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      • KCI등재

        Naringenin enhances NK cell lysis activity by increasing the expression of NKG2D ligands on Burkitt’s lymphoma cells

        김정화,이재권 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.11

        Natural killer (NK) cells are capable of identifyingand killing tumor cells as well as virus infected cellswithout pre-sensitization. NK cells express activating andinhibitory receptors, and can distinguish between normaland tumor cells. The present study was designed todemonstrate the importance of the expression level ofNKG2D ligands on the Burkitt’s lymphoma cell line, Raji,in enhancing NK cell cytolytic activity. Various flavonoidswere used as stimulants to enhance the expression ofNKG2D ligands. NK cell lysis activity against Raji was notchanged by pre-treatment of Raji with luteolin, kaempferol,taxifolin and hesperetin. However, treatment of Raji withnaringenin showed increased sensitivity to NK cell lysisthan untreated control cells. The activity of naringenin wasdue to enhanced NKG2D ligand expression. These resultsprovide evidence that narigenin’s antitumor activity maybe due to targeting of NKG2D ligand expression andsuggests a possible immunotherapeutic role for cancertreatment.

      • KCI등재

        Anti-inflammatory effects of Dendrobium nobile derived phenanthrenes in LPS-stimulated murine macrophages

        김정화,오수연,한상배,Golam Mezbah Uddin,김철영,이재권 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.6

        Dendrobium nobile belongs to the Orchidaceaefamily and is one of the medicinal herbs used in traditionalChinese medicine as a therapeutic agent for gastrointestinaland cardiovascular diseases. In this study, we separatedthree phenanthrenes (ephemeranthol A (EA), 1,5,7-trimethoxyphenanthren-2-ol (TP), dehydroorchinol (DO))from D. nobile, and compared their anti-inflammatoryactivities. TP is a new phenanthrene compound and itsstructure was determined from 1H, 13C NMR and HR-ESIMSdata. To analyze the anti-inflammatory activities of thephenanthrenes, Raw 264.7 cells were used, since they areimmature-macrophages and easily matured by LPS stimulation. EA and DO showed anti-inflammatory activities inthe activated Raw 264.7 cells. That is, we showed that EAis a potent inhibitor of the production of nitric oxide andpro-inflammatory cytokines. The inhibitory activities ofphenanthrenes were found to be caused by blockage of NFjBactivation and the phosphorylation of MAP kinases inthe macrophages. These results are expected to serve as aguide for future studies on the ability of phenanthrenes toinhibit acute and chronic inflammatory diseases.

      • KCI등재

        우수언어학습자의 언어 학습전략 및 특성 분석에 관한 연구-한일 국제회의통역사를 중심으로-

        김정화 한국일본어문학회 2015 日本語文學 Vol.64 No.-

        In this study, excellent language learners were defined as Korea-Japan international conference interpreters who have the highest level of communication skills in Japanese language, and, based on analysis of tendencies and learning characteristics related to learning strategies they use for learning Japanese, factors that can influence successful learning of Japanese language were discussed and analyzed.The result shows that. First, international conference interpreters use various learning strategies for learning Japanese language and, particularly, cognitive strategy to understand and use the target language, alternative strategy to supplement insufficient linguistic knowledge, and meta-cognitive strategy to control the learning process.Second, as a factor that influences successful learning of Japanese language, in terms of learning environment, constant learning of and exposure to Japanese language by media, etc., had the most positive effect on the learning result rather than staying in JSL (Japanese as a Second Language) environment.

