모 연취급장 근로자들의 연폭로지표들과 혈압과의 관련성

임상복,김용배,이용진,리갑수,김화성,황규윤,장봉기,이성수,안규동,이병국 순천향대학교 산업의학연구소 1998 순천향산업의학 Vol.4 No.1

In order to investigate the relationship between blood lead with other lead exposure indices and blood pressure in occupationally lead exposed male workers, 629 workers(515 lead exposed workers and 114 non lead exposed workers) in a storage battery factory were studied. Blood lead(PbB), zinc protoporphyrin(ZPP) and urinary δ-aminolevulinic acid(ALAU) were selected as an index of lead exposure. Height and weight were also meaured with calibrated automatic height-weight machine to produce fatness index directly. Personal information on smoking and drinking history were also collected. Blood pressure was mearured by trained nurses with automatic sphingomanometer. All workers took at least 30 minute rest before their measurement of blood pressure. The results obtained were as follows: 1. The prevalence rate of hypertension of lead exposed and non-exposed workers were 3.5% in both group without any difference. 2. There were no differences of systolic and diastolic pressure between groups divided by lead exposure, smoking habit, drinking habit. but the increase of age group made the difference of diastolic pressure, and only differenct of systolic pressure observed in age group of less than 20 and that of more than 40. 3. In pearson's correlation analysis, PbB was correlated with systolic pressure significantly, but not with diastolic pressure. PbB was also correlated with pressure difference(systolic pressure-diastolic pressure). 4. There were no significant increase of systolic, diastolic pressure and pressure difference by the increase of PbB and ZPP grouping. 5. Stepwise multiple regression analysis using systolic pressure as dependent variable and PbB, ZPP, ALAU, age, work duration, smoking habit, drinking habit and fatness (weight*0.9/height-100) as independent variables, revealed that PbB, age, drinking habit and fatness in order were significantly contributed to the dependent variable. 6. Stepwise multiple regression analysis using diastolic pressure as dependent variable and PbB, ZPP, ALAU, age, work duration, smoking habit, drinking habit and fatness (weight*0.9/height-100) as independent variables, revealed that ALAU, age and fatness in order were significantly contributed to the dependent variable. 7. Stepwise multiple regression analysis using pressure difference as dependent variable and PbB, ZPP, ALAU, age, work duration, smoking habit, drinking habit and fatness(weight*0.9/height-100) as independent variables, revealed that PbB, age and fatness in order were significantly contributed to the dependent variable. 8. Logistic analysis of hypertensive conditions with categorized blood lead and other selected categorized independent variables indicated that only age(40> and 40≤) and fatness(1.0> and 1.0≤) were significantly contributed to dependent variable with 95% significant odd ratio confidence interval. With above results, lead exposure in terms of blood lead seemed to be minimally contributed to the raise of blood pressure, and the effect of blood lead was found to be more prominent on the pressure difference than the systolic and diastolic pressure themselves.

Close-type 와류형 분사기의 유량계수에 대한 연구

안규복 ( Kyu Bok Ahn ),최환석 ( Hwan Seok Choi ) 한국액체미립화학회 2014 한국액체미립화학회 학술강연회 논문집 Vol.2014 No.-

An experimental study on discharge coefficients of close-type swirl injectors has been performed. 27 close-type swirl injectors with different geometric dimension were designed and manufactured. Changing pressure differential through the injector (10 ± 2 bar), hydraulic cold-flow tests using tap water were conducted to measure the discharge coefficients. The discharge coefficients obtained from cold-flow tests are compared with the previous well-known empirical equations to investigate their accuracies. The novel empirical equation, which is useful in designing a new close-type swirl injector for a liquid rocket engine, is suggested from the results of present cold-flow tests.

