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관상동맥질환 환자에서 스텐트 시술 후 재협착에 관한 연구
강진환,권영주,박상호,한대희,이상철,김명구,변정득,최병조,심규혁,온영근,현민수,김성구 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2
Background and aims : In the coronary artery disease, a rate of restenosis was much decreased by placement of coronary stent than when percutaneous transluminal coronary angioplasty has been applied, but there are still important clinical problems of restenosis. There has been many progressive studies about various factors contributed to this restenosis. So, we studied a relation between restenosis after placement of coronary stent in the coronary artery disease and many clinical factors, characteristics of stenotic lesion and procedural factors, and also assessed the restenosis rate of various coronary stents. Methods : Total 58 lesions(46 cases of patients ; man 30, woman 16) were evaluated, which has been performed a follow-up coronary angiography after 6 months (mean 188 days) since coronary stent had been placed. Various stents were implanted and assessed a relation between restenosis and many factors. Results : Of 58 lesions were target stenotic studies, there were 22 of restenotic lesions(37.9%), and the restenosis rate wes statistically significant difference in the relation with diabetes mellitus(p<0.05), group of acute myocardial infarction(p<0.05) among clinical diagnosis of ischemic heart disease(stable angina, unstable angina and acute myocardial infarction) in clinical factors and with high dilation pressure of stent(p<0.05) in procedural factors. When the rate of restenosis was evaluated among implanted stents, it was lowest in the Multilink^(®) stent and highest in the Nir Royal^(®) stent(60%). Conclusion : In this study of restenosis and various factors after placement of stents in the coronary artety disease, factors such as diabetes mellitus, group of acute myocardial infarction and a dilation pressure of stent were significant related with restenosis and the restenosis rate of Multilink^(®) stent was lowest and the highest restenosis rate was of Nir Royal^(®) stent.
불균일 클러터 환경에서 다중 표적탐지 성능 향상을 위한 반복 백색화 투영 통계 기법
박혁,강진환,김상효 大韓電子工學會 2012 電子工學會論文誌-SP (Signal processing) Vol.49 No.4
본 논문에서는 불균일한 클러터 환경에서 다중 표적탐지 성능을 향상시키기 위한 변형된 반복 백색화 투영 통계(modified iterative pre-whitening projection statistics: MIPPS) 기법을 제안하였다. MIPPS 기법은 항공기용 레이더에서 사용하는 시공간 적응 처리(space-time adaptive processing) 알고리듬의 불균일성 검출(non-homogeneity detection: NHD) 기법으로 반사신호 세기가 서로 다른 다수의 표적이 근접거리에 혼재되어 있는 환경에서 우수한 표적탐지 성능을 나타낸다. 모의실험을 통해 기존의 다양한 NHD 기법들의 성능을 분석하고, 본 논문에서 제안하는 MIPPS 기법이 강한 표적신호에 의해 야기되는 마스킹 효과(masking effect)를 최소화하면서 반사신호 세기가 약한 표적에 대한 평균 탐지 확률을 향상시킬 수 있음을 확인하였다. In this paper, we propose a modified iterative pre-whitening projection statistics (MIPPS) scheme for improving multi-target detection performance in non-homogeneous clutter environments. As a non-homogeneity detection (NHD) technique of space-time adaptive processing algorithm for airborne radar, the MIPPS scheme improves the average detection probability of weak target when multiple targets with different reflection signal intensities are located in close range. Numerical results show that the conventional NHD schemes suffers from the masking effect by strong targets and clutters and the proposed MIPPS scheme outperforms the conventional schemes with respect to the average detection probability of the weak target at low signal-to-clutter ratio.
심광보,강진환,유우식 한국CDE학회 2023 한국CDE학회 논문집 Vol.28 No.3
The objective of this study is to reduce the size and weight of a manual micro-injection mold- ing machine while increasing the injection capacity through the development of a resin nozzle device and improving temperature variation within the cylinder. By operating the molding machine manually, it eliminates the needs of skilled workers and enables the production of products by the operator's own strength, leading to the advantages of quick and intuitive defect detection and on-site responsiveness. This feature distinguishes it from the drawbacks of 3D printing, such as low precision and slow output speed. The primary target audience for this research includes individuals such as prototype developers or small-scale entrepreneurs who aim to provide fast service to customers or minimize development costs in high-quality, diverse, and small-volume production. Additionally, it is expected to offer a good solution for companies seeking an optimal production system through compact space utilization.
만성 심부전환자의 혈액에서 측정한 Tumor necrosis factor-α 및 Interleukin-6의 임상적 의의
김명구,김성구,박상호,한대희,강진환,변정득,심규혁,최병조,방덕원,온영근,현민수,권영주 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2
Background and objectives: Many conditions are responsible for the pathophysiology and progressive mechanisms of congestive heart failure. More recently, it has also become evidence that another class of biologycally activated molecules generically reffered to as cytokine these are also over expressed in congestive heart failure. Therefore, the purpose of this study was to measure concentrations of tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) in mild to severe symptoms of heart failure and compare their values with those found in normal control and analysed correlation relationship between cytokine level, clinical findings and hemodynamic indicies. Subjects and Methodology: Levels of TNF-α and IL-6 were measured on pulmonary artery during cardiac catheterization in heart failure patients(n=32) and normal subjects(n=8) as well as physical examination and echocardiogram. Cytokines assay were performed on plasma using commercially available ELISA(Enazyme-Linked Immunosorbent Assay) kits. Results: Although the levels of TNF-α and IL-6 tend to increase in congestive heart failure group, the cytokines level was not made significantly statistical difference between congestive heart failure group and controls. When analyzing the correlation between the levels of PCWP(pulmonary capillary wedge pressure) and cytokines(TNF-α, IL-6), respectively, there were statistically significant correlation coefficient 0.32,(p<0.05), 0.39(p<0.01). The cytokine IL-6 and pressure of pulmonary artery were significant correlation.(correlation coefficient 0.36, p<0.02) More significantly, there was correlated with TNF-α and IL-6.(correlation coefficient 0.57, p<0.001) Conclusions: There was tended toward high concentration of TNF-α & IL-6 in congestive heart failure and significant difference for PCWP between TNF-α & IL-6, thus may be correlated with development and progression in congestive heart failure.