40세 이하 관상동맥 질환자에서 장기적 임상 관찰

이승욱,정명호,박종철,박형욱,조상희,김원,김계훈,이상현,강경태,조장현,김남호,김건형,안영근,조정관,박종춘,강정채 全南大醫大 2001 전남의대학술지 Vol.37 No.2

용접공들의 면역능에 관한 연구

이수일,조봉수,김영욱,고광욱,조원근,김영실,강수용,황인경,조병만,김돈균 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.1

The authors examined human immunity indicators such as CD4, CD8, Natural Killer(NK) cell, IgG, IgA, and IgM, and heavy metals such as Pb, Cr, Cd to evaluate the health hazard of welders. We selected total 126 male subjects, 60 welders who had more than 5 year working history as an exposure group, and 66 office workers and medical college students as a control group. This immunity evaluation approach is the first newly designed study that has never been tried in past studies on welder's heath evaluation. And the results were as follows. 1. Total lymphocyte count of peripheral blood was significantly higher in welder group, 2,615±650 ea/㎕ compared with 2,368±681 ea/㎕ in control group(p>0.05). 2. The proportion of CD4, CD8, NK cell in welder group was 37.5±9.4%, 24.0±8.8%, and 21.0±9.5%, respectively, and 35.5±6.5%, 25.0±6.9%, and 19.6±8.8% in control group. CD4 and NK cell were slightly higher, and CD8 was slightly lower in welder group. but there was no statistical significance between two groups(p≥0.05). 3. IgG, IgA, and IgM in welder group were 15.9㎎/㎗, 2.7㎎/㎗ and 1.5㎎/㎗, respectively, and 15.6㎎/㎗, 2.9㎎/㎗ and 1.7㎎/㎗ in control group. There was no statistical significance between two groups(p≥0.05). 4. Blood lead, cadmium and chromium concentrations were 4.2±1.8㎍/㎗, 0.4±0.38㎍/㎗, 1.2±0.6㎍/㎗ in welder group and 3.2±1.7㎍/㎗, 0.44±0.29㎍/㎗, 1.1±0.6㎍/㎗ in control group, respectively, and these value were within normal ranges.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Co-계비정질 리본의 자기특성에 미치는 열처리 효과에 관한 연구

조치현,신용진,문현욱,서강수 明知大學校 産業技術硏究所 1993 産業技術硏究所論文集 Vol.12 No.-

This thesis describes the effect of annealing on the magnetic properties of Co-bsaed amorphous. The basic composition of the chosen samples were Co82Si2B15 of zero magnetostriction. The sample was melted in the quartz tube with 0.5[mm∮) nozzle. and the single roll technique was used to make a amorphous ribbon, under Ar-gas pressure 0.6〔kg/cm2] and ro11 speed 28[m/sec]. The average width and thickness of sample ribbons 2.4[mm] and 45(㎛). The sample ribbons were annealed to improve the magnetic properties at temperature of 325,350,375,400 and 450℃ respectively, for 15,30,45,60 and 120 [min] at each temperature. And I have measured high per meability of 8,000∼ 13,000 through the annealed amorphous ribbons. Especially, when the amorhpous samples were annealed at 325 for 45min, the permeability of the ribbon was 13,589. Consequently. I had effects of the improvment of permeability and the average loss at the low-frequency region.

표면 조도의 변화에 따른 마찰 및 마멸 특성

조용주,이상욱,구영필,서만식 釜山大學校生産技術硏究所 1999 生産技術硏究所論文集 Vol.56 No.-

마찰과 미끄럼 마멸에서 표면 거칠기의 특성에 대한 효과는 실험적으로 볼-디스크 마멸 시험기를 가지고 연구되어졌다. 실험은 서로 다른 하중, 미끄럼 속도, 그리고 윤활유 점도 조건하에서 산술평균값, skewness, kutosis를 변화시켜 수행되었다. 음의 값을 가지는 더 낮은 skewness 또는 더 높은 kutosis의 표면조도를 가진 같은 상술평균 값에 대하여 더 낮은 마찰을 가지는 경향이 있다. The effect of characteristic of surface roughness on friction and sliding wear was studied experimentally with ball-on-disk type wear tester. The test was conducted with specimens those have varying arithmetic mean value, skewness and durtosis under the condition of different load, sliding speed and lubricant viscosity. The surface of the lower skewness in negative value or the higher kurtosis tends to have low friction for the same arithmetic mean value.

