前腕部 經穴 取穴에서 骨度分寸法과 一夫法의 比較 硏究

박히준,채윤병,차웅석,박종배,이혜정,이향숙,인창식,고형균,김수영,최일환,김강식,문정배,배기태,유경환,육근영,정병주,손인철,임사비나 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Background : The cun measurement System, an essential and convenient method in locating acupoints, has been widely used in the practice of acupuncture. However, traditional cun measurement has been criticized for its lack of reliability. Objectives : The purposes of this study are to determine if one cun measured by the directional methods have a consistency with that of proportional methods and to investigate which factors are related with these differences, especially in forearm. Methods : The distance between the elbow crease and the wrist crease of forearm was compared to a reference value of one cun obtained by the directional method. In this method, one cun is one third of the distance between index finger and Small finger of a subject, measured at proximal interphalangeal joint. In addition, to investigate the factors influencing the differences between these two methods, we measured the height and body weight and calculated body mass index (BMI). Finally we analyzed the factors correlated with these lengths by linear regression test. Results : The results showed that one cun obtained by the directional methods were significantly different from one cun by the proportional methods in forearm. It was demonstrated that the length acquired with the directional method was more correlated with body weight and body mass index, while the length obtained by the proportional method was more correlated with the height.

P92강의 고온피로특성

원성준,정찬서,임병수 성균관대학교 기계기술연구소 2001 성균관대학교 논문집 기계기술편 Vol.4 No.1

In this paper, fatigue characteristics of P92 steel at high temperature are investigated to obtain basic mechanical properties and to study effect of temperature on fatigue crack growth behavior in P92 steel. Both tensile test and fatigue crack growth test were cared out at 55O℃, 600℃ and 650℃. From the tensile tests, yield strengths, tensile strengths, reduction rates in area and elongations were obtained. From the fatigue crack growth tests, fatigue crack growth rates were calculated at each test temperature and they were compared with each other to study the effect of temperature on fatigue crack growth rate.

웹트랜젝션 데이터를 이용한 고객세분화와 고객 가치측정

김윤정,양동훈,문병준 한국인터넷비즈니스학회 2002 인터넷비지니스연구 Vol.3 No.2

본 논문의 목적은 인터넷 유통경로 상의 고객행동을 나타내는 웹트랜젝션 로그 데이터의 분석을 토대로 하여 유용한 고객세분화 방안을 실증적으로 제시하는 데 있다. 이를 위하여 인터넷 애완동물용품 상점과 온라인 커뮤니티 상의 고객행동과 수익과의 관계를 분석하였다. 데이터마이닝 기법으로 decision tree법이 사용되고 세분화를 위하여 군집분석이 수행되었다. 연구는 크게 두 단계로 진행되었는데 일단계로 연구대상으로 삼은 인터넷 애완동물 용품 상점의 회원고객 및 비회원 고객 모두의 인터넷 소비행동을 분석하였다. 이 단계로 범위를 좁혀 회원고객의 인구통계학적 데이터 및 웹 트랜젝션 데이터를 분석하였다. 이를 토대로 거래행동 및 인구통계학적 특성을 기준으로 하여 몇 개의 의미있는 세분시장을 도출하였다. 소비자의 거래행동을 분석하기 위하여 웹 로그 데이터가 사용되었고 인구통계학적 특성을 파악하기 위하여는 등록정보가 사용되었다. 도출된 세분시장이 주는 온라인 쇼핑몰 마케팅에 대한 시사점이 제시되었다. Relationship between customer behavior and revenue were studied by statistical analysis of web log data over online pet shops in Korea with online community. Clustering analysis is used for this research. We perform this at two stages: first we study the full data set including the transaction data of member and non-member of Korean online pet shop. In the second stage, we research member users" demographic data and one"s web transaction data. Through this research, we segment several meaningful sub groups according to their transaction or demographic data in both stages. Web log data is used for identifying users" transaction data and registration information is used for users" demographic data. Segment of both stages has its own specification, which gives some marketing insights for online shopping mall with virtual community.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Appropriate Resistance Intensity for Activation of Infraspinatus and Control of Anterior Translation of the Humeral Head

Won-Jeong Jeong(Won-Jeong Jeong),Byeong-Jin Kim(Byeong-Jin Kim),Sun-Shil Shin(Sun-Shil Shin),In-Joon Uh(In-Joon Uh) 한국임상움직임치료학회 2022 한국임상움직임치료학회지 Vol.2 No.2

