정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

유한요소법을 이용한 수종 심미수복물의 응력 분석

조진희,방몽숙 전남대학교 치과대학 1990 전남치대논문집 Vol.2 No.1

The purpose of this study was to analyze the stresses and displacements of various esthetic restorations and abutment teeth. The finite element models of central incisor were divided into four groups according to the types of restoration. Three load cases were applied ; 1) 45 degrees on the incisal edge, 2) horizontal force on the labial surface, and 3) 26 degrees diagonally on the lingual surface. Material property, geometry, and load conditions of each model were inputed to the two dimensional finite element program and stresses and displacements were analyzed. Results were as follows ; 1. In the cases of porcelain fused gold crown and porcelain laminate veneer, stresses were equally distributed in supporting abutment tooth. The metal coping of porcelain fused gold crown and collarless porcelain fused gold crown functioned as a good stress distributor. 3. When the horizontal load applied, the highest tensile and compressive stresses were seen in the cervical margin of restoration and the dentin of the abutment tooth. 4. The highest displacement of restoration was seen when load was applied at an angle of 26 degrees diagonally in lingual surface of tooth in centric occlusion. 5. The influence of loading direction on the stresses and displacements in the restoration was greater than that of various design. 6. The possibility of fracture was highest in porcelain jacket crown.

심실 조기 수축의 발생 부위 및 연결 간격의 차이에 따른 혈역학적 변화

진승원,김재형,노태호,조은주,김희열,이만영,김종진,박준철,채장성,홍순조,최규보 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.7

공개키 보안 시스템에서 계층 및 동등 레벨 링크만을 이용한 PKI(Public Key Infrastructure)연구

조인준,정희경,김진수 培材大學校 1997 培材論叢 Vol.2 No.-

공개 키 방식의 보안 시스템에서 키 관리는 PKI(Publie Key Infrastructure)를 기반으로 이루어진다. 디렉토리 인증 프레임워크(directory Authentication Framework) 표준으로 X.509가 제시된 후 이를 구현하기 위한 여러 방법들이 제안 되었다. 본 논문에서는 X.509 PKI 표준을 기반으로 동종조직들간의 효율적 보안 서비스제공이 가능한 동등 레벨 링크 PKI(PLL-PKI : Peer Level Link-PKI)를 새롭게 제안 하였다. A asymmetric form of key management is based the PKI(Public Key Infrastructure). After the directory authentication framework published to X. 509, the several methods for this implementation were proposed. In this paper, the PLL-PKI(Peer Level Links-PKI) is newly proposed for efficient security services on the same level of organizations.

임부의 연령에 따른 보완대체요법에 관한 인식 태도 경험 비교 연구

김연진,김지연,노경민,신혜리,유예지,이지민,장희조,정아인,최소정,강숙정,이향연,민혜영 이화여자대학교 간호과학대학 2016 이화간호학회지 Vol.- No.50

Purpose: This study aims to test if the age of pregnant women affects the perception, experience, and attitude towards complementary alternative therapy (CAT), by investigating the perception, experience, and attitude of pregnant women under the age of 35, and above 35 (Advanced Maternal Age). The study will 1) find the general characteristics of pregnant women under and over the age of 35 2) compare the perception, behavior, and experience of pregnant women under and over the age of 35, and 3) find the comparison of the perception, behavior, and experience according to the general characteristics of pregnant women under and over the age of 35. Method: The subjects of this study are composed of 44 women under the age of 35 and 44 women above the age of 35, totaling 88 pregnant women visiting midwiferies, obstetrics and gynecology, and baby fairs in Seoul and Gyeong-Gi area. Data for this study was collected from November 28, 2015 to January 6, 2016 for 40 days. The collected data analyzed mean, standard deviation, t test, ANOVA, and chi-square by using SPSS 23.0. Result Results show that there is a significant difference in the perception, attitude, and experience of the two-sample groups in the use of CAT. The question of “what is most necessary when applying CAT in a hospital clinical environment” for the perception criteria came out with the results of t=9.980, p<.05. For the attitude, results showed that the answers of pregnant women under the age of 35 displayed a more positive attitude towards CAT. (t=2.421, p<.05) Lastly, in the experience section, pregnant women under the age of 35 showed more CAT use than the other sample group. Conclusion Results have shown that there is a difference in the perception, behavior, and experience between the two sample groups. Therefore further research on the efficacy and the adverse effects of CAT needs to be done.

