월경전불쾌장애에서 특성불안과 섭식행동 증상의관계에 대한 예비연구

하주원,김은진,서호석,김찬형,오강섭 대한신경정신의학회 2016 신경정신의학 Vol.55 No.1

ObjectivesZZThe aim of this study was to examine the correlation between anxiety and premenstrual eating symptoms in premenstrual dysphoric disorder (PMDD). MethodsZZA total of 49 women in the late luteal phase participated in this study. The psychiatric symptoms were assessed by Hamilton Rating Scale for Depression, State Trait Anxiety Inventory, and Menstrual Distress Questionnaire. Eating symptoms were assessed using the Dutch Eating Behavior Questionnaire and cocoa intake experiment. Estradiol, progesterone, and leptin were collected through venous blood. ResultsZZParticipants with PMDD (n=25) showed a higher level of depression (p<0.001), trait anxiety (p=0.012), restrained eating symptoms (p=0.039), and leptin (p=0.015). Among PMDD patients in the luteal phase, trait anxiety showed correlation with emotional eating (p=0.023), alcohol (p=0.022), and unrestricted intake of cocoa (p=0.001). ConclusionZZOur data suggest that PMDD subjects showed higher trait anxiety, depression, and difficulty in eating behavior control. Trait anxiety plays an important role in increased and uncontrolled eating symptoms during the premenstrual period and chronic course of PMDD.

가토에서 Pentoxifylline, Aspirin 및 Heparin이 피부피판의 생존 및 출혈 경향에 미치는 영향

하주원,백승,박홍주,오희균,유선열 전남대학교 치의학연구소 2002 구강과학 Vol.14 No.2

The skin flap, which has been frequently used in the maxillofacial soft tissue defects, can be failed due to insufficient blood supply to the flap. To increase its survival rate, antithrombotic agents has been used. The agents have, however, been restrictly used because of their side effects, such as bleeding tendency or hematoma formation on the operation site. The present study aimed to the effect of pentoxifylline, aspirin, and heparin on the skin flap survival rate and bleeding tendency. Twelve adult white rabbits, weighing about 2.0 kg, were used. Five random skin flaps, which is 1mm thickness, were prepared on the dorsal surface of each rabbit by using 1.5 X 7.5 cm prefabricated template. The animals were divided into 4 groups on the basis of drugs used: Control group, animals in which no drug was given (n=3); Pentoxifylline group, animals in which pentoxifylline was given intraorally (n=3); Aspirin group, animals in which aspirin was given intravenously (n=3). On the 3rd and 7th day after operation, prothrombin time (PT) and activated partial thromboplastin time (aPTT) were measured to evaluate the bleeding tendency. The animals were sacrificed on the 7th day and the mean skin flap survival rate of each group was measured. The results obtained were as follows : 1. The skin flap survival rates of pentoxifylline (84.3±7.9%) and heparin (79.5±10.9%) groups were significantly increased, compared with control group (68.0±10.8%)(ㅔ<0.05). The survival rate of aspirin group (73.0±11.1%) was not increased. 2. In bleeding tendency, the PT values were prolonged in heparin and aspirin groups at the 3rd day after operation (p<0.05), and prolonged in order of heparin group, aspirin group, and pentoxifylline group at the 7th day after operation. The aPPT values in heparin and aspirin groups were also prolonged at the 3rd day after operation (p<0.05), and prolonged in order of Aspirin group. Heparin group, and Pentoxifylline group at the 7th day after operation. These results suggest that pentoxifylline may be the most useful drug among three drugs to increase skin flap survival rate and less increase the bleeding tendency.

공황장애의 수면과 야간 공황발작

하주원,은홍배,임세원,Ha, Ju-Won,Eun, Hong-Bae,Lim, Se-Won 대한수면의학회 2011 수면·정신생리 Vol.18 No.2

Sleep disturbance is a one of common complaints among patients with panic disorder. However, clinicians and researchers did not give much attention to the sleep symptoms of panic disorder yet. Several previous studies suggested that the sleep disturbance in panic disorder is mediated by nocturnal panic attack. In terms of the pathophysiology of panic disorder, nocturnal panic attack seems to be closely associated with the sleep problems in panic disorder. In this article, the authors reviewed various previous studies about sleep of panic disorder and intended to give importance of evaluating sleep disturbances and nocturnal panic attack in panic disorder for both clinical and research purpose.