Background In general, external rotation (ER) exercises are commonly used in rotator cuff retraining programs to improve stabilization ability. ER exercises at 90° of shoulder abduction are common and effective in strengthening the infraspinatus (ISP). However, if the ISP is weak during ER at 90° shoulder abduction, the posterior deltoid muscle (PD) is overactivated, which can lead to anterior translation of the humeral head. Therefore, the selective activation of ISP muscles is an important factor in rehabilitation. Objectives We investigated the muscle activities of the ISP, PD, and middle trapezius (MT), the ratio of the ISP to PD muscle activities, and the anterior translation of the humeral head in response to three resistance intensities during sitting external rotation (SITER) exercises. Methods A total of 12 healthy women recorded changes in the anterior translation of the humeral head using a load cell, the muscle activities of the ISP, PD, and MT, the ratio of the ISP to PD muscle activities using surface electromyography (EMG) during SITER under three different intensities [low (10-20%) medium (45-55%) high (60-70%)]. Results The ISP, PD, and MT amplitudes were highest at high intensity, followed by medium and low intensities during SITER (p < 0.001). The muscle activity ratio was significantly highest at medium intensity compared with low and high intensities (p = 0.031). The anterior translation of the humeral head was highest at high intensity, followed by medium and low intensities during SITER (p < 0.001). Conclusions Medium intensity (45-55%) was the most appropriate intensity during the SITER exercise. However, anterior gliding of the humeral head was the lowest at low intensity. Therefore, during ER exercises, we should think about how to control the anterior gliding of the humeral head.

Comparisons of Development Potential in Bovine SCNT Embryos using Donor Cells treated with Different Demethylating Inhibitors

Byeong-Gyun Jeon,Gie-Joon Jeong,Gyu-Jin Rho 한국수정란이식학회 2015 한국동물생명공학회지 Vol.30 No.3

To improve the developmental potential of bovine somatic cell nuclear transfer (SCNT) embryos, this study compared the developmental rates to blastocyst stage in the SCNT embryos using donor fibroblasts treated with 5-azacytidine (5AC) and S-adenosylhomocysteine (SAH) at different concentrations. Their reprogramming efficiency level was investigated with level of telomerase activity. Donor fibroblasts isolated from adult ear skin of a cow were exposed to 5AC and SAH at different concentrations during 2 passages. After nuclear transfer into enucleated recipient oocytes, the cleavage and developmental rates were significantly (p<0.05) decreased in the SCNT embryos using 5AC-treated fibroblasts (5AC-SCNT embryos), compared with those of non-treated control (control-SCNT embryos) and SAH-treated fibroblasts (SAH-SCNT embryos). The developmental rates to blastocyst stage tended to be slightly increased in the SAH-SCNT embryos at each of the concentrations, and especially, the developmental rates in the SCNT embryos using 1.0 mM SAH-treated fibroblasts were significantly (p<0.05) higher than that of control SCNT embryos. The mean numbers of total and ICM cell in blastocysts were also significantly (p<0.05) decreased in the 5AC-SCNT embryos, compared with those of other SCNT blastocysts. Further, the level of telomerase activity was also significantly (p< 0.05) decreased in the 5AC-SCNT embryos than those of control and SAH-SCNT embryos. Whereas, a significantly (p<0.05) up-regulated telomerase activity was observed in SAH-SCNT embryos, compare with that of control-SCNT embryos. In conclusion, SCNT embryos using hypomethylated donor cells with SAH, not 5AC, may improve the developmental potential and reprogramming efficiency.

Differential Cytotoxicity of Penta-O-galloyl-β-D-glucose in Human Cancer and Normal Cell Lines of Various Origins

Hyeon-Jeong Lee(이현정),Min-Gyeong Kim(김민경),Song-Yeong Lee(이송영),Min-Hyock Song(송민혁),Yoon-Dong Kim(김윤동),Jeong-Sook Ha(하정숙),Gie-Joon Jeong(정계준),Gyu-Jin Rho(노규진),Byeong-Gyun Jeon(전병균) 한국생명과학회 2016 생명과학회지 Vol.26 No.11

본 연구는 다당체의 한 종류인 penta-O-galloyl-β-D-glucose (PGG)가 사람의 여러 조직에서 기원하는 여러 암세포주(A-549, MDA-MB-231, U87-MG, MCF-7 및 PANC-1), 정상 MRC-5 태아 섬유아세포 그리고 사랑니에서 유래한 간엽줄기세포(DPSCs)에 미치는 세포독성 효과를 조사하였다. IC50값은 다른 세포주에 비해 높은 증식률을 나타내는 A-549 및 MDA-MB-231 암세포주에서 유의적으로 낮게 관찰되었다. 10 uM의 PGG가 포함된 배양액에서 세포를 7일 동안 배양한 결과, 세포배가시간은 모든 세포주에서 유의적으로 늘어났고, 세포배가시간과 IC50값의 관계를 조사한 결과, 세포배가시간이 늘어남에 따라 IC50값은 비례적으로 증가됨을 증명하였다. 또한, 10 uM의 PGG로 처리된 세포주들은 노화와 관련된 ß-galactosidase의 활성도가 높게 관찰되었다. 특히, telomerase 활성도는 A-549 및 MDA-MB-231 암세포주에서 다른 세포주에 비하여 현저히 감소하는 것을 관찰하였다. 이러한 결과를 바탕으로 PGG는 높은 증식률을 보이는 암세포주에서 높은 세포독성효과를 나타내어 잠재적인 항암물질임을 증명하였다. The present study examined the cytotoxic effects of 1, 2, 3, 4, 6-penta-O-galloyl-β-D-glucose (PGG), known as the pentahydroxy gallic acid ester of glucose, in the various human cancer cell lines (A-549, MDA-MB-231, U87-MG, MCF-7 and PANC-1), normal MRC-5 fetal fibroblasts, and dental papilla tissue-derived mesenchymal stem cells (DPSCs). Significantly (p<0.05) lower half maximal inhibitory concentration (IC50) values were observed in the A-549 and MDA-MB-231 cells showing a high proliferation capacity, compared with other cancer and normal cell lines with a relatively low proliferation capacity. The population doubling time (PDT) was significantly (p<0.05) higher in the 10 μM PGGtreated cell lines than those of untreated control cell lines. The present study demonstrated that the IC50 value increases proportionally to the extending PDT. A high cell number with senescence-associated ß-galactosidase activity was also observed in the 10 μM PGG-treated cells compared with those of untreated control cells. Moreover, the level of telomerase activity was significantly (p<0.05) decreased with 10 μM PGG treatment, especially in A-549 and MDA-MB-231 cells showing a high proliferation capacity. Based on these observations, PGG could serve as a potent agent for cancer chemotherapy, as its treatment was more effective in cells with a high proliferation capacity.

