정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

네이티브 광고의 브랜드 및 제품 노출이 수용자의 광고 인지와 태도, 공유 의도에 미치는 영향

이수범(Lee, Soo?Bum),송민호(Song, Min?Ho),문원기(Moon, Won?Ki),신명희(Shin, Myoung?Hee) 한국광고홍보학회 2016 광고연구 Vol.0 No.111

본 연구는 60명을 대상으로 아이트래킹과 실험연구를 병행하여 네이티브 광고의 효과를 파악하기 위해 네이티브 광고에 대한 인지, 수용자 태도, 공유 의도를 검증하였다. 구체적으로 네이티브 광고를 콘텐츠와 브랜드 및 제품의 노출 형태(직접 노출/간접 노출)를 고려하여 두 유형의 네이티브 광고에 대한 시각적 주의가 피험자들의 광고 인지에 미치는 영향을 비교하였다. 또한 두 유형의 네이티브 광고에 대한 태도(콘텐츠 태도, 브랜드 태도, 공유 의도)를 측정하여 각 유형에 따른 차이를 비교하였다. 분석결과, 직접 노출 형태의 네이티브 광고의 구성 요소 중 콘텐츠 본문에 브랜드 관련 문구를 포함하였을 때 피험자들의 광고 인지에 긍정적인 영향을 미치는 것으로 나타났다. 또한 각 노출 유형별 콘텐츠 태도의 차이는 유의미하지 않았으나, 직접 노출일 때 브랜드 태도가 더 호의적인 것으로 나타났다. 마지막으로 직접 노출일 때 네이티브 광고의 공유 의도는 상대적으로 높게 나타났다. 이러한 결과를 종합하여 네이티브 광고 제작을 위한 실무적 제언을 담았다. This study explored the effects of native advertising on readers’ recognition, attitude, and sharing intention. This study used both quasiᐨexperiment and eyeᐨtracking for 60 participants to analyze advertising effectiveness (Attitudes toward contents/brands, and sharing intention) of two types native advertisements such as brand exposure (direct/indirect). According to the result of this study, direct exposure type ads had a high advertisement recognition that included brand wording in ad contents. In addition, there was no significant difference of attitudes toward contents among each ad types but direct exposure type ads had more favorable brand attitude than indirect type ads. Finally, this study also showed that the sharing intention of direct exposure type ads were higher than indirect type ads. Based on the findings, this study provided a practical implication for the production of native advertising.

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

CFRP 복합재 적층판의 파괴메카니즘에 관한 연구

이권범,박환규,홍석주,김기형 조선대학교 동력자원연구소 1996 動力資源硏究所誌 Vol.18 No.1

In this study, when CFRP lamimates are subjected to static loading by the indentation of steel ball to examine a failure mechanism of lamimates, the fracture surface of interlaminar delamination generated at interfaces is investigated by the scanning electron microscopy (SEM). When orthotropic CFRP laimates stacked with two interface are subjected to static loading, interlaminar delaminations extend from the loading side to delamination edge even at any interface, and the fracture surface fo interlaminar delamination generated at two interfaces is symmertrically formed. In the CFRP laminates, the fracture mechanism sppears mainly to be the mixed mode(modes Ⅰ+Ⅱ), and the ratio of mixed mode varies partially. After the fracture initiates at the interface near the loading side with mode Ⅰ, the mixed mode gradually developes, but the total surface at the opposite plane to the loading side fractures with the mixed mode(modes Ⅰ+Ⅱ). While transverse cracks are generated, the direction of shear stresses reverses itself ar the delaminated surface, clarified by the hackle direction of fracture surface.

박복되는 현훈으로 발현한 보크트-고야나기-하라다 증후군 1예

이태경,남상원,박선아,성기범 대한평형의학회 2003 Research in Vestibular Science Vol.2 No.2

현무암 분말(Basalt Powder)을 첨가한 콘크리트의 물리·화학적 특성

이규영,송기범 한밭대학교 2004 한밭대학교 논문집 Vol.21 No.-

In this study, the physical and chemical properties of Basalt powder mixed concrete are investigated. Basalt powder is made by crushing hardened larva with dark green and black color which has properties of temperature resistance, chemical resistance, shock resistance, and durability. To investigate the variations of the physical and chemical properties of the Basalt powder mixed concrete, the proportioning strengths of the concrete were set to 240, 270, and 300kgf/cm². The applied amounts of Basalt powder mixed in the concrete were 10%, 20%, and 30% of the amount of cement in the concrete. The results are summarized as follows: 1. The compressive strength of concrete increases by 5 to 10% compared to the proportioning strength as the mixing ratio of Basalt powder increases. The tensile strength also increases by 10 to 30%. The bending strength also increases by 5 to 15%. 2. In high strength concrete, as the amount of cement increases, the oxidation ratio becomes greater, The oxidation ratio increases as the water cement ratio decreases. It was to show lowest oxidation ratio that the mixing concrete for 10% Basalt powder. 3. The neutralization depth decreases as the mixture ratio of Basalt powder increases. Therefore, it can be concluded that the use of Basalt powder in concrete can assist to prevent the neutralization of concrete.

