The Safety and Efficacy of Daclatasvir and Asunaprevir with Chronic HCV Genotype 1 Infection and Hemodialysis

( Myeong Jun Song ),( Jung Hyun Kwon ),( Soon Woo Nam ),( Tae Hee Lee ),( Young Woo Kang ),( Ji Woong Jang ),( Seok Hyun Kim ),( Byung Seok Lee5 ),( Sea Hwan Lee ),( Hong Soo Kim ),( Ji Hoon Kim ),( S 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: We aimed to evaluate the efficacy and safety of Daclatasvir (DAV) and Asunaprevir (ASV) in patients with chronic hepatitis C virus (HCV) and chronic renal failure (CRF). Methods: 22 chronic hemodialysis patients with HCV infection at 12 medical centers have prospectively enrolled from Feb, 2016 to Feb, 2017 (NCT02580474). Of those, 9 patients who were followed 12 weeks after treatment ended were included. We evaluated the virological responses at each week 4, 12, 24 and the 12-week sustained virologic response (SVR12). The tolerability and safety of patients were also evaluated. Results: Of these 20 patients, there had no resistance-associated variant of NS5A (NS5A RAVs) and 2 patients showed indeterminate NS5A RAVs. 12 patients (54.5%) completed the 24 weeks treatment of DAV and ASV. 6 patients (27.2%) have continued, but 4 patients discontinued study prior to 12 weeks. Overall, all patients (n=9) achieved SVR12. Virologic response at week 4, 12 and 24 showed 94.4% (17/18), 93.3% (14/15), and 100% (12/12) respectively. DCV and ASV were well tolerated among the majority of patients and discontinuation of the treatment due to adverse events (hypertension, bradycardia, leukemia) was occurred in 3 patients. In two patients with indeterminate NS5A RAVs, one achieved SVR12 but the other showed viral breakthrough and discontinued treatment. Conclusions: In this study, DAV and ASV combination therapy for chronic hemodialysis patients with HCV infection achieved high sustained virological response with few adverse events. Close monitoring of safety and tolerability may be necessary when treating chronic hepatitis C patients with CRF receiving DCV and ASV.

Characterization of cricket song patterns and the behavior observation of Teleogryllus emma (Orthoptera:Grylloidea)

Ji Chang Woo,Kim Nam-Jung,Lee Sang-Guei,Hwang-Yong Kim,Choi Hoon-Sik,Song In-Sun,Ko Jee Sun 한국응용곤충학회 2010 한국응용곤충학회 학술대회논문집 Vol.2010 No.05

We analyzed the chirp sound and behavior of Teleogryllus emma with observation system, which was consisted of computer, ccd-camera and microphone. Computational methods of wavelet transformation and Self-Organizing Maps (SOM) were utilized to characterized the chirp sound of insect species for automatic counting in this study. Wavelets were initially applied to feature extraction of the chirp sound. Wavelet coefficients were accordingly calculated based on the basis function (e.g., Morlet). The obtained coefficients were subsequently provided to count number of chirps in each song. Sound structure of insect specimens consisted with long chirp and short chirp and the patterns of song were grouped by frequency of long chirp and short chirp. The song patterns of insect specimens were divided by Self-Organizing Map (SOM) that was used number of chirp as input data. Application of computational methods to automatic detection of chirp sound was further discussed for obtaining objective assessment in behavior science.

전국 10개 종합병원 중환자실 환자의 직장내 Vancomycin-resistant Enterococci(VRE) 보균율, 보균의 위험요인 및 유전적 다양성 조사

정희진,송준영,엄중식,김우주,최선주,최정현,이혁,정문현,이광미,신동현,손보라,최종성,우흥정,권정아,이경원,최강원,박승철 대한감염학회 2002 감염 Vol.34 No.5

제20대 대선 유튜브 선거캠페인 댓글연결망 분석 - 삼프로TV를 중심으로

송화영(Hwa-Young Song),이정민(Jung-Min Lee),박한우(Han-Woo Park) 한국콘텐츠학회 2023 한국콘텐츠학회논문지 Vol.23 No.2

