과산화수소수로 유도된 배양신경세포손상에 대한 참죽나무잎 추출물의 보호효과

이순복,김주연,조순옥,반주연,주현수,배기환,성연희 한국약용작물학회 2007 한국약용작물학회지 Vol.15 No.6

Dried leaves from Cedrela sinensis A. Juss. (CS), have been observed to possess various pharmacological activity and contain various antioxidant constituents. The protective effect of ethanol extract of CS on hydrogen peroxide (H2O2)-induced neurotoxicity was examined using primary cultured rat cortical neurons in the present study. Exposure of cultured neurons to 100 μM H2O2 caused a significant neuronal death as assessed by a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide (MTT) assay and Hoechst 33342 staining. The addition of CS, over a concentration range of 10 to 50μg/ml, concentration-dependently prevented the H2O2-induced neuronal apoptotic death. CS (50μg/ml) significantly inhibited H2O2-induced elevation of the cytosolic Ca2+ concentration ([Ca2+]c), which was measured by a fluorescent dye, Fluo-4 AM. CS (30 and 50μg/ml) inhibited glutamate release and generation of reactive oxygen species (ROS) induced by 100μM H2O2. These results suggest that CS may mitigate the H2O2-induced neurotoxiciy by interfering with the increase of [Ca2+]c, and then inhibiting glutamate release and generation of ROS in cultured neurons.

STEAM(융합인재교육)기반 미술교육이 유아의 미술성향과 창의성에 미치는 효과

이순복 인지발달중재학회 2019 인지발달중재학회지 Vol.10 No.1

The purpose of this study was to examine the effects of art education in a STEAM program on young children’s art disposition and creativity and to provide basic data for the development of STEAM-based art education to improve such educational features. A total of 40 children participated in this study; they were 5 years old and attendees of D private kindergarten located in P City. An art disposition inventory (Chi) was used to test the children’s art disposition, and the Torrance Test of Creative Thinking (TTCT) was used to test creativity. The collected data were analyzed using means, standard deviation, and covariance to determine the program’s effects. The results of this study were as follows. The program had positive effects on overall art disposition and creativity as well as originality, abstractness, and persistence, but not on fluency or the elaborative nature of creativity. In conclusion, art education in a STEAM program is an effective teaching and learning method for developing children's art disposition and creativity. 본 연구는 STEAM(융합인재교육)기반 미술교육이 유아의 미술성향과 창의성에 미치는 효과를 알아보고, 유아의 미술성향과 창의성 향상을 위해 유아 STEAM(융합인재)교육 교수학습방법 개발의 기초자료를 제공하는데 목적이 있다. 연구대상은 P시에 소재하고 있는 D유치원 만 5세 2개 학급 40명이었으며, 실험집단과 비교집단으로 나누어 18회기의 STEAM(융합인재)교육 기반의 미술교육을 실시하였다. 연구결과는 다음과 같다. 첫째, STEAM(융합인재)교육 기반의 미술교육이 유아의 미술성향에 유의미하게 효과가 있는 것으로 나타났다. 둘째, STEAM(융합인재)교육의 기반의 미술교육이 유아의 전체 창의성에, 그리고 유창성, 정교성을 제외한 독창성, 추상성, 종결에 대한 저항에 유의미하게 효과가 있는 것으로 나타났다. 이러한 결과는 STEAM(융합인재)교육 기반의 미술교육이 유아의 미술성향과 창의성 발달에 효과적인 교육활동으로 유아교육현장에서 효용가치가 있음을 시사하고 있다.

Lidexⓡ Cream의 임상효과

이순복,변동길,차몽기 대한피부과학회 1975 대한피부과학회지 Vol.13 No.4

Lidex^ⓡ cream (Fluocinonide 0.05% in FAPG base) is a new fluorina,ted topical corticosteroid, and its clinical effect was assessed by applying topically three to four times daily to the lesions of 50 patients with a variety of inflamrnatory skin condi- tions. The results revealed excellent effect in 16 patients, moderate effect in 23 patients, slight improvement in 9 patients, and no effect in 2 patients. No unfavorable side effects were noted except blanching. The findings suggest that fluocinonide is an excelIent addition to the topical corticosteroid agents that are available for clinical use at the present time.

