정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

도시 개발에 따른 기상장 변동의 3차원 수치해석에 관한 연구

이희철,이범주,이도훈,이은태 경희대학교 산학협력기술연구원 1999 산학협력기술연구논문집 Vol.5 No.-

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

10주간의 체계적 운동이 노인들의 골밀도에 미치는 영향

이규문,최종환,김창범,김태헌 忠北大學校 平生體育硏究所 1997 平生體育硏究所 論文集 Vol.9 No.-

An experimental study was designed to investigate the effects of 10-weeks exercise on the bone mineral density (BMD) in women (ages 55 to 74). The subjects were placed into two age groups; middle aged group(n=19, 62.2±2.5 yrs) old group(n=16, 69±2.3 yrs). All subjects completed the bone mineral density test ( Radius and Ulna) by computed tomography both prior to and immediately following 12-weeks program. Both experimental groups participated in an 12-week exercise program consisting of three 80-min supervised exercise bouts a week. A pairs T-test was used to examine differences between pre-and post-test scores in the bone mineral density, depending on each age group. First the significant improvement (1.7%) appeared on BMD in all subjects together after 10-weeks exercise. Specifically, the middle aged group showed statistically significant increase(1.2%) between pre-and post-test scores in he bone mineral density after 10-weeks program. However, even though the improvement (2.2%) of BMD in the older group was not significant in statistics, the improvement(2.2%) of BMD in the older group is bigger than the improvement (1.2%) of BMD in the middle aged group. Therefore, the results suggest that improvements in BMD may be affected by acute exercise and may support the affective beneficence of exercise for older populations.

춘천지역 도시열섬의 특성과 대기질에 미치는 영향

이종범,김용국,김태우 江原大學校 附設 環境硏究所 1994 環境硏究 Vol.11 No.-

An observational study of urban heat is1and was carried out using field data obtained during 6 day in May and August 1992 in Chunchon(Population size 180,000). Air temperature was measured at 04 points along two sampling routes by thermisters attached to cars, Both routes cover urban and rural area and across the center of urban area, Continuous observation of air sonde was performed to clarify heights of nocturnal boundary layer(NBL) at the center of urban area. Surface meteorological observations were performed at both urban and rural site. This study showed that heat island Phenomena was obvious1y observed at the urbanized area during the night time With low wind Speed. The average NBL heights extended to about 100 meters, but varied with meteorological conditions. After sunset the air temperature decreased with time at both sites and cooling rate at the urban site was Heater than the rural site. The maximum heat island intensity was 7.5°C at 21 LST May 4. Using the two meteorological data gets obtained from urban and rural sites, the air Pollutant concentration was calculated by Gaussian plume model which can obtain not only horizontal distribution of concentration but also vertical distribution. The result indicated that the concentration resulted from urban meteorological data set was lower than that from rural meteorological data set. It was also calculated that the air pollutant extended to higher level in urban meteorological data set than that in rural meteorological data set.

광원 및 광조사 방법에 따른 심미충전재의 중합수축

이용근,윤태호,임범순,김철위 대한치과기재학회 2000 대한치과재료학회지 Vol.27 No.4

The polymerization shrinkage of dental esthetic filling materials of five kinds of resin composite and three kinds of compomer was measured with a thermal dilatometer (Thermal Dilatometer, DIL 402C, TASC 414/3A Controller, Netzche, Germany) during polymerization with a halogen lamp curing unit (VIP, Bisco, U.S.A.) or a plasma arc curing unit (Flipo, Serial No. P03G02221, Lokki, France). The irradiation time of the halogen lamp was 40, 80 and 120 s with the intensity of 400 ㎽/㎠, and that of the plasma arc was 9 s. The pulse-cure mode with a halogen lamp was 5 s pre-polymerization at 200 ㎽/㎠, 3 minutes wait and then 120 s irradiation at 400 ㎽/㎠. From this experiment, the following results were obtained : 1.Depending on the irradiation source and mode, the amount of polymerization shrinkage after 14 minutes from the start of irradiation was significantly different in some materials. However, there was no significant difference in most of materials (p>0.05). 2.Most of the polymerization shrinkage occurred within two minutes from the start of irradiation except for pulse-cure. 3.In all the materials studied, the amount of polymerization shrinkage after 14 minutes from the start of irradiation was not different between the results from 120 seconds irradiation with the halogen lamp and these from pulse-cure (p> 0.05), and the amounts of shrinkage from a plasma arc was generally lower than those from other curing modes. 4.The amount of polymerization shrinkage after 14 minutes from the start of irradiation was not different between the results from 120 seconds irradiation with a halogen lamp and those from plasma arc (p>0.05) in all the eight materials studied.

위에 발생한 거대 위장관 간질종양 1예

이경영,유영범,김태원,이경룡 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-

Gastrointestinal tumors(GIST) are rare group of neoplasias of the gastrointestinal track, which originate from or differentiate into interstitial cells of Cajal (ICC). GIST traditionally have been designated as smooth muscle tumor. However, with increasingly accurate analytic tools, immunohistochemistry and ultrastructure, most investigators were able to demonstrate that ICC, a complex cellular network postulated to act as pacemaker cells of the gastrointestinal track, which exhibit both myoid and neural features, could be a candidate for tumor histogenesis. Most ICC are only c-kit-positive, however a subset are positive for both c-kit and CD34. Most GISTs are asymptomatic and are thus usually discovered incidentally during routine check, at operation of other organs. When symptoms occur, GISTs usually present with gastrointestinal bleeding due to ulceration of the overlying gastric mucosa. Bleeding may be massive, leading to hematemesis and melena. Recently, we experienced a large sized(5×5×5 cm) GIST on the upper body of the stomach, which caused massive upper gastrointestinal bleeding in a 61-year-old man and was treated by local resection with adequate safety margin about 2 cm.

