FRTL-5 세포주에서 갑상선 전사인자-1 발현에 대한 classⅡ Transactivator의 영향 : 대한내분비학회지: 17:48-56, 2002, 김원배 외 6인

김원배 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.2

Unmet Clinical Needs in the Treatment of Patients with Thyroid Cancer

김원배,전민지,김원구,김태용,송영기,김원배 대한내분비학회 2020 Endocrinology and metabolism Vol.35 No.1

The increased incidence of thyroid cancer is a worldwide phenomenon; however, the issue of overdiagnosis has been most prominent in South Korea. The age-standardized mortality rate of thyroid cancer in Korea steeply increased from 1985 to 2004 (from 0.17per 100,000 to 0.85 per 100,000), and then decreased until 2015 to 0.42 per 100,000, suggesting that early detection reduced mortality. However, early detection of thyroid cancer may be cost-ineffective, considering its very high prevalence and indolent course. Therefore, risk stratification and tailored management are vitally important, but many prognostic markers can only be evaluatedpostoperatively. Discovery of preoperative marker(s), especially for small cancers, is the most important unmet clinical need for thyroid cancer. Herein, we discuss some such factors that we recently discovered. Another unmet clinical need is better treatment of radioiodine-refractory (RAIR) differentiated thyroid cancer (DTC) and undifferentiated cancers. Although sorafenib and lenvatinib areavailable, better drugs are needed. We found that phosphoglycerate dehydrogenase, a critical enzyme for serine biosynthesis, couldbe a novel therapeutic target, and that the lymphocyte-to-monocyte ratio is a prognostic marker of survival in patients with anaplasticthyroid carcinoma or RAIR DTC. Deeper insights are needed into tumor-host interactions in thyroid cancer to improve treatment.

아스팔트 혼합물의 공용특성과 상관성이 높은 시험특성 분석

김원배,김영삼,이성진,김광우 한국아스팔트학회 2024 한국아스팔트학회지 Vol.14 No.2

The rut and crack are two most-typical damage patterns in asphalt pavement, and they are induced due to the change of binder stiffness under loading at different temperature. Two test properties used for evaluating rutting resistance at 60°C in this study are wheel tracking (WT) rut depth and strength against deformation (SD). The test property used for evaluating crack resistance is indirect tensile strength (ITS) at 25°C. In addition, Marshall stability (MS) was used as another high-temperature property. Regression analyses were performed to evaluate correlation between two properties each other among the four using various asphalt mixtures. The rut resistance represented by rut depth of WT showed a good correlation with SD with R2 ≒ 0.90 on average. The regressions between ITS and SD, and ITS and WT showed R2 ≒ 0.61 and 0.69 on average, respectively. The reason why one property showed good correlation with another among the three is that those properties are related with binder stiffness. It is well known fact that the mixture with higher stiffness binder showed higher rut resistance and good tensile property. On the other hands, all three regressions between MS and WT, MS and SD, and MS and ITS showed poor correlations with R2 ≒ 0.2 on average. Therefore, it was found that the MS is not the property showing good relation with any performance of asphalt mixture. It was concluded that the WT results could be reliably estimated by SD. Although SD showed somewhat noticeable correlation with ITS, it should be studied further for practical application for estimation of tensile property by . However, it is better not to use Marshall stability as a serviceability index of asphalt mixture.

Si 저감 CMnAlCo계 TRIP형 합금화 용융도금강판의 열처리 조건에 따른 기계적 특성 (초)