이 연구는 제20대 대통령 선거의 소셜 미디어 선거 캠페인에 대한 대중들의 반응을 사회연결망분석을 이용해 살펴보았다. 구체적으로 유튜브 채널 ‘삼프로TV: 경제의 신과 함께’에 게시된 2022년 대통령 선거 후보자 토론 영상과 댓글을 수집하였다. 수집된 데이터를 기반으로 댓글 이용자 연결망 구조를 확인하기 위한 사회연결망분석, 댓글 이용자의 어휘 다양성 파악과 핵심이슈 파악을 위한 의미연결망분석을 수행하였다. 그 결과, 이재명 후보의 연결망이 윤석열 후보에 비해 이용자들 간 밀집도가 더 높았다. 어휘 다양성에 있어서는 윤석열 후보 영상 댓글이 더 다양한 어휘를 구사하는 것으로 나타났다. 이로써 영상 댓글 이용자들 간 ‘관계’에 초점을 두었을 때는 이재명 후보자의 영상이 윤석열 후보에 비해 더 집합적(collective)이었으나, 어휘의 다양성 측면에서 보았을 때는 윤석열 후보가 더 결합적(connective)인 것을 알 수 있다. 핵심 이슈의 경우, 이재명 후보는 후보자 발언에 대한 이용자의 생각이 주로 나타났고, 윤석열 후보는 후보자에 대한 평가나 비판의 내용이 나타났다. 이 연구는 ‘말’보다 ‘행동’에서 비롯된 데이터의 중요성과 약한 유대의 힘 이론이 설명력을 지니고 있음을 시사한다. Using social network analysis, this study investigated people’s responses to Youtube-mediated debate during the 2022 presidential election in Korea. Videos and comments, that were uploaded on the YouTube channel “Sampro TV: With the God of Economy”, were collected using Webometric Analyst 2.0 software. Several network techniques was performed on the obtained data to uncover the structure of the comment user network, and a semantic network analysis was also performed to identify the linguistic diversity of comment users and to identify critical issues. As a result, candidate Lee Jae-Myung’s network had a greater user density than candidate Yoon Suk-Yeol’s network. Yoon Suk-Yeol’s video comments were found to employ more diversified terminology. As a consequence, when focused on the strength of relations between video comment users in a core group, Lee Jae-Myung’s video was more collective and communal than Yoon’s, although Yoon is more connective in terms of vocabulary diversity. In the case of major issues, Lee’s commenters mostly displayed their supporting thoughts on his discussions, whereas Yoon’s commenters displayed the contents of evaluation or critique. The findings of this study is discused from a perspective of the strength of weak ties in social networks.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

새로운 Fluorene계 발광 고분자 합성

李愚鵬,吳東元,朴美淑,黃悳海,宋智怜,朴在均 慶北大學校 科學敎育硏究所 2004 科學敎育硏究誌 Vol.28 No.-

Poly [2,7-(9,9-di-n-hexyl-fluorene-co-9,9-dibenzylidenylflourene)-2,7diyl] was synthesized through nikel-catalyzed coupling between 9,9-disubstituted 2,7-dibromofluorene and new fluorene-based monomer, 9,9-dibenzylidenylflurene in good yield. The polymer containing new fluorene monomer, 2,7-dibromo-9,9-dibenzylidenyflu -orene, which not only has extended π conjugation, but also has sterically hinderd sudstituents at the 9-position. The polymer obtained is found to be soluble in conventional organic solvents such as chloroform and was characterized by GPC, ^(1)H NMR and ^(13)C NMR. Also the UV absorption band showed the peak of maximum absorption at 373 nm and the photoluminescence (PL) spectra emission band showed the peak at 558 nm yellowish green region.

부품의 모델번호 실시간 인식 제어

이우송,Nguyen Van Quyet,오세봉,조창제,한성현 한국공작기계학회 2008 한국공작기계학회 추계학술대회논문집 Vol.2008 No.-

The purpose of this research is to develop the character recognition technology based on pattern recognition for non-contacting inspection optical lens slant or precision parts, and including external form state of lens or electronic parts for the performance verification, this development can achieve badness finding. And, establish to existing reflex data because inputting surface badness degree of scratch's standard specification condition directly, and error designed to distinguish from product more than schedule error to badness product by normalcy product within schedule extent after calculate the error comparing actuality measurement reflex data and standard reflex data mutually. Developed system to smallest 1 pixel unit though measuring is possible 1 pixel as 37㎛×37㎛ (0.1369×10-4㎟) the accuracy to 1.5×10-4㎜ minutely measuring is possible performance verification and trust ability through an experiment prove.

수증기 활성화법으로 제조된 영월 석탄계 활성탄의 특성 연구

이송우,권태훈,나영수,최동훈,류동춘,송승구 한국환경과학회 2000 한국환경과학회지 Vol.9 No.4

Activated carbons were prepared from Youngwall coal by steam activation in this study. The feasibility of the Youngwall coal to commercial activated carbon was examined. The variation of pore structures and the development of porosity in activated carbons were investigated by changing activation conditions in batch type apparatus. The values of BET surface area and adsorption capacity of iodine and methylene blue of the resulting activated carbons were obtained as high as 1,000㎡/g, 900㎎/g, 150㎖/g, respectively. Youngwall activated carbon prepared in this study showed much higher pore volume in pore diameter over l0Å than that of commercial reference activated carbon(Ningxia Taihua ZJ-15C) produced from China anthracite.

