서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

백서의 복강내에 투여한 Mitomycin-C-Polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

송규상,강대영,최정목,노승무,정경수,오정연,김진향,양준목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

To evaluate the in-vivo effects of mitomycin-C-polyglycolic acid composite(MMC-PGA) the disk: shaped composite were implanted into the peritoneal cavity of the Sprague-Dawley rats. The pathologic changes were examined at various time points up to 12 weeks. Initially the soft tissue around the inserted disks showed capillary congestion at 3 days. Inflammatory infiltrates with foreign body giant cells appeared from the 2nd week and reached peak response at 6-8 weeks. These reaction diminished prominently at 12 weeks. No specific pathologic change was found in the liver, the kidneys, and the heart. The above results suggest that the MMC-PGA composite can serve as a new device for intraperitoneal chemotherapy of various types of cancers.

붕어입 모양 절개를 이용한 미세혈관문합술

송상용,하범준,박영진 大韓成形外科學會 1998 Archives of Plastic Surgery Vol.25 No.7

There are various methods of anastomosing or attaching the two ends of a severed blood vessel together. The most popular method is suturing, but it is tedious and time-consuming, has a tendency to leak between suture sites, and requires special training in microvascular surgery. Other anastomosis methods such as mechanical devices, tissue adhesives, lasers and modified suturing also have problems in achieving easy, reliable and fast anastomosis, and high patency rate. We developed a new eversion method to eliminate some of the current problems by allowing a quicker, simpler, and more reliable method of attachment. Our method consists of fish-mouth incision to the severed ends of vessels parallel to the vascular direction simultaneously accompanied by 2 stitches to the top of the incised vessels to obtain complete eversion and intima-to-intima contact. In this study, four clinical methods of attachments were compared; group 1, conventional interrupted suture, group 2, fish-mouth incision method with fibrin glue, group 3, fish-mouth incision with continuous horizontal mattress suture, group 4, fisy-mouth incision with angulated vascular ligating clips. We compare the patency rate and time required for anastomosis. histological changes(postoperative 1 week, 3 weeks) were also investigated to illustrate the endothelial regeneration, hyaline degeneration, microthrombus, and microaneurysm of anastomosis site. All the groups has similar high patency rate(p > 0.05). But, there was significant difference in anastomosing time among conventional suture method(group 1; average 45 minutes) and other methods(group 2; average 24 minutes, group 4; average 18 minutes). Especially, using fish-mouth incision with ligating clips, we could shorten the anastomosing time extremely. Microscopically, we found the relatively smooth healing surface of the anastomosis site with less hyaline degeneration, microthrombus, and microaneurysm in the groups using fish-mouth incision with fibrin glue and with ligating clip compared to conventional suture group. With fish-mouth incision method, possible advantages include consistent eversion of intima producing a continuous intimal surface within the lumen, tight sealing of the vascular edges, and minimal leakage. Moreover, operative time by using fibrin glue and ligating clip was significantly shorter and the patency rates were similar to the conventional suture method.

Hydroxy Apatite가 피복된 치과매식체의 주위골조직 반응에 관한 조직학적 연구

송준기,허성주,조인호 단국대학교 치의학연구소 1991 논문집 Vol.3 No.-

Even if we can recover the function of mastication, pronunciation and esthetic using the fixed or removable prosthesis in the loss of teeth or hard tissue in the oral cavity, we use several kinds of implants in order to solve the problem which can be occured when we can't install the denture because of excessive bone resorption or psychlogical affairs. At present Titanium implant plays a major role in this field and has osseointegrated. And the study on the modern material is going on, that result in developing and using the implant which is coated with HA, bone induced material. In this, I studied histologically the change of the bone tissue which is occured when three kinds of HA coated implants. Such as Integral, Sustain, Biovent implanted into mandible of dog and got a 8-weeks healing period. I got the conclusion as follows : 1. Most of the implant which is covered with serveral kinds of HA coating implant in bone affter 8 weeks being implanted and has osseointegrated, partially converted into the connective tissue. 2. Biovent formed the connective tissue in the perforated area of inferior alveolar canal and has osseointegrated.

온톨로지 매핑 정보를 이용한 웹 서비스 자동발견

송재경,김도현,변영철,이상준 제주대학교 공과대학 첨단기술연구소 2004 尖端技術硏究所論文集 Vol.15 No.2

Web Service is a new model based on web to offer dynamic information for a user's request. Currently, the web service discovery mechanism is not efficient because it does not support automatic discovery based on the semantics or capabilities of a web service. The language for semantic web service, such as OWL-S, is being developed to express the capability of a web service semantically. Such semantics can support the more flexible discovery of web services. Web service discovery occurs when the provider's description matches to that of requester. But the matching can fail when the ontologies of service description differ from that of the requester although the requester wants that Web Service. In distributed environment service providers develope their semantic web services independently and tend to use their ontologies to describe web services. So a new approach must be required to avoid service discovery failure. In this paper, a method of annotating the query of requester and discovering semantic web services without service discovery failure is proposed.

