group.3) CIWA-Ar scale : There was no difference in the CIWA-Ar scale between the genetic polymorphisms of ADH1B. However, the patients with D allele of NQO2 showed significantly higher scores in the CIWA-Ar scale than those with I/I allele. Conclusion : With current results, we suggested that ADH1B*2 and D allele of NQO2 may have a possible association with alcohol withdrawal symptoms and that they may play a protective role in the onset of alcohol dependence.
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현직 영어교사의 영어로 진행하는 영어수업능력 평가에 대한 타당도 검증 연구
이영식 한국영어교과교육학회 2015 영어교과교육 Vol.14 No.4
The purpose of this paper is to validate the assessment of teaching English in English (TEE) for English teachers which was conducted by a regional Office of Education in Korea. For the research data 64 English teachers were assessed by three groups of invited raters (twenty-two raters in total): eight native university lecturers, nine Korean university professors and five Korean English teachers. In assessing the teachers’ TEE performances the raters used the TEE rating scale which comprised four domains of TEE: Organizational Skills, English Proficiency, Teaching Skills and Learner’s Activity. In order to investigate the reliability of TEE scoring, the computer program of Facets, which was developed based on the many-facet Rasch measurement (MFRM) model, was used. The analysis results showed that the ratings for the TEE performances of participating English teachers were generally reliable and appropriate, although a few cases of unreliable scoring by a couple of raters were found. A suggestion is made to develop the validation framework for the current TEE assessment in terms of MFRM analysis.
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