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슬링뉴렉기법을 적용한 안정화운동이 전방머리자세를 가진 젊은 성인의 통증, 목뼈 앞굽음각 및 중력중심선에 미치는 영향
이진욱,임문균 한국컴퓨터정보학회 2023 한국컴퓨터정보학회논문지 Vol.28 No.5
The purpose of this study was to the effects of the Sling Neurac stabilization exercise(SNSE) on pain, cervical lordosis angle(CLA), and cervical gravity line(CGL) in young adults with a forward head posture. The subjects of the study were selected as SNSEG(n=10) and control group(n=10), they were conducted for 70 minutes three times a week for 8 weeks. Study results showed that pain(p<.001), CGLe(p<.01) were significantly decreased and CLA(p<.001) were also significantly increased in the SNSEG. In conclusion, SNSE is effective in improving the proprioceptive sense of the LM group and activating the muscle. Co-activation with the GM group was found to be effective in improving the CLA and CGL. Therefore, reactivation of the deep neck flexors and suboccipital muscles is an important factor in pain control and postural alignment, and is suggested as an effective intervention method to improve forward head posture. 이 연구의 목적은 전방머리자세를 가진 젊은 성인을 대상으로 슬링뉴렉안정화운동이 중재방법이 통증 및 목뼈 앞굽음각, 중력중심선에 어떠한 영향을 미치는지 알아보고자 실시되었다. 연구의대상자는 슬링뉴렉안정화운동그룹(SNSEG) 10명, 통제그룹(CC) 10명으로 선정하였으며, 8주간 주3 회 70분간 실시하였다. 이 연구 결과 슬링뉴렉안정화운동은 통증은 감소(p<.001), 목뼈 앞굽음각은증가(p<.001)와 중력중심선은 감소에(p<.01) 유의한 효과가 나타났다. 이상의 결과 종합해 보면 슬링뉴렉안정화운동은 속근육(LM)군의 고유수용성감각 개선 및 근활성화에 효과적이며, 대근육(GM) 군과 공동활성화하여 앞굽은각과 중력중심선에 개선에 효과적인 것으로 나타났다. 따라서 깊은목굽힘근과 뒤통수밑근의 재활성화는 통증 조절과 자세 정렬에 중요한 요소로 전방머리자세 개선시킬 수 있는 효과적인 중재방법으로 제안한다.
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TOPKAT®, Derek®, OECD toolbox를 활용한 화학물질 독성 예측 연구
이진욱,박선영,장석원,이상규,문상아,김현지,김필제,유승도,성창호 한국환경보건학회 2019 한국환경보건학회지 Vol.45 No.5
Objectives: Quantitative structure-activity relationship (QSAR) is one of the effective alternatives to animal testing, but its credibility in terms of toxicity prediction has been questionable. Thus, this work aims to evaluate its predictive capacity and find ways of improving its credibility. Methods: Using TOPKAT®, OECD toolbox, and Derek®, all of which have been applied world-wide in the research, industrial, and regulatory fields, an analysis of prediction credibility markers including accuracy (A), sensitivity (S), specificity (SP), false negative (FN), and false positive (FP) was conducted. Results: The multi-application of QSARs elevated the precision credibility relative to individual applications of QSARs. Moreover, we found that the type of chemical structure affects the credibility of markers significantly. Conclusions: The credibility of individual QSAR is insufficient for both the prediction of chemical toxicity and regulation of hazardous chemicals. Thus, to increase the credibility, multi-QSAR application, and compensation of the prediction deviation by chemical structure are required.