경식도 심초음파도의 Direct Planimetry를 이용하여 측정한 대동맥판 면적의 심박출량 및 좌심실 구출율의 변화에 따른 정확도

진승원,김종진,김희열,박지원,전두수,윤호중,박준철,노태호,채장성,김재형,홍순조,최규보 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

적조생물구제농도의 Sodium Hypochlorite (NaOCl)의 노출에 따른 조피볼락 및 바지락의 조직학적 영향

한조희,김영석,허민도,정해진,박관하 한국환경독성학회 2001 환경독성보건학회지 Vol.16 No.2

In a previous study by Kim et al. (2000), sodium hypochlorite (NaOCI) has been demonstrated to be effective against algae that cause red tides. To secure the environmental safety of the chemical in practical use, effect of NaOC1, at concentrations. required for algicidal activity, on the histology of rockfish and little neck clam was examined. When the animals were exposed to NaOCI at concentrations of 0.5 or 2 ppm for I hr, there was no exposure-associated histological change in either animal. As the experimental exposure condition was set in consideration of the use, our results provide safety information necessary for practical application to marine fields.

14K 금합금과 Ti-Ni-Cu 합금의 납재를 이용한 티타늄 납접부의 인장 및 피로강도

김태조,최진용,원대희,배태성,亘理文夫,大川昭治 대한치과기재학회 1999 대한치과재료학회지 Vol.26 No.3

This study was performed to evaluate the tensile and fatigue strengths of butt joints in titanium soldered with 14K gold and Ti-Ni-Cu alloys. Titanium rods. 30㎜ in length and 3㎜ in dimeter, were polished with #2,000 emery paper and soldered using the electric resistance heating and the infrared radiation heating devices. Tensile test was done with a crosshead speed of 0.5㎜/min, and fatigue test was subjected to a cyclic tensile stress of 30 Hz using tension-type fatigue machine. The solder-matrix interface region and the fracture surfaces were examined by scanning electron microscope. The results obtained were summarized as follows; 1. Mean tensile strength and fatigue strength values of 394.2 MPa and 189.2 MPa were obtained at the joint soldered with 14K gold alloy using the electric resistance heating device. 2. Mean tensile strength and fatigue strength values of 385.2 MPa and 191.2 MPa were obtained at the joint soldered with Ti-Ni-Cu alloy using infrared radiation heating device. 3. Many gas and shrinkage porosities were observed in the both solder joints. 4. partially oxidized surfaces and characteristic striations were observed in the fractured surfaces of the both solder joints.

관상동맥질환 환자에서 스텐트 시술 후 재협착에 관한 연구

강진환,권영주,박상호,한대희,이상철,김명구,변정득,최병조,심규혁,온영근,현민수,김성구 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and aims : In the coronary artery disease, a rate of restenosis was much decreased by placement of coronary stent than when percutaneous transluminal coronary angioplasty has been applied, but there are still important clinical problems of restenosis. There has been many progressive studies about various factors contributed to this restenosis. So, we studied a relation between restenosis after placement of coronary stent in the coronary artery disease and many clinical factors, characteristics of stenotic lesion and procedural factors, and also assessed the restenosis rate of various coronary stents. Methods : Total 58 lesions(46 cases of patients ; man 30, woman 16) were evaluated, which has been performed a follow-up coronary angiography after 6 months (mean 188 days) since coronary stent had been placed. Various stents were implanted and assessed a relation between restenosis and many factors. Results : Of 58 lesions were target stenotic studies, there were 22 of restenotic lesions(37.9%), and the restenosis rate wes statistically significant difference in the relation with diabetes mellitus(p<0.05), group of acute myocardial infarction(p<0.05) among clinical diagnosis of ischemic heart disease(stable angina, unstable angina and acute myocardial infarction) in clinical factors and with high dilation pressure of stent(p<0.05) in procedural factors. When the rate of restenosis was evaluated among implanted stents, it was lowest in the Multilink^(®) stent and highest in the Nir Royal^(®) stent(60%). Conclusion : In this study of restenosis and various factors after placement of stents in the coronary artety disease, factors such as diabetes mellitus, group of acute myocardial infarction and a dilation pressure of stent were significant related with restenosis and the restenosis rate of Multilink^(®) stent was lowest and the highest restenosis rate was of Nir Royal^(®) stent.

국제 스포츠 정보 시스템의 동향 분석

육조영,임정일,윤찬호,이무연,노덕선,배진희,이승훈 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.6

As Follow suggested : The purpose of this study was to consider tendency of modern sports information. today Modernst information system had four areas such as collection, clearance, communication and application So, most literuture of America and Europe was collected, cleared, communicated and apilcated in international sports data base. If we utillited communication circuit properly, we could use sports information beneficently at the laboratory and office. In the future and now, one was that special sports institution needed to obtain Education about sports imformation such as information of specialization, and information of knowledge on both soft phase and hard phase of new media. Although korea used date base of foriegn country efficiently, korea had to make effort to create its own information system and wish to avoid friction of economy and fiction of information.