폐경기후 골다공증의 약물요법

노흥규,송치운,이진홍,안미애,송민호 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

Postmenopausal osteoporosis is an enormous public health problem. Estrogens, and various drugs were developed and used for prevention and treatment of postmenopausal bone loss. In this study, We evaluated the effects of cycloprogynova, cyclofenil and ipriflavone on postmenopausal bone loss. Fourty post menopausal women were divided into 3 groups by treatment modalities Cyclofenil group (groupl), Cycloprogynova group(group 2) and Ipriflavone group(group 3). Basal bone mineral densities in all subjects were determined by DEXA(Dual Energy X-ray Absorptiometry) and those were compared with bone mineral densities after medication. The durations of medication in all groups were showed no statistical difference, group 1 11.4 ± 3.4 months, group 2 10.6 ± 3.9 months, group 3 12.9 ± 3.4 months. The patients of group 2 showed significant increase in bone mineral densities and the patients of group 1 and group 3 revealed no significant bone loss on paired T-test. Comparing with rates of bone loss in normal Korean postmenopausal women, the rates of bone loss in all subjects were effectively retarded. The significant bone loss (above longterm intertest coeffcient of variation) was noted in 8 patients out of 23 subjects in group 1, in 9 patietns out of 11 subjects in group 2 and in 2 patients out of 6 subjects in group 3. In conclusion, estrogen/progesteron(Cycloprogynova) replacemnt therapy showed most prominent bone preserving effect and Cyclofenil and Ipriflavone also effectively delays shorterm bone loss in postmenopausal women.

방사면역측정법의 원리와 임상적 응용

노흥규 한국의학사 1985 診斷과治療 Vol.5 No.5

만성갑상선염에서 항갑상선항체의 출현율에 관한 연구

노흥규,전병숙 충남대학교 의과대학 지역사회의학연구소 1982 충남의대잡지 Vol.9 No.2

To evaluate the diagnostic significance of thyroid autoantibodies in chronic lymphocytic thyroiditis, the serum anti-thyroglobulin antibody and anti-microsomal antibody were detected in 48 cases of chronic lymphocytic thyroiditis by RIA and TRC agglutination method, and compared with those of Graves' disease, simple goiter, thyroid cancer and adenomatous goiter treated at the Dept. of Internal Medicine, CNUH, since Oct. 1981 till Nov. 1982. The results were as follows: 1. The serum TG-Ab was positive in 47.9% of chronic thyroiditis, 40% in Graves' disease and 5.3% in simple goiter, whereas the serum MC-Ab was positive in 84.6% in Graves' disease and 77.1 % in chronic thyroiditis. 2. In 82.9% of 35 cases of chronic thyroiditis, any one of both TG-Ab or MC-Ab was positive. 3. Hypothyroidism were more prevalent in those cases whose antibodies were positive in both two, while euthyroidism in MC-Ab positive only.

연구모델로서 갑상선의 특성과 최근 갑상선학분야의 발전 개요

노흥규 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.3

B형간염 Vaccination후의 혈청 항HBs 항체 양성율에 관한 고찰 : According to the Method of Vaccination and Serologic Test

노흥규,한성필 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.1

To evaluate the positive rate of serum Anti-HBs antibody after vaccinaton for Hepatis B, the authors screened out the serum Anti-HBs Ab by PHA and RIA methods in 377 healthy subjects who finished 3 times of Hepatitis B vaccination. Those were serologically negative for HBsAg and HBsAb before vaccination in mass screening test with PHA test. The results were as follows. 1. The serum Anti-HBs were positive in 76.8% among 254 subjects with either PHA or RIA methods at 16 months after vaccination on hip or triceps muscle at various clinics. 2. In 57 cases who received the vaccine on the gluteal area the Anti-HBs(+) were in 59.6% with PHA and 63.2% with RIA test 12 months after vaccination. 3. In 66 cases who received the vaccine on triceps muscle, the Anti-HBs(+) were in 78. 0% with PHA and 92. 0% with RIA tests 4 months after vaccination at Dept. of Nuclear Medicine, CNUH. With the above results, it would be recommended that the site of injection, the careful handling of the vaccine were important to obtain immunity and the RIA method was much more correct to detect the serum Anti-HBs Antibody.

각종 위장관 질환에서의 빈혈에 관한 연구

노흥규 충남대학교 의과대학 지역사회의학연구소 1979 충남의대잡지 Vol.6 No.2

50 cases of peptic ulcer disease, 19 cases of gastric cancer,. 22 cases of gastritis were analysed clinically in the aspect of anemia and iron metabolism, comparing with 7 cases of liver diseases, 8 cases of intestinal diseases who were complicated with anemia and 15 healthy control group, since Feb. 1979 till Oct. 1979, at the Department of Internal Medicine, CNU Hosp. The results were as follows ; 1. The total observed cases were 56 males(46.7%) and 64 females(53.7%), aging 16-64, in which the peptic ulcer and gastric cancer were prevalent in the older males, while in the female, the age were evenly distributed. 2. Anemia were found in 31 (63.3%) cases of peptic ulcer and 14 cases (73.7%) of gastric cancer, but only 9 cases (40.9%) of gastritis and the degrees of anemia were more severe in the cases who had the history of actual bleeding. 3. The overall mean serum Fe, TIBC and Transferrin Iron Saturation of the disease groups shows no significant differences from the normal control, but in the anemic cases of the disease groups, the above date shows the tendency of low body iron and high TIBC. 4. In the cases of peptic ulcer and gastric cancer who had the history of actual bleeding, the serum iron, TIBC and iron saturation rate shows that of iron deficiency anemia patient of other authors.

