정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

유전체의 과도 산란 해석을 위한 시간영역 결합 적분방정식

박재권,김형진,윤희상,정백호 湖西大學校工業技術硏究所 2003 工業技術硏究所論文集 Vol.22 No.-

In this paper, we propose a time domain combined field integral equation (TD-CFIE) formulation to analyze the transient electromagnetic response from three-dimensional dielectric objects. The solution method in this paper is based on the method of moments(MoM) that involves separate spatial and temporal testing procedures. A set of the RWG(Rao, Wilton, Glisson) functions is used for spatial expansion of the equivalent electric and magnetic current densities and a combination of RWG and its orthogonal component is used as spatial testing. We also investigate spatial testing procedures for the TD-CFIE to select the proper testing functions that are derived from the Laguerre polynomials. These basis functions are also used for temporal testing. Numerical results computed by the proposed formulation are presented and compared with the solutions of the frequency domain combined field integral equation(FB-CFIE).

제2형 당뇨병 환자에서 우연히 발견된 기종성 방광염 1례

박보민,김윤정,이영태,노정현,권수경,김동준,고경수,이병두,임경호,이순희,박정현 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Emphysematous cystitis is an uncommon disease in which bacterias produce gas within the bladder wall and surrounding tissue. Patients with diabetes, neurogenic bladder and chronic urinary tract infection are predisposed to the disease. It is usually caused by E.coli and Klebsiella. Severity of illness ranges from an asymtomatic condition to life threatening cystitis. Succesful management depends on early diagnosis with correction of underlying causes, administration of appropriate antibiotics, establishment of adequate bladder drainage and surgical excision of involved tissue when required. We report a case of 52-year-old woman who did not compain of symtoms of cystitis but epigastric pain, nausea, and vomitting. Emphysematous cystitis was revealed on the abdominal X-ray series incidentally. CT scans of the pelvis showed mottled gas bubble within the bladder. After treatment, the symtoms subsided and plain abdominal film showed no evidence of gas shadow in the pelvic cavity.

척수압박으로 발현된 급성 골수성 백혈병에 동반된 과립구성 육종 1 례

윤상준,김영곤,김희종,박유환,정춘해,김양수,김태균,박영진,전호종 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

저자들은 척수압박으로 하지마비를 보인 환자에서 수술 후에 급성 백혈병에 동반된 과립구성 육종으로 진단된 환자 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Granulocytic sarcoma(GS) is an uncommon tumor composed of immature cells of the granulocytic series. Most case of GS occur in the course of acute leukemia and the blast crisis of chronic leukemia, Rarely, however, it may present before leukemia becomes clinically apparent. It may also occur in patients with myeloproliferative disoders. GS has been reported that it occurs in 3% to 9% of patients with acute myelogenous leukemia(AML) and the incidence of GS is reported to be higher in patients with t(8;21). GS occurs relatively commonly in africa and has been reported to affect 10-25% of black children presenting with AML. This is very rare case of granulocytic sarcoma with AML(FAB M5) presented with spinal cord compression which was supported by decompression laminectomy.

백금(Ⅳ)착체의 약리학적 연구

박은희,임경화,신윤진,박미화 숙명여자대학교 약학연구소 1994 약학논문집-숙명여자대학교 Vol.10 No.-

The platinum complex, PtCl₄(2-CEen), was previously synthesized and shown to have anti-tumor activity. In the present study, toxicologic profile of PtCl₄(2-CEen) and its acute anti-inflammatory activity on carrageenin edema was observed with oral administration. The ef-4feet of this agent on acetic acid-induced writhing in mice were also examined. In male and female mice given a single intragastrical dose of PtCl₄(2-CEen), we determined that LD_(50) values were over lOOOmg/kg B.W. In the method of carrageenin edema and writhing test, the PtCl₄(2-CEen), orally administered in a single dose, tended to inhibit the development of hind paw edema in rats, and the number of writhing induced by acetic acid in mice. These facts suggest that PtCl₄(2-CEen) may have weak anti-inflammatory effect.

