시간의 흐름에 따른 핸드폰의 품질동태성에 관한 연구

윤성필(Sung-Pil Yoon),임성욱(Sung-Uk Lim),박만희(Man-Hee Park),조인희(In-Hee Cho) 한국엔터테인먼트산업학회 2010 한국엔터테인먼트산업학회논문지 Vol.4 No.3

본 연구는 선행연구에서 조사된 핸드폰의 고객요구속성을 Kano 모델의 품질특성에 적용하여 시간의 흐름에 따라 어떤 변화가 있는지를 살펴보고자 한다. 또한 고객들의 새로운 요구속성이 나타났는지도 함께 살펴보고자 한다. 많은 문헌과 선행연구에서 나타나고 있는 시간에 따른 품질특성의 이동이 매력적 품질에서 일원적 품질로 일원적 품질에서 당연적 품질로 변화하는 진부화(陳腐化)현상이 나타나는지도 함께 살펴보고자 한다. In this study, previous research (Sung-Uk Lim, 2004) surveyed in customer demand for mobile phones the quality characteristics of properties applied to the Kano model, the flow of time, depending on whether any changes will be discussed. In addition, our customers" new requirements will be examined along with the property map appeared. The movement of time-dependent quality characteristics appeared in many previous studies Obsolescence Phenomenon - from Attactive Quality Element to One-Dimensional Quality Element, from One-Dimensional Quality Element to Must-Be Quality Element - may appear be examined together.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Bacillus sphaericus ts-U311의 단백질 합성변화의 전기영동적 분석

임헌길,황성희,이형환 建國大學校基礎科學硏究所 1992 理學論集 Vol.17 No.-

Bacillus sphaercus 1593 K-5와 ts-U311의 총 세포 단백질을 전기영동적인 방법으로 비교했다. 1. B. sphaercus 1593 K-5와 ts-U311의 총 단백질간에는 분자량과 등전점에서 많은 차이가 있었으나,동일 균주에서는 성장온도 변화에 따른 단백질 양상에서 거의 차이가 없었다. 2.B.sphaericus 1593 K-5는 분자량이 최고 225Kd에서 최저 13Kd에 걸쳐 총 26개 밴드가 분리되었고,ts-U311 은 최고 220K 달톤에서 최저 13.5K달톤까지 24개 밴드가 분리되었드며, 두 균주의 단백질은 분자량이 150,94,77,57,40,32,19Kd인 곳에서 존재유무와 양에 차이가 있었다. 3. B.sphaericus 1593 K-5 ts-U311은 pH 4.2에서 pH 4.8 사이에서 등전점을 가지는 단백질이 이차원젤상에 나타나지 않았으나, B.sphaericus 1593 K-5는 진하게 염색된 4번과 5번 단백질 점이 나타났다. 4. 이차원젤 상에서 두 균주의 단백질 종류의 차이점은 다음과 같다. 4번,5번,12번,19번,20번,21번은 B.sphaericus 1593 K-5에 존재하나 ts-U311에는 없었고, 36번,37번,38번,39번은 ts-U311에는 존재하지만 B.sphaericus 1593 K-5에는 없었다. 또한,3번,6번,27번,28번,29번,35번은 단백질의 양에서 차이가 있었고,여러 곳에서 전개위치가 약간씩 다르게 나타났다. 5.B.sphaericus 1593 K-5의 단백질 중에서 분자량이 150Kd인 것이 독소인 것으로 확인되었고 ts-U311에서는 이 단백질이 없었다. 생체검정시험에서도 B.sphaericus 1593 K-5는 강력한 독성을 보였지만 ts-U311은 전혀 독성이 없었다. Protein syntheses by B. sphaericus 1593 wild type strain and ts-U311 mutant were studied by gel electrophoretic analysis. The protein patterns of the two strains were different in the molecular weight bands of 150,94,77,57,40,32 and 19 kilodaltons by SDS-polyacryl-amide gel electrophoresis analysis. In the isoelectric-focusing the proteins from B. sphaericus ts-U311 were not banded in the pH ranges 4.2 to 4.8 In the analysis of two-dimentional polyacrylamide gel electrophoresis the wild type strain had number 4,5,12,19,20 and 21 sptted proteins, but the ts-U311 did not. Number 36,37,38 and 39 spotted proteins were produced from the proteins of ts-U311,but the wild type strain did not. The 150 Kd protein from B.sphaericus wild type strain was toxic to the larvae of Culex pipiens, but it was not produced from the B.sphaericus ts-U311.