구개부에 발생한 다형선종의 처치

하주원,백승,송종운,박충열,이용욱,박홍주,오희균,유선열,김옥준 大韓顎顔面成形再建外科學會 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.6

Pleomorphic adenoma of the palate is the most common of all intraoral salivary tumors. It can occur at any age but it presents most commonly in the 40∼60 age group, and there is no significant sex preponderance. It grows slowly and is usually painless, firm, well-circumscribed nodule. Because of high rate of recurrence, extra-capsular excision including the overlying mucosa and margin of normal tissue is recommended. We report 10 cases of palatal pelomorphic adenoma which have been successfully treated by extra-capsular excision. The surgical defects smaller than 3㎝ in diameter were covered with palatal acrylic splint for the secondary healing. The larger defects were repaired using palatal island flap in 3 cases, rotation flap and buccal fat graft in each 1 case. No patient showed any recurrence or malignant change during the mean follow-up period of 4 years and 9 months. These repair methods seem to be simple, reliable and uncomplicated procedures in the palatal surgical defects.

망상과 관련되어 발생한 정신분열병 환자의 Refeeding Syndrome 1예

하주원,권영도,임세원,Ha, Ju-Won,Kwon, Young-Do,Lim, Se-Won 대한생물정신의학회 2008 생물정신의학 Vol.15 No.3

Refeeding syndrome is a life-threatening but treatable condition occurring in any patients with starvation. Electrolyte imbalance, especially hypophosphatemia and fluid shift result in metabolic changes in various systems. The authors reported a case of refeeding syndrome associated with prolonged starvation due to delusion and hallucination in a 38-year-old schizophrenia patient. Hypophosphatemia, hypokalemia, edema and elevation of liver enzyme was occurred despite careful treatment. The symptoms were improved after consistent electrolyte supplement. Close observation and repetitive monitoring are important to prevent refeeding syndrome.

원삼국시대 낙동강 하류 지역의 주거지 전개

하주원 영남고고학회 2018 嶺南考古學 Vol.- No.80

This paper examines the developments of dwelling in the downstream area of the Nakdong River during the Proto-Three Kingdoms Period. In the middle of the 2nd century BC, the period of the 2nd century AD was divided into three stages according to the advanced years suggested by advanced researchers. The first stage is the second stage of the first century BC, and the second stage is the second stage of the second century BC. The third stage consisted of the earthenware pottery as the second century. The area was mainly located in Gimhae, Changwon, and Busan, which are located in the lower part of the Nakdong River, and the relics were set up in a residential area located about 5 km from the tomb site. As a result, the selected dwellings are located in 12 places, and the steps are set up referring to the earthenware excavated from the dwellings and tombs. Residential areas classified by phase were analyzed for attributes by location type, plane type, fire facility, and Columna layout and were derived using a combination of time-specific plane forms, fire facility and Columna layout. The type is set for the following types of dwellings : ' ‘A-a-ㄱ, A-a-ㄷ, A-d-ㄱ, A-d-ㄷ, B-a-ㄷ, B-b1-ㄷ, B-d-ㄷ ’. A local review of the dwelling corresponding to III stage was attempted. As a result, it was found that fire facilities differed and generally preferred wall columna arrangements. The development of the dwelling by level was examined by referring to the natural environment, nearby sites, and documents. The dwelling was located in the hills around the coast and the river to ensure safety, but it seems to have grown by touching the new culture through communication with others. 이 논문은 원삼국시대 낙동강 하류 지역의 주거지 전개양상을 살펴본 것이다. 기원전 2세기 중엽에서 기원후 2세기대에 해당하는 시기를 선진연구자들이 제시한 편년안에 따라 3단계로 구분하였다. Ⅰ단계는 기원전 2 세기 중엽에서 기원전 1세기 전반으로 삼각형점토대토기를 지표로 하였으며, Ⅱ단계는 기원전 1세기 후반에서기원후 2세기 초엽으로 주머니호, 조합식우각형파수부호, 승문타날문을 지표로 설정하였다. Ⅲ단계는 2세기대로 노형토기와 대부호, 격자문이 타날된 토기를 지표로 하였다. 지역은 낙동강 하류에 위치하는 김해, 창원, 부산을 중심으로 하였으며, 유적은 무덤유적에서 5㎞ 내외에 위치하는 주거지를 대상으로 설정하였다. 이에 따라선별된 주거지는 12개소이며, 주거지와 무덤에서 출토된 토기를 참고하여 단계를 설정하였다. 단계별로 분류한주거지는 입지유형, 평면형태, 노 시설, 주혈배치로 나누어 속성을 분석하였으며, 시간적으로 유의미한 평면형태, 노 시설, 주혈배치를 조합하여 형식을 도출하였다. 형식은 ‘A-a-ㄱ, A-a-ㄷ, A-d-ㄱ, A-d-ㄷ, B-a-ㄷ, B-b1-ㄷ, B-d-ㄷ’식의 7가지가 설정되며, Ⅲ단계에 해당하는 주거지에 대하여 지역별 검토를 시도하였다. 그결과 노 시설에서 차이를 보였으며, 공통적으로 벽주식 주혈배치를 선호한 것으로 확인되었다. 단계별 주거지의 전개를 자연환경과 주변유적, 문헌자료 등을 참고하여 살펴보았다. 주거지는 해안 및 하천 주변 구릉에 입지하여 안전을 도모하였으나 외부와 교류를 통하여 새로운 문화를 접하며 성장한 것으로 사료된다.

