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      • Graves병에서 발생한 갑상선 암

        권수경,임동현,강상중,김성만,최영식,박요한 고신대학교 의학부 2000 高神大學校 醫學部 論文集 Vol.15 No.1

        Background Thyroid nodules in patients with Graves' disease are common and raise concern about coexistent thyroid malignancy. Furthermore, it was reported that thyroid cancers in patients with Graves' disease were more aggressive than those without. Thus, it is important to detect thyroid cancer in the patients with Graves' disease prior to surgery. However, there has been no standard guideline suggested for the management of thyroid nodules in the Graves' disease. Therefore, we tried to characterize thyroid nodules associated with Graves' disease and to assess the usefulness of ultrasonography and high resolution ultrasound-guided fine needle aspiration (FNA) in the management of thyroid nodules associated with Graves' disease. Methods Sixty-five patients were included in the study who underwent high resolution ultrasound-guided FNA for thyroid nodules of the 341 patients with Graves' disease at Kosin Medical Center from June, 1996 to January, 1999. Thyroid nodules were classified according to the internal echo pattern, numbers and the size of nodule. Results Thyroid nodules occurred in 19.1% of patients with Graves' disease. The age of the patients with nodules distributed evenly through third to seventh decade (18-68 years, mean 43 years). Thyroid nodules occurred evenly between third decade seventh decade. Male to female ratio was 1:4.09. Thyroid cancers occurred in 6 patients (9.2%) of nodules, and was 1.76% of the total Graves' patients. Eight cases underwent operation. Of those 5 were papillary carcinoma and 2 adenomatous goiter, and 1 Hu¨rthle cell carcinoma. Malignant thyroid nodules occur evenly between third decade to seventh decade. The incidence of malignancy was 10.7%(3/28) in solitary nodule and 8.1%(3/37) in multiple nodules. Thirty-six cases (55.4%) were measured 1㎝ or less, 27 cases (41.4%) between 1.0㎝ to 3.0㎝, and 2 cases (0.32%) above 3㎝, and malignant nodules were 3 (11.1%), 2(7.4%), and 1 (50.0%) respectively. The size of malignant nodule ranged between 0.5㎝ and 4.2㎝. Three of malignant nodules were microcarcinoma (≤1㎝) and the smallest one (0.5㎝) metastasized to regional lymph node. Of the 65 nodules, 50 cases were solid, 4 cystic, and 11 mixed. Malignant nodules were more frequent in the solid nodule, but there was no significant difference between each group. The titers of thyrotropin binding inhibitory immunoglobulin(TBⅡ) in the malignant patients were 9.2% to 350.0% and TBⅡ was positive in the 4 of 6 cases of malignacy. The obtainability of adequate cytologic specimen by ultrasound-guided FNA was 95.9%. No complication except pain on aspiration site was noted during this study. Conclusion The incidence of thyroid nodule in Graves' patients was high and the rate of malignancy also high in Graves' patients with thyroid nodule. Malignant thyroid nodules occurred relatively evenly through third to seventh decade. Large proportions of malignant nodules were microcarcinomas and even the smallest on of the malignant nodules metastasized to regional lymph node. Therefore, for the proper management of thyroid nodule associated with Graves' disease, it is suggested that ultrasonography be needed to detect thyroid nodule in all Graves' patients, and ultrasound-guided FNA be performed for the diagnosis of small thyroid cancer.

