정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

폐광미 조립분을 잔골재로 활용한 시멘트 경화체의 특성

윤성진,문경주,소양섭 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)

Presently Metal-Mine waste is filled in the revertment, soil dike and undercurrent facilities of waste matter at piles, but this ways are not fundamental method of waste matter and it takes long time to maintain and it spends a lot of money so that we have need of a effective treatment plan and recycling method. In this study, to predict a effective treatment plan of Metal-mine waste(tailing) that is heaped. We observe tailing's physical and chemical basic features. According to examinate a hydration using tailing we evaluate its utilizable possibility as construction materials.

陸上競技選手들의 心肺機能 特性에 관한 實驗的 硏究

尹良津,魯永泰 釜山大學校 附設 體育科學硏究所 1990 體育科學硏究所 論文集 Vol.6 No.-

This study had been executed to see the characteristics of cardiopulmonary function for runners. For this study II male college runners had become the objective of comparison and analysis, all of whom were spinters, middle and long distance runners. For the purpose of the test we had practiced a gradual increasing load test by means of treadmill. The result is as follows; 1. In all out time, a group of middle distance runners among the runners who were mobilized for this study were the most excellent in performing their abilities of the endurance training; i. e 126.0±122.47sec, on the other hand a group of long distance runners were inferior to those of the former; i. e 123.0±162.94sec. Therefore this study proved that there were few excellent long distance college runners in Pusan. 2. In H.Rmax, all three groups increased highly without a wide difference than rest; i. e group of sprinters, 193.25±3.42beats/min, i. e group of middle distance runners, 191.67±8.38beats/min, i. e group of long distance runners, 189.75±3.34beats/min 3. Concerning cardiopulmonary function, generally a group of middle distance runners was excellent in aerobic capacity, and a group of long distance runners was rather excellent than that of middle distance runners in ??, VOc₂max(㎖/kg/min) on the other hand a group of sprinters was higher than that of long distance runners in VO₂max(ℓ/min).

폴리에스테르 모르타르용 충전재로서 금속광산 폐광미의 활용 연구

윤성진,최낙운,문경주,소양섭 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2

The purpose of this study is to examine the basic properties of polyester mortars using fine tailing(FT) as a filler. The FT is obtained by centrifugal separation of tailing(TA), and checked for basic properties of shape, particle size distribution, chemical composition, resin absorption. Polyester mortars with FT and ground calcium carbonate(GC) are tested for working life, flexural and compressive strengths. The test results showed that FT has much the same properties as GC in the shape, size and resin absorption. The working life of the polyester mortars is lengthen with an increase in the filter/binder ratio. The polyester mortars with a filter/binder ratio of 1.0 have the maximum flexural and compressive strengths.

당뇨병환자에서 게이트심장혈액풀신티그라피를 이용한 심기능 평가

윤상임,송치운,이진홍,안미애,성기양,송민호,이강욱,신영태,김영건,노흥규 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

Major cardiovascular complications of diabetes are coronary atherosclerosis, diabetic dilated cardiomyopathy, autonomic neuropathy and those are major causes of morbidity and mortality in diabetic patients. Gated blood pool heart scan is noninvasive and useful method for evaluation of functional status of heart in diabetics. We evaluated 52 patients with diabetes and divided 3 groups. Group 1 were 11 patients without proteinuria or with proteinuria less than 550mng during 24 hours. Group 2 were 9 patients with proteinuria more than 550mg during 24 hours and group 3 were 32 patients with endstage renal diasese due to diabetes. We performed 99mTc-HSA cardiac gated blood pool scan and used left ventricular ejection fraction(LVEF), peak ejection rate(PEF) to indices of LV systolic function and peak filling rate(PER) to index of LV diastolic function. The results were follows : 1) LVEF, PER were significantly lower in diabetics with ESRD than diabetics without ESRD, but there were no significant difference between normal controls and diabetics without ESRD 2) PFR was significantly lower in diabetics than normal controls, but there were no significant differences in diabetics with or without nephropathy. 3) There were negative correlation between PER, PFR and duration of diabetes. On the basis of results, PFR is a LV functional index of GBPS which can disclose early change of LV dysfunction in patients with diabetes.

