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박준수,최두호,박희철,박원,유정일,박영석 대한방사선종양학회 2014 Radiation Oncology Journal Vol.32 No.2
To determine the prognostic and predictive value of liver volume in colorectal cancer patients with unresectable liver metastases. Materials and Methods: Sixteen patients received whole liver radiotherapy (WLRT) between January 1997 and June 2013. A total dose of 21 Gy was delivered in 7 fractions. Results: The median survival time after WLRT was 9 weeks. In univariate analysis, performance status, serum albumin and total bilirubin level, liver volume and extrahepatic metastases were associated with survival. The mean liver volume was significantly different between subgroups with and without pain relief (3,097 and 4,739 mL, respectively; p = 0.002). Conclusion: A larger liver volume is a poor prognostic factor for survival and also a negative predictive factor for response to WLRT. If patients who are referred for WLRT have large liver volume, they should be informed of the poor prognosis and should be closely observed during and after WLRT.
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Predictive Characteristics of Malignant Pheochromocytoma
박준수,송채린,박명찬,유상준,박세준,홍석준,홍범식,김청수,안한종 대한비뇨의학회 2011 Investigative and Clinical Urology Vol.52 No.4
Purpose: The prognosis of patients with malignant pheochromocytoma is poor, but the predictive factors are not well understood. We aimed to identify the clinical characteristics predictive of malignancy after initial surgical removal in patients with pheochromocytoma. Materials and Methods: We retrospectively reviewed the records of 152 patients diagnosed with pheochromocytoma, including 5 (3.3%) with metastasis at the time of the initial surgical excision and 12 (7.9%) who developed metastasis during follow-up. To determine the factors predictive of malignancy, we compared clinical, radiographical, and urinary chemical findings between patients with benign and malignant disease. Mean follow-up was 41.5 months (range, 0.9-298 months) after surgery. Results: Malignant tumors were significantly larger than benign tumors (11.1±4.0 cm vs. 6.2±3.4 cm, p<0.001), and postoperative persistence of arterial hypertension was more frequent after removal of malignant than benign tumors (p=0.001). Among the 147 patients without metastatic disease at diagnosis, those who developed metastasis had significantly lower concentrations of urinary catecholamine metabolites per unit of tumor, including vanillylmandelic acid (1.2 vs. 3.7 mg/day/cm, p=0.049), epinephrine (4.5 vs. 168.9 mg/day/cm, p=0.008), and norepinephrine (13.1 vs. 121.8 mg/day/cm, p<0.001). The overall 5-year metastasis-free survival rate was 84.4% and was significantly higher in patients with smaller tumors (≤5.5 vs. >5.5 cm; 90.6% vs. 81.2%, p=0.025) and higher 24-hour secretion of vanillylmandelic acid (>2.1 vs. ≤2.1 mg/ day/cm; 94.9% vs. 70.9%, p=0.019). Conclusions: Large tumor size (>5.5 cm) and minimally elevated 24-hour urinary vanillylmandelic acid (≤2.1 mg/day/cm) were significantly associated with a higher probability of a malignant pheochromocytoma portending a lower metastasis-free survival and mandating more rigorous follow-up after surgery.
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강제환기식 모돈사의 여름과 겨울철 암모니아 배출 특성 분석
박준수,박소연,정민웅,서시영,우샘이,황옥화,조슈아나이젤할더,장유나,조광곤 한국대기환경학회 2022 한국대기환경학회지 Vol.38 No.6
In Korea, about 74% of ammonia emission is from livestock manure in the agricultural sector. Ammonia emission control is being more important because it not only harms the health of humans, animals, and plants but also acts as a precursor to generating secondary organic aerosol. Therefore, this study was conducted for 92 days in summer and 74 days in winter, in order to estimate the amount of ammonia emission in the sow house. By collecting data on ammonia concentration, ventilation rate, temperature, and humidity in real-time, the diurnal pattern was identified, and the ammonia emission factor in the gestating sow house was calculated. As a result, the ammonia concentration in the gestating sow house in summer and winter were 3.95~9.80 ppm and 10.50~31.52 ppm, respectively. And ventilation rate was measured in the range of 60.54~104.39 m3/h/pig in summer and 26.61~64.39 m3/h/pig in winter. In this study, the average ammonia emission factors per gestating sow in summer and winter were 7.38 and 16.90 g/day/pig, respectively. Since the emission factor differs depending on the season, it seems necessary to consider the season when evaluating ammonia emission. The results of this study are considered to be useful data for improving the domestic ammonia inventory.
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사우디 라빅발전소 터빈 블레이드 파손 분석기술 현장 적용
박준수,Park, Jun Su 한국전력공사 2021 KEPCO Journal on electric power and energy Vol.7 No.1
한전에서 운영중인 사우디라빅발전소에서 저압터빈 블레이드가 파손되었다. 블레이드의 경우 터빈의 핵심부품으로서 증기를 활용하여 발전기를 회전시켜 전기를 생산하는데 필수 부품이다. 반복적인 사고발생을 예방하기 위해 조직분석, 운전신호 분석등을 활용하여 원인을 규명하였고, 대책을 제시하였다.
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박준수,박순규,신요안,유명식,이원철 대한전자공학회 2007 電子工學會論文誌-SP (Signal processing) Vol.44 No.2
본 논문에서는 최적화 알고리즘의 속도를 향상시킬 수 있는 방안으로 설계자가 원하는 목적함수들의 수렴 범위를 Goal로 설정하여 최적화를 수행하는 GBNSGA(Goal-Pareto based Non-dominated Sorting Genetic Algorithm)를 제안한다. 많은 공학 문제들은 하나의 목표치를 충족하는 해를 찾는 것이 아니라 다수 목적함수들을 충족하는 해를 찾는 것이 일반적이다. 특히, 이러한 목적함수들은 서로 상충적인 관계를 갖는 경우가 대부분이기 때문에 모든 목적함수들을 만족하는 유일해를 찾는 것은 거의 불가능하다. 그 대안으로 일부 목적을 희생하며 설계에 부합되는 최적해를 찾는 파레토(Pareto) 방식의 최적화 알고리즘들에 대한 많은 연구가 진행되었다. 본 논문에서는 이러한 파레토 기반의 최적화 알고리즘들의 성능 향상을 도모하기 위하여 설계자의 목적을 파레토 할당에 반영하는 GBNSGA를 제안하고, 그 성능을 NSGA와 weighted-sum 접근 방식과의 비교를 통해 그 우수성을 검증하였다. This paper proposes a new optimization algorithm prescribed by GBNSGA(Goal-Pareto Based Non-dominated Sorting Genetic Algorithm) whose result satisfies the user's needs and goals to enhance the performance of optimization. Typically, lots of real-world engineering problems encounter simultaneous optimization subject to satisfying prescribed multiple objectives. Unfortunately, since these objectives might be mutually competitive, it is hardly to find a unique solution satisfying every objectives. Instead, many researches have been investigated in order to obtain an optimal solution with sacrificing more than one objectives. This paper introduces a novel optimization scheme named by GBNSGA obeying both goals as well as objectives as possible as it can via allocating candidated solutions on Pareto front, which enhances the performance of Pareto based optimization. The performance of the proposed GBNSGA will be compared with that of the conventional NSGA and weighted-sum approach.
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