일개 대학병원에서 일년간 분리된 반코마이신 내성 장구균의 임상 분자역학적 연구

송진영,김창억,김성욱,우흥정,김미란,이규만,이란,장미화,정희진,김우주 대한화학요법학회 2001 대한화학요법학회지 Vol.19 No.4

목적 : 한강성심병원에서는 2000년 3월 반코마이신내성 장구균이 처음 분리되어, 원내전파를 막기 위한 노력을 하였으나, 분리가 지속되었다. 따라서 이에 대한 좀더 자세하고 객관적인 자료를 얻기 위해 본원에서 분리된 반코마이신내성 장구균에 대한 임상분자 역학적 연구를 시행하게 되었다. 방법 : 2000년 3월부터 2001년 2월까지 한림대학교 한강성심병원에서 분리된 장구균을 대상으로 디스크 확산법, 최소발육억제 농도등의 측정을 통해 반코마이신 내성여부를 확인하였으며, 반코마이신내성 장구균을 대상으로 PFGE를 시행하여 형별 분석을 하였다. 결과 : 분리된 균주는 총 32균주로 모두 E. faecium이었다. 항생제 내성 검사 결과 모두 Van A형이었다. PFGE 결과 1a형이 8검체, 1b형이 5검체, 2a형이 4검체, 2b형이 4검체, 3a형이 2검체, 3b형이 5검체였고, 그 외 4, 5, 6형이 각각 1검체씩이었다. 총 32균주 중 56%(18/32)의 균주가 같은 시기, 같은 병실에서 동일한 PFGE 형을 보이면서 분리되었다. 결론 : 반코마이신내성 장구균의 PFGE 분석 결과 여러 종류의 반코마이신내성 장구균이 유행하였음을 알 수 있다. 그러나 같은 기간, 같은 병실에서 분리된 균주의 PFGE 형이 같은 것이 상당수 있었다. 이는 반코마이신내성 장구균의 원내 전파가 있었음을 의미한다. 따라서 반코마이신내성 장구균의 전파의 발생 및 전파 방지를 위해서는 보다 효과적인 감염관리 활동이 필요할 것으로 생각된다. Background: Vancomycin-resistant enterococci(VRE) have been a rising problem worldwide. In March 2000, VRE was first isolated from a patient in Hangang Sacred Heart hospital. Although efforts to prevent transmission of VRE were performed, isolations continued. So molecular epidemiological study of VRE was done. Method : The minimal inhibitory concentration(MIC) to vancomycin and teicoplanin, and pulsed field gel electrophoresis(PFGE) pattern of VRE isolated from March 2000 to February 2001 were evaluated. Results : 32 VRE were isolated. All of the VRE were Enterococcus faecium and showed Van A resistance phenotype. We found out that a significant number of VRE isolated during same period and in same room, were same PFGE patterns. (18 cases/ 32 isolates= 56%) Conclusion: This study demonstrated the spread of VRE of same PFGE patterns. It suggests the nosocomial spreads of VRE.

CBD법으로 제작된 Cd₁-xZnxS 박막의 전기적 및 물리적 특성 분석

송우창,박종국,임윤희,이상교 三陟大學校 2001 論文集 Vol.34 No.1

Cd1_-xZn_xS films were grown by chemical bath deposition (CBD), which is a very attractive method for low-cost and large-area solar cells. To improve the electrical conductivity of Cd1_-xZn_xS films, thin indium films(10-40nm thickness) were evaporated on the surface of Cd1_-xZn_xS films. Experimental parpmeters such as indium film thickness, Zn mole fraction, and the annealing temperature in terms of structural and electrical properties of Cd1_-xZn_xS films were investigated. The diffusion process was carried out by heating the sample in air at 150-550℃ for 20 minute. X-ray diffraction patterns of Cd1_-xZn_xS films indicate that the minimum thickness and annealing temperature for the formation of an In2O3 surface layer, which act as a barrier preventing the outdiffusion of indium, are 20nm and 350℃, respectively. This layer allows indium diffusion into the Cd1_-xZn_xS films and results in an indium-doped Cd1_-xZn_xS films. As the indium film thickness is increased, the resistivity decreases and the lowest value(0.3Ω-㎝) is obtained for Cd1_-xZn_xS films annealed at 450℃ with 40nm of the thickness.