韓國에 있어서 肝吸蟲症 分布에 관한 疫學的 硏究

宋寅喆,李駿商,林漢鐘 고려대학교 의과대학 1983 고려대 의대 잡지 Vol.20 No.1

Korea, a total number of 19,758 stool specimens were collected from the inhabitants who lived in the basins of main 6 rivers, i.e. the Han River, the Gum River, the Nakdong River, the Mangyong River, the Yongsan River and the Seomjin River. The specimens were examined both by cellophane thick smear method and Stoll's egg counting technique during the period from March 1973 to October 1982. The distribution and infection rates were compared in those of river and non-river sides, and the epidemiological statrs was analysed statistically by the regression equations and catalytic curves with the results obtained from two endemic areas. The results are as follows: 1. High egg positive rates were revealed among the inhabitants in the areas of all above river basins, whereas low egg positive rates were obtained among the inhabitants in the areas apart from the riversides. However, in some areas which are not directly connected with the rivers, relatively high rates of Clonorchis infection were also observed. 2. The infection rates of Clonorchis sinensis by sex age were shown significantly different among the population in the most of these studied areas. The rates for males were significantly higher than that for females, and the rates were increased by the higher age groups up to 40 to 59 years old. However in the high endemic areas such as Kimhae the infection rates of both sexes were almost parallel and practically similar high rates revealed in all age groups for 20 to 60 years old. 3. The mean E.P.G. count of Clonorchis infection in the surveyed areas was found higher in the areas which shown as higher infection rates. The degree of the intensity of Clonorchis infection by E,P.G. counts was evenly distributed to heavy and very heavy infections as well light and moderate infections in the areas showed high infection rates. 4. The intensity of endemicity in all surveyed areas was compared with the regression equations calculated with the cumulative percentages of E.P.G. counts. 5. For the quantitative analysis of epidemiology of clonorchiasis in Kimhae and Pyongtrek areas, special type of simple catalytic model was applied to the age prevalence rates revealed through stool examination for Clonorchis eggs and intradermal test for the detection of positive reactors. 6. It was suggested that the two-stage catalytic was well fitted to the prevalince rates by sex and age in the egg positive cases in Kimhae and Pyongtaek areas, and the calculation lead to the equation y=1.042(e-^(0.003t)-e^(-0.074t), a=0.074〉b=0.003 in Kimhae area, and y=1.412(e^(-0.024t)-e^(-0.041t), a=0.024〈b=0.041 in Pyongtaed area. 7. In the high endemic area such as Kimhae, the tendency of familial aggregation was not recognized by statistical analysis. In this area, the mean E.P.C. obtained from same persons in 1973 were compared and descussed statistically.

최종당화산물이 혈관평활근세포 증식에 미치는 영향 및 그 기전

송진영,임성희,서지영,조영중,유형준,박성우,임자혜 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.26 No.2

연구배경:혈관평활근세포의 증식은 죽상경화증의 주된 변화로 당뇨병과 동반된 죽상경화증에서도 관찰된다. 최종당화산물(AGE)은 NO와 결합함으로써 이의 혈관평활근세포 증식 억제 작용을 차단한다고 알려져 있으나. 혈관평활근세포에도 최종당솨산물에 대한 수용체가 발견되었음에도 불구하고 최종당화산물이 혈관평활근세포의 증식에 직접 미치는 영향 및 기전에 대하여는 잘 알려져 있지 않다. 본 연구에서는 최종당화산물이 백서 대동맥에서 분리 배양한 혈관평활근세포 증식에 미치는 영향 및 그 기전을 알아 보고자 하였다. 방법:혈관평활근세포는 male Sprague­Dawley 백서의 대동맥에서 분리하여 10% FBS­DMEM 내에서 배양하였고, 세포 증식 실험은 24­well plate에 well당 1×10⁴세포를 0.1% FBS­DMEM(with or without AGE­BSA, anti­AGE antibody, MAP kinase inhibitor, antioxidants)내에서 배양하여 48시간후 MTT assay로 세포 증식을 측정하였다. 결과:AGE­BSA를 2.5, 5.0㎍/mL 농도로 첨가한 경우 혈과평활근세포 수는 AGE­BSA를 가하지 않은 대조군에 비해 1.5, 1.6배 증가되었다. 이러한 AGE­BSA에 의한 혈관평활근세포 증식 촉진 효과는 anti­AGE antibody(100㎍/mL), MAP kinase 억제제인 PD98509(50μM)및 항산화제인 N­acetylcysteine(1μM)이나 butylated hydroxyanisole(10μM)에 의해 차단되었다. 결론:이러한 결과는 AGE가 혈관평활근세포에서 산화 스트레스의 변화를 초래하고 MAP kinase 경로를 통해 혈관평활근세포의 증식 및 죽상경화증의 발생에 기여할 가능성을 뒷받침한다. Background : Diabetes mellitus is an epidemiologically proven risk factor for atherosclerosis. Advanced glycation end products (AGE) have been implicated in the pathogenesis of many diabetic vascular complications. AGE not only change the physicochemical properties of proteins, but also AGE on the vascular smooth muscle cells (VSMCs) have not been fully explained despite of presence of an AGE-receptor on the VSMCs. Methods : In order to test whether AGE promotes atherosclerosis by stimulation of the growth promoting signal transduction pathways in the VSMCs, the proliferation of rat aortic VSMCs cultured in the presence of AGE-BSA with/without anti-AGE antibodies, the MAP kinase inhibitor and antioxidants was measured. The VSMCs (1x10^4 cells in 24-well plates) isolated from the aorta of Sprague-Dawley rats were incubated for 48 hours and the proliferation was assessed by a MTT assay. Results : AGE-BSA increased the proliferation of rat aortic VSMCs by 1.5~1.6 fold at the ㎍/mL level. The stimulatory effect of AGE-BSA (5㎍/mL) was blocked by the anti-AGE antibodies (100 ㎍/mL). PD98059 at 50? inhibited the AGE-BSA-induced VSMC proliferative response of the VSMCs to AGE. AGE-BSA-induced VSMC proliferation was also attenuated by N-acetylcysteine (1?) and butylated hydroxyanisole (10?), implying that increased intracellular oxidative stress might be also involved in the proliferative response to AGE. Conclusion : These results suggest AGE play a role in diabetic atherosclerosis by stimulating of the growth promoting signal transduction pathways in the VSMCs (J Kor Diabetes 26:91~99, 2002).

