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Induction of erythroleukaemia by F - MuLV and Purification of Erythropoietin
김정곤 한국유전학회 1986 Genes & Genomics Vol.8 No.1
Friend Murine Leukemia Virus (F-MuLV) is affective against 2-day old new borns in NFS/n Swiss mice. Infected babies suffer from splenomegaly and anemia at the age of 4-5 weeks beyond which the condition worsens and is fatal. However, the spleen size can be reduced by hypertransfusion for 8 weeks. If left alone after this treatment, the spleen enlarges and becomes palpable again. This time the spleen cells are transplantable and inflict the same disease if injected to normal adults. While these leukemic cells were considered to be hormone-independent, addition of erythropoietin (EPO) was found to be essential for maximum growth in culture. Influence of EPO on the in vivo growth of leukemic cells was indicated by our findings that administration of the hormone caused a more severe leukemia and rapid death while, transfusion of red blood cells, which lowers endogenous EPO, led to increased survival of leukemic mice. It is suggested that hormone-associated therapy may be efficacious in the treatment of this and perhaps, other leukemias. Several erythroleukemic cell lines released factors which stimulated erythropoiesis in vivo and in vitro. A simple five step scheme has been devised which allows purification of this erythropoietic activity to apparent homogeneity. The methods employed included lectin affinity chromatography (wheat germ agglutinin), gel filteration (ultro gel ACA 44), ion exchange, hydroxylapatite, and high performance liquid chromatography, Following polyacrylamide gel electrophoresis, biological activity was recovered in an area corresponding to a molecular weight of 35,000 daltons. Silver staining of a polyacrylamide gel after electrophoresis of our most purified preparation revealed a single band of 35,000 daltons.
Blind speech segmentation과 에너지 가중치를 이용한 문장 종속형 화자인식기의 성능 향상
김정곤,김형순,Kim Jung-Gon,Kim Hyung Soon 대한음성학회 2003 말소리 Vol.47 No.-
We propose a new method of generating client models for HMM based text-dependent speaker verification system with only a small amount of training data. To make a client model, statistical methods such as segmental K-means algorithm are widely used, but they do not guarantee the quality or reliability of a model when only limited data are avaliable. In this paper, we propose a blind speech segmentation based on level building DTW algorithm as an alternative method to make a client model with limited data. In addition, considering the fact that voiced sounds have much more speaker-specific information than unvoiced sounds and energy of the former is higher than that of the latter, we also propose a new score evaluation method using the observation probability raised to the power of weighting factor estimated from the normalized log energy. Our experiment shows that the proposed methods are superior to conventional HMM based speaker verification system.
친환경 Ag-SnO<sub>2</sub> 전기접점재료의 분말야금 공정 최적화
김정곤,Kim, Jeong-Gon 한국분말야금학회 2007 한국분말재료학회지 (KPMI) Vol.14 No.5
In a view point of environment, the advanced electric contact material without environmental load element such as cadmium has to be developed. Extensive studies have been carried out on $Ag-SnO_2$ electric contact material as a substitute of Ag-CdO contact materials. In the present study, powder metallurgy including compaction and sintering is introduced to solve the incomplete oxidation problems in manufacturing process of $Ag-SnO_2$ electrical contact material. The $Ag-SnO_2$ contact material, fabricated in this study, was actually set in an electric switchgear of which working voltage is 462V and current is between 25 and 40A, for the purpose of testing its performance. As a result, it exceeded the existing Ag-CdO contact materials in terminal-temperature ascent and main contact resistance.
김정곤,박창일,정재욱,김성곤,Kim, Jung-Gon,Park, Chang-Il,Jung, Jae-Wook,Kim, Seong-Gon 한국재난정보학회 2021 한국재난정보학회 논문집 Vol.17 No.1
Purpose: Traditional markets often have irregular space utilization patterns because the spaces are created and divided as time passed. Internally, there is high risk of fire due to problems such as aging facilities and high-density of stores and externally, there is high risk of fire spread since it is often adjacent to deteriorated residential and commercial facilities. Method: In this paper, on-site investigations were carried out to check fire risk factors and fire spread risk, and fire occurrence and expansion risk factors were investigated for traditional markets in Hwanghak-dong and Dong-daemun by using large-scale fire data from existing traditional markets. Result: As a result of the analysis, there are likely to be various problems such as high fire load and lack of safety awareness due to aging facilities and high-density of stores. In particular, it is necessary to prepare countermeasures because deteriorated residential facilities with narrow alleys around traditional markets have high fire spread. It is situation that while traditional markets mainly are managing for fire and disaster centering on the merchant association, the surrounding residential areas are not properly managed. Conclusion: It is necessary to manage deteriorated residential facilities with traditional markets, also to be linked early warning system and information to evacuate rapidly in case of fire there. 연구목적: 전통시장은 시간적인 차이를 두고 필요에 의하여 공간이 생성 및 구획되어 불규칙적인 공간 활용 패턴을 갖는 경우가 많다. 그 영향으로 내적으로는 시설노후화, 점포의 과밀화 등과 같은 문제로 화재발생 위험성이 높고, 외적으로는 노후 주거 및 상업 시설과 인접한 경우가 많아 화재확산의 위험성이 높다. 연구방법: 본 논문에서는 기존 전통시장 대형화재 자료를 활용하여 황학동과 동대문 일대의 전통시장을 대상으로 화재 위험요인 및 화재 확산 위험성에 대하여 현장조사를 실시하고 화재 발생과 확대 위험요인에 대해 검토하였다. 연구결과: 분석결과, 노후화시설과 점포과밀화로 인한 높은 화재하중 및 안전의식 부재 등과 같은 다양한 문제점이 존재하는 것으로 파악되었다. 특히, 전통시장주변의 좁은 골목과 함께 발달한 노후주거시설은 화재확산 위험성이 매우커서 대책마련이 필요하다. 전통시장은 상인회를 중심으로 화재 및 재난관리를 하는 반면 주변 주거지역은 제대로 관리되고 있지 못하였다. 결론: 전통시장과 함께 주변의 노후주거시설을 함께 관리할 필요가 있으며, 전통시장과 노후주거시설에서 발생한 화재에 대하여 신속한 대피가 가능하도록 조기경보체계와 정보연계가 필요하다.