정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

이족로봇의 경사면 균형 유지와 보행에 관한 연구

오성남,윤동우,손영익,김갑일,임승철,강환일 명지대학교 산업기술연구소 2007 産業技術硏究所論文集 Vol.26 No.-

This paper aims to provide a way to improve dynamic stability of biped robots against undesirable disturbances and in a slope. By using an angular velocity sensor and an acceleration sensor on its waist, we can make a medium-sized biped robot walk stably in a slope against impulsive disturbances. In addition, it is possible for the robot to walk stably in an unknown slope. The measured signals from the sensor are used for compensating the reference angles of ankle, knee, and pelvis joints. Some experiments show that the stability of the robot is much enhanced by using cheap sensors and a simple algorithm. This work helps biped robots walk more stably in real environments.

경동맥 죽종의 색혈류 도플러 초음파 소견

오연희,김승현,이성우,어경윤 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

한국인의 뇌경색의 가장 중요한 원인은 경동맥 죽종으로 알려져 있다. 저자들은 경동맥 죽종의 복식 초음파 및 색혈류 도플러 초음파영상을 비교·분석 하였다. 죽종 침범의 범위는 총경동맥+내경동맥+외경동맥 혹은 분지부 47.9%, 총경동맥 24.4%, 총경동맥+분지부+내경동맥 11.1%등이었다. 경동맥 협착은 중등도 53.6%, 경도 26.1%, 중도 16.3%, 위험도 3.1%, 완전폐쇠 0.9%. 표면의 형태는 매끄러운 경우 53.1%, 경도 불규칙 41.3%, 심한 불규칙 3.9% 그리고 표면 궤양이 동반된 경우 1.7%였다. 또한 죽종 내부구조의 음영도상 균일한 경우 90.5% 였고 죽종의 음영은 등에코성 40.2% 석회화 25.1%, 저에코서 22.3%등이었다. 결론적으로 복식 초음파와 색혈류 도플러 영상은 경동맥 죽종 진단에 있어서 정확하고 안전한 비침습적인 진단방법이다. Several reports have been documented that carotid atheroma presented as the mostimportant cause of cerebral infarction in Korea. Authors analysed the atheroma imaging of the carotid artery in the patients with cerebral infarction patients using duplex sonography and color flow imaging. The atheroma extents were CCA(common carotid artery)+ICA(intemal carotid artery)+ECA(external carotid artery) or BIF(bifurcation) 47.9%. CCA(common carotid artery) 24.4%, CCA(common carotid artery)+BIF(bifurcation)+ICA(lntemal carotid artery) 11.1 %. The percents of stenosis of carotid arteries were moderate 53.6%, mild 26.1 %. severe 16.3%, critical 3.1 % and occlusive 0.9%. The surface characters were smooth 53.1 %, mild irregular 41.3%, severe irregular 3.9% and ulcerated 1.7%. The atheroma texture was homogenous 90.5%, and the echogenicities of atheroma were isoecboic 40.2%, calcification 25.1 %, hypoechoic 22.3%. We concluded that duplex sonography and color flow imaging were accurate and safe non-invasive method detecting of carotid atheroma.

高學歷 農業人力需給과 卒業生의 進路方向에 關한 硏究

오성삼,강승희 건국대학교 1995 學術誌 Vol.39 No.1

There has been a large influx of Korean society to the agricultural since the last three decades from 1963 to 1993. According to the statistic, Korean population has increased from 27,262,000 to 44,056,000 which means there has been a 106% increase during the years. Like many industrialized countries there has also been a change in the ratio of urban population. It has increased 28.0% in 1960 to 41.1% in 1970, 57.3% 1980, and 74.4% in 1990. There were trends shifting from rural areas to urban areas to seek job markets and better schools. According to the report from the Ministry of Agriculture and fishery, in December, 1994 the population 54.1 million in 1993 is expected to be droped to 31.2 million in the year 2004 which means the rural population ratio of the whole Korean population would decreased from 7.1% to 3.6%. Besides the labor dements in the area SOC and Service industry is also expected to have a very high increase in the near future. This study has set an analytical model Input problems for the college students sellection, Process problem for curriculum contents, Output problems for college garduate supplying, and Context problems like intra and extra social and policy change. This study has pointed out a few facing problems in Korean agricultural colleges in relation to the analytical model. First Agricultural colleges would face a serious shortage of applicants in the near future related from the input problem. As a measure to counter the decrease of applicants for agriculture studies, and to single out qualified students in the educational goals of agricultural studies, special screens for admitioning is needed to develop a seperate admition system for agricultural high school graduates to seek out those who fit the goals of agricultural corteges. Second, the quality of the education must be focused on to come forward in competitive agricultural graduates, instead of the quantity of graduates. Third broader general education in recommended rather than narrowly specialized education for under graduate curriculum. Fourth, to seek high-tech agricultural areas such as agricultural environment studies or life science in relation to agricultural fields, integrating current similar majors or departments in agricultural colleges is needed. Last, it is important to advertize to high school graduates, parents, and high school counselors on what life science is and how it will be high-lighted as a science in the future with easily understandabable explanations.

