정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

간암 환자에 합병된 Citrobacter braakii 패혈증 1례 보고

이해미,배성하,이수남,이정우,신아영,류시영,이수연,윤문희,한선영,한남익,이영석,유진홍 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Citrobacter species is a gram-negative bacilli that can cause opportunistic infections in immunocompromised hosts. Citrobacter braakii refers to the genomospecies 6 of the Citrobacter freundii complex. There are no detailed studies on infections caused by this newly identified specific genetic species in Korea. We herein report a case of a patient with hepatocellular carcinoma who, after undergoing transcatheter arterial chemoembolization, developed biloma which later progressed to C.braakii sepsis and did not respond to treatment. To our knowledge, this is the first reported case in Korea on C. braakii infection resulting in septic shock in a patient with malignancy in Korea.

장애인 입소시설과 특수학교의 구강건강관리 실태에 대한 조사 연구

이광희,김대업,하순영,박종석 대한소아치과학회 2000 大韓小兒齒科學會誌 Vol.27 No.2

전국의 123개 장애인 입소시설과 102개 특수학교를 대상으로 구강건강관리 실태를 파악하여 장애인의 구강건강관리 계획을 수립하는 데 사용할 수 있는 근거를 마련하고자 하였다. 설문지 조사법으로 연구하였다. 정기구강검진은 특수학교에서 연2회 실시하고 있었으나, 장애인 입소시설에서는 56.8%에서 시행하였다. 우식 예방 프로그램은 장애인 입소시설의 69.1%, 특수학교의 86.3%에서 시행하였으며 프로그램의 종류는 입소시설에서 규칙적 칫솔질이 58.1%, 특수학교에서 예방교육이 65.7%로 가장 많았다. 불소를 이용한 우식예방은 입소시설과 특수학교에서 각각 8.6%, 11.8%에서 시행하고 있었으며, 열구전색은 각각 6.8%, 6.9%에서 시행하였다. 치과치료를 시행하고 있는 입소시설과 특수학교에서는 각각 84.2%, 39.2%이었고, 입소시설에서 치료를 받기 위해 이용하는 곳은 치과의원(60.2%), 보건소(16.8%), 자원봉사자(15.3%), 대학병원(1.0%) 등이었다. 치료를 위해 치과의원에 방문하여 치료를 거부당한 경험이 있는 응답자는 17.7%이었다. 주요어 : 장애인, 입소시설, 특수학교, 정기구강검진, 우식예방, 치과치료. The purpose of study was to investigate the oral health care status in institutions and special schools for the disabled in Korea. Nurses in 123 institutions and nurse-teachers in 102 special schools were asked to fill questionnaires regarding periodic oral examination. preventive dental programs, and dental treatment. The results of this study were as follow. 1.56.8% of institutions implemented regular oral examinations and all of special schools did it twice a year. 2.Preventive programs for dental caries were done in 69.1% of the institutions and 86.3% of the special schools. Programs included regular toothbrushing and dental health education. 3.Dental treatment was done in 84.2% of the institutions and 39.2% of the special schools. Institutions utilized private dental clinics(60.2%), public health centers(16.8%), volunteers(15.3%), and dental hospitals. 4.17.7% of the institutions experienced the refusal to treat the disabled by private dental clinics.

구개부에 발생한 다형선종의 처치

하주원,백승,송종운,박충열,이용욱,박홍주,오희균,유선열,김옥준 大韓顎顔面成形再建外科學會 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.6

Pleomorphic adenoma of the palate is the most common of all intraoral salivary tumors. It can occur at any age but it presents most commonly in the 40∼60 age group, and there is no significant sex preponderance. It grows slowly and is usually painless, firm, well-circumscribed nodule. Because of high rate of recurrence, extra-capsular excision including the overlying mucosa and margin of normal tissue is recommended. We report 10 cases of palatal pelomorphic adenoma which have been successfully treated by extra-capsular excision. The surgical defects smaller than 3㎝ in diameter were covered with palatal acrylic splint for the secondary healing. The larger defects were repaired using palatal island flap in 3 cases, rotation flap and buccal fat graft in each 1 case. No patient showed any recurrence or malignant change during the mean follow-up period of 4 years and 9 months. These repair methods seem to be simple, reliable and uncomplicated procedures in the palatal surgical defects.

알코올의 섭취가 흰쥐의 혈액과 간의 지질대사에 미치는 영향

이명숙,김영연,김효숙,김매하,전진순,서진숙,송선미,양영재,윤원손,이미라,이효영,정승현 誠信女子大學校 生活文化硏究所 2004 生活文化硏究 Vol.18 No.-

To investigate the effects of ethanol on the lipid metabolism in blood and liver, twenty one male Sprague Dawley rats had orally taken the 25% alcohol and 50% alcohol by 5g per Kg of weight during 3 weeks after the adjusting period. For the energy balance, 85% sucrose and 45% sucrose was added in control group and 25% alcohol group each. The weight was reduced by alcohol treatment according to the levels, otherwise the weight of liver and heart was little increased in alcohol groups rather than in control without significance. Moreover, RBC, WBC, hemoglobin and hematocrit were increased by alcohol treatment according to the levels without significance. Otherwise, adjusted bilirubin levels by 100g of weight was significantly increased by alcohol treatment dose dependently. Alcohol induced RBC degradation and increased circulated bilirubin because of liver damage. For blood lipid profiles, blood cholesterol was increased in 50% of alcohol group compared to that of 25% and control groups, otherwise, blood triglycerides (TG) was increased by 30% in 25% alcohol groups rather than in control but not significantly different. The hepatic lipid composition, cholesterol levels in alcohol treatment groups was lower than those in control. The hepatic TG was not influenced by alcohol treatment. The two reasons of decreasing hepatic lipids were suggested by 85% sucrose of control for energy balance more synthesized cholesterol and TG than those in 25 or 50% alcohol groups, and by cholesterol and TG could not be synthesized because of liver damage from alcohol.

