정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Cobb syndrome 1례

박정욱,박지현,나정호,김영인,이광수,김범생 대한신경과학회 1996 대한신경과학회지 Vol.14 No.4

일개 중소도시에서의 보건소 주도 NPO 참여유도형 건강도시 추진모형에서의 도시건강 개발계획 개발사례

김정민,고광욱 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.1

Background: The aim of this study was to develop City Health Development Plan(CHDP) which based on the situations of public health center supported NPO participatory style Healthy cities model of mid-sized city. Methods: The beginning of planning is Jan, 2006 and it completed in Jan, 2008. Overall planning process were consist of 21 steps which categorized in 6 stages and the process was based on the working tools for CHDP of WHO centre for Urban health. Jinju public health center and research team of Kosin University conducted every steps of processing with participation of NPOs(Non Pofit Organizations) of Jinju city. Results: Jinju CHDP was consist of three part. First part was goals and objectives, and second part was subjective plans which categorized in 6 divisions. Third part was approaching strategies for CHDP. Conclusion: This study was the first case of development of CHDP in Korea. Following the steps in this study, improved city health development planning will be conducted in another cities in Korea which are in similar public health conditions.

라인케 부종의 Videostrobokymography 소견

김광현,성명훈,김동영,이동욱,이상준,이승신,박민현,김정준 대한이비인후과학회 2000 대한이비인후과학회지 두경부외과학 Vol.43 No.11

자발적 운동이 고령자의 혈액성분에 미치는 영향

정일호,이광욱,조명곤 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.2

The purpose of this study was to compared the blood variance following spontaneously exercise for 10weeks in healthy the elderly. When spontaneously exercise, for 10 weeks in exercise intensities between low and middle exercise intensities was participated, the HDL-C in factors of anti-atherosclerosis increased highly. Also, HDL-C/Total-C and HDL-C/LDL-C ratio in atherosclerosis index was improved. The results suggest that, in general, in participation aerobic exercise spontaneously was prevented on disease of lifestyle in the elderly.

안동지방 서리현상의 예보가능성에 관한 고찰

정민수,이재균,박광오,이채욱 대구대학교 정보통신연구소 2004 情報通信硏究 Vol.3 No.2

본 연구에서는 서리 발생에 직접적인 영향을 미치는 여러 가지 기후학적인 요소들을 10년 동안 안동지방을 대상 지역으로 선정하고 분석하여 안동지역 서리 발생의 예보 가보 가능성에 관하여 연구하였다. In this paper we analyzed various meteorologicals in Andong during 10 years, so the objective forecast possibility of frost in Andong are examined and analyzed.

Azithromycin으로 치료한 임신 중 쓰쓰가무시병 1예

김광석,최진욱,서호종,김기훈,박성호,서광섭,고성만,김순혜,김호정 대한감염학회 2001 감염 Vol.33 No.5

We report a case of tsutsugamushi disease in a 26 year-old pregnant woman who was treated with azithromycin. Her gestation period was 27 weeks and she admitted with fever, rash, and eschar on the right shoulder. Currently recommended medications for the treatment of scrub typhus are doxycycline or chloramphenicol. But, these drugs are class D drugs according to the U.S. Food and Drug Administration (FDA) Fetal Risk Summary, so they couldn't be used to treat pregnant women. Recently, a few case reports suggested that azithromycin, a relatively new macrolide antibiotic, was effective and safe for the treatment of scrub typhus in pregnant women. And, there is no evidence that azithromycin causes harmful effects to the developing fetus or to children. On the basis of current in vivo test that confirms the effectiveness of azithromycin, it may be the drug of choice for the treatment of scrub typhus in pregnant women and children. (Korean J Infect Dis 33:380-382, 2001)