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장거리승마운동이 비만중년여성의 혈중지질, 아디포칸인, 염증지표에 미치는 영향
이진욱,박종화 한국컴퓨터정보학회 2022 한국컴퓨터정보학회논문지 Vol.27 No.8
The purpose of this study was to verify the effects of long-distance horseback riding on blood lipid, adipokines and inflammatory markers in obese middle-aged women. The subjects of this study were 9 obese meddle aged women and the data analysed using the paired t-test. The result of this study were as follows: First, TC(p<.01), LDL-C(p<.01), and HDL-C(p<.001) were significantly increased after long-distance horseback riding(LDHR). Second, adiponectin was significantly increased(p<.01) and also PAI-1 was significantly decreased(p<.01) after LDHR. Third, IL-6 was significantly increased(p<.01) after LDHR. These results suggest that long-distance horseback riding has positive effect on changes blood lipid, adipokines, and inflammatory markers in obese middle-aged women. Therefore we consider that effects of long-distance horseback riding has partial examine on prevention and therapy of obesity in middle-aged obese women who undergo physical and emotional big changed. 이 연구는 장거리 승마운동이 비만중년여성들의 혈중지질, 아디포카인 및 염증지표에 미치는영향을 분석하여 장거리 승마운동의 효과를 검증하고자 하였다. 이 연구의 대상자는 비만중년여성 9명으로 하였으며 수집된 자료는 대응표본T-검증을 이용하여 분석하였다. 이 연구의 결과는 다음과 같다. 첫째, 혈중지질성분은 장거리 승마운동 후 TC(p<.01), LDL-C(p<.01) HDL-C(p<.001)는유의하게 증가하였다. 둘째, 아디포카인은 장거리 승마운동 후 Adiponectin은(p<.01) 유의하게 증가하였고, PAI-1은 통계적으로 유의하게 감소하였다(p<.01). 셋째, 염증지표는 장거리 승마운동 후IL-6은 유의하게 증가하였다(p<.01). 이상의 결과에서 장거리 승마운동은 비만중년여성의 혈중지질성분과 아디포카인, 염증지표의 변화에 긍정적인 효과가 있는 것으로 생각되며 이는 신체적, 정서적으로 큰 변화를 겪고 있는 중년여성의 비만예방 및 치료에 대한 장거리 승마운동의 효과를 부분적으로 검증한 것으로 생각된다.
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이진욱,임현창,이은웅,박진영,이중석,이동운,정의원,최성호 대한치주과학회 2014 Journal of Periodontal & Implant Science Vol.44 No.4
Purpose: The aim of this study was to assess the possible paracrine effect of bone morphogeneticprotein-2 (BMP-2) at the experimental site on the adjacent control site for validating a rabbit calvarial defect model as a means of verifying the effect of BMP-2. Methods: Sixteen rabbits were divided into two groups (n=8 in each) according to whether or not BMP-2 would be used. Two circular defects (8 mm in diameter) were created side by side, 2 mm apart, in the calvarium of all of the rabbits. In each animal, one of the defects was grafted with either BMP-2-loaded carrier or carrier material alone. The control defects adjacent to these grafted defects, designated CB (the nongrafted defect adjacent BMP-2-loaded carrier-grafted defect) and CC (the nongrafted defect adjacent to carrier only-grafted defect), respectively, were the focus of this study, and were filled only with a blood clot in all of the animals. Histologic observation and histomorphometric analysis were performed at 2 and 8 weeks (n=4 animals per point in time) after surgery. Results: There was no noteworthy difference in the healing pattern, and no statistically significant differences in histomorphometric parameters such as the defect closure, new bone area, or total augmented area between the CC and CB groups. Conclusions: The results of this study suggest that rabbit calvarial defects separated by a distance of 2 mm are suitable for evaluating the effects of BMP-2 and the control defect can be regarded not to be affected by BMP-2 applied defect.
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이진욱,이성규 한국환경보건학회 2014 한국환경보건학회지 Vol.40 No.1
Objectives: 32P-postlabeling assay is the most sensitive method of detecting DNA adduct formation. However,it is limited by a low sample throughput and use of radioisotopes (RI). In this study, we modified it to minimizethese limitations and applied it to Z. platypus exposed to Benzo(a)pyrene (BaP) in order to investigate DNAadduct formation (effect biomarker for pollutants) in Z. platypus for assessing risk of waterborne BaP exposure. Methods: DNA hydrolysis was performed only with Micrococcal nuclease (MNase), RI reduction test was performedand the overlapping steps between thin layer chromatography (TLC) and radioisotope high-performanceliquid chromatography (RI-HPLC) were omitted. The application of a modified method to Z. platypus exposedto BaP was performed. Results: The results revealed that the amount of RIs used can be reduced roughly 10-fold. Because the analysistime was shortened by 8.5 hours, the sample throughput per hour was increased compared with the previousmethod. The results of applying modified 32P-postlabeling assay to Z. platypus, DNA adduct formation in Z. platypus showed dose-dependency with the BaP concentration. Only BPDE-dGMP was detected as a DNAadduct. Conclusion: These results demonstrate that the modified 32P-postlabeling assay is a suitable method for detectingDNA adduct formation in Z. platypus exposed to waterborne BaP and will be useful in risk assessment of carcinogeniceffect in aquatic environment due to BaP.
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