심한 골병변으로 발현된 기능성 낭종성 부갑상선 선종

전숙,김영희,박지영,고관표,박철영,김덕윤,우정택,김성운,김진우,김영설,고석환 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.2

낭종성 부갑상선 선종과 심한 골병변을 동반한 부갑상선 기능항진증은 매우 드문 질환으로서, 저자들은 양측 고관절의 통증을 초기 주소로 내원한 환자에서 고칼슘혈증과 부갑상선 호르몬 증가, 골병변의 방사선적 소견을 통해 부갑상선 기능항진증을 진단하고, 경부 초음파와 컴퓨터 단층 촬영, 부갑상선 스캔검사 및 수술중 부갑상선 낭종액 검사 등을 통해 기능성 부갑상선 낭종의 한 종류인 낭종성 부갑상선 선종을 진단하고 수술적 제거를 통하여 정상화된 1예를 경험하였다. A cystic parathyroid adenoma is rare. A case of primary hyperparathyroidism, with the cystic formation of a parathyroid adenoma and a severe bony lesion, is reported. A 52-year-old male was admitted due to pain in both hips and for evaluation of hypercalcemia. The plasma level of the intact parathyroid hormone (iPTH) was elevated to 1424 pg/mL. Ultrasonography and the computed tomography revealed a parathyroid cyst on the left thyroid lower pole. Parathyroid scintigraphy detected a parathyroid adenoma. A radiograph showed a subperiosteal bone resorption on the phalanges, and a brown tumor (osteitis fibrosa cystica) on the femur shaft was noted. A surgical excision of the parathyroid adenoma was performed. The PTH level in the cystic fluid was increased. A histological examination confirmed a cystic parathyroid adenoma. The PTH level was normalized after the operation (J Kor SOC Endocrinol 18:214-220, 2003).

유년기 안구적출술 및 방사선치료로 인하여 발생된 안와 열성장에 대한 재건 치험례

홍관석,김성문,김훈,임재석,최미숙,최성원,권종진 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.1

There are many reports of the surgical management for the craniofacial abnormalities arising from the irradiation of the head and face for treatment of childhood cancers. Since the mordern combined-modality theraphy for childhood cancers began in the late 1960s and the early 1970s, recent reports have described the occular, dental and maxillo-facial abnormalities after irradiation in long-term survivors of cancers of the head and face. The resultant deformities may be known to be difficult to reconstruct with surgical techniques. This paper describes the late reconstructive surgery for the unilateral orbital and malar hypoplasia after eyeball enucleation and irradiation during childhood to correct the facial asymmetry and expand the contracted orbital socket into the functional dimension for the retaining eyeball prosthesis with spherical implant. We reports the satisfactory preliminary results from the midfacial osteotomy through the supero-lateral orbital rim and malar bone and the antero-lateral repositioning with the autogenous bone grafting in 26 year-old female patient who will be planned to make the new eyeball prosthesis by the department of ophthalmology.

야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

포러스콘크리트의 기초물성에 미치는 시멘트페이스트의 유동성 및 진동다짐시간의 영향에 관한 실험적 연구

김무한,백용관,최영욱,강석표,김재환,이성일 忠南大學校 産業技術硏究所 2001 산업기술연구논문집 Vol.16 No.2

This study analyzed the influence of paste fluidity and vibration time for fundamental properties of porous concrete. Results of this study were shown as follows: 1) Even if target void ratio is same, void ratio and compressive strength of porous concrete is different according to w/c, paste flow and vibration time. So, In case of target void ratio, we must consider the influence of w/c, past flow and vibration time. 2) Though w/c and vibration time is same, as paste flow increase, all void ratio, continuous void ratio, and compressive strength decrease and difference between upper and lower void ratio increase. 3) Though w/c and paste flow is same, as vibration time increase, all void ratio and continuous void ratio decrease and difference between upper and lower void ratio increase. Also, compressive strength increase by 10 seconds and decease after 10 seconds. 4) As types of superplasticizer is different, all void ratio, continuous void ratio, and compressive strength is different. So, we must give consideration to paste fluidity and vibration time in order that increase of strength of porous concrete and distribution of uniform void.