한국의 발톱진균증 환자의 삶의 질에 관한 연구

조백기,박종갑,김형옥,김성욱,백승철,김진우,김시용,안규중,전재복,오지원,김낙인,이규석,오칠환,김수남,김상태,손숙자,신용우,김동석,이원우,권경술,서대헌,황규왕,이종석,고재경,강원형,정기양,최응호,김기홍,박석돈,강승주,함정희,명기범,김방순,구상완,김병수,원영호,김한욱,송은섭,정병수,노병인,홍창권,박장규,한지윤,김광중,구대원,김종민,김재홍,유희준,양경미 대한의진균학회 1998 대한의진균학회지 Vol.3 No.2

Background: Onychomycosis, especially toenail onychomycosis has become one of the common fungal infection and has historically been regarded as a cosmetic rather than medical problem by many patients, even by physicians. Recently, however, there are several reports that is a refractory disease which may cause a deleterious effect on patiets quality of life (QOL). Objective: The purpose of this study was to investigate the impact of toenail onychomycosis on QOL in Korea and to assess the chandes of QOL after treatment. Methods: Total 1004 patients with toenail onychomycosis which was confirmed by clinical findings and KOH preparation were were enrolled at 47 dermatologic centers in Korea, and interviewed with standardized QOL questionnaire before and after sytemic antifungal treatment. Responses to the questionnaire were scored by 5-point scale (1∼4) and averaged, and were analyzed for 5 dimensions of emotional impact, social impact, symptorn and functional impact, patients views concerning treatment, and relationship with doctor. Results: 1. Before and after treatment, the most serious impact was emotional dimension showing 1.90 and 1.30 in average score (AS), and social (AS: 1.14 and 0.83) and symptom and functional impact (AS: 1.05 and 0.92) was also affected. 2. In female rather than male, statistically more significant impact on patients QOL was observed in all dimensions. 3. After treatment, 3 of 5 dimensions were improved significantly - emotional dimension (AS : from 1.90 to 1.30), social dimension (AS: from 1.14 to 0.83), patients view concerning treatment (AS: from 1.34 to 1.02). 4. The drgree of patients satisfaction at the therapeutic effect was very high- 62.4% (immediately after treatment) and 65.8% (9 months affer initiation of treatment) of patients answered excellent or good. Conclusion: This study confirms that toenail onychomycosis has significant impact on the overall QOL of patients. Also the effect of antifungal therapy on patients QOL were watisfactory. Therefore, both doctor and patient should pay more attention to the treatment of onychomycosis. [Kor J Med Mycol 3(1): 115∼124]

DNA methylation predicts recurrence from resected stage III proximal colon cancer

Ahn, Joong Bae,Chung, Woon Bok,Maeda, Osamu,Shin, Sang Joon,Kim, Hyun Soo,Chung, Hyun Chul,Kim, Nam Kyu,Issa, Jean‐,Pierre J. Wiley Subscription Services, Inc., A Wiley Company 2011 Cancer Vol.117 No.9

<P><B>Abstract</B></P><P><B>BACKGROUND:</B></P><P>In colorectal cancer (CRC), DNA methylation anomalies define distinct subgroups termed CpG island methylator phenotype 1 (CIMP1), CIMP2, and CIMP‐negative. The role of this classification in predicting recurrence and disease‐free survival (DFS) in resected stage III CRC was evaluated.</P><P><B>METHODS:</B></P><P>Sporadic cancers from 161 patients were analyzed. Bisulfite pyrosequencing was used to examine the methylation of 2 global DNA methylation markers (LINE‐1, Alu) and 9 loci (<I>MINT1, MINT2, MINT31, P16, hMLH1, P14, SFRP1</I>, SFRP2, and WNT5A). Mutations in BRAF and KRAS were assayed.</P><P><B>RESULTS:</B></P><P>Gene hypermethylation clustered in discrete groups of patients, indicating the presence of CIMP. K‐means clustering analysis identified 3 discrete subgroups: CIMP1 (n = 22, 13.7%), associated with proximal location and <I>BRAF</I> mutations; CIMP2 (n = 40, 24.8%), associated with <I>KRAS</I> mutations; and CIMP‐negative (n = 99, 61.5%), associated with distal location. In proximal CRC, CIMP1 was correlated with a higher recurrence rate (53% for CIMP1, 18% for CIMP2, and 26% for CIMP‐negative) and a worse DFS (<I>P</I> = .015). Also in proximal CRC, LINE‐1 methylation was lower in patients whose cancer recurred compared with those whose cancer did not recur (<I>P</I> = .049). In multivariate analysis, CIMP1 and low LINE1 methylation were independent prognostic factors for DFS in proximal CRC (<I>P</I> = .008 for classification by K‐means clustering analysis; <I>P</I> = .040 for LINE‐1 methylation status).</P><P><B>CONCLUSIONS:</B></P><P>DNA methylation is a useful biomarker of recurrence in resected stage III proximal but not distal CRC. However, as the number of CIMP1 cases was small in distal CRC, further study is required to validate our findings. Cancer 2011. © 2010 American Cancer Society.</P>

