췌장 선방세포암 1예

이화정,지준호,박승찬,박정철,최은정,서혜진,이원식,이정림,배병조,손경락,이경희 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Acinar cell carcinoma is a rare tumor that represents 1~2% of al1 pancreatic cancers. Clinical and radiologic findings are inconclusive in this disease Acinar cell carcinoma is characterized by rapid progression and early metastasis, which lead to its poor prognosis. A 41-year-o1d man was admitted to our hospital for abdominal pain. Abdominal computed tomography (CT) and positron emission tomography-computed tomography (PET-CT) showed a splenic mass, which was being invaded by a pancreatic tail mass and which had increased ^(18)F-fluorodeoxyglucose (FDG) uptake Primary radical distal pancreatectomy and splenectomy were performed. Pathologic findings revealed an acinar cell carcinoma of the Pancreas The patient underwent a total gastrectomy three months later because of gastric recurrence Four months later, multiple hepatic metastases were discovered, and the patient underwent a left hepatectomy During treatment with capecitabine, there was no evidence of tumor progression for 14 months. We report a case of metastatic pancreatic acinar cell carcinoma, which did not progress for an extended period while the patient was being treated with capecitabme.

원발성 후복막 점액낭샘암종 1예

지준호,이화정,박승찬,박정철,최은정,서혜진,이원식,이정림,배병조,손경락,이경희 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Primary retroperitoneal mucinous cystadenocarcinoma is a very rare malignancy, and little is known concerning its Pathogenesis, optimal treatment, and prognosis. A 29-year-o1d pregnant woman (21 weeks) Presented with abdominal discomfort CA 19-9, CA 125, and CEA were normal Abdominal CT scanning revealed a 19x15x13 cm retropentoneal tumor Exploratory laparotomy and tumor excision were performed. Mucinous retropentoneal implants were removed as completely as possible Histologically, the tumor showed focal areas of capsular invasion, but free resection margins The uterus and both ovaries were normal in appearance No adjuvant therapy was pursued. Six months later, Peritoneal and bilateral ovarian metastases were discovered. Hence, we report the details of this case of primary retroperitoneal mucinous Cystadeno-carcinoma and present a review of the literature.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

에탄올을 장기간 섭취한 백서에서 Acamprosate 투여가 Nitric Oxide Synthase 발현에 미치는 영향

정홍경,이기철,이정호,이승휘,이희제,정주호 대한생물치료정신의학회 2002 생물치료정신의학 Vol.8 No.1

頭蓋內壓上昇과 厥의 相關性에 對한 東西醫學的 考察

정승현,박성식,李源哲 東國大學校韓醫學硏究所 1994 東國韓醫學硏究所論文集 Vol.3 No.-

The purpose of this study is the approach to I.I.C.P. centered on the meaning of consciousness disorder and the pathological aspect of Kwul(lose consciousness ; faint, fall, into a coma). The meaning of consciouseness disorder and apoplexy is evidently involved the definition of Kwul. 1. It is found that the etymological interpreation on Kwul which the energy rises back to go through blocked space and the meaning interpretation of regarding Kwul as apoplexy with medical viewpoint, are related with consciousness disorder and motor distrubance in IICP in the aspect of the rise fo Kwul and the abnormal rising of vital energy and blood, In addition, the overall of meaning of Kwul is showed in table <1-1> by reference to doctors of many generations. 2. The pathology of Kwul includes abnormal rising, sthenia-syndrome in the upper part and asthenia in the lower, the origin of Kwul, the lower, looking like Yin by too sthenic Yang and looking like Yang by too sthenic Yin. The headache, vomiting, papilledema, paralsis of nervi craniales, coma, blood pressure rising, tachycardia by I.I.C.P can be regarded as a conception of trouble of vitalenergy, sthenia-syndrome of Kwul. The pulse pressure, brachycardia, bradypnea can be regarded as the conception of looking like Yin by too sthenic Yang. 3. In the emergency of Kwul, the abnormal ternimal reversion of the Kwulyin channel, Kuyang channel, and three Yins are realted with the phenomenon in I.I.C.P. It is considered that the reverse movement of materials, I,I.C.P. can be closely observed by giving meaning on the meridian of Kwul in Somunkwulron. And the content of phrases of Naelyung which includes consciousness disorder refered in the chapter of Kwul, is compared with I.I.C.P. 4, The followings should be considered ; examination of optic symptom and abnormal posture in cerebral herniation ; understanding and working out counterplans of factors and symptoms of consciousness disorder by the observation of vital sign, check of general stages, neurologic inverstigation, clinical diagnosis, and subsidiary diagnosis ; application of morphological change of opinion ; addtion of the conception of demonstration centered on Yunkyoungm, Samyinkwulruk, asthenia and thenia of healthy energy in oriental medicine. 5. The similarity of Kwul and I.I.C.P. can be found from etilolgy and pathotenic factor. The similarity is clearly found by investigation of etiology, pathotenic factor, symptoms and thrapy of Kwul, disease symptom and other symptoms.