Quinlolone 유도체 국소도포에 의한 좌창치료의 임상적 연구

권철욱,노영석,김재홍,조소연,강형철,함정희 大韓臨床藥理學會 1994 臨床藥理學會誌 Vol.2 No.2

하악 대구치 근심근관에 대한 전자근관장 측정기의 정확도

조영린,손욱희,황호길 大韓齒科保存學會 2005 Restorative Dentistry & Endodontics Vol.30 No.6

근단부위 형성이 완료되고 우식이 없는 하악 대구치 근심치근 50개를 대상으로 주파수 의존형 전자근관장 측정기를 이용하여 측정한 근관장의 정확도를 평가하기 위해 치수강 개방 후 동일한 치아에서 방사선 사진으로 확인한 실측 근관장을 대조군, 각종 전자근관장 측정기로 측정한 근관장을 실험군 (Ⅰ군: Root-ZX, Ⅱ군: Bingo, Ⅲ군: Propex, Ⅳ군: Diagnostic)으로 분류하여 근심협측과 설측의 근관장을 근관의 입구 측으로부터 치근단 1/3까지 확대여부 및 서로 다른 측정시기에 비교 평가한 결과 다음과 같은 결론을 얻었다. 하악 대구치 근심치근의 협측과 전자근관장은 측정기의 종류, 근관의 입구 측으로부터 치근단 1/3까지의 확대여부 및 측정시기에 상관없이 0.5 ㎜ 이내의 오차범위를 나타내었으며, 근관치료시 오차한계인 ± 1 ㎜ 에서 정확성은 근관의 입구 측으로부터 치근단 1/3까지 미리 확대한 후에 근관장을 측정할 경우와 측정시기가 반복될 경우에 증가되는 경향을 보여 임상에 유용하게 활용할 수 있을 것으로 사료된다. The aim of this study was to compare the length between the mesio-buccal and mesio-lingual canal of the mandibular molars before and after early coronal flaring at the different measuring time using several electronic apex locators. Fifty mandibular molars with complete apical formation and patent foramens were selected. After establishing the initial working length of the buccal and lingual canal of the mesial root using a surgical microscope (Carl Zeiss Co. Germany) at 25X with #15 K-file tip just visible at the foramen, radiographs were taken for the working length. After measuring the length of mesio-buccal and mesio-lingual canal (control group), the electronic lengths were measured at different times using several electronic apex locators (experimental groups; Ⅰ-Root ZX, Ⅱ-Bingo, Ⅲ-Propex, Ⅳ- Diagnostic). After early coronal flaring using the K^(3) file, the additional electronic lengths were measured using the same manner. The results were as follows: One canal has a correct working length for the mesial root of the mandibular molar, it can be used effectively for measuring the electronic working length of another canal when the files are superimposed or encountered at the apex. In addition, the accuracy of the electronic apex locators was increased as the measurement was accomplished after the early coronal flaring of the root canal and the measuring time was repeated.

간암과 간세포이형성 부위의 철침착 저항성에 대한 조직학적 연구

조욱행,강대영 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.1

Liver cell dysplasia(LCD) is commonly associated with some liver diseases such as liver cirrhosis or hepatocellular carcinoma and has been regarded as a premaligant condition. In order to clarify the question of whether or not LCD is a premalignant liver lesion, iron special staining, Prussian blue, was done. The specimens were collected at the department of pathology, Chungnam National University College of Medicine from January 1983 to September 1992. The results were as follows: 1. Of observed 48 cases, 34 were hepatocellular carcinoma(70.8%), 11 were metastatic carcinoma(22.9%), and 3 were hepatoblastoma(6.3%). 2. LCD was present in 26 of 34 cases(76.5%) of hepatocellular carcinoma, 5 of 11 cases(45.5%) of metastatic carcinoma, and 1 of 3 case(33.3%) of hepatoblastoma. 3. The carcinoma cells were free of iron deposition(iron excluding foci) in contrast to the neighboring dysplastic or nonneoplastic normal hepatocytes. 4. The presence of iron deposition in LCD cases was similar to or more severe than that of normal hepatocytes. In summary, the results obtained from the present study indicate that LCD reflects neither a regenerating condition nor a premalignant lesion but suggests a reactive change or accompaning lession.

복합 모반 주위에 발생한 Halo Dermatitis 1예

조영훈,이진욱,박상건,이민걸 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.9

Halo dermatitis was first described as a halo-shaped eczematous change around a nevocellular nevus. Howeyer, other cases developed around various kinds of lesions including seborrheic keratosis or lentigo were reported later on, so it is now considered not to be specific for melanocytes or nevus cells. It has never been reported to be associated with regression of central lesion, in contrast to halo nevus. We report a case of halo dermatitis developed around a compound nevus in a 20-year-old male patient. On histopathologic examination, the central lesion was a compound nevus and the surrounding lesion was consistent with chronic eczematous dermatitis. (Korean J Dermatol 2003;41(9) : 1261~1263)

Ti-Ni 형상기억합금의 변형특성에 미치는 pre-strain의 효과

조용배,오세욱,김득진,박영철 東亞大學校 海洋資源硏究所 1994 硏究論文集 Vol.7 No.1

In SMA(Shape Memory Alloy), the degradation by fatigue is one of the most important problems to be overcome, when SMA is used for robot-actuator materials. The acuator is operated repetitively for long time and its repeating operation develops the fatigue degradation of SMA. The fatigue degradation changes the transformation temperature and deformation behavior and results in inaccurate operation control of robot. Accordingly, the changing behavior of transformation temperature and deformation which results from repeating operation is to be investigated in advance and the scheme to resolve those problems have to be made for the design of actuator. In this paper, for the improvement of the fatigue degradation by repetive movement and better control of the correct movement by the stability of martensite transformation in the developement of Robots actuator, Pre-strain(0, 1.5, 5, 8%)were loaded in the specimens and fatigue testing were carried out by the method of heating and cooling in direct condition. From the results of these experiments, the effects on pre-strain which affect the transformation characteristic and fatigue degradation phenomena were correctly investigated