Weber - christian Disease 의 사망 1 예

원영호,전인기,김영표 대한피부과학회 1982 大韓皮膚科學會誌 Vol.20 No.2

Weber-Christian diaease is characterized by recurrent crops of subcutaneous nodules or plaques which occur during febrile periods and usually has spontaneous regression. Since the earlier case reports there have been instances of nodular panniculitis affecting visceral fat as well as the subcutaneous tissue. Death may rarely occur follow ing visceral involvement. We experienced a fatal case of Weber-Christian disease in a 32 year old female, who had prominent hepatomegaly and leukopenia accompanied by various general symptoms such as nausea, vomiting, abdominal pain, and cough. This case also had unusually large erythematous swelling of the face and abdomen in addition to multiple subcutaneous nodules in the extremities and trunk.

대상포진의 예방과 치료

원영호 메디메디아코리아(주) 2004 피부과 전문의를 위한 Update in Dermatology Vol.2 No.2

피부 스포로트리쿰증에서 Itraconazole 경구 투여의 효과에 대한 관찰

원영호,전선도,김성진,이승철 대한의진균학회 1998 대한의진균학회지 Vol.3 No.2

Background: The effectiveness of some therapeutic modalities for cutaneous sporotrichosis may be changed depending on the individual and geographic characteristics, and the clinical type. Itraconazole has been known to be effective for it, however, there have been no standard and ideal guideline on the oral dosage and duration yet. Objective 8: Methods: In this study, we evaluated the effectiveness of oral itraconazole in patients with cutaneous sporotrichosis in relation to dosage and clinical status. The observation of 17 patients with sporotrichosis were made retrospectively, Oral itraconazole was administered at the dose of 200 mg daily in 15 adults over 18 years old and 100 mg in the other 2 children. Results: The duration for healing was within 30 days in 4 cases, within 60 days in 4 cases, within 90 days in 2 cases, within 120 days in 3 cases, and within 150 days of therapy in 2 cases. The average duration in all cases was 12.1 ± 8.6 weeks. Comparison our results to the previous reported one revealed that more shorter treatment time was needed in cases treated with 200 mg daily than that with 100 mg. There was no treatment failure by drug intolerance or resistance. The duration for healing was significantly shorter in the patient groups with prevalence duration more than 5 months, however there was not any significant difference in sex of patients, and the clinical types. The cases with the lesion on the face and cases with fixed type tended to be healed more rapidly than the others, Conclusion: Oral itraconazole may be a safe and effective antifungal agent for the treatment of cutaneous sporotrichosis in a daily dose of 200 mg for 3 months on the average. However, duration for healing could be influenced by the clinical status.

족부백선에서 Terbinafine 1% 1주와 Clotrimazole 1% 4주 국소도포 치료에 대한 이중맹검 비교 연구

원영호,이형우,김준협,전인기 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.2

Tinea pedis is the most common and chronic dermatophyte infection. Clotrimazole 1% cream is well known antifungal agent and to be applied generally for 4 weeks at the treatment of tinea pedis. Terbinafine is a newly developed antifungal agent with a fungicidal action. The short-term treatment of tinea pedis by terbinafine has veen suggested as an effective topical treatment. We tried to compare the efficacy of terbinafien 1% cream and clotrimazole 1% cream for tinea pedis in double-blind, parallel fashion. The 113 patients with tinea pedis diagnosed by clinical feature and mycological findings including KOH mount and fungus culture, were enrolled in this study. Terbinafine 1% cream applied twice daily for 1 week and inert cream for the next 5 weeks. Clotrimazole 1% cream applied twice daily for 4 weeks and inert cream for next 2 weeks. Mycologic characteristics and clinical symptoms and sings were assessed at baseline, at the end of 1, 2, 4 and 6 weeks. Total one hundred patients consisted of 50 for terbinafine and 50 for clotrimazole were finally evaluated, and paralleled in age, sex and total clinical scores of the baselines. The total reduced percent of clinical signs and symptoms from baseline were 72% at week four and 81% at week six in terbinafine, and 61% and 66% respectively in clotrimazole(P<0.05). The percent of negative mycology at week two, were 92% in terbinafine and 78% in clotrimazole(p<0.05), however no significant difference in the other week six, were 30%(p<0.05) for very good and 46% for good in terbinafine, and 14% respectively in clotrimazole. These result indicated that a one week treatment of terbinafine 1% cream may be more effective than a four week treatment of clotrimazole 1% cream for tinea pedis.

족부백선 치료에서 Terbinafine과 Itraconazole의 비교 임상연구

원영호,박경옥,전인기 대한화학요법학회 1992 대한화학요법학회지 Vol.10 No.2

With the objective of assessing efficacy and safety, sixty patients (30 in each group) with clinically and mycologically confirmed tinea pedis were randomised in a single-blind fashion to receive either 250㎎ orally once daily Terbinafine(Lamisil®) for 2 weeks or 100㎎ orally once daily ltraconazole(Sproanox®) for 4 weeks, Terbinafine is an allylamine, fungicidal antimycotic agent, while Itraconazole is an anti-fungal of triazole series. The patients were well matched for age, clinical features and type of dermatophytes. Clinical response was measured by scoring system(0?3) at weekly intervals for 4 weeks, while tolerability (on a scale of 1-5), adverse events and liver biochemistry were assenssed every 2 weeks. Any variance compared to the base-line was recorded by the repeated measure analysis of Variance(Anova) and Wilcoxoson test. At 4 weeks, clinical respose mean of seven scores changed from 1.23±0.85 to 0.27±0.34 for Terbinafine (P<0.05) and from 1.46±0.85 to 0.36±0.39 for Itraconazole (P<0.05). Both drugs are effective, however, there is no significant difference of the relative effectiveness of both drugs at 4 weeks. The overall tolerability scores for Terbinafine were significantly lower compared to Itraconazole (P<0.05). In conclusion, it may be suggested that both drugs are equally effective in the treatment of Tinea pedis; however, Terbinafine proves to be better in terms of better tolerability and shorter duration of treatment(2 weeks vs 4 weeks).