급성 일산화탄소중독 환자에서의 혈청 Myoglobin 치

노흥규,신영태,한현석,유철재,안원전 대한내과학회 1986 대한내과학회지 Vol.30 No.2

The serum myoglobin level was measured in 20 patients with acute Co poisoning and 20 healthy control subjects. The patients were classified into 3 groups based on clinical severity of intoxication. Group I included 7 casea with mild symptoms such as headache or exertional dyspnea, group II included 6 cases with moderate degree symptoms such as nauea, vomiting, dizziness, or drowsy mental state and group III included 7 cases with severe symptoms such as stuporous or comatous mental state, convulsion, or shallow respiration and heart rate. The results were as follows: 1) The mean value of serum myoglobin of 20 normal healthy persons was 19.6±0.27ng/ml. 2) The serum myoglobin was slightly increased in mild cases (30.4±4.02) compared to control groups. And in patients with moderate to severe symptoms was showed each significant increase compared with normal controls. The more severe symptoms of acute CO poisoning were presented, the more elevated level of serum myogloin. (moderate; 141.6±55.9, severe; 707.1±1) 3) There was significant relationship between elevated myoglobin and leukocytosis. Hypoxemia was noticed in 3cases with marked elevated level of serum myoglobin. 4) There was no significant relationship between serum myoglobin and BUN and creatinine.

폐경후 여성에서 에스트로겐, 이프리플라본, 칼시토닌 투여에 따른 골대사 표지자의 변화

노흥규,주원찬,한희정,채수흥,송민호 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.2

The measurements of metabolic bone markers are important for assesment of risks of osteoporotic fractures and efficacy of anti-osteoporotic treatment in postmenopausal women. We measured bone mineral densites, serum total alkaline phosphatases, and osteocalcin levels in estrogen replacement group(n=13), lpriflavone group(n=8), Calcitonin gruop(n=8) and untreated group(n=50). We used the dual energy X-ray absorptiometry for measurement of bone mineral densities in vertebra, used the p-nitrophenylphosphate and radioimmunoassay for serum alkaline phosphatase and serum osteocalcin, repectively. We compared the metablic hone markers, serum alkaline phosphatase, and osteocalcin between differrent treatment groups and analyzed the correlation between bone mineral densities with above metahlic bone markers. The treatment groups; estrogen, ipriflavone, and calcitonin groups showed significant low osteocalcin (p<0.05) levels but total alkaline phosphatase levels showed no significant difference compare to untreated group (p>0.05). There were no statistical significance of serum osteocalcin and alkaline phosphatase levels beween Ipriflavonc and untreated control group. Calcitonin group showed significant high alkaline phoshatase levels compare to untreated group(p<0.05) but osteocalcin levels showed no significant difference to untreated group. In conclusion, The biochemical bone markers such total alkaline phosphatase and serum osteocalcin are useful markers for the assesment of anti-osteoporotic treatment efficacy in postmenopausal women and reflect the high bone turnover in untreated postmenopausal women

細菌性 腦膜炎의 臨床的 觀察

盧興圭 충남대학교 의과대학 지역사회의학연구소 1977 충남의대잡지 Vol.4 No.1

A clinical study was done on the 33 cases of bacterial meningitis who were admitted to, the dept. of internal medicine, Chungnam Nat. Univ. Hoap. since Jan. 1974 to Mar. 1977, especially on the aspect of differential diagnosis. The results were as followings: 1. Acute pyogenic meningitis were 13 cases and tuberculous 20 among the 33 cases, in which the most prevalent age group was the 3rd decade without any significant difference in the sex in both diseases. 2. The most frequent symptoms were headche and fever, while the neck stiffness was the most frequent physical finding on admission in bath pyogenic and tuberculous meningitis. 3. In the pyogenic meningitis, the duration since the onset to first visit was 1-10 days but in the tuberculous meningitis, it was much longer, upto 70 days. 4. The degree of leakocytosis in per peripheral blood and the C.S.F. were more severe in the pyogenic than the tuberculous meningitis, but there was no definite statistical significance. 5. In the pyogenic meningitis the differential count of the WBC in C.S.F. shows neut rophlia, while lymphocytosis in the tuberculous meningitis.

갑상선 질환 환자에서 골밀도와 혈청 Osteocalcin 농도의 분석

노흥규,송치운,윤상임,성기양,송민호 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.2

Spontaneous hyperthyroidism and that due to excessive administration of thyroid hormone result in osteopenia. However there has been no general agreement on the incidence of osteopenia in hyperthyroidism or the recovery of the mineral loss after treatment of hyperthyroidism or the recovery of the mineral loss after treatment of hyperthyroidism. We conducted a cross sectional study on the effect of hyperthyroidism and its treatment on vertebral bone mineral density using dual energy x-ray absorptiometry. We measured vertebral bone mineral density, serum Gla protein and serum intact PTH in 21 postmenopausal Graves' patients who maintained euthyroid state with antithyroid drug treatment and in 10 patients with nontoxic nodular goiter that received no suppressive thyroid hormone. Bone mineral densities of lumbar spine in patients with Graves' disease showed no significant decrease compared to patients with nontoxic nodular goiter. The level of serum Gla protein in patients with Graves' disease was significantly higher than that of patients with nodular nontoxic goiter and it was positvely correlated with serum T_3level. The level of serum intact PTH showed no significant difference between both groups of patients with Graves' disease and nodular nontoxic goiter. The serum levels of Gla protein were positively correlated with the values of serum PTH in all patients with Graves' disease and nodular nontoxic goiter. The bone mineral densities of the postmenopausal patients with Graves' disease following induction of euthyroid state with antithyroid drug treatment showed no significant decrease compared to controls.