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다양한 조사료를 이용해 제조한 TMR이 흑염소 반추위 in vitro 발효성상에 미치는 영향
이진욱,이성수,김찬란,최봉환,이상훈,김동교,이은도,김관우,류채화,Lee, Jinwook,Lee, Sung-Soo,Kim, Chan-Lan,Choi, Bong-Hwan,Lee, Sang-Hoon,Kim, Dong-Kyo,Lee, Eun-Do,Kim, Kwan-Woo,Ryu, Chae Hwa 한국초지조사료학회 2021 한국초지조사료학회지 Vol.41 No.2
In this study, the effect of forage sources in the total mixed ration (TMR) on in vitro goat rumen fermentation was investigated. Rice straw (RS), Italian ryegrass (IRG), timothy (TIM), and alfalfa (ALF) were used as forage sources. Each forage source was mixed with a commercial goat concentrate diet in the ratio of 1:1. Total 4 TMR were prepared. Rumen simulated in vitro fermentation using goat rumen fluid collected from the slaughterhouse was conducted until 72<sup>th</sup>. For fermentation parameters, gas production (GP), volatile fatty acids (VFAs), and ammonia nitrogen (NH<sub>3</sub>-N) were examined. All assays were performed at 24<sup>th</sup>, 48<sup>th</sup>, and 72<sup>th</sup> h of incubation individually. Contents of crude protein and non-fibrous carbohydrate were greater in the order of RS < IRG < TIM < ALF. Significant treatment effects were found in valerate and NH<sub>3</sub>-N at 24<sup>th</sup> h of incubation (p<0.05). ALF showed the greatest contents of them and RS was the lowest. At 48<sup>th</sup> incubation, a significant effect was detected at GP (p<0.05) and RS was greater than others. However, GP of RS was lower than others at 72<sup>th</sup>. Significant effects on Total VFA, butyrate, and valerate productions were found at 72<sup>th</sup> h of incubation (p<0.05). ALF showed the greatest production. Methane production from all treatments was not significantly different for each incubation time (p>0.05). The present study provided primary information on how goat rumen fermentation responds to different nutrient contents and forage sources of TMR. And the information could be used for the design or optimizing economical diet formulation for goats.
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5-fluorouracil 사용 중인 식도암 환자에서 발생한 관상동맥연축
이진욱,박무인,박선자,문원,김성은,김재현,정경원,Jin Wook Lee,Moo In Park,Seun Ja Park,Won Moon,Sung Eun Kim,Jae Hyun Kim,Kyoungwon Jung 대한소화기암연구학회 2017 Journal of digestive cancer reports Vol.5 No.1
5-Fluorouracil (5-FU) has been widely used in the treatment of various solid tumors. However, 5-FU cardiotoxicity is being reported with increasing frequency. The main symptom of cardiotoxicity is chest pain at rest with ischemic electrocardiographic changes. Up until now, the underlying mechanism has been suspected to be coronary artery spasm. However, this chest pain associated with 5-FU has several characteristics that are incompatible with coronary artery spasm; eg, inefficacy of calcium-channel blocker and a slow increase in cardiac enzyme levels. We experienced a case of 5-FU-induced cardiotoxicity which showed clinical findings consistent with acute myocardial infarction. Based on the clinical findings, coronary angiography, and no stenosis was noted. However, we concluded that the cardiotoxicity in this case was due to ischemia caused by coronary artery spasm. Because vasodilatator was effective and secondary attack was followed.
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