공황장애 호흡기 아형과 비호흡기 아형의 임상 특성 비교

하주원,임세원,오강섭,Ha, Ju-Won,Lim, Se-Won,Oh, Kang-Seob 대한생물정신의학회 2009 생물정신의학 Vol.16 No.1

Objectives : The goal of this study was to compare the clinical characteristics of panic disorder respiratory subtype(PD-R) and non-respiratory subtype(PD-NR). Methods : 84 patients with panic disorder were enrolled and divided into 2 groups, 29 PD-R and 55 PD-NR. Diagnosis of panic disorder was evaluated using Diagnostic and Statistical Manual of Mental Disorders $4^{th}$ edition and Mini International Neuropsychiatric Interview. They were also measured with Hamilton Rating Scale for Anxiety(HAM-A), Hamilton Rating Scale for Depression(HAM-D), and Panic Disorder Severity Scale (PDSS). Results : PD-R group showed significantly higher scores in PDSS than those of PD-NR group(p=.027). After controlling for the severity of panic disorder and gender, PD-R group showed higher HAM-D and somatic anxiety subscale of HAM-A than those of PD-NR group. Furthermore, results of logistic regression analysis suggested that the somatic anxiety was a possible risk factor of PD-R(OR=1.404,p=0.009). Conclusion : These results suggest that somatic anxiety and depressive symptom would be important clinical characteristics of PD-R.

사회 불안 장애에 대한 한국형 인지행동집단 치료의 효과

하주원,임세원,오강섭 대한신경정신의학회 2010 신경정신의학 Vol.49 No.4

Objectives: The aim of this study was to evaluate the therapeutic effect of Korean-type cognitive behavioral group therapy (CBGT) in the treatment of social anxiety disorder (SAD). Methods: Twenty-nine patients with SAD completed the Korean-type CBGT or SAD. The Koreantype CBGT for SAD is characterized by Korean-culture specific methods such as paradoxical intention,video feedback, and Korean cultural receptivity process on the classical CBGT course. The main outcome measure was a self-report version of the Liebowitz Social Anxiety Scale (LSAS-SR). Results: After the treatment, the total score on the LSAS-SR had significantly improved (15.80±29.14, p=0.006, cohen’s d=0.69), with both fear and avoidance subscales decreased (7.60±13.94, p=0.006 vs. 8.30±16.31, p=0.009, respectively). We also found significant correlation between the effect of the Korean-type CBGT (r=0.414, p=0.026) and the educational level of subjects. Accompanying pharmacotherapy for SAD did not elicit any differences in the treatment response. Conclusion: Our study showed that the Korean-type CBGT was effective in the treatment of SAD patients in reducing both fear and avoidance symptoms.