텅스텐-Amine 錯物의 合成과 赤外線分光學的 및 熱分析的 調査

李善行 慶北大學校 師範大學 1975 敎育硏究誌 Vol.17 No.-

New tungsten complexes of WCl_4A_2 and WCl_4(NHPh_2)_3 have been prepared without reducing agents in acetone solution. The compositions of the tungsten-amine complexes were estimated from the elemental analysis for tungsten, chlorine, and nitrogen and by the infrared spec-trophotometry and thermal analysis. (A=Aniline, NHPh_2=diphenylamine)

氣體一液體 크로마토그래피에 의한 C_1-C_5 탄화수소류의 同時分析과 그 適用

李善行,李華心,徐幀起 경북대학교 과학교육연구소 1989 科學敎育硏究誌 Vol.13 No.-

The 18 components of C_1-C_5 hydrocarbons were well separated on a single, packed column operated around 40℃ within 20 min. The chromatographic column is 25% sebaconitrile/chromosorb P-AW(10m x 0.3㎝, 60-80 mesh). The optimum flow rate was determined by making a simple Van Deemter plot of the number of theoretical plates VS. Iinear gas velocity. The most efficient flow-rate of N_2 carrier gas was at 35㎖/min, and the mumber of theoretical plates was 5,000-10,000. The linearity of calibration curves were checked ranging ppm to % concentration of CH_4 and C_3 H_8. Peak area was used for quantitating the C_1 hydrocarbon through C_5 hydrocarbons, and relative standard deviations of 10 measures were less than 2.1%.

지양호의 오염원 및 수질 조사

하호성,서정윤,진종석,이근석 경상대학교 환경보전연구소 1994 環境保全硏究所報 Vol.2 No.1

The upper area of the Chinyang Lake was devided into four segments, the Gyeongho River, the Yangcheon River, the Deokcheon River and the vicinity of the Chinyang Lake. The water pollution sources and the water quality of four segments were investigated and evaluated. This region was composed of a Dong in a city and 141 Ries in 6 Guns except for Yurunggun and Namwongun. Population density is low in all area except for Hamyang Up and Sancheong Up. Population is 84.903(58%) in the vicinity of the Gyeongho River, 26,093(18%) in the Yangcheon River, 23,039(16%) in the Deokcheon River and 11,468(8%) in the Chinyang Lake. Total occurance of BOD in the upper area of the Chinyang Lake was 45,493 ㎏/day, whose 66% was generated from domestic animals, 17% from the land and 26% from human wastes, respectively. The occurance of BOD in the views of segments analysis showed that 57.1% originated from the vicinity of the Gyeongho River, 28.4% from that of the Yangcheon River, 9.8% from that of the Deokcheon River and 4.8% from that of the Chinyang Lake. The most amount of BOD was discharged to the Gyeongho River, the second to the Deokcheon River and the least to the Chinyang Lake. Total occurance of SS in the upper area of the Chinyang Lake was 137,445 ㎏/day. The most amount of SS was discharged to the Gyeongho River, the second to the Yangcheon River, and the least to the Chinyang Lake. The waste of domestic animal produced the 66% of BOD and the 92% of SS in their total occurance and the 31% of BOD and the 76% of SS in their total discharge. It is concluded that the waste of domestic animal is the important pollution sources, which greatly impact the water quality of the Chinyang Lake. Total nitrogen and phosphorous content in the water of the upstream of the Chinyang Lake were very high. The water quality of the Yangcheon and the Deokcheon River was classified as 4 grade by high pH and numbers of coliform group especially. The high nitrogen content in the upstream of the Gyeongho and the Yangcheon River implies that much nitrogen is originated from the farm land. It is found that the Chinyang Lake is in the process of the eutrophication.

생쥐 중이와 상기도 점막의 섬모세포운동

정하원,오승하,유원석,이강수,모지훈,전상준,김인상,김종선 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.9

고흥 연안의 사구 염생식물 분포와 현존량에 관한 연구

이점숙,이강세,임병선,김하송,이승호 군산대학교 기초과학연구소 2000 基礎科學硏究 Vol.15 No.-

The coastal vegetation was classified by the Braun-Blanquet's method and the biomass was investigated at the wetland of Kohung. The vegetation of the study area was classified with 7 coastal communities as follows: Carex scabrifolia community, Suaeda maritime community, Carex kobomugi community, Tetragonia tetragonoides community, Zoysia sinica community, Vitex rotundifolia community and Phragmites communis community. Biomass was highest in Phragmites communis community(2,087g.d.w./㎡), followed by Zoysia sinica community(741g.d.w./㎡), Suaeda maritime community(535g.d.w./㎡), Vitex rotundifolia community(334g.d.w./㎡), Carex kobomugi community(267g.d.w./㎡), Carex scabrifolia community(236g.d.w./㎡) and lowest in Tetragonia tetragonoides community(195g.d.w./㎡)