김원배,이강노,김동은,문만빈,나상묵,박성준,오창석 대한금속재료학회 2007 대한금속재료학회 학술대회 개요집 Vol.2007 No.1

2007년도, 지방행정(地方行政)을 결산한다 ; FTA와 지역경제, 그리고 지자체의 역할

김원배 대한지방행정공제회 2007 지방행정 Vol.56 No.650

한국기업의 무역사기에 관한 형태와 대응방안

김원배 한국무역학회 2000 한국무역학회 국제학술대회 Vol.2000 No.12

개립마찰포장용 아스팔트 혼합물의 소성변형 특성연구

김원배,조재원,김광우 한국아스팔트학회 2024 한국아스팔트학회지 Vol.14 No.2

The objective of this study was to evaluate rut resistance characteristics of open-graded friction course (OGFC) asphalt mixtures. Two maximum size aggregates (10 mm and 13 mm) with three polymer-modified asphalt mixtures were used to prepare OGFC asphalt mixtures for the strength against deformation (SD) and asphalt pavement analyser (APA) tests. Three polymers included LDPE (low-density polyethylene), CRM (crumb rubber modifier) and SBS (styrene-butadiene-styrene). Six OGFC mix specimens were prepared at optimum asphalt content with the air void ratio of 16.2~17.3% using gyratory compactor. The SD test results showed that LDPE mixes showed approximately 4.2 MPa on average, while CRM and SBS mixes showed 3.6 MPa and 2.7 MPa, on average, respectively. APA test results was similar to those of SD; rut depths of LDPE, CRM and SBS mixtures being 1.35 mm, 3.5 mm, and 4.2 mm, on average, respectively. Therefore, the OGFC mixes using LDPE was found to show strong rut resistance properties in both tests, although SD was slightly lower than 4.25 MPa, which is the minimum limit of 1st class highway dense-grade asphalt pavement in Korea. Since OGFC specimen has air void ratio of 16-17%, which is 4 times greater than dense-grade specimen, instead of applying the dense-grade property limit directly to OGFC, it is suggested to prepare reasonable limits for OGFC mixes in the future. The regression analysis between APA rut depth and SD showed that the two properties has relatively high correlation with R2 > 0.81. Therefore, it will be possible to use SD for estimation for OGFC rut resistance by SD after further studies.

[시] 그대 오지 않는 밤 외

김원배 도서출판 천우 2023 월간 문학세계 Vol.- No.-

갑상선결절 및 암 진료 권고안

김원배,김태용,권혁상,문원진,이재복,최영식,김석기,김선욱,정기욱,백정환,김병일,박도준,나동규,최준호,정재훈,정혜승,김정한,남기현,장항석,정웅윤,홍순원,홍석준,이정현,이가희,조영석,강호철,송민호,박진우,윤종호,강성준,이광우 대한내분비학회 2007 Endocrinology and metabolism Vol.22 No.3

Structural and Optical Properties of Co- and Ti-ZnO Composite Nanofibers Prepared by Using an Electrospinning Method

김원배,Manish Anand,심희상,김용석,김해진 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.5

We report here a simple preparation method that involves a room-temperature sol-gel process to prepare Co- and Ti-composited ZnO nanofibers via electrospinning. By choosing a combination of two solvents for the low-temperature sol-gel process and proper using the process parameters, we could get improved morphology and reduced diameters of the doped and the undoped ZnO nanofibers. The morphology of the undoped, as well as the doped, ZnO nanobers was porous with diameters in the range of 40 to 100 nm. The undoped ZnO nanofibers were found to be crystalline and their crystallinity appeared to be unaffected, even by doping with Ti and Co up to 3 atomic%. The band gap values of pure ZnO and doped ZnO nanofibers with Ti (3 atomic%) and Co (3 atomic%) were estimated by to be 3.29, 3.30 and 3.02 eV, respectively, using UV-vis absorption spectra. We report here a simple preparation method that involves a room-temperature sol-gel process to prepare Co- and Ti-composited ZnO nanofibers via electrospinning. By choosing a combination of two solvents for the low-temperature sol-gel process and proper using the process parameters, we could get improved morphology and reduced diameters of the doped and the undoped ZnO nanofibers. The morphology of the undoped, as well as the doped, ZnO nanobers was porous with diameters in the range of 40 to 100 nm. The undoped ZnO nanofibers were found to be crystalline and their crystallinity appeared to be unaffected, even by doping with Ti and Co up to 3 atomic%. The band gap values of pure ZnO and doped ZnO nanofibers with Ti (3 atomic%) and Co (3 atomic%) were estimated by to be 3.29, 3.30 and 3.02 eV, respectively, using UV-vis absorption spectra.