EU와 한국의 IT를 통한 에너지효율화 정책 비교 연구

이각범,박찬국,용태석 한국정보사회진흥원 2008 정보화정책 Vol.15 No.3

에너지 효율화를 이루기 위해 세계 각국은 IT 인프라를 적극 활용하고 있다. 특히, EU는 에너지와 IT의 융합 범위를 지속적으로 확대하고 있고, 참여와 협력을 기반으로 공동연구과제를 추진해오고 있다는 점에서 주목할 만하다. 반면, 우리나라의 경우 IT를 통한 에너지 효율화 연구주제는 전력분야에 국한되어 있으며, 에너지 융합 논의가 아직 초기 단계에 머물러 있다. 본 연구에서는 EU와 우리나라의 IT를 통한 에너지 효율화 정책을 연구주제 선정 과정 및 연구개발 범위와 추진방향, 에너지와 IT 두 부문의 유기적인 연계성, IT확산에 따른 리스크 대응 측면에서 비교 분석하고, 국내의 IT와 에너지 간 융합 전략을 설정함에 있어 시사점을 도출한다. 앞으로 IT를 통한 에너지효율화 정책은 에너지 정책과 정보화 정책 간 긴밀한 연계성을 갖추어가야 하며, 차세대 IT를 어떻게 에너지 효율화에 접목시킬 것인가에 대해 그 기술도입의 우선순위와 응용범위를 구체화시켜 나가야 한다. 또한, 에너지 부문에 정보화가 확산되면서 나타나는 부작용과 위험요소 등에 적극 대응하면서 에너지산업의 성장 동력화를 위한 인프라를 갖추어가야 한다. The world has been making active use of IT(information technology) infrastructure for the energy efficiency. Especially EU's energy informatization strategy is prominent in terms of i scope and systematicness, based on participation and collaboration. Korea, however, does research on energy-IT convergence focusing just on power grid and does not have a long history of research on energy-IT convergence. We carry out an in-depth study on comparing the energy efficiency policies of EU and Korea in terms of the R&D process, range, and direction. We try to draw implications in setting an strategy on the future convergence policy of energy and IT. The energy efficiency strategy and informatization strategy should be closely connected and policy makers should show concrete action plans to apply the next generation IT for energy efficiency. Furthermore the policy makers should pay attention to measures to cope with the risks stemming from energy informatization.

1. 06㎛ Nd : YAG Laser를 이용한 요추간판탈출증의 경피적 수핵감압술

이흥선,변박장,최순관,신원한,권귀향,이인수,이경석,김범태 순천향대학교 1994 논문집 Vol.17 No.4

The 1.06㎛ Neodymium-YAG Laser(800 micron hemisherical) is revealed a useful tool for percutaneous laser disc decompression(PLDD). Especially PLDD would be applied to the management of lumbar disc herniation with minimal intervention. Total irradiated energy to one level of disc space was bout 1000 to 2000 joules. We performed this method at 10 levels, in 7 cases of patients, consisting of 4 males and 3 females with an average age of 37.7 years. Five cases showed excellent and good results, were observed. In two cases, open surgery was required because of unsatisfactory results. The best results were obtained in the protrusion type of disc herniation. We have summarized some advantages of PLDD: a) safe and simple procedure in an outpatient setting, b) avoiding general anesthesia, late spinal instability, c) possibility of repetitive use.

두경부 편평세포암종세포주에서 retinoic acid가 linear-quadratic 모델을 적용한 방사선감수성과 apoptosis 유발에 미치는 영향

이은숙,강범현,허민석,이삼선,최현배,최순철,박태원 대한구강악안면방사선학회 2001 Imaging Science in Dentistry Vol.31 No.3

Purpose : To evaluate the effect of all-trans-retinoic acid on radiosensitivity and radiation-induced apoptosis in NHOK, HEp-2 and FaDu cell lines. Material and Methods : We measured the changes in survival fraction at 2 Gy (SF2), α and β after treatment of retinoic acid (1μM) prior to irradiation with doses of 2,4,6 and 10 Gy and correlated the radiosensitizing effect of retinoic acid with them. Also, apoptosis induction was assayed with the flow cytometry on days 1, 2, 3, 4 and 5 after irradiation (2,10 and 20 Gy) combined with retinoic acid. Results and Conclusion : SF2 values for NHOK, HEp-2 and FaDu cell lines were 0.54, 0.64 and 0.41, respectively and the cell line of FaDu was the most radiosensitive, For cell lines of NHOK and HEp-2, pretreatment of cells with retinoic acid resulted in a significant decrease of the SF2 values. The α/β ratios of x-ray survival curve were 8.714(NHOK), 4.098(HEp-2) and 11.79(FaDu). The α/β ratio for NHOK decreased on pretreatment with retinoic acid, whereas those for HEp-2 and FaDu increased. Radiation induced apoptosis in all cell lines but, retinoic acid did not affect the apoptosis. (Korean J Oral Maxillofac Radiol 2001; 31 : 135-43)