紅花가 高Cholesterol 食餌에 의한 家兎의 高脂血病에 미치는 影響

鄭承鉉,朴性植,李源哲 동국대학교 경주대학 1995 東國論集 Vol.14 No.-

In order to evaluate the effects of Carthami Flos on the Hyperlipidemia induced by high cholesterol diet, rabbit were fed with 4% cholesterol diet, 4% cholesterol - Carthami Flos diet (2g/㎏/day) during 12weeks. After 12 weeks, serum lipid levels of rabbits were studied. The results were obtained as followed ; Carthami Flos Group had a decrease effect of serum total cholesterol, triglyceride, total lipid, free fatty acid and LDL-cholesterol level. Whereas Carthami Flos Group had a decrease tendency effect of serum phospholipid level and a increase tendency effect of serum HDL-cholesterol level but P-value did not show a significance.

대학생의 여가활용능력이 여가만족에 미치는 영향

정수진,이승철,심상신 한국레크리에이션 교육학회 1999 한국여가학회지 Vol.1 No.1

The purpose of this study was to examine the relationships of types of leisure activity on leisure diagnotice battery among college student. The main purpose of this study was to examine the difference of the leisure diagnotice battery by comparing of gended, a college year, types of leisure activity. Subjects of this study were sampled 277 college student. Statistic employed in this study were Frequency analysis, t-test. Base on the procedures and results, the following conclusions were warranted ; First, There are significant difference of leisure confidence, leisure control, leisure flow by gender. that is to say, the male student are to be high than the female student. Second, There are significant difference of leisure confidence, leisure control, leisure flow, leisure need by a college year. that is to say the sophomore are to be high than the freshman. Third, There are significant difference of leisure confidence, leisure control, leisure need by a types of leisure activity. that is to say, the positive types of leisure activity are to be high than the negative types of leisure activity.

『국어문법』(주시경)과 English Lessons

정승철 국어국문학회 2003 국어국문학 Vol.- No.134

This study aims to revaluate Ju Si-gyeong(1876-l9l4)'s grammatical theory. To achieve the aim, we compared his grammar Gugeomunbeop(that is, The Korean Grammar, 1910) with English Lessons, Book Two(l 903/1 906), which was compiled by California State Text-Book Committee. The main points of this paper can be summarized as follows: Ju Si-gyeong accepted positively the grammatical aspects implied in the English Grammars. Especially, it is clear that English Lessons, Book Two had a great effect on his grammar in its format and contents as well as processes of sentence parsing and diagramming. Futhermore, Ju Si-gyeong tried to set up his own grammatical theory, in his grammar Gugeomunbeop, through scrutinizing the linguistic properties of Korean.

濟州韓牛의 飼養管理와 繁殖狀況에 관한 硏究 : 第Ⅱ報; 濟州韓牛에 있어서 舍飼期間中 飼養管理가 體重變化와 隔年分娩에 미치는 影響 Ⅱ. The Effect of Winter Feeding on Body Weight Changes and Alternate Year Calving Rate in Jeju Native Cows and Heifer