      • 우수녹용 생산을 위한 엘크 사용

        권수경 안동대학교 농업개발원 2000 最高農業經營者課程 論文集 Vol.4 No.-

        우리 나라의 사슴 사육은 사치성, 고소득, 애완 동물 인식에서 1992년 수입개방 이후 소, 돼지, 닭 다음의 가축으로 자리를 잡아가고 있으며, 타 가축에 비해 친 환경적인 가축으로 인식되고 있다. 현재 1만여 농가에 22만여 두 사육에 이르고, 사슴 특징상 4계절이 뚜렷한 우리 나라가 사슴 사육의 최고 적지인 점을 감안 할 때 종록 개량과 품질 개선으로 수입녹용과 경쟁이 가능해 지리라고 생각된다. 세계 녹용 생산의 80%를 소비하면서 아직까지 국내생산은 20%에 불과 하고 소비에도 어려움이 있다. 원인은 여러 가지가 있겠지만 많은 양의 녹용 수입과 국산 녹용과의 가격차이로 한약 업소 및 제약회사에서 기피하는 현상으로서 막대한 외화 유출은 물론이고, 사슴 사육 농가에 부담을 주고 있다. 국내 사육 농가 규모를 보면 70%가 영세 소규모 농가이다. 앞으로 규모 확대가 이루어져야 될 것으로 생각된다. 사슴 사육 비율을 보면 꽃사슴 74% 레드디어 13.4%, 엘크 12.6% 구성되어 있는 것을 볼 때, 한약 약재화 규격에 타당한 품종은 생산성과 경제성 감안한다면, 타 품종(꽃사슴 레드디어)에 비해 녹용 생산성이 월등히 높다. 엘크의 경우 녹용성장 80일 절각에 평균 8∼9kg 생산을 하고 있으며, 회분함량과 녹용성장 일수를 비교하면 타 품종과 비교하면 월등히 낮다. 따라서, 엘크사슴으로 전환이 필요하다고 생각되며, 국내 우수 혈통의 사슴 정액 채취하여 민·관이 합동으로 인공수정 및 수정란 이식 및 종록 개량을 한다면 우수 록 보급으로 몇 년 내 외국과 품질 및 가격 경쟁이 가능하리라고 보며, 동시에 보건복지부 생약 규격집 회분함량 25% 이하 녹용과 25∼35% 이하 중품 녹용을 규격에 맞게 조지 절각으로 품질 우수한 녹용을 생산한다면, 품질 및 생산량으로 가격인하 조정을 해 한약 업소 및 제약회사에도 대량 소비체에 납품 가능하리라고 본다.

      • 대사성 증후군

        권수경 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5

        Concept of syndrome X for the clustering of cardiovascular risk factors like hypertension, obesity, high triglyceride, and low HDL cholesterol concentration was introduced in 1988 by Reaven. And it was also known as insulin resistance syndrome or metabolic syndrome. First unifying definition for metabolic syndrome was proposed by WHO in 1998 and WHO chose to call it the metabolic syndrome rather than insulin resistance syndrome or syndrome X. Recently, in 2001 the National cholesterol Education Program (NCEP) proposed new definition for metabolic syndrome. Presence of metabolic syndrome is associated with reduced survival, particularly because of increased cardiovascular mortality.

      • KCI등재후보

        호박씨유, 복분자,대두복합혼합물 (콘티나연질캅셀)의배뇨장애개선에 관한 유효성연구

        권수경,이희영,최은미,강명자,심상섭,정애경,신대희,고성규 대한한방부인과학회 2004 大韓韓方婦人科學會誌 Vol.17 No.4

        Purpose : To determine the efficacy of Contina soft capsule on dysuria Methods : 53 patients with urinary incontinence or frequency were enrolled in a open clinical trial. They were taken Contina soft capsule(pumpkin seed oil, soybean, Rubus coreans Miq) two times a day after meals for 8 weeks. 9 patients were excluded from the study for low compliance, participation refuse, increased AST/ALT. 44 patients were analysed. Following parameters were analysed ; voiding diary, residual urine, urinary symptom questionaire, labaratory finding, vital sign Results : The result were as follows 1)Questionaire score, frequency of incontinence, frequency, nocturia improved by 93.2%, 90%, 66.7%, 88.9%. 2)The mean±SD of frequency of incontinence was reduced from 4.77±5.10 to 2.00±3.48 after treatment (p<0.001). 3)The mean±SD of quantity of incontinence score was reduced from 1.93±1.26 to 1.09±1.25 after treatment(p<0.001). 4)The mean±SD of nocturia was reduced from 0.70±0.82 to 0.37±0.58 after treatment(p<0.001). 5)The mean±SD of urgency score was reduced from 2.20±0.95 to 1.56±0.66 after treatment(p<0.001). 6)The mean±SD of residual urine was reduced from 36.36±75.00 to 9.95±23.97 after treatment (p<0.05). 7)Daily frequency was reduced, but it was not significant statistically. 8) There was significant improvement in low urinary tract symptoms (p<0.001), QoL (p<0.001), QoSL(p<0.01) 9)After discontinence of drug, effect of contina soft capsule were maintained for 2 weeks. Conclusion : The contina soft capsule can be effective, relatively safe regimen for urinary incontinence.