Irradiation and Operating Temperature Effects on the Tensile Characteristics of CANDU Pressure Tube Material

Ahn, Sang Bok,Kim, Do Sik,Kim, Young Suk,Oh, Dong Joon,Kim, Jung Kyu Trans Tech Publications, Ltd. 2005 Key Engineering Materials Vol.297 No.-

<P>To investigate the degradation of mechanical properties induced mainly by neutron irradiation and operating temperatures, tensile tests were conducted from room temperature to 300°C using irradiated and unirradiated Zr-2.5Nb pressure tube materials. The irradiated longitudinal and transverse specimens collected from the coolant inlet, middle and outlet parts of the tube which had been operated in the CANDU reactor and showed different operating temperatures and irradiation fluence. The different tensile behavior was characterized by the tensile loading direction in the unirradiated tube. The transverse specimen showed higher strength and lower elongation than those of the longitudinal one. The increased strength hardening and the decreased elongation embrittlement of the irradiated material were compared to those of the unirradiated one. While the tensile strength of the inlet was higher than that of the outlet, the elongation of the inlet was lower than that of outlet. Considering the operation condition, it was proposed that the operating temperature could be a more effective parameter than the irradiation fluence for long-time life. Through TEM observation, it was also found that while the a-type dislocation density was increased, the c-type dislocation was not changed in the irradiated material. The fact that the higher dislocation density was sequentially distributed over the inlet to the outlet parts was consistent with the distribution of the tensile strength. </P>

엘라스타제의 토끼에 대한 최기형시험

안병옥,백남기,이순복,김원배,양중익,이영순,임윤규 A.R. Liss 1990 ENVIRONMENTAL MUTAGENS AND CARCINOGENS Vol.10 No.2

한국인 성인 인슐린의존형 당뇨병 환자의 HLA DQ A1, DQ B1 유전자 형별 분석

안종호,조보연,이홍규,고창순,민헌기,김성연,박경수,홍성관,고경수,장연복 대한당뇨병학회 1992 Diabetes and Metabolism Journal Vol.16 No.2

만성 바이러스성 간염에서 중간엽 조직 반응에 대한 전자 현미경적 연구

안병민,윤승규,박수헌,한준열,한남익,김재광,이영석,최상욱,이창돈,차상복,정규원,선희식 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.2