金重桂,金文哲,金承贊 제주대학교 1983 논문집 Vol.16 No.-

舍飼期間中 濟州韓牛의 飼料給與狀態가 體重變化, 繁殖狀況 및 隔年分娩牛에 미치는 影響을 調査하기 爲하여 濟州道內 六個部落에서 飼育되고 있는 供試畜 400餘頭를 調査한 結果는 다음과 같다. 冬期間 飼料給與狀態에서는 各部落別 큰 差異는 없었고 補充飼料를 1kg以上 給與하는 戶數는 全體의 4.8%로 매우 낮았으며 糠類飼料(單用)을 每日 若干씩 주고 있는 農家는 46.6%로 過去보다 增加르 보였으나 乾草만으로 飼育하는 農家는 48.6%로서 漸次減少 現象을 보이고 있다. 冬期間 月別體重變化는 大部分 一月에서 四月까지는 大體로 20∼30kg 減少 趨勢를 보이다가 放牧場에 入殖된 五月에는 約 10∼20kg 增加되는 傾向을 보였으며 濟州韓牛와 交雜種間의 比較에서는 Brahman 交雜種이 體重變化가 가장 적은 反面 韓牛와 Santa 交雜種은 體重 減少幅이 極甚하였다. 未經産牛에서 初分娩月齡은 가장 빠른 地域이 38.2個月이 었고 늦은 地域은 40.5個月로 2個月差異가 있었으며 經産牛의 分娩後 初發情 再歸日에에서 隔年分娩牛를 除外했을 때는 平均 90.4日이고 地域別 10-20日差가 있었는데 反하여 隔年分娩牛를 包含시켰을때에는 平均 174.2日로 상당히 길었으며 地域別 差異도 甚하였음을 보여 주었다. 隔年 分娩牛의 發生率은 地域別로 볼 때 平均 13%에서 23%의 差異를 나타내고 있었으나 年度別로 比較할 때는 1980年度 9.5%, 1981年度 33.5%, 1982年度 11.9%로 隔差가 甚하였다. To investigate the effect of giving different feeds, during the winter, on body weight changes, reproductive performence and alternate year calving cows. 400 Jeju native and cross bred cows and heifers housed in villages were studied. Results showed no appreciable difference amongst the 6 villages feeding different foods during the winter period. Percentage of farms feeding various brans, over 1kg per day, was 4.8% ; a small quantity(0.5kg) of various brans was fed daily to 46.6% and those feeding only natural hay, 48.6%. The number of villages feeding various brans is increasing and those feeding hay decreasing. Cattle weights decreased by 20-30kg monthly per head during the winter feeding period(January-April) but by May increased in the range of 10-20kg per head with arrival of the new grass. Comparison of monthly body weight changes of Jeiu native cows and cross breds, Brahman cross breds showed the least body weight changes during winter while Native and Santa cross bred cows the weight changes were considerable. The average age at first calving, in the regional groups, varied by two months and when averaged out was 38.2 and 40.5 months in the early and late regions respectively. There was an average of 90.4 days from calving to first estrus excluding alternative year calving cows which had an avarage of 174.2 days from calving to first estrus. The alternate year calving percentages averaged from 13% to 23% in regional groups, and were 9.5% in 1980, 33.5% in 1981 and 11.9% in 1982.

파트너십에 의한 지하철 입구 공간의 쌈지공원 설계 및 시공

김승환,강현우,손용욱,박승범,남정칠,이기철,차민준 東亞大學校 建設技術硏究所 2009 硏究論文集 Vol.32 No.2

A pocket park is valued in securing green space in downtown and improving urban view in the aspect of natural and environmental values, and it signifies a lot as the center of local residents’ community and harmony as well. Since subway exits and surroundings that have high portions in taking up street space due to lack of green space in downtown aren't made full use of, valuable pocket park place. Dangni Pocket Park of subway exits is a park completed with cooperative works and partnership by students, specialists, administrative organizations, businesses and civilian organizations, etc. without support of special budget. The study site was finally chosen to the space between exit No.1 of Dangni subway station, after analyzing the surrounding circumstances, availability and accessibility of the space among the several subway station exits of Saha, Dangni, and Hadan Station in Busan Metropolitan city. For the designing process, The Citizens organization for Million Amenity Park performed the planning and project proceeding, and 19 design drafts were proposed during the class of landscape architecture in Dong-a University. Design review panel members discussed to select the best draft in practical and authentical, and the related experts reviewed and revised to present the final design plan. The construction was conducted was performed under the cooperation between the civil, authorities, and industrial organizations, among which Saha District office managed for the waste treatment and maintenance matters. The graduates of landscape architecture department of Dong-a University and related industrial enterprises supplied landscape materials and related labors, were supported by 20 members of GPM, one of clubs of Dong-a University volunteered durig the most of construction progress, completing the Pocket Park of subway exits through partnership.