ULSI 금속배선용 구리의 전착

이동녕,김기범,최창희,이효종,민석홍 대한금속재료학회(대한금속학회) 1998 대한금속·재료학회지 Vol.36 No.10

The microstructural evolution of Cu films deposited by electroplating was investigated with the variation of the deposition rate from 0.1 ㎛/min to 3 ㎛/min by using a copper sulfate solution. Electrodeposition of copper was conducted on 0.1 ㎛ or 0.5 ㎛ thick copper seed layer deposited by sputtering process. The growth characteristics were investigated by monitoring the surface microstructure, electrical resistivity and chemical composition. The feasibility of electroplating process for ultra-large-scale integration(ULSI) metallization scheme was demonstrated through preferred crystallographic growth direction, resistivity and step coverage. The uniform Cu film was successfully electroplated at deposition rates from 0.5 to 3 ㎛/min and its continuous growth on the copper seed layer was observed in every specimen. The resistivity of as-deposited copper film made at deposition rates from 0.5 to 3 ㎛/min was about 2.5μΩ-㎝ and subsequent annealing in a vacuum at 200℃ for 2 min reduced it to 2.3μΩ-㎝.

역세권 개발에 따른 개발이익 예측

이상경,김기범 경성대학교 공학기술연구소 2003 공학기술연구지 Vol.S1 No.2

The objective of this paper is to forecast profit of TOD(Transit Oriented Development). Case study is performed on Magok district in Gangseo-gu, Seoul. The traditional hypothesis of urban economics on relation between land value and use is examined, and a pilot model to be used as practical tool is proposed. This paper is a help to urban planner and public developer.

1―不規則 매쉬를 利用한 CAE의 模型構成

李炯,陳祈範 단국대학교 통계문제연구소 1991 數學 및 統計硏究 Vol.19 No.-

The abstract statements of the geometrical requirement on the curved surface are represented by the differential equations and the boundary condition. The finite element method is used to obtain the approximate solution for the problems involving the difficult equations and the boundary conditions. When solving the complicated problem for the entire domain, the domains partitioned into elements, and trial functions are defined separately over each element using shape function. This approach is much easier to analyse the abstract equation, but the amount of data to be handled is increased extremely according to the number of elements when the domain is devided. The irregular mesh, one of the mesh refinements, a few restrictions gives enough control of the horrible data management problems of changing the mesh size. So we choose the 1-irregular mesh for the local mesh refinement to improve the approximate solution without using transition element. In result, the error is reduce at each refinement in a remarkably fast rate, hence 1-irregular mesh refinement is superior to any other mesh refinements to improve the approximate solution.

정중과잉치로 인해 회전된 상악 중절치의 치험례

이범의,김영재,김정욱,장기택,이상훈,김종철,한세현 大韓小兒齒科學會 2004 大韓小兒齒科學會誌 Vol.31 No.4

정중과잉치의 원인은 잘 알려지지는 않았지만 dental lamina의 hyperactivity에 의해 발생한다는 가설이 가장 많이 받아들여지고 있다. 이러한 정중과잉치의 병발증으로는 주변 영구절치의 맹출 장애, 만곡 치근, 치근흡수, primordial 혹은 follicular cyst의 형성, 회전, 이환된 부위의 총생 및 비정상적인 정중이개를 일으킬 수 있다. 이러한 이유로 영구전치의 회전이 야기되면 보통 공간의 부족은 적거나 없으며 재발이 흔하므로 과개선이 요구된다. 재발의 방지를 위해서는 조기치료, 과개선, 긴 보정기간, 적절한 접촉면의 형성, 짝힘의 사용, 그리고 수술적인 방법 등이 제안되어왔다. 이에 저자는 정중과잉치로 인하여 심하게 회전된 상악중절치를 주소로 내원한 환아에서 교정적, 외과적 술식을 이용하여 양호한 결과를 얻은 두 증례를 보고하는 바이다. The etiology of mesiodens is unknown but the most widely accepted theory is the hyperactivity of the dental lamina. Complications of mesiodens are delayed or prevented eruption of maxillary central incisors, displacement or rotation of permanent teeth, crowding of affected region, abnormal diastema or permanent space closure, dilaceration or abnormal root development of permanent teeth, primordial or follicular cyst formation, root resorption of adjacent teeth, eruption into nasal cavity. If mesiodens rotate the maxillary central incisors, space deficiency is not common and relapse is very common. So overcorrection is needed. To prevert the rotational relapse, early treatment, overcorrection, long retention period, properly formed proximal surface, use of coupled force, and surgical techniques have been suggested. The authors present two cases, whose chief complain were severely rotated maxillary incisors by mesiodens, treated by orthodontic and surgical technique and showed good results.