목적 : 만성 바이러스 간염에서 간염 정도에 따른 중간엽 조직 반응의 변화를 알아보기 위하여 전자 현미경 검사를 이용해 미세 구조 변화를 관찰하였다. 대상과 방법 : 만성 바이러스 간염 20 명을 대상으로 복강경 하에서 간침 생검 조직 검사를 시행하여, 간 조직을 H & E 염색, Masson's trichrome 염색을 실시하고 광학 현미경 관찰 및 조직 활성도 검사를 시행 한 후 전자 현미경 검사를 시행하였다. 결과 : 심한 만성 간염 일수록 문맥역 주위의 중간엽 조직의 간세포는 재생 또는 변성 과정을 보여주는 세포로 구성되었다. 재생 간세포들은 Disse 강에 기저막으로 둘러싸여 있었으며 (capillarization), Disse 강은 확장되어 있고 교원 섬유의 축적과 간 세포 괴사부에 간성상세포에서 유래되는 섬유아 세포의 증식이 관찰되었다. 중간엽 조직에는 섬유아 세포의 증식과 교원 섬유 속의 현저한 증식 소견을 보였으며, 모세 혈관의 신생, 세 담관의 증식 등 심한 간질 세포 반응을 보였다. 결론 : 심한 만성 바이러스 간염에서의 간 섬유화는 간성상세포 및 섬유아세포의 증식과 유동의 capillarization에 의해서 진행되며, 이로써 간기능 부전의 한 원인이 될 수 있다고 생각된다. Background/Aims: This study was designed to clarify the fine structures of the hepatocytes and mesencymal tissues in chronic hepatitis according to severity. Method: For the purpose of elucidating the ultrastructural characteristics of mesenchymal tissues, liver biopsy specimens were studied by light and electron microscopy in 20 patients with chronic hepatitis. Results: 1) Hepatocytes in mesenchymal tissues were thought to be in the stage of regenerated or degenerated process. 2) Regenerating nodules were surrounded by a basement membrane-like materials in the space of Disse. 3) In the widened Disse space the deposition of collagen fiber bundles and increased numbers of hepatic stellate cells in necrotic area were observed. 4) In necrotic areas, hepatic mesenchymal cell response including an increase of collagen fibers and fibroblast, angiogenesis, and a proliferation of bile ductules were also observed. Conclusions: These observations suggest that the fibrosis in severe chronic hepatitis was accompanied by the mesenchymal response including the proliferation of hepatic stellate cells, fibroblasts, capillarization of Disse space, and mesenchymal proliferation. Finally, this fibrosis observed electron microscopically may be a cause of functional hepatic failure.(Korean JHepatol 2002;8:167-172)

간장 및 담도 : 삼출성 복수증의 감별진단과 복강경 검사

정규원(Kyu Won Chung),차상복(Sang Bok Cha),선희식(Hee Sik Sun),김부성(Boo Sung Kim),정인식(In Sik Chung),안병민(Byung Min Ahn),김재광(Jae Kwang Kim),김태룡(Tae Ryong Kim),최규용(Gyu Yong Choi) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.1

N/A Exudative ascites should initiate an evaluation for peritoneal processes, most importantly infection and tumor. And the pathological diagnosis is required for a approapriate treatment in most cases. To assess the diagnostic accuracy and complication rates of diagnostic laparoscopy in patients with exudative ascites we studied in 73 patients with exudative ascites retrospectively. Thirty three patients had malgnancy related ascites, and peritoneal carcinomatosis was confirmed in thirty one patients. Twenty seven patients had tuberculous peritonitis, and thirteen patients had miscellaneous causes, among them eight patients had underlying liver cirrhosis and clinically spontaneous bacterial peritonitis were suspected in three patients in whom bacteria were cultivated in ascites. Pancreatic pseudocyst and leakage into peritoneal cavity was confirmed by endoscopic retrograde pancreatography in one case, but the remained four cases had not known the diagnosis. The most common primary cancer was gastric carcinoma which was diagnosed in fourteen patients, and then ovarian cancer in five patients, colon cancer in four patients, pancreatic cancer in three patients, mesothelioma in one patient and unknown origin in four patients. Cytology evaluation of the ascitic fluid was positive for tumor cells in 62% of patients with peritoneal carcinomatosis. Blind Cope needle biopsy yielded positive diagnosis of neoplastic or tuberculous in 65.4 per cent of rases. The major and minor complication rates of laparoscopy were 0% and 26.4%, respectively, with no fatalities. These findings compare favorably with general experience. We conclude that laparascopy is relatively safe and accurate diagnostic method of choice in exudative ascites, especially in cases when other non-invasive methods were failed.

Two Marine Littoral Species of the Genus Medon (Coleoptera: Staphylinidae: Paederinae) New to Korea

Tae-Kyu Kim,Young Bok Cho,Kee-Jeong Ahn 한국동물분류학회 2011 Animal Systematics, Evolution and Diversity Vol.27 No.1

The taxonomy of marine littoral species of the genus Medon Stephens in Korea is presented. The genus and two species-Medon prolixus (Sharp) and M. rubeculus Sharp-are identified for the first time in the Korean Peninsula. Redescriptions of M. prolixus and M. rubeculus with an illustration of its habitus and line drawings are provided.