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Pityriasis lichenoides et varioliformis acuta, also been known as Mucha-Haber-mann's disease, occurs with the acute polymorphous eruption which heals with superficial scarring and pigmentation. It is classified into both parapsoratic group or vasculitis. In the walls of superficial dermal vessels, IgM and C_3 have been observed on direct immunofluorescence study and this impleis that pityriasis lichenoides is an immine complex disorder. A 30-year-old man was first seen with a side spread polymorphous eruption composed of pink papules, micaceous scales, reddish-brown crsut and occasional vesicles on the truck, thigh and upper arm. This clinical impression was Mucha-Habermann's disease and it was confirmed by skin biopsy. Direct immunofluorecence study revealed C_3 deposition in the wall of superficial dermal vessel. Patient showed rapid clearing of lesions while he received 4 weeks of therapy with methotrexate but recurred after methotrexate was discontinued.
Granuloma annulare is a benign, usually self-limited chronic dermatasia of unknown cause, charaeterized by akin colored papules that may be arranaged in an annular configuration. Histopathologically, it is charicterized by camplete or incomplete foeal degeneration of collagen of chronic infliammatory cells. The authors obaerved an atypical case of granuloma annulare in a 4-year-old girl. She showed multiple papules and nodule on hands and feet. On inital examination, her skin lesions suggested histiacytosis, xanthanulama, rheumatoid nodule, or benign skin tumor. But the skin biopey revealed typica1 findings of granuloma awulare. Focal degeneration of colagen was confirmed by toluictine blue stain. Her skin lesions were almoatly cleared by skin biopsy and intralesional injectian of corticosteroid.
This study was undertaken to investigate the skin sensitivity to 54 different allergens in 248 patients of 81 acute urticaria, 141 chronic urticaria and 26 atopic dermatitis, who visited in Department of Dermatology, College of Medicine, Chung Ang University Hospital from February 1986 to January 1987. The results were as follows . 1. The sex ratio of male to female of 248 patients with allergic state was 1.1: 1 (130: 118) and third and fourth decades occupied 56.5%. In regard to the duration of chronic urticaria, less than 1 year were 31.2% and between 1 to 3 years were 28.3%. 2. In acute urticaria, the prick test positive reactivity to allergens were in descending order to mite, household insect mixture, Trichophyton mixture, house dust, mold mixture C and silk, whereas in chronic urticaria ', mite, household insect mixture, house dust, cockroaeh mixture, Trichophyton mixture and silk and in atopic dermatitis ; mite, house dust, Trichophyton mixture, household insect mixture, mold mixture A and C. 3. The positive reactivities of allergens in patients with atopic dermatitis, chronic urticaria and acute urticaria were 69.2%, 52.5% and 35.8%, respectively. 4. The positive reactivity to compound allergens were higher than to single and the most frequent combinations were 2 to 5 allergens (85.4%). 5. Out of 54 allergens used in this study, 49 allergens were reactive and the most frequent group of allergens were house dusts (41.5%) and commonly involved allergens were mite (27.8%), household insect mixture (15.7%), house dust (13.7%), Trichophyton mixture (11.7%) and cockroach mixture(7.7%). 6. Common other allergic diseases combined with atopic dermatitis were rhinitis and bronchial asthma, occuring in 23.1%.
A 47 year-old woman with generalized fresh tense or ruptured bullae was diagnosed as bullaus pemphigoid by histopathological and direct immunofluorescent test. We treated her with prednisolone and bethamethasone for 3 weeks. And soon after, herpes zoster developed along the right T9 dermatome. It is not precise whether true association or only incidental concomitance, but, there may be present some relatioship.
Background : Superoxide disrnutase(SOD) provides a protective defease mechanism against potential cytotoxicity of superoxide radical in the aerobic organism. Although human skin is constantly at risk for developing acute and chronic changes by ultraviolet radiation and phototoxic reactions with exogenous and endogenously procluced photosensitizing molecules, studies in SOD in the human skin are rare. Objective : We measured the level of SOD activities in the scar tissues and the normal human skin specimens. This study was to investigate changes of SOD activity by age, sex, and regional differences of SOD activities in the scar issues and the normal skin. Methods : Aut,hors assayed the level of SOD activit,ies in 32 scar tissues(male 8, female 24) and 11 normal human skin specimens(male 8, female 3), which were obtaine 3 from face/neck(17 and 3 specimens), forearm(only 4 scar tissues), trunk(10 and 8 specimens), and lower extremity(only 1 scar tissue). Results : First, activities of total SOD, Cu, Zn-SOD, and Mn-SOL ere 18.93+5.49, 16.97+55.31, and 1.96+0.90 units/mg proteiii respectively in the scar tissues. Second activities of total SOD, Cu, Zn-SOD, and Mn-SOD were 17.27+7.09, 13.82+6.44, and 3.45+1.07 units/mg protein respectively in the normal skin. Third, the changes of total SOD, Cu, Zn-SOD, and Mn-SOD activities by age and sex were similar each other and three were no significant, differneces between age groups in total, Cu, Zn- SOD, and Mn-SOD activities. Fourth, in sun exposed area and unexposed area there were no significant differences in the scar tissues in SOD activities. But, SOD activite.(total, Cu, Zn, and Mn-SOD) in face/neck were higher than those in trunk and lower extremity in tae normal skin(P$lt;0.05). Conclusion : These findings suggest that there are no differences in the intrinsic SOD activities by age and sex in the mature scar tissues and the normal skin. Differences between exposed and unexposed area in the normal skin are due to the induction of exogenous SOD activity by sun-light generation of superoxide radicals. In wound, increased production of leukocyte derived superoxide radicals is the main factor of increased level of SOD activity. (Kor J Dermatol 1994; 32(2): 277-285)
This statistical analysis was made out of 2, 259 clinical cases (9.9%) of akin disorders in the aged group over 50 years of age, among from the total 22,931 cases of outpatients, from 1974 to 1978, at Department of Dermatology, Sung-Sim HospitaI. Sex difference of the patients-male, 1,057 (46.8%), female, 1, 202 (53.2%)-was found statistically significant. The results were as follows: 1. The common disease groups were eczema(42.3%); fungal infections(17.6%); urticaria, drug eruption and toxic erythema(12.3%); viral infections(9.2%); bacterial infections(4.8%); pruritus(4.1%); and tumor(2.3%). 2. The most frequent disease in the respective group was contact dermatitis, fungal infection of hand and foot, acute urticaria, herpes zoster, folliculitis, generalized pruritus, and benign tumor. 3. The disorders prevalent in man were fungal infections, the men-women ratio being 2:1. In contrast, the disorders prevalent in woman included eczema group(men-women ratio was 1:1.3), and pruritus group(men-womne ratio was 1:2). 4. 53 cases(2.3%) of skin tumors were 31 cases of beingn tumor(1.4%) and 22 cases of premalignant and malignant tumor(0.9%), the latter including squamous cell carcinoma, basal cell carcinoma, metastatic carcinoma, malanoma, and lymphoma.
Xeroderma pigmentosurn is a photosensitive hereditary disorder and especially rare in Korea. A 30-year old male patient had been suffered from walnut sized tumor and several ulcerated papules on the face, and scattered brownish macules on the sun-exposed area. Clinical features and histopathologic findings were consistent with malignant malanoma and basal cell epithelioma developing in a xeroderma pigmentosum respectively. Malignant melanoma was surgically excised.