음식물 쓰레기 퇴비가 오이 발아와 유묘생장에 미치는 영향

박진영,조경철,김희경,지연태,정순주 全南大學校 農業科學技術硏究所 2001 農業科學技術硏究 Vol.36 No.-

This study was conducted to find out toxicity of compost made of food waste to cucumber seed germination and seedlings growth when it was mixed with Mixlite for bed substrate. Mixlite was solely used as bed soil, or mixed with food waste compost ranging 1% to 100% (w/w). Germination percentage and seedling growth of cucumber were examined in 4 weeks after seedling. When cucumber seeds were sowed in Mixlite mixed with food waste compost at 100, 50, 30, 20, 10 or 1%, germination percentages were 30, 36, 38, 46, 74 and 84% compared to with control(100%), respectively. It showed that germination percentage percentage was adversely affected by the amount of food waste composed mixed in the bed substract. Plant height and hypocotyls diameter, root length and root fresh weight, hypocotyls fresh weight and cotyledon fresh weight of cucumber seedling were similarly adversely affected by the amount of food waste compost. Optimum content of the food waste compost for cucumber nursery substrate was found to be 1% of Mixlite.

시판 동물성 식품의 저장온도 및 저장기간별 세균균속의 변화

박석기,이용욱,윤희정 대한보건협회 2000 대한보건연구 Vol.26 No.1

It is very important to prepare the sanitation criteria for the animal foods through the microbiological examination and the investigation of tendency to change of the organisms according to the storage temperature and period. As the results of identification of total 110 genera isolated from commercial animal foods, 15 genera were identified and predominant genera were Staphylococcus(29.1%), Pseudomonas (13.6%) and Enterococcus(12.7%) and followed by Enterobacter, Lactobacillus, Achromobacter, Aeromonas, Escherichia, Micrococcus, Bacillus, Klebsiella, Serratia and yeast. As the results of identification of 1323 isolates from commercial animal foods stored at 10℃, 20℃ and 30℃, 21 genera were identified and Staphylococcus(22.5%), Enterococcus(15.9%), Pseudomonas(15.9%), Bacillus(10.3%) were predominant. The predominant genus among 405 isolates from commercial animal foods stored at 10℃ was Pseudomonas(28.9%), followed by Staphylococcus(19.8%), Enterococcus(16.0%) and Bacillus(11.1%). The predominant genus among 483 isolates from commercial animal foods stored at 20℃ was Staphylococcus(23.4%), followed by Enterococcus(16.0%) and Pseudomonas(11.1%) but the predominant genera among 436 isolates from commercial animal foods stored at 30℃ was Staphylococcus(23%), followed by Enterococcus(15.4%) and Bacillus(11%).

구개부 소타액선에 발생한 호산성 과립세포종

박현진,김경원,조용석,이경호,강지연,최희원 충북대학교 의학연구소 2002 忠北醫大學術誌 Vol.12 No.2

호산성 과립세포는 타액선을 포함하여 갑상선, 부갑상선 등 주로 선조직에서 발견되는 커다란 과립상의 호산성 상피세포를 말한다. 호산성 과립세포종은 모든 타액선 종양중 약 1.5%의 비율로 발생하는 비교적 드문 양성 종양이며, 주로 노년의 이하선에서 발생하고 악하선과 소타액선에서는 드물게 발생한다. 임상적으로 크기는 약 3-4 ㎝이며 잘 분화된 낭으로 싸여있다. 조직학적 검사에서 광학현미경상 호산성 과립세포로 채워진 세포질이 관찰되며 전자현미경상 과립을 함유한 다량의 비대된 미토콘드리아가 관찰된다. 호산성 과립세포종은 본질적으로는 양성 종양이며 치료를 위하여 완전한 절제가 추천된다. 국소적인 재발은 드물며 다발성인 경우에는 재발하기도 한다. 증례는 38세의 남자 환자로서 구개부의 소타액선에 발생한 약 2.0×2.5 ㎝ 크기의 무통성의 종괴로 절제술을 시행하였으며, 광학현미경과 전자현미경을 이용한 조직병리 검사상 호산성 과립세포종으로 진단되었으며, 수술 후 특별한 합병증 없이 치유되었다. 저자들은 구개부의 소타액선에서는 아주 드물게 발생하는 호산성 과립세포종에 대하여 진단 및 치료를 시행하고 양호한 결과를 얻었기에 문헌 고찰과 함께 보고하는 바이다. Oncocytes are large, granular, eosinophilic epithelial cells mainly found in many glandular tissue including salivary glands, the thyroid, parathyroid, pituitary, adrenal gland, testicle, fallopian tube, liver and stomach etc. Oncocytoma, which originate from oncocytes are uncommon benign neoplasm that present approximately 1.5% of all salivary gland tumors. They typically occur in parotid gland of elderly patients and rarely in submandibular gland or minor salivary gland. On gross examination, they are usually 3 to 4 ㎝ is size and possess a well-defined capsule. Histologically oncocytoma peculiarly consisted of oncocyte which has cytoplasm, filled with eosinophilic granules on light microscopy and a large number of enlarged and morphologically altered mitochondria by electron microscopy. Oncocytomas are essentially benign tumors and complete excision is recommended. Local recurrence is extremely rare, but when it occurs, it may be multifocal. We report a case of oncocytoma raised from minor salivary gland of palate in 38 years old male patient with literature.