가토에서 Pentoxifylline, Asprin 및 Heparin이 피부피판의 생존 및 출혈 경향에 미치는 영향

하주원,백승,박홍주,오희균,유선열 大韓顎顔面成形再建外科學會 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.5

The skin flap, which has been frequently used in the maxillofacial soft tissue defects, can be failed due to insufficient blood supply to the flap. To increase its survival rate, antithrombotic agents has been used. The agents have, however, been restrictly used because of their side effects, such as bleeding tendency or hematoma formation on the operation site. The present study aimed to the effect of pentoxifylline, aspirin, and heparin on the skin flap survival rate and bleeding tendency. Twelve adult white rabbits, weighing about 2.0 ㎏, were used. Five random skin flaps, which is 1㎜ thickness, were prepared on the dorsal surface of each rabbit by using 1.5×7.5㎝ prefabricated template. The animals were divided into 4 groups on the basis of drugs used: Control group, animals in which no drug was given (n=3); Pentoxifylline group, animals in which pentoxifylline was given intraorally (n=3); Aspirin group, animals in which aspirin was given intravenously (n=3), and Heparin group, animals in which heparin was given intravenously (n=3). On the 3rd and 7th day after operation, prothrombin time (PT) and activated partial thromboplastin time (aPTT) were measured to evaluate the bleeding tendency. The animals were sacrificed on the 7th day and the mean skin falp survival rate of each group was measured. The results obtained were as follows : The skin flap survival rates of pentoxifylline (84.3±7.9%) and heparin (79.5±10.9%) groups were significantly increased, compared with control group (68.0±10.8%)(P<0.05). The survival rate of aspirin group (73.0±11.1%) was not increased. In bleeding tendency, the PT values were prolonged in heparin and aspirin groups at the 3rd day after operation (P<0.05), and prolonged in order of heparin group, aspirin group, and pentoxifylline group at the 7th day after operation. The aPPT values in heparin and aspirin groups were also prolonged at the 3rd day after operation (P<0.05), and prolonged in order of Aspirin group, Heparin group, and Pentoxifylline group at the 7th day after operation. These results suggest that pentoxifylline may be the most useful drug among three drugs to increase skin falp survival rate and less increase the bleeding tendency.

투석 환자에서 연령에 따른 우울, 불안 및 긍정사고의 차이

노기원,하주원,임세원,이재은,이규백,김향,오강섭,Noh, Ki-Won,Ha, Juwon,Lim, Se-Won,Lee, Jae-Eun,Lee, Kyu-Beck,Kim, Hyang,Oh, Kang-Seob 대한불안의학회 2013 대한불안의학회지 Vol.9 No.1

본 연구는 혈액 투석 중인 성인 환자 집단과 노인 환자 집단 간의 우울, 불안 및 자율신경기능의 차이를 비교해 보고자 하였다. 정신의학적 특징들과 자율신경기능을 비교해보았을 때 만성질환에 견디어 내는 능력에 있어서 노인 환자 집단이 성인 환자 집단에 비해 취약하지 않은 결과를 보였다. 이는 만성질환을 앓고 있는 동일한 상황에서 노인들이 보다 긍정적 사고 경향을 가지고 있는 것과 관련되어 있을 것으로 생각된다. Objective : The end-stage renal disease patients who shared fear of death, functional impairment due to hemodialysis are vulnerable to depression, anxiety and other mental problems. It is possible that their psychiatric characteristics and related autonomic nervous functions have some differences depending on their age. We purpose to find the differences of psychiatric characteristics and related autonomic nervous functions between adult and elderly hemodialysis patients. Methods : Our subjects are end-stage renal disease hemodialysis patients composed of 39 adults (<65 years) and 24 seniors (${\geq}65$ years). Outcome measures included the 17-item Hamilton Rating Scale for Depression, The Hamilton Rating Scale for Anxiety, The Apathy Evaluation Scale and Mini-International Neuropsychiatric Interview by clinician. And subjects fulfilled self-report scale, The Positive thinking scale and The Snaith-Hamilton Pleasure Scale. The autonomic nervous functions are measured by heart rate variability. Results : There are no significant differences in demographic factors between two groups. The 17-item Hamilton Rating Scale for Depression, The Hamilton Rating Scale for Anxiety, The Apathy Evaluation Scale, The Snaith-Hamilton Pleasure Scale and autonomic nervous functions are also not different. But only positive thinking scale is higher in adult hemodialysis group than the elderly (F=5.395, p=0.024). Conclusion : This study compared depression, anxiety and autonomic nervous functions between adult and senior hemodialysis patients. There are no significant differences in psychiatric characteristics and autonomic nervous functions between two groups except positive thinking traits. Senior patients endured their chronic disease similar to adult patients did in spite of their old age. This result suggests that elderly's higher positive thinking traits affect their endurances about the negative situations.