      • Graves병에서 발생한 갑상선 암

        권수경,임동현,강상중,김성만,최영식,박요한 고신대학교(의대) 고신대학교 의과대학 학술지 2000 고신대학교 의과대학 학술지 Vol.15 No.1

        Background : Thyroid nodules in patients with Graves' disease are common and raise concern about coexistent thyroid malignancy. Furthermore, it was reported that thyroid cancers in patients with Graves' disease were more aggressive than those without. Thus, it is important to detect thyroid cancer in the patients with Graves' disease prior to surgery. However, there has been no standard guideline suggested for the management of thyroid nodules in the Graves' disease. Therefore, we tried to characterize thyroid nodules associated with Graves' disease and to assess the usefulness of ultrasonography and high resolution ultrasound-guided fine needle aspiration (FNA) in the management of thyroid nodules associated with Graves' disease. Methods : Sixty-five patients were included in the study who underwent high resolution ultrasound-guided FNA for thyroid nodules of the 341 patients with Graves' disease at Kosin Medical Center from June, 1996 to January, 1999. Thyroid nodules were classified according to the internal echo pattern, numbers and the size of nodule. Results : Thyroid nodules occurred in 19.1% of patients with Graves' disease. The age of the patients with nodules distributed evenly through third to seventh decade (18-68 years, mean 43 years). Thyroid nodules occurred evenly between third decade to seventh decade. Male to female ratio was 1:4.09. Thyroid cancers occurred in 6 patients (9.2%) of nodules, and was 1.76% of the total Graves' patients. Eight cases underwent operation. Of those 5 were papillary carcinoma and adenomatous goiter, and 1 Hurthle cell carcinoma. Malignant thyroid nodules occur evenly between third decade to seventh decade. The incidence of malignancy was 10.7% (3/28) in solitary nodule and 8.1% (3/37) in multiple nodules. Thirty-six cases (55.4%) were measured 1cm or less, 27 cases (41.4%) between 1.0cm to 3.0cm, and 2 cases (0.32%) above 3cm, and malignant nodules were 3 (11.1%), 2 (7.4%) and 1 (50.0%) respectively. The size of malignant nodule ranged between 0.5cm and 4.2cm. Three of malignant nodules were microcarcinoma (≤1cm) and the smallest one (0.5cm) metastasized to regional lymph node. Of the 65 nodules, 50 cases were solid, 4 cystic, and 11 mixed. Malignant nodules were more frequent in the solid nodule, but there was no significant difference between each group. The titers of thyrotropin binding inhibitory immunoglobulin (TBII) in the malignant patients were 9.2% to 350.0% and TBII was positive in the 4 of 6 cases of malignancy. The obtainability of adequate cytologic specimen by ultrasound-guided FNA was 95.9%. No complication except pain on aspiration site was noted during this study. Conclusion : The incidence of thyroid nodule in Graves' patients was high and the rate of malignancy also high in Graves' patients with thyroid nodule. Malignant thyroid nodules occurred relatively evenly through third to seventh decade. Large proportions of malignant nodules were microcarcinomas and even the smallest one of the malignant nodules metastasized to regional lymph node. Therefore, for the proper management of thyroid nodule associated with Graves' disease, it is suggested that ultrasonography be needed to detect thyroid nodule in all Graves' patients, and ultrasound-guided FNA be performed for the diagnosis of small thyroid cancer.

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