외상성 뇌손상 환자의 지능 장애와 K-WAIS 소검사내 분산도

오상우,김지영,노승호 圓光大學校 醫科大學 神經精神科學敎室 1997 圓光精神醫學 Vol.13 No.2

본 연구는 외상성 뇌손상 환자의 병전 지능을 추정하여, 추정된 지능을 현재 지능과 비교하고, K-WAIS 소검사내 분산도 분석을 시행하여 인지 기능의 효율성을 평가하고자 하였다. 연구 결과, 외상성 뇌손상 환자 집단은 정신분열증 집단이나 기타 임상 집단의 환자들에 비해 지능이 유의하게 저하되어 있었다. 그러나 소검사내 분산도 분석에서는 외상성 뇌손상 환자 집단이 다른 두 집단보다 인지적 효율성이 더 높았다. In this study, premorbid IQ in patients with traumatic brain injury were estimated and compared with measured IQ, and examined efficiency of cognitive function through K-WAIS intrasubtest scatter analysis. These results suggested that traumatic brain injury patient's IQ were significantly lower than those of the schizophrenia and other psychiatric patients. But traumatic brain injury patient's cognitive efficiency were higher than those of the schizophrenia and other psychiatric patients.

심한 낙타혹(Hump)의 형성을 동반한 제 2 형 막증식성 사구체신염(Dense Deposit Disease) 1예

오희정,유민아,이영숙,김미연,김승정,강덕희,윤견일,최규복,성순희 이화여자대학교 의과대학 2004 EMJ (Ewha medical journal) Vol.27 No.1

Dense deposit disease (DDD), known as type Ⅱ MPGN, is an uncommon form of glomerulonephritis. It is an acquired primary glomerular disease, characterised by electron microscopic evidence of a continous, dense membrane deposition replacing the lamina densa. There is associated alternative pathway complement activation and a C3 nephritic factor maybe present. Patients with dense deposit disease tend to be young at clincal onset and more commonly have persistent nephrotic syndrome, gross hematuria, and acute nephritis episode and persistent depression of the serum complement level. The prognosis of dense deposit disease is worse than that of typeⅠMPGN. We experienced a patient with dense deposit disease that presenting persistent nephrotic syndrome, gross hematuria and having subepithelial hump. It is a first report of dense deposit disease having subepithelial hump in Korea, therefore we report this case with the review of relevant literatures.

Eagle씨 증후군의 치험례

오승환,이상철,윤옥병,지유진,김여갑,류동목 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.3

Eagle's syndrome is the term given to symtomatic elogation of the styloid process or mineralization of the stylohyoid or stylomandibular ligament. Since ossification of stylohyoid ligament at cadeva was fist described by De Manchetics in 1652 and Weinlecher described clinical symptom which produced by elongated styloid process and osteotomy of styloid process in 1872, Clinical symptom which include sensation of a foreign body on the pharynx, dysphagai, dysphonia, referred pain, and mouth opening disturbance was termed by Eagle as Eagle's syndrome. then, case reports of Eagle's syndrome are presented. in these cases, the patient's chief complaints included periauricular radiating pain, mouth opening disturbance, foreign body sensation, dysphagia, tenderness on the neck. Through vairous X-ray examination and palpation of tonsillar fossa, elongted styloid process were confirmed. Under the general anesthesia there were successfully removed out via transoral approach technique, described by Eagle. after resented styloid process, they were freed from the symptoms without further complication. Therefor we reported these cases treated by surgical resection of styloid process with good results.

기관골 신생증 1예

오영상,이은우,정종혁,문승원,김수현,김동한,양혁승,박정환,박경옥,강성수,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Tracheobronchopathia osteoplastica is a rare disorder of unknown cause characterized by the projection of numerous bony or cartilaginous submucosal nodules into the tracheobronchial lumen with sparing of the posterior membranous portion of tracheobronchial tree. In the past, most of the cases were diagnosed as secondary finding at autopsy. Nowaday, the key component of the evaluation is flexible fiberoptic laryngoscopy and bronchoscopy, which typically demonstrates irregular spicules of subrnucosal bone and cartilage projecting into the tracheobronchial lumen and causing various degrees of airway obstruction. A 45 years old man was visited Sunchon St. Carollo hospital due to discomfort on throat. We saw several nodules just below vocal cord via laryngoscope. The computed tomography revealed multiple small calcified nqdules on trachea and both main bronchi. Pathologic finding of bronchoscopic biopsy showed abnormal proliferation of bony and cartilagious nodules in the tracheal submucosa. These fingdings were consistent with tracheobronchopathia osteoplastica. We report here on a case of tracheobronchopathia osteoplastica with review of literature.

소아 고환 배세포종양의 치료와 예후

윤상진,김용태,이안기,오승준,김광명,최황 大韓泌尿器科學會 1998 Korean Journal of Urology Vol.39 No.4

Linear eruptive collagenomas on chest and neck

( Sang Woo Lee ),( Seung Hyun Cheong ),( You Won Choi ),( Hae Young Choi ),( Chee Won Oh1 ) 대한피부과학회 2012 대한피부과학회 학술발표대회집 Vol.64 No.1