레이저 시트광을 이용한 엔진 연소진단 기술

원영호 慶尙大學校 工科大學 機械設計學科 1997 WORKSHOP 자료집 Vol.1997 No.1

Diesel combustion is very complex phenomena which is unsteady non-uniform, and two phase and which occurs in high temperature and pressure environment. Recently the laser sheet technique has been developed to improve our limited understanding of the in-cylinder diesel combustion. The technique is capable of high temporal and spatial resolution, so that it is proved to be an adequate combustion diagnostics to finding out diesel fuel mixture and exhaust emission formation. Some techniques -which are based on the different interaction between laser and particles have been developed especially for diesel combustion. Their principles and application to diesel combustion are reviewed in this paper. The measurement results are very helpful to extending our information about diesel combustion toward good combustion efficiency and low exhaust emissions.

對象變化地動詞構文 의 再歸性에 대한 소고

원영호 동덕여자대학교 1999 人文科學硏究 Vol.5 No.-

3 영역 연소모델에 의한 디젤엔진의 유해배기가스 예측

원영호 울산대학교 1997 공학연구논문집 Vol.28 No.1

최근 디젤엔진에서 배출되는 유해배기물질인 매연입자를 줄이기 위하여 연료를 1500 기압 이상의 초고압으로 분사하는 방법이 시도되고 있다. 이 방법을 사용하면 매연입자의 배출량은 현저히 줄일 수 있는 반면 도 다른 유해물질인 NOx 배출량은 증가한다. 따라서 매연입자와 NOx 배출량을 동시에 저감시키기 위해서는 초고압연료분사와 병행하여 기존엔진의 연소조건을 적절하게 변경시켜야 한다. 이러한 변경은 주로 실험에 의존하고 있으나, 다양한 수치 시뮬레이션도 보조적으로 사용되고 있다. 본 연구에서는 분사압력의 변화에 따른 매연입자 및 NOx의 배출량의 예측이 가능한 3영역 연소 및 배기가스 생성모델을 개발하였다. 개발된 모델을 사용하여 초고압 연료분사시 NOx 배출을 증가시키지 않으면서 매연입자를 대폭 줄이기 위한 연료분사시기, 노즐분공경, 연료분사율 형상 등의 연소변수의 설정에 관하여 조사하였다. A phenomenological model of the combustion and emission processes of a diesel engine was formulated to evaluate the effect of the high-pressure fuel injection which is a promising solution to reduce soot emissions. The combustion chamber was divided into the premixed and diffusion combustion zone and the combustion process of each zone was assumed to be controlled by the combustion parameters. The parameters were derived from the experimental results and simplified theories. The model was calibrated using experimental results reported in the literature. After calibration, the model was used to estimate the effects of injection pressure, injection timing, injection rate shape, and nozzle diameter on soot and No emissions.

디젤분무의 액적분열 모델에서 초기 액적형상 및 항력의 영향

원영호 울산대학교 2001 공학연구논문집 Vol.32 No.2

디젤분무의 거동을 해석하기 위한 미립화 및 액적분열 모델에 대한 연구가 활발히 이루 어지고 있다. 공기역학적 항력에 의한 액적의 변형을 고려한 미립화 모델인 TAB 모델을 개선한 ETAB, DDB, APTAB 모델을 최근에 개발된 커먼레일 고압 연료분사장치에 의한 연료분무에 적용하여 각 모델의 예측성능을 비교하였다. 또한 초기에 분출하는 액적이 구 형이 아닌 편원체로 가정하고, 주위액적에 의한 공기역학적 항력의 변화를 고려한 새로운 모델을 제시 한다. KIVA 코드를 사용한 수치계산에서 ETAB, DDB, APTAB 모델 모두 분무선단도달거리 는 실험결과와 잘 일치하였으나 분무내 액적의 평균직경은 실험보다 다소 크게 예측한다. 초기 액적 형상을 구형이 아닌 편원체로 가정한 경우에는 구형인 경우와 거의 차이가 없는 결과를 보인다. 반면에 주위액적의 영향을 고려하기 위하여 액적의 공기역학적 항력계수를 액적분열기간 중에 분출 후 경과시간에 비례하여 증가시키면, 분무내 액적의 평균직경이 작아져 실험에 근접한 결과를 얻을 수 있었다. A number of droplet breakup models have been developed to predict the diesel spray. The capabilities of droplet deformation and breakup models such as ETAB, DDB and APTAB models are evaluated in modeling the high pressure diesel sprays of a common rail injection system. A new model that takes into account the non-spherical shape of droplets and the reduced drag force by the presence of neighbouring droplets. The KIVA calcuriations with ETAB, DDB, and APTAB models predict well the spray tip penetrations of the experiment, but overestimate the tauter Mean Diameter(SMD) of droplets. The calculation with non-spherical droplets injected from the nozzle shows very similar results with the calculation with spherical droplets. The drag coefficient which is linearly increased with the time after start of injection during the breakup time gives the smaller SMD that agrees well with the result of the experiment.

피부진균증 치료의 국소요법

원영호 메디메디아코리아(주) 2003 피부과 전문의를 위한 Update in Dermatology Vol.1 No.2