      • KCI등재후보

        음수율과 <음보율>, <음량율>의 거리

        김정화 영남대학교 민족문화연구소 2006 민족문화논총 Vol.34 No.-

        A point of difference in syllabic meter, foot meter and quantity Kim, Jeong-Hwa Understanding of Korean poem by syllabic meter, foot meter or quantity is closely connected how to explain metrical phenomenon of korean traditional poem properly. Division of metrical typology is for good understanding of poem of each country, especially on actual state of those meter. A system which can explain a feature can be the desirable typology one exceedingly. Based on those viewpoint, generalization of foot meter in society of Korean language and literature has a lots of blind point. Here, it is pointed out that the terminology of foot in korean poem has a lot of problems. Furthermore, it is explained that foot meter can't be existence on the viewpoint of metrical typology. In addition, there is no proper and correct evidence about scan of basic unit which shows limitation of foot meter. A base of scan is possible using only the number of syllable. Even though Korean poem should be explained using syllabic meter, it is still claimed using theory of foot meter due to accumulation of misunderstanding in syllabic meter for a long time. It might be occurred that syllabic meter persist theory of syllabic meter in its early phase without any revision. Above all, it is necessary that a notion of syllabic meter= fixed syllabic meter is touched up. Metrical typology of fixed syllabic meter and unfixed syllabic meter should be classified as a subordinate division of syllabic meter. Also, it should be recognized level of meter in poem of syllabic meter. Based upon these understanding, Korean poem can be explained as syllabic meter in its fullness.

      • KCI등재

        채원배의 북경대학 개혁 ( 1 ) : ' 겸용병포 (兼容倂包) ' 와 신구논전 (新舊論戰) 을 중심으로

        김정화 중국사학회 2000 中國史硏究 Vol.8 No.-

        蔡元培相信了敎育眞正的價値. 他在敎育救國立場上答應了腐朽的北大校長. 當時中國, 企圖强化國權啓發民智. 使人民具備淸雅品德. 這就是通過敎育能到達. 從開始高等敎育. 國外只小規模辦的留法勤工儉學無法救廣大中國. 通過大學培養人才能改革中國, 再派這些人到全中國去要敎育人民. 蔡元培在北大就職談話中, 向學生提出 “抱定宗旨”. “砥礪德行”. “敬愛師友”盡力給學生提供學術環境. 最首先課題是必須招聘有學問的敎授. 他認爲所謂大學, 應組成所有的思想和學派 “낭括大典, 網羅衆家.” 因而. 選拔敎員采取了兼容幷包方針. 這樣原則上. 陳獨秀·李大釗·魯迅·胡適·錢玄同·劉半農·高一涵·沈尹默等被招爲敎員, 他們都是『新靑年』主編. 因此, 北大自然被成爲新文化運動搖籃. 與此同時. 蔡元培招納有高學問而思想方面上堅持保守的一些人. 就是高鴻銘·劉師培·黃侃. 以垂下변髮支持復벽的高鴻銘與發起籌安會的劉師培爲領袖形成了北大保守派. 蔡元培認爲講話有道理, 主張有理致. 可以展開自己思想, 還使學生可以自由選擇. 根據兼容幷包與思想自由, 北大從蔡元培之後日益組成新學術環境, 激烈地論戰主義主張. 活潑了學生思想. 蔡元培采取民主和自由學風不但使新文化運動發展起來, 還大力强化『新靑年』編輯力量以後其作用也大幅提高了. 這明確地說明北大成爲新文化運動中心. 那是與蔡元培提唱新文化運動有密接地關系. 北大改革當中, 特別新文學者和舊文學者大擧被聘文科. 以文科新知識人爲中心提唱文學革命. 其結果使新文化運動得到有力地位. 以『新靑年』爲團結更多的新知識人, 擴大了改革範圍向學生吸收新思潮和政治活動機會. 可是. 北大從此激烈地遇到舊派挑戰. 以林서爲領袖舊勢力고賴軍閥政府卦崇拜孔子的牌子打擊了蔡元培和新知識人. 蔡元培表示贊同新知識人又參加了他們的論戰. 他基本上不反對舊文化和舊文學. 他明確表示這樣的立場. 然而, 林서不是代表個人, 而是代言了對新文化運動的舊勢力的嫌惡. 由于以蔡元培支持新文化運動, 北大雖被衆矢之的, 反而其結果是使新文化運動得到更快發展. 北大改革是在五四運動史上産生深刻的意義. 他采取兼容幷包方針在主觀上反映折衷主義以及中庸的道理. 可是在客觀上能看得見新文化運動之中做出了極大的作用. 蔡元培的立場與陳獨秀和新文化運動那些人不同. 他反對儒家派只是中國因兩天多年堅持孔子學術, 而産生在政治和文化及敎育上造成흔大弊病. 文學革命仍是那樣, 革命目的是要改革文學形式和內容. 蔡元培認爲中國文言文相近拉丁文字, 拉丁語已成爲過去的東西. 他主張白話最主要是在實用方面. 他認爲目前隨着科學發展需要其他學問, 文字也要求普遍化. 學問逐漸多樣化和文化範圍亦擴大了, 那能有餘閑學舊文字?而此將舊文字즘樣表達現代人的思想和言語?他提出以白話代替文言文, 這是必然的趨勢. 他支持白話, 而不是全面地排斥文言文, 主張在美術文和一些學術方面上要使用文言文. 蔡元培認爲不矛盾中國傳統文化與西方文化. 他總是以西方自由·平等 ·博愛當作中國仁·誓·義的同樣內容. 蔡元培從小有系統地學過經學, 他在思想方面影響到深刻的儒家學術. 外國留學時期, 他雖學了西方文化 , 却是自覺地堅持立場擁護中國文化. 他在深淵依然有着對中國傳統文化的驕傲. 這是他一生當中一向不變的.

