일부 영세 도금사업장의 국소배기성능과 공기중 총크롬 , 6가 크롬 및 니켈농도와의 관계분석

박동욱,박두용,신용철,오세민,정규철 한국산업위생학회 1993 한국산업보건학회지 Vol.3 No.1

To evaluate efficiencies of the local exhaust systems installed in chromium and nickel electroplating tanks, specifications of each tank and general performances of the local exhaust systems were measured in 16 electroplating plants from July 3 to