유아 무용 교육이 유아의 긍정적 자아개념에 미치는 영향

이광욱,조연숙,정일호,강성환 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.4

The purpose of this study was to examine through 24weeks whether dance education with 6-year old preschool-Kindergarten may increase positive self-concepts. The results of analysis of self-concept's change that the dance education served K kindergarten and not in the S kindergarten in Seoul were as follows. 1. There is a statistically significant relation of the generally satisfactory self-concepts between the two preschool-Kindergarten groups(P<0.05). It means that the development of satisfactory self-concepts are generally influenced by dance education programs. 2. There was no statistically significant relation of the same-aged children's self-concepts between the two preschool-Kindergarten groups (P>0.05). It means that the same-age children's self-concepts are not influenced effectively by dance education programs. 3. There was no statistically significant relation of the children's self-concepts about their teachers and kindergartens between the preschool-Kindergarten groups(P<0.05). It means that their teachers and kindergartens the children's self-concepts are not influenced effectively by dance education programs. 4. There was no statistically significant relation of the children's self-concepts about their classes between the two preschool-Kindergarten groups(P<0.05). It means that the children's self-concepts about their classes are not influenced by dance education programs. 5. There was no statistically significant relation of the children's self-concepts about their physical exercises between the two preschool-Kindergarten groups(P<0.05). It means that the children's self-concepts about their physical exercises are not influenced by dance education programs.

번데기동충하초(Cordyceps militaris CMO02)의 인공자실체 형성조건

이준우,강신욱,방광웅 慶北專門大學(영주경상전문대학) 2002 慶北專門大學 論文集 Vol.21 No.-

This study was conducted to investigate cultural conditions for artificial fruiting body production of Cordyceps militaris CMO02. The artificial fruiting body showed redness in colour and the length was 89∼93mm, and the number was 150∼170 in a bottle. The length and number of fruiting body were longer and many in media of the hulled rice and naked barley than that of silkworm pupa. The culture medium of hulled rice and naked barley showed higher artificial fruiting body compared to that silkworm pupae. The formation period of an artificial fruiting body of Cordyceps militaris treated with hulled rice and naked barley were 45 and 46 days, respectively. The optimum illumination was 400 lux for the fruiting body formation. Pinheading and development of Cordyceps militaris was quickly decreased at passage of three subculture.

온실재배와 노지재배한 금산 깻잎의 품질 특성과 향기성분

현광욱,구교철,장정호,이재곤,김미리,이종수 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2004 한국식품저장유통학회지 Vol.11 No.1

깻잎을 이용한 건강 식품을 개발하고자 먼저 깻잎의 주산지인 금산에서 5월 온실재배한 깻잎과 8월 노지재배한 깻잎들의 품질특성과 향기성분을 조사하였다. 시료깻잎 모두 4.0%의 조단백질과 0.8%의 조지방을 함유하고 있었고, 플라보노이드의 함량은 온실재배 깻잎 25.2%, 노지재배 깻잎 26.5%로 시료깻잎간에 큰 차이는 나타나지 않았으며 조사포닌 함량도 2,7%와 2,8%로 비슷하였다. 시료깻잎의 효소 활성은 오직 알칼리성 단백질 분해효소 활성만이 8월 노지재배 깻잎에서만 물 추출물 7.1 unit, 에탄올 추출불 11.8 unit을 보였고 기타 효소 활성은 없었다. 8월 노지재배 깻잎의 조직감 특성으로 먼저 견고성과 탄력성 등은 잎의 상층부와 중층부 보다 잎받침을 포함하는 하층부에서 높았고 응집성은 하층부가 약간 약하였으며 5월 온실재배 깻잎은 씹힘성이 다서 낮았을 뿐 노지재배 깻잎과 비슷하였다. 5월 온실재배와 8월 노지재배 깻잎에는 1-octen-3-ol, linalool, β-caryorhyllene, α-caryophyllene, α-famesene, perilla ketone, nerolidol, eugenol. α-cadinol 등 14종∼15종의 향기성분을 함유하고 있었고 주요한 향기성분은 perilla ketone 이었다. Quality and flavor compounds of perilla leaves cultivated in greenhouse(May) and field (August) in Geumsan province were investigated and compared. All perilla leaves contained 4.0% crude protein and 0.8% crude lipid. C겨de flavonoid contents of perilla leaves cultivated in greenhouse and field showed 25.2% and 26.5%, respectively and each crude saponin content was cultivated in field. Hardness and chewness of bottom parts of field-perilla leaves were higher than those of top and middle part, whereas the cohesiveness of top parts and middle parts of perilla leaves were higher than that of bottom part. Furthermore, texture properties of greenhouse-perilla leaves were similar with those of field-perilla leaves except chewness. Nine kind of flavor compounds such as 1-octen-3-ol, linalool, β-caryophyllene, α-caryophylene, α-franesene, perilla ketone, nerolidol, eugennl, α-cadinol were identified in greenhouse-perilla and field-perilla leaves, showing that main flavor compound was perilla ketone.