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2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석
이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3
목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.
생약추출물 유도형 Nitric Oxide Synthase 저해활성 검색
류재하,이소영,박재현,이화진,장세란,은진희,김남이,정연수,장미경,최영은,이숙현,손행자,안한나,고혜진 숙명여자대학교 약학연구소 2001 약학논문집-숙명여자대학교 Vol.17 No.-
Nitric Oxide (NO), derived from L-arginine, is produced by two types (constitutive and inducible) of nitric oxide synthase (NOS: cNOS and iNOS). The NO produced in large amounts by the iNOS is known to be responsible for the vasodilation and hypotension observed in septic shock and inflammation. The inhibitors of iNOS, thus, may be useful candidate for the treatment of inflammatory diseases accompanied by the overproduction of NO. We prepared alcoholic extracts of herbal drugs which have been used for the treatment of inflammation in oriental medicine. We have screened the inhibitory activity of NO production in lipopolysaccharide (LPS)-activated macrophages after the treatment of these extracts. Among the 81 kinds of extracts of herbal drugs, 34 extracts showed potent inhibitory activity of NO production above 50% at the concentration of 50 (μg/ml. The inhibitory activities of NO production were also evaluated for several solvent fractions at three different concentrations. Especially, hexane soluble fractions of Agrimonia pilosa, Hydrangea serrata, Machilus thunbergii, Prunella vulgaris, Saussurea lappa, Tussilago farfara, and ethyl acetate soluble fractions of Angelica gigas, Ostericum koreanum, Torilis japonica, Perilla frutescence showed moderate activity at 10 and/ or 25 (μg/ml. These fractions are promising candidates for the study of the activity-guided chromatographic purification of active compounds.
진치섭,최영근,박현재 부산대학교 생산기술연구소 2000 生産技術硏究所論文集 Vol.59 No.-
본 연구의 목적은 현장에서 반품되는 콘크리트를 신선하게 유지하여 다음날 사용할 수 있도록 재활용하는 데 있다. 본 연구에서는 반품콘크리트에 지연제를 첨가하여 시멘트의 수화작용을 일시적으로 정지시켜 콘크리트를 신선한 채로 장시간 보존한 후 다음날 활성화제를 첨가하여 보통의 콘크리트와 동일하게 사용 가능한 방법을 제시하였다. 슬럼프 값이 19.8cm인 보통콘크리트에, 3시간 후에 지연제를 첨가했을 때의 슬럼프 값은 22cm, 다음날 활성화제와 유동화제를 첨가한 후에는 19.2cm의 슬럼프 값을 얻었다. 활성화된 반품콘크리트의 응결시간이 보통콘크리트의 응결시간보다 길어지는 결과를 얻을 수 있었다. 또, 활성화된 반품콘크리트와 보통콘크리트의 압축강도 및 인장강도, 휨강도는 거의 같은 것으로 나타났다 To use concrete returned from job sites, the method to remain the fresh properties of the returned concrete for a long time was studied by stopping cement hydration temporarily and adding an activator to the concrete next day to reuse in the same manner as an ordinary concrete. When the slump value of an ordinary concrete was 19.2 cm, the slump value of 22cm was obtained by adding a retarder after 3 hours, next day after adding an activator and a superplasticzer, the slump value of 18.2cm was obtained. The setting time of returned concrete reactivated was in retard compared with ordinary concrete. The reactivated concrete and ordinary concrete exhibits almost equal compressive strength, tensile strength, and flexural strength.
신경회로망에서 뉴런간의 연결도를 이용한 4백 배치 문제 해결 알고리즘
현해진,김덕주,강부식,이기태,임재윤 濟州大學校 工科大學 産業技術硏究所 1993 産業技術硏究報告 Vol.4 No.-
In this paper we have proposed a method for solving a four-coloring problem using adjusted information transmission between adjacent neurons in neural networks. These algorithms are based on McCclloch-Pitts binary neuron model neural networks. If a map shares n regions, a 4×n neural array is used to color a map of n regions where each neuron as a processing element performs it. By programming these algorithm by a C-language in IBM PC 486 DX and adapting it to various examples, we have showed the ability of our system. If one neuron is selected among four neurons, the strength of order three neurons is wakened. So, by transmitting the information of selected neuron, adjacent neurons cannot share the same color.