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ADH1B와 NQO2 유전자 다형성이 알코올 의존의 발병연령과 금단증상에 미치는 영향
이영식,한덕현,윤성구,최삼욱,조근호,서정석 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.3
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Objectives : We hypothesized that polymorphisms of ADH1B and NQO2 could have an effect on the onset of alcohol de-pendence and withdrawal symptoms. Methods : PCR (polymerase chain reaction) and RFLP (restriction fragment length polymorphism) were used to analyzegenetic polymorphisms of ADH1B and NQO2 in 194 male patients with alcohol dependence (AD) and 152 healthy Compari-sons. The AD were classified into the early and late onset groups with the onset age of 25. Alcohol withdrawal symptoms were measured by Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA-Ar). Results : 1) Alcohol dehydrogenase 1B gene : There was no difference in genotype distribution between the patients group and the control group. However, the frequency of ADH1B*2 allele in late-onset alcohol dependence was higher compared to the early-onset group. 2) NRH-quinone oxidoreductase 2 (NQO2) : The patients group had higher Sequency of D allele than the healthy comparisons, In patients grouP, the frequency of the D allele in the late-onset group was higher than the early-onset group.3) CIWA-Ar scale : There was no difference in the CIWA-Ar scale between the genetic polymorphisms of ADH1B. However, the patients with D allele of NQO2 showed significantly higher scores in the CIWA-Ar scale than those with I/I allele. Conclusion : With current results, we suggested that ADH1B*2 and D allele of NQO2 may have a possible association with alcohol withdrawal symptoms and that they may play a protective role in the onset of alcohol dependence.
李英植 全北産業大學校 産業經營硏究所 1993 産業經營硏究 Vol.1 No.-
This paper eximines the two main views of exchange rate determination(that is, Asset market approach) that have evolved since the early 1970s: the monetary approach(in flexible-price, sticky-price, and real interest differential formulations) and the portfolio approach. Then eximines the empirical evidence on these models and conclude by speculating how the future research strategy is likely to develop. Thus this paper is organized as follows. Chapter one : Introduction. Chapter two : Theories of Exchange Rate Determination. Section one : Monetary Approach. Section two : Portfolio Balance Approach. Section three : Synthesis Model of Asset Market Approach. Chapter three : Empirical Evidence on Exchange Rate Models. Section one : Tests on Monetary Models. Section two : Tests on Portfolio Balance Models. Section three : Out - of - Sample Forecasting Performance of Exchange Rate Models. Chapter four : Result - New Directions -
이영식,정호인,이정식 梨花女子大學校 醫科大學 醫科學硏究所 1993 EMJ (Ewha medical journal) Vol.16 No.1
We retrospectively reviewed chest radiographs of 101 patients with primary pneumonia treatedat department of pediatrics between January 1990 and June 1992 to understand pnelimoniaradiologic patterns in ages of children and to attain helpful information in diagnosing pediaoicpneumonia hereafter. Results were as follows : 1) The cases of infantile pneumonia (under 1 year of age) were 42. The most frequent Hadingwas peribronchial infiltration with overaeration(24 cases, 57.1% ), followed by multiple patchyatelectasis associated with peribronchial infiltration and overaeration(8 cases, 19.0%). parahilarperibronchial infiltration (5 cases. 11.9%), peribronchial infiltration and air space consolidation(2 cases,4.8%), air space consolidation(2 cases,4.8%) and bronchopneumonia pattern(1 case,2.4%). 2) The cases of 1∼6 years of age were 52. The most common finding was parahilar peribron-chial infiltration(29 cases, 55.8%), followed by air space consolidation(13 cases. 25.0%), andbronchopneumonia pattern(10 cases, 19,2%). 3) The rases of 7∼13 years of age were 7. All cases showed air space consolidation.Under 6 years of age, the radiographic findings of pneumonia differed from that of adultOver 7 years of age, the pattern of pneumonia was similar to that of adult.
방사선조사와 마이크로파 온열요법이 기니아피그 심근에 미치는 영향에 관한 실험적 연구
이영식,이경자,이정식 梨花女子大學校 醫科大學 醫科學硏究所 1991 EMJ (Ewha medical journal) Vol.14 No.1
Radiobiological and clinical evidences indicate that irradiation combined with hyperthermia produce a significant improvement in therapeutic effect of cancer. Hyperthermia can enhance the radiation effect as a synergistic reaction in irradiation combined with hyperthermia. Hyperthermia sensitize radioresistant S-phase and inhibit cellular recovery from the sublethal damage. Ninety guinea pigs were divided into 4 groups for the experiment of application of irradiation combined with hyperthermia on their heart; (1) normal control group. (2) group receiving only hperthermia. (3) group receiving a single dose of irradiation of 10, 20 and 30 Gy resepectively. (4) group receiving varying single dose of irradiation like group (3) irradiation combined hyperthermia. Heating by 100 watt. 2450 ㎒ microwave hyperthermia on the heart was applied for 30 minutes maintaining 42~45℃ immediately following irradiation. Microscopic examination and calculation of thermal enhancement ratio were carried out and results were as follows: 1) Hyperthermia alone did not evoke much changes. compared to normal control group. 2) In the group of irradiation alone. myocrdial muscle degeneration was noted in l0Gy irradiation and its severity was increased along with radiation dose. 3) In the group of irradiation alone. myocardial muscle necrosis was noted at 15 days after 20Gy irradiation. In the group of irradiation cmbined with hyperthermia. myocardial muscle necrosis was noted in l0Gy irradiation. 4) In the group of irradiation alone, interstitial fibrosis was noted at 15 days after 30Gy irradiation. In the group of irradiation combined with hyperthermia. interstitial fibrosis was noted at 15 days after 20Gy irradiation and its severity was increased along with radiation dose. 5) The thermal enhancement ratio(TER) was 1.5 on the end point of interstitial fibrosis of the guinea pig heart.
SUS 육각봉 인발성형용 가변형 롤유닛에 관한 구조해석 연구
이영식,양영준 한국기계기술학회 2017 한국기계기술학회지 Vol.19 No.6
SUS hexagonal bar, which is manufactured by drawing process of SUS circular bar, have been widely used to make various adapters and fittings. The purpose of this study is to investigate the characteristics and stability of variable roll unit including stand module. Stand module is essential part of variable roll unit. Structural analysis was performed to predict the stability of stand module using 3 loads (50, 75, 100 Ton), thus it may be of help to the manufacture of stand module. As the results, internal ring of bearing showed maximum equivalent stress, and moreover bearing, shaft and roller had to be preferentially considered in order to maintain its stability. In cases of 50 and 75 Ton, there were no problems for stabilities, respectively, on the other hand, problem for stability may occur in case of 100 Ton.