벼 생육중기 및 출수기 태풍 "올가" 건풍에 의한 엽신 피해의 품종간 차이와 수량 및 품질 변화

윤영환,김정곤,정남진,곽강수,강양순 한국국제농업개발학회 2003 韓國國際農業開發學會誌 Vol.15 No.4

1999년 8월3일~8월4일간 태풍 올가 도래시 건풍에 의한 생육중기 엽신 피해의 품종간 차이와 출수기 이삭 갈변에 따른 수량 및 품질에 미치는 영향을 조사하여 다음과 같은 결과를 얻었다. 1. 잎의 증산량 및 수분저하속도가 클수록, 잎이 길이가 길고 폭이 넓을수록 엽신의 피해정도가 컸다. 2. 이삭의 피해 정도가 증가될수록 임실 및 등숙비율은 현저히 낮아지는 경향이며, 쌀 수량은 무피해 대비 피해 3~5는 14~16%, 피해 7은 28%, 피해 9는 48% 감수하였다. 3. 이삭의 피해 정도별 백미 완전미 비율은 피해 정도가 클수록 감소를 보였으며 피해 0~3에서 63~65%, 피해 5~9에서 42~58%의 분포를 보였다. 4. 이삭의 피해정도가 증가할수록 백도 및 색도치가 낮아지며, 단백질 함량은 증가하고 식미치는 저하하는 경향을 보였다. This study was carried out to characterize the influence of dry wind by typhoon "Olga" during Aug. 3~Aug. 4, 1999 on the rice plant(Oryza sativa L.). For the purpose, the affection of the dry wind during the mid-growing stage and heading stage on the leaf damage, yield and rice quality were investigated. The extent of the leaf damage increased with the increase of leaf size and transpiration rate, and also with the decrease of moisture content in the leaves. The percentage of fertile grain decreased in proportion to the increase of the extent of the panicle damage. Compared with none-damaged rice plants in the panicle, the milled rice yield decreased by 14~16% in the degree 3~5 of the panicle damage, and 28~48% in the degree 7~9. The percentage of head rice was the same in the both milled and brown rice in the degree 0~3 of the panicle damage. Above the degree 5, however, it decreased with the increase of the panicle damage. The whiteness and lightness decreased in proportion to the increase of the degree in the unhulled, brown and milled rice. And, there was a tendency that the protein content in the milled rice increased but eating quality decreased with the increase of the panicle damage.

항정신병약물로 야기되는 초과민성 정신병에 관한 연구

양동균,윤진상,이형영 大韓神經精神醫學會 1989 신경정신의학 Vol.28 No.2

Chronic antipsychotic treatment can induce tardive dyskinesia and supersensitivity psychosis, and these may be explained by supersensitivity phenomena of the dopamine receptor in the brain. This study was conducted to compare the clinical characteristics between tardive dyskinesia and supersensitivity psychosis in schizophrenia. The subjects of the study were composed of 8 schizophrenics with tardive dyskinesia(TD ), 10 schizophrenics with supersensitivity psychosis(SP), and 5 schizophrenics with both syndromes(TD with SP). They all had been treated with antipsychotics. We compared the difference in general and antipsychoti-related characteristics among the three groups. The results are as follows : 1) In the comparison of general characteristics ; There was a significant difference in the number of hospitalizations among the three groups. The number of hospitalizations was most frequent in SP group, and this was followed by TD with SP group(P<0.05). There was also a significant difference in the length of hospitalization : the longest in SP group and the shortest in TD group. Among the schizophrenic subtypes by Andreason-0lsen's criteria, the number of positive schizophrenics were significantly greater in SP and TD with SP group than in TD group(P<O.05) . 2) In the comparison of antipsychotic-related characteristics : There was a significant difference in the current antipsychotic dose among the three groups. The current antipsychotic dose was highest in SP group and this was followed by TD with SP group(P<0.05). The therapeutic response to antipsychotics was significantly better in SP group than in TD group, and the serum prolactin level was significantly higher in SP group than in TD group, and the serum prolactin level was significantly higher in SP group than in TD group(P<0.05; respectively) 3) Regardless TD, if SP was present, the serum prolactin level was significantly correlated to the current antipsychotic dose(P<0.05). 4) But, there was no significant difference in mean age, age of onset, duration, schizophrenic subtype by DSM-Ⅲ criteria, duration of antipsychotic treatment, prognosis, and antipsychotic potency among the three group.

지역사회거주 노인에서 한국어판 세계보건기구 장애평가조사표의 개반

윤진상,김재민,신일선,양수진,정태길,이형영 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.1

효과적인 다차원 분석을 지원하는 스트레드시트 방식의 OLAP 인터페이스 설계 및 구현

윤민희,김진호,문양세 강원대학교 정보통신연구소 2006 정보통신논문지 Vol.10 No.-

OLAP systems support effectively data analysis over a large volume of business data to make decisions for an enterprise. In order to process data analysis efficiently, OLAP systems pre-compute the summary of business data over various dimensions and store them into data warehouses. Several specialized tools have been developed to display and to browse the results of complex analytical queries on data warehouses. In this paper, we developed a spreadsheet-like tool to support OLAP operations and to browse the results of analytical queries. Spreadsheet is one of the most popular and user-friendly data analysis tool. It also has lots of advantages, which is interactive, easy to learn, etc. Thus this paper implemented an OLAP tool using spreadsheet-style interface to analyze large OLAP data on World-Wide Web. Through this tool, users can process OLAP activities easily and effectively by using the same ways as well-known shreadsheet tools like Microsoft Excel.

成人男子의 體格, 身體構成 및 上腕의 方向別 筋力에 관한 硏究

梁點紅,尹良津,徐國段 부산대학교 사범대학 1991 교사교육연구 Vol.22 No.-