Phosphorylation of 14-3-3ζ at serine 58 and neurodegeneration following kainic acid-induced excitotoxicity

Eun Ae Jeong,Byeong Tak Jeon,Jeong Bin Kim,Joon Soo Kim,Yong Woon Cho,Dong Hoon Lee,Hyun Joon Kim,Sang Soo Kang,Gyeong Jae Cho,Wan Sung Choi,Gu Seob Roh 대한해부학회 2010 Anatomy & Cell Biology Vol.43 No.2

Oxidative stress-induced cell death leads to phosphorylation of 14-3-3ζ at serine 58. 14-3-3ζ is detected at significant levels in cerebrospinal fluid after kainic acid (KA)-induced seizures. Here we examined temporal changes in 14-3-3ζ phosphorylation in the hippocampus and amygdala of mice after KA treatment. Mice were killed at 2, 6, 24, or 48 h after KA (30 mg/kg) injection. We observed an increase in TUNEL and Fluoro-Jade B (FJB)-stained neurons in the hippocampus and amygdala of KA-treated mice. Phospho (p)-14-3-3ζ and p-JNK expression was increased in the hippocampus 2 and 6 h after KA treatment, respectively. In immunohistochemical analysis, p-14-3-3ζ-positive cells were present in the CA3 region of the hippocampus and the central nucleus of amygdala (CeA) of KA-treated mice. Thus, phosphorylation of 14-3-3ζ at serine 58 may play an important role in KA-induced hippocampal and amygdaloid neuronal damage.

석류 신품종 ‘단미홍’

정현주(Hyeon ju Jeong),박문영(Moon Young Park),조혜성(Hye Sung Cho),조윤섭(Youn Sup Cho),정병준(Byeong Joon Jeong),박재옥(Jae Ok Park),이소미(So Mi Lee),변만호(Man Ho Byeon),조경철(Kyung Chul Cho),김병삼(Byeong Sam Kim),황인택(In Tae 한국원예학회 2018 한국원예학회 학술발표요지 Vol.2018 No.10

Effects of bodily retraction of mandibular incisors versus mandibular setback surgery on pharyngeal airway space

Byeong-Tak Keuma,Sung-Hwan Choi,Yoon Jeong Choi,Hyoung-Seon Baik,Kee-Joon Lee 대한치과교정학회 2017 대한치과교정학회지 Vol.47 No.6

Objective: The purpose of this study was to compare the changes induced in the pharyngeal airway space by orthodontic treatment with bodily retraction of the mandibular incisors and mandibular setback surgery without extraction. Methods: This retrospective study included 63 adult patients (32 men and 31 women). Thirty-three patients who had been treated via four-bicuspid extraction and bodily retraction of the mandibular incisors (incisor retraction, IR group) were compared with 30 patients who had been treated via mandibular setback surgery (MS group) without extraction. Lateral cephalograms were acquired and analyzed before (T1) and after treatment (T2). Results: The superior pharyngeal airway space did not change significantly in either group during treatment. The middle pharyngeal airway space decreased by 1.15 ± 1.17 ㎜ and 1.25 ± 1.35 ㎜ after treatment in the IR and MS groups, respectively, and the decrease was comparable between the two groups. In the MS group, the inferior pharyngeal airway space (E-IPW) decreased by 0.88 ± 1.67 ㎜ after treatment (p < 0.01). The E-IPW was larger in the MS group than in IR group at T1, but it did not differ significantly between the two groups at T2. No significant correlation was observed between changes in the pharyngeal airway space and the skeletal and dental variables in each group. Conclusions: The middle pharyngeal airway space decreased because of the posterior displacement of the mandibular incisors and/or the mandibular body. The E-IPW decreased only in the MS group because of the posterior displacement of only the mandibular body.