다용도 성능시험기 개발

이순복,김환두 대한기계학회 1984 대한기계학회 춘추학술대회 Vol.- No.-

한국의 해외직접투자 정책과 그 개선방향

李淳福 慶南大學校 産業經營硏究所 1997 産業經營 Vol.20 No.-

Corticosteroid의 局所 塗布가 멜라닌 및 멜라닌 細胞에 미치는 影響에 關한 實驗的 硏究

李順福,金秀男 고려대학교 의과대학 1980 고려대 의대 잡지 Vol.17 No.1

Conflicting results have been reported as to whether or not the melanogenesis is influenced by topical application of corticosteroids on the skin of human and animals. In animals study, mealnogenesis was observed macroscopically when using natural corticosteroids. In human studies, the reports were based on the observation of complications in use of topical corticosteroids on inflammatory skin conditions and disorders of pigmentation such as melasma and vitiligo. The author observed hyperpigmentation of the normal skin around the lesions of vitiligo during the use of topical synthetic corticosteroids. The present studies were undertaken to evaluate the effects of topical Fluoinoclone on melanogenesis with and without the use of ultraviolet light as observed on the skin of colored rabbits' external ears. The changes of the skin color were observed macroscopically and microscopically after the daily topical application of Fluocinolone with or without daily irradiation of ultraviolet light (wave length : 2537-3660Å, lamp to target distance: 30㎝, exposure time : 5minutes). To observe the microscopic findings, the skin specimens which were taken at 7 day intervals for 28 days were stained with DOPA, silver nitrate and hematoxylin-eosin respectively. The results were as follows: 1. There were no macroscopic or microscopic changes of melanin or melanocytes in the control group which had been applied with cream base daily for 28 days. 2. In the ultraviolet irradiated group mild increments of melanin were observed on the 7th day of the experiment. These increased moderately or prominently on the 14th day and on the 21th day. The degree of increments decreased thereafter. Enlargement of meannocytes was paralleled with the increase in increments of the melanin. Proliferation of melanocyes was observed from mild to moderate degree until the 21th day of the exmperiment, but these decreased after that time. 3. Mild increments of melanin were observed on the 7th day of the experiment in the 0.01% Fluocinolone applied group and on the 14th day in the 0.025% Fluocinolone applied group. These increased moderately in the first group and prominently in the second group one week later. The following week, the degree of increments decreased mildly, but did not change thereafter. The enlargement of melanocytes was similar to the increase in increments of melanin. Mild proliferation of melanocytes was noted on the 14th day. This increased moderately one week later, but was not changed after that. There were no differences in the increments of melanin or in the size and number of melanocytes in response to the various concentrations of the applied creams. 4. The increments of melanin were observed mildly on the 7th day of the experiment and moderately on the 14th day in the 0.01% and 0.025% Fluocinolone applied groups with the additional irradiation of ultraviolet light. There was no change after the 14th day. The change in size of melanocytes was similar to the increase in increments of melanin. Mild proliferation of melanocytes was noted on the 14th day of the experiment. This increased moderately on the 21st day with no further change. There were no differences in the increments of melanin or the size and number of melanocytes observed in the use of concentrations of the applied creams. Above findings suggest that topical Fluocinolone has enhancing effect on the synthesis of melanin and prolong the effect of irradiation of ultraviolet light.

多國的企業에 대한 國際的 規制에 관한 硏究

이순복 慶南大學校 産業經營硏究所 1998 産業經營 Vol.22 No.-

한인진 추출물의 간장보호 작용에 관한 연구

이순복,조태순,윤기욱,이종찬,이선미,심성보 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

The dose-response effect of polysaccharide extracts(PS-1) from Artemisia iwayomogi was investigated under various hepatic disease models. Silymarin, DDB and UDCA were used as reference compounds. We found that the maximal effective dose of PS-1 was 100 ㎎/㎏ b.wt. in CCl_4-induced hepatotoxicity, D-galactosamine-induced hepatitis, in ANIT-induced cholestasis and 300 ㎎/㎏ b.wt. in CCl_4-induced chronic liver disease, 30 ㎎/㎏ b.wt. in chronic bile duct ligation and chronic ethanol fatty liver. These findings suggest that PS-1 fraction protects the hepatocyte against various hepatic injuries, and this fracton might be of therapeutic value.

國際環境法의 生成과 發展에 관한 硏究

李淳福 경남대학교 법학연구소 1994 慶南法學 Vol.9 No.-

죽초액의 유·무기물 제거와 악취제거

이순복,윤민우,정우술,허관,이상섭 대한환경공학회 2006 대한환경공학회 학술발표논문집 Vol.2006 No.12