방사선사진에서의 골질과 임상적으로 평가한 골질 분류의 상관관계

김현우,허경회,박관수,김정화,이원진,허민석,이삼선,최순철 대한구강악안면방사선학회 2006 Imaging Science in Dentistry Vol.37 No.1

Purpose : To investigate the validity of digital image processing on panoramic radiographs in estimating bone quality before endosseous dental implant installation by correlating bone quality in radiographic images with clinical bone quality classification. Materials and Methods : An experienced surgeon assessed and classified bone quality for implant sites with tactile sensation at the time of implant placement. Including fractal dimension eighteen morphologic features of trabecular pattern were examined in each anatomical sites on panoramic radiographs. Finally bone quality of 67 implant sites were evaluated in 42 patients. Results : Pearson correlation analysis showed that three morphologic parameters had weak linear negative correlation with clinical bone quality classification showing correlation coefficients of -0.276, -0.280, and -0.289, respectively (p<0.05). And other three morphologic parameters had obvious linear negative correlation with clinical bone quality classification showing correlation coefficients of -0.346, -0.488, and -0.343 respectively (p<0.05). Fractal dimension also had a linear correlation with clinical bone quality classification with correlation coefficients -0.506 significantly (p<0.05). Conclusion : This study suggests that fractal and morphometric analysis using digital panoramic radiographs can be used to evaluate bone quality for implant recipient sites. (Korean J Oral Maxillofac Radiol 2006; 36 : 25-32)

호흡기 감염에서 Sparfloxacin 의 임상적 유용성에 대한 Enoxacin과의 비교 검토

김주옥,김선영,김관형,서지원,박석영,이종진,박성학 대한감염학회 1995 감염 Vol.27 No.4

목적:폐렴, 기관지염, 만성기관지염에서 fluoroquinolone제제로서 항균력이 강하고, 혈중 반감기가 길고, 객담과 조직내 농도가 높은 sparfloxacin의 안전성과 효과를 enoxacin과 비교하기 위해 본 연구를 시행 하였다. 방법:1994년 10월부터 1995년 4월까지 충남대 부속병원과 대전 성모병원에 내원한 폐렴, 급성기관지염, 만성기관지염이 급성으로 악화된 환자 63명을 대조군(32명)(enoxacin 100 mg 1일 3회 경구투여), 실험군(31명)(sparfloxacin 200mg 1일 1회 경구투여)으로 나누어 임상증상, 세균학적 객담 검사, 혈액검사, 실험실내 항균력검사로 그 치료율 및 안전성을 비교하였다. 결과: 1) 임상종합 평가, 세균학적 균소실, 안전성, 유용성에서 두군간에 의미 있는 차이는 없었다. 2) 시험관내 항균력검사상 MIC가 실험군이 대조군보다 현저하게 낮았다.(p<0.05). 3) 경미한 두통, 식욕감퇴, 상복부 불쾌감, 설사등이 대조군 9예, 실험군 7예에서 발생하였고, 검사실 소견상 SGOT 혹은 SGPT 의 일시적 경미한 상승이 대조군 2명, 실험군 3명에서, 혈중 creatinine 상승이 실험군 2명에서 있었으나 경미하였다. 결론:이상의 결과로 sparfloxacin은 폐렴, 급성기관지염, 만성기관지염의 악화에서 하루 한번 투여로 enoxacin 하루 3번 투여와 유사하게 효과적이고 안전하며, 시험관내 항균력이 enoxacin보다 월등히 우수하여 임상에서도 유용하게 사용될수 있을것으로 생각된다. Background: Sparfloxacin, a new oral quinolone, has a broad spectrum, potent antimicrobial activity, prolonged half life, high concentration in sputum. The clinical efficacy and safety of sparfloxacin have been reported by some previous clinical studies performed in Japan. The objectives of this study were to evaluate the clinical and antimicrobial efficacy of this drug in respiratory tract infections compared to those of enoxacin. Methods:We performed an open controlled, randomized study in 63 patients with acute bronchitis, pneumonia, and exacerbation of chronic bronchitis at Chung Nam University hospital and Dae Jeon St. Mary's hospital from October, 1994 to April, 1995. In the control group(n=32), 100 mg enoxacin was administered orally 3 times a day and in the test group(n=31), 200 mg sparfloxacin once a day. Results: The results were as follows; 1) There were no significant differences between the two groups in clinical efficacy, bacteriological finding, and usefulness. 2) Means and SD of MICs were 0.44±0.89 ㎍/ml in the control group, 0.13±0.24 ㎍/ml in the test group. There was a significant difference in MICs between the two groups(p<0.05). 3) Headache, epigastric discomfort, and loss of appetite were observed in 7 cases of the control group and in 9 cases of the test group, and transient elevations of hepatic enzyme in 2 cases of the control group, and in 3 cases of the test group. There was mild elevation of serum creatinine in 2 cases of the test group. Those laboratory abnormalities by therapy might be associated with their underlying diseases. There were no significant adverse effects caused by the drugs Conclusion:In conclusion, sparfloxacin of 200 mg once a day was as effective and well tolerated as enoxacin of 100 mg three times per day in the treatment of respiratory tract infections. Sparfloxacin is more potent antibiotics because MICs of sparfloxacin were very lower than those of enoxacin.