지하구내에 설치된 변압기의 극간 거리에 따른 연면방전 특성

박하용,임윤희,심낙순,이상교,송우창 三陟大學校 産業科學技術硏究院 2005 産業科學技術硏究論文集 Vol.10 No.-

The electric equipment of the recently building is established in underground of the building, it is the actual condition where the immediacy countermeasure preparation which is special regarding an electric equipment is deficient. The dissertation which it sees the case where the mold transformer which is established in the underground enclosure will be flooded minimizes the damage regarding the 1st disaster it could occur and a 2nd disaster in the test Book of Psalms to select the mold transformer which at fundamental phase of the research for is established on th actual underground enclosure, it analyzed the surface discharge voltage which it follows in distance and the electric current corrugated back. It appears with the fact that the recording surface discharge voltage where the analysis result electrode for interval will become larger increases, peek of discharge current highly there is a possibility of knowing the burden. Also, it caused by with increase of the surface discharge hour and the recording discharge hour when the interval of electrode for will become larger to increase also the insulation scandal damage will be augmented with the fact that it is thought.

대기확산모델(AirMaster)을 이용한 울산 산단 지역의 아황산가스(SO₂) 대기환경용량 산정 연구

구윤서,박찬희 안양대학교 산업기술연구소 2004 自然科學硏究 Vol.11 No.1

정부 주도로 추진된 중화학공업 육성시책에 따라 조성된 울산지역의 산업단지 지역은 오랜 기간 동안 다양한 오염물질을 대량으로 배출하였다. 특히 SO_(2)는 최근 2~3년 내에 순간 오염도도 일부 측정소에서 단기간 환경기준을 초과하였으며, 타 도시 지역과 비교하여 상대적으로 오염도가 높은 것으로 나타났다. 이러한 울산 산단 지역의 대기질 개선을 위한 선행연구로, 울산 산단 지역에서의 SO_(2) 대기오염도 현황을 조사하고 고농도가 자주 발생되거나 그러할 가능성이 높은 기간에 대하여 배출량 기여도 평가와 함께 대기 확산 모델(AirMaster)을 이용하여 안정적으로 대기환경기준을 달성할 수 있는 수준의 대기환경용량을 산정하였다. 또한 대기환경용량 유지에 적합한 대기질 배출량의 삭감량을 산정하였다. 각각의 모델 수행 기간 모두 면오염원이 약 40% 정도의 기여도를 나타냈고, 점오염원에서는 석유정제시설과 제조업-연소시설이 큰 비율을 차지하는 것으로 파악되었다. 이것으로 보아 울산 산단 지역은 면오염원에서 일정 수준 이상의 오염도를 유지한다는 것과 점오염원 중 대형 배출 시설에 의한 오염도가 최고 농도를 결정하게 된다는 것을 알 수 있었다. The Ulsan industrial complex discharged various pollutants at the large facilities during long duration. Specially, it appeared that the SO_(2) emission of the Ulsan area was higher than that of the other city area. In this research, critical loads of atmospheric environmental to meet the ambient air quality standards were estimated by using air dispersion model-AirMaster. And it bought reduction of SO_(2) emission in order to be below air environmental standards. Among model execution results in area source, it showed about 40% effect degree, in point source, it appeared with the fact that the oil refining facility and combustion facility is the highest.