Pb(Sn_½Sb_½)O₃-PbTiO₃-PbZrO₃계 압전 세라믹의 필터로서의 응용

임진호,조상희 경북대학교 공과대학 1987 工大硏究誌 Vol.16 No.-

The effect of the size of sintered body on the resonant characteristic of the Pb(Sn_½Sb_½)O_3-PbTiO_3-PbZrO_3 ceramics was investigated. The attenuation characteristics of ring-dot type and ladder type filter were also investigated. As the sintered body are small, the resonant characteristic (f_γ, f_α) and the center frequency are increased. The big difference between the ring-dot type and ladder type filter was the sharpness of bandwidth and the movement of center frequency. As the poling field increased, the K_p and bandwidth were also increased.

질산칼슘 주입에 의한 저수지 퇴적물의 인용출 제어효과

임봉수,박희동,유성환 대한상하수도학회 2003 상하수도학회지 Vol.17 No.1

This study was conducted to investigate the control effect of phosphorus release from the sediments in lake by calcium nitrate injection. The maximum release rate of T-P after 5 days was 53.5㎎ T-P/㎡ · d for release experiment, while reduced to 28.9㎎ T-P/㎡ · d when 8.3L/㎡ as 5% calcium nitrate was injected, decreased to about 46%. The maximum release rate of PO_4-P after 2 days was 9.0㎎ PO_4-P/㎡ · d and little release at the beginning of the experiment. The PO_4-P release control by injection of calcium nitrate was very effective. Control effects of organics oxidation and phosphorus release in sediment was good since COD was reduced, PO_4-P content was fixed, and NAI-P was almost fixed compare to raw sediment after release.

12-O-Tetradecanoylphorbol-13-Acetate에 의한 HL-60 세포 분화유도중 Vimentin 유전자 전사조절에 대한 AP-1의 역할

임규,김진희,권도원,김승민,이명선,윤경아,손미영,박종일,윤완희,황병두 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1

Purpose: To gain insight on the role of AP-1 in transcriptional regulation of vimentin gene during differentiation of HL-60 cells by 12-O-tetradecanoylphorbol-13-acetate (TPA), the levels of vimentin mRNA and AP-1 have been investigated with Northern blot hybridization and DNA mobility shift assay. Materials and Methods: HL-60 cells were grown in RPMI 1640 medium supplemented with 10% heat-inactivated fetal calf serum and antibiotics in a humidified 5% CO_(2) at 37°C. Total RNA was prepared by a modification of the method of Karlinsey et al. Northern blot hybridization was performed by the method of Virca et al. EcoRI fragment of pVIM-GEM was used as probe for vimentin mRNA. DNA mobility shift assay was performed by the method of Lim et al. End labeled DNA probe(Upper strand, 5'-CGCTTGATGAGTCAGCCG- 3') for AP-1 binding activity was mixed with nuclear extracts in a 20 μl reaction volume containing 300 mM KC1, 60 mM HEPES, pH 7.9, 25 mM MgCl_(2), 1 mM EDTA, 1 mM DTT, 60% glycerol, and 2μg of poly[dI-dC]. Results: TPA increased vimentin mRNA levels, with maximal stimulation reached at 24 hr. The level of vimentin mRNA was induced in proportion to the concentration of TPA. TPA-induced vimentin mRNA was almost reduced by actinomycin-D pretreatment. TPA-induced stimulation of vimentin gene was completely reduced by staurosporin pretreatment. In DNA mobility shift assay, AP-1 newly appeared at 24 hr during TPA-induced differentiation and was almost not detected after the pretreatment of staurosporin. Conclusions: These results suggest that the induction of vimentin mRNA during TPA-dependent differentiation in HL-60 cells may be mediated by protein kinases C signal transduction and AP-1 is important to transcriptional regulation.