DBD 반응기에서 플라즈마 방전형태에 따른 PFC_(s) 가스의 분해 특성

김관태,김용호,차민석,송영훈,김석준,류정인 한국대기환경학회 2004 한국대기환경학회지 Vol.20 No.5

Perfluorocompounds(PFC_(s)), such as tetrafluoromethane (CF₄) and hexafluoroethane (C₂F_(6)), have been widely used as plasma etching and chemical vapor deposition (CVD) gases for semiconductor manufacturing processes. Since these PFC_(s) are known to cause a greenhouse effect intensively, there has been a growing interest in reducing PFC_(s) emissions. Among various CF₄ decomposing techniques, a dielectric barrier discharge (DBD) is considered as one of a promising candidate because it has been successfully used for generating ozone (O₃) and decomposing nitrogen oxide (NO). Firstly, optimal concentration of oxygen for CF₄ decomposition was found to figure out how many primary and secondary reactions are associated with DBD process. Secondary, to find effective discharge method for CF₄ decomposition, a streamer and a glow mode in DBD are experimentally compared, which includes (ⅰ) coaxialcylinder DBD, (ⅱ) DBD reactor packed with glass beads. and (ⅲ) a glow mode operation with a helium gas. The test results showed that optimal concentration of oxygen was ranged 500 ppm~1% for treating 500 ppm of CF₄ and helium glow discharge was the most efficient one to decompose CF₄.

효모 세포벽 분해효소 생산균의 탐색 및 효소생산 최적조건의 조사

차성관,최혜숙,김왕준,윤석후,김영배 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.2

담자효모 세포벽을 분해하는 효소 생산균의 탐색을 위하여 50여 토양시료와 방선균 1000여개의 미생물을 가지고 3차에 걸친 탐색작업을 실시한 결과 1차적으로 autolysed washed yeast 배지 위에서 투명한 생성크기로 493개 균주를 선발하였으며, 이 균주들을 2차적으로 생효모 한천배지 위에서의 투명한 생성 크기로 117개 균주를 선발 하였다. 선발된 균주들을 가지고 용해활성도의 측정방법을 이용하여 최종적으로 St-1702 균주가 선발되었고, St-1702 균주는 동정 실험결과 잠정적으로 Streptomyces eurythermus 또는 그 유연균으로 동정되어졌다. St-1702 균주를 이용하여 효소생산 최적조건을 조사한 결과 최적배지 및 배양조건은 다음과 같았다 : freeze dried yeast 2% glucose 1%, K_2HPO_4 1%, MgSO_4·7H_2O, 1% peptone 0.5% (NH_4)_2CO_3 0.2% 초기 pH 값 7.0의 배지 및 30℃에서 3일간 배양. 최적배지에서 선발균주를 배양한 배양액을 이용하여 담자효모들의 원형질체 형성 실험을 한 결과 시중에서 구입된 효모 세포벽 분해 효소들보다 더 높은 원형질체 형성률을 보여 주었다. Thousand actinomycetes and 50 soil samples were used for the isolation of microorganisms producing yeast cell wall lytic enzymes. Among 493 strains producing large clear zones on autolysed washed yeast (AWY), 117 strains were selected on living yeast cell agar plates. With the method of lytic activity, one strain (St-1702) was selected, which was temporarily identified as Streptomyces eurythermus. The optimal condition for enzyme production of this strain was partially determined as follows: incubation of the strain for 3 days at 30℃ in the medium containing 2% freeze dried yeast cell, 1% glucose, 1% K_2HPO_4, 0.01% MgSO_4·^7H_2O, 0.5% peptone, and 0.2% (NH_4)_2CO_3 with pH 7.0. The protoplast formation of yeast by using the enzyme produced by this strain was compared with commercial enzymes.

EG-모드 마이크로스트립 아이소레이터에 관한 연구

田啓石,丁寬秀,金容平 慶熙大學校 1980 論文集 Vol.10 No.-

In X-band, a edge-guided(EG) mode microstrip isolator is designed in which nonreciprocal attenuation is due to the ferromagnetic resonance absorption caused by a strong d-e magnetic field applied locally at the shorted edge of a ferrite microstrip. From modal analysis. the dominant EG mode has been shown to propagate alone the microstrip with one edge shorted to the ground plane. Dispersion relations and rf electric field distributions have been calculated numerically. And the upper limit and the cutoff frequency of band width have been discussed with several design parameters. A practical EG-mode microstrip isolator based on these results has been successfully designed, which has more than 25dB isolation.

골형성부전증 10예의 임상적 특징

이형숙,김현주,조재현,이승원,김현아,최준혁,송영준,김대중,이관우,정윤석 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.5

연구배경 및 방법: 골형성부전증은 비교적 희귀한 유전병으로 교원질 대사 장애로 인한 골의 취약성과 다발성 골절 및 척추측만증 등을 특징으로 한다. 유전방식과 표현형의 발현 정도에 따라 다양한 임상 양상을 보이며, 임상적 중증도에 따라 4가지 형태로 분류된다. 지금까지 국내 보고는 분만과정이나 태아 진찰시 골격이상으로 발견된 증례보고가 주였다. 저자들은 비교적 경미한 임상 양상을 보이는 예를 포함한 다수의 골형성부전증 환자들의 전반적인 임상적 특징에 대해 보고하는 바이다. 결과: 2001년 6월부터 2003년 2월까지 골형성부전증으로 진단받은 6 가계, 10예를 대상으로 하였다. 평균 나이는 27.3(5∼56)세였고 소아가 2예였다. 모두 상염색체 우성으로 유전되었으며, 제 I형이 4예, 제 III형이 4예, 그리고 제 IV형이 2예였다. 전 예에서 다수의 골절 경험이 있었고, 골밀도 저하와 골피질 두께 감소 소견이 관찰되었다. 전신의 평균 골밀도는 0.690(0.421∼1.039) g/cm²였다. 골형성지표로 측정된 sAlk는 소아의 경우만 증가되어 있었고, 골흡수지표로 측정된 uDPD의 평균치는 12.9(4.4∼36.3) nM/mM Cr으로 증가된 소견을 보였다. mobility score는 대부분 3,4단계에 속해 있었다. 중증형일수록 진단 시의 mobility score가 낮은 경향을 보였다. 결론: 한국인 골형성부전증 환자의 임상적 특징을 살펴본 결과 기존의 보고된 II형 외에도 I, III, IV형이 다양하게 존재함을 알 수 있었으며, 모든 예에서 상염색체 우성으로 유전됨을 확인할 수 있었다. 또한 모든 예에서 증가된 골흡수로 인한 골밀도 저하와 골절을 확인할 수 있었다. Osteogenesis Imperfecta (OI) is a relatively rare hereditary disease, which is characterized by multiple bone fractures and spine scoliosis, due to the fragility of bone, and is often associated with blue sclerae, deafness and dentinogenesis imperfecta. Four types of OI can be distinguished, according to the clinical findings. Although mutations affecting type I collagen are responsible for the disease in most patients, the mechanism by which the genetic defects cause abnormal bone development remains to be fully understood. Here, the clinical characteristics of 10 OI patient cases are reported, with a review of the literature. All the cases, including 4 type I, 4 type III and 2 type IV, inherited OI as an autosomal dominant trait. All the subjects had multiple old fractures and decreased bone densities. In this study, the biochemical marker of bone formation, serum alkaline phosphatase, was found to be increased only in the pediatric OI patients, while the biochemical marker of bone resorption, urinary deoxypyridinoline, was increased in all cases. The mobility score was found to correlate with the severity of the type on diagnosis (J Kor Soc Endocrinol 18:496∼503, 2003).