모노 펄스 레이더 시스템에서 선전원 배열 안테나의 차패턴 합성을 위한 최적화 방법

송창현,전상재,박의준 금오공과대학교 2005 論文集 Vol.26 No.-

In this paper, an optimization method is presented to directly synthesize the desired line source difference patterns from the well-known Taylor sum pattern formula by developing the generally updated Fourier transform pair, and then the line source distributions are numerically adapted to the specified difference patterns by using an appropriate iterative sampling method.

폴리에틸렌 코팅 가스배관의 광범위탐상을 위한 유도초음파 모드 선정 및 결함 검출

송성진,박준수,신현재 한국비파괴검사학회 2001 한국비파괴검사학회지 Vol.21 No.4

폴리에틸렌 코팅 가스배관의 결함탐상을 위해 광범위 비파괴탐상기법인 유도초음파를 적용하였다. 가스배관의 내경은 190.7mm, 두께는 5.3mm, 그리고 바깥 표면은 1.9±0.5mm의 폴리에틸렌 층으로 코팅되어 있다. 폴리에틸렌 코팅 배관의 외면에 0.5MHz 탐촉자와 가변각 웨지를 사용하여, 비축대성 유도초음파를 가진 시겼다. 주파수와 위상속도 조정을 통하여 가스배관의 결함 탐상을 위한 적절한 모드를 찾아내고, 모드의 특성을 단시간 퓨리어 변환을 이용하여 분석하였다. 결함탐상 결과를 두께 손실 및 원통형 관통결함에 대한 인위결함에 대해 나타내었다. 그리고 가스배관에 인위적으로 삽입한 두께 손실과 원통형 관통결함에 대한 검출 성능을 평가하였다. Ultrasonic guided waves were explored to apply them to the long range inspection of polyethylene coated steel gas pipes. The steel pipes have such dimensions as 190.7mm inside diameter and 5.3mm thickness. The outside surface of the pipe is coated by a polyethylene layer of 1.9±0.5mm thickness. Non-axisymmetric guided waves were excited on the outside surface of the polyethylene coated pipe by using a 0.5 MHz transducer with a variable angle shoe. Frequency and phase velocity tuning was used to find optimum guided wave modes for the inspection. The dispersive characteristics of the modes were analyzed in time-frequency representation obtained by short time Fourier transforms. Sample results were presented for artificial defects such as wall thinning and hole.

규칙기반 CC/PP 프로파일 생성 방법

송재경,변영철,이상준 제주대학교 공과대학 첨단기술연구소 2005 尖端技術硏究所論文集 Vol.16 No.2

In the ubiquitous computing environment, service providers should able to deliver their services to various devices, such as PDA, Smart Phone, Telematics devices. For this purpose, W3C announced 'Composite Capabilities / Preference Profile (CC/PP) Standard' for delivery-context description. At present, only a small number of mobile phone supports the CC/PP standard, But most of contents servers do not. In this paper, by analyzing request headers which are received from various ubiquitous devices, a rule-based CC/PP profiling method in ubiquitous environment is developed. Service providers can use these profiles for providing optimized services to the various devices which have different capabilities.