용융슬래그로부터 합성된 제올라이트 이용한 해수 중의 N, P 제거

임준혁,정진영,이성우,홍성호,김경희,이제근 한국공업화학회 2003 응용화학 Vol.7 No.1

This study examined, as the one way of using zeolite, the about the removal of ammonia nitrogen and phosphorus that cause the eutrophication occurred the adjoining seas.4A type zeolite was used as an adsorbent to remve NH_4-N, PO_4^3-P ion in the artificial seawater. Zeolite is more required than in the fiesh water, under the same conditions, in order to remove NH_4-N in the sea water. The lower the thickness of NH_4-N is in the early stage, the more Freundlich type equation the value of 1./n increases. In case of PO_4^3-P indicated that the removal efficiency was relatively independent of PO_4^3-P concentration. Freundlich parameter 1/n has the value nuder 2. So it shows that absorption is made with relatively ease.

Physiochemical Characteristics of Lim’s Valley Potatoes in Korea

Hee-Don Choi,Hae-Chang Lee,Sung-Soo Kim,Yun-Sook Kim,Hak-Tae Lim,Gi-Hhyung Ryu 한국원예학회 2008 한국원예학회 기타간행물 Vol.- No.-

혈액 투석 환자에서 중심정맥 협착에 대한 스텐트 삽입술 : Wallstent Placement

임대승,노상필,이유선,정승현,김보영,이정우,강정아,김정희,이민수,정준용,최시완,정진옥,성인환,이강욱,신영태 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.1

Stenosis of central vein is a common complication arising after percutaneous subclavian vein catheter insertion performed for temporary vascular access in chronic renal failure patients undergoing hemodialysis. There are several treatment methods for the condition like percutaneous angioplasty(PTA), stent insertion, and surgery, but recent trend is toward PTA and stents. Among the patients diagnosed with chronic renal failure from March 1993 to May 2002 and undergoing hemodialysis through AV fistula, the 14 Patients in whom central vein stenosis arose were selected for the study. A total of 28 percutaneous interventions(5 PTA and 23 stent placement) were performed, and restenosis rate and the time taken till the restenosis in de novo lesions and instant lesions were compared. All 28 cases were operated successfully. The 14 cases that received both anigioplasty and stent placement initially. (de novo lesion : 14 cases), Among the 10 cases with de novo lesion that followed up more than 1 year, 3 cases are currently undergoing hemodialysis without restenosis, and the remaining 7 cases have recurred stenosis with the mean time to restenosis of 10.9 months. In the 7 cases in whom stenosis recurred, 11 interventions were done(instent lesion: 11 cases). 4 of these were using only ballon angioplasty with 100% restenosis rate and the mean time of 3 months until restenosis. The remaining 7 cases were using both balloon angioplasty and stent placement, also with 100% restenosis rate but with the mean time of 12 months until restenosis, which was later than the group receiving only balloon angioplasty. In treating the patients with central vein stenosis, stent placement seems to be more advantageous over PTA in terms of restenosis rate and the mean duration of patency. In the case of instent lesion, inserting the stent for the second time after stenosis recurred lengthened the duration of patency compared to performing balloon angioplasty alone.

폐가스에서 황화수소 제거를 위한 바이오필터/광촉매반응기 시스템의 활용

임광희,박상원 한국공업화학회 2005 응용화학 Vol.9 No.1

Transient behavior of biofilter/photo-catalytic reactor system was observed to eliminate hydrogen sulfide from waste air at its four sampling ports. The biofilter was packed with a eqivolume mixture of granular activated carbon(GAC) and compost as packing media on which Thiobacillus sp. IW was inoculated and was fixed. The biofilter/photo-catalytic reactor system was run for eight stages of operation under various operating conditions. As a result the removal efficiency began to decrease from 100% after the inlet load of hydrogen sulfide surpassed ca. 100 S-g/㎥/h and was finally continued at 60%. The maximum elimination capacity of biofilter/photo-catalytic reactor system was ca. 130 S-g/㎥/h.