      • KCI등재
      • 여급의 등장과 목소리가 지니는 문학사적 의미 고찰

        김정화 선문대학교 문학이후연구소 2021 문학이후 Vol.1 No.-

        1930년대 카페는 유흥과 소비문화를 향유할 수 있는 대표적인 공간 중 하나였으며, 이 공간에 속한 노동자였던 여급은 도시 향락 문화로 대 표되는 직업의 유형으로 받아들여졌다. 카페 여급의 노동은 ‘성적’노동과 동일시되었는데, 이러한 여급의 정체성을 ‘노동’에 의미에서 재조명하고 자 시도한 잡지가 바로 1934년 발행된 『여성(女聲)』이다. 본고는 이 잡지 를 통해 식민지 카페라는 공간에 속해 있었던 여급이 갖는 유희적 관념에 서 벗어나 직업여성으로서 자신들의 권리를 확보하고자 하는 주체적 태 도에 집중하고자 하였다. 이를 통해 여성노동자 여급의 노동 문제를 카페 공간에 투영된 식민자본주의 담론과 연결함으로써 카페가 갖는 도시문화적 특성과의 관계성을 유추해 보고자 한다. 여급은 카페라는 공간에서 사회구조의 모순을 인식하고, 그에 대한 문 제의식을 확장해 나아간다. 그리고 이러한 의식의 변화는 잡지 『여성(女聲)』을 통해 구체화된다. 잡지에 글을 게재한 여급들은 모두 종로의 대표 적인 카페에 소속되어 있었으며, 종로는 여급들의 투쟁이 가장 적극적으 로 이루어진 장소이기도 했다. 그러므로 잡지 『여성(女聲)』을 통해 확인 할 수 있는 여급의 목소리는 성과 노동이라는 이중 착취구조에 대한 불합 리성을 강조하면서 여급의 정체성을 재조명하고자 했을 뿐만 아니라 식 민자본주의가 빚어낸 문제점에 대한 비판적 시각으로까지 확장하고자 했음을 확인할 수 있었다. In the 1930s, cafes were one of the representative spaces where one could enjoy entertainment and consumption culture. Waitresses were the laborers of this space and waitressing was accepted as a representative type of occupation of the urban entertainment culture. The work of waitresses in cafes was synonymous with ‘sexual’ labor and the magazine that attempted to re-examine the identity of waitresses in light of ‘labor’ was “Women,” published in 1934. Using this magazine, this paper tried to focus on the autonomous attitude of waitresses in the colonial cafe setting who tried to secure their rights as professional women, breaking away from the sexual conception tied to being a waitress. Through this, it aims to infer the relationship with the urban cultural characteristics of cafes by linking the problem of the labor of waitresses with the discourse of colonial capitalism projected on cafe spaces. Waitresses recognized the contradictions in the social structure in the cafe spaces and expanded their awareness of the problem. This change of awareness was materialized through the magazine “Women.” All the women who published articles in the magazine belonged to the representative cafes of Jongno, which was also where the protests of the waitresses were most active. Therefore, it could be seen that the voices of the waitresses, which can be confirmed through the magazine “Women,” emphasized the absurdity of the dual exploitation structure of sex and labor, and tried to re-examine the identity of waitresses, as well as expand it to a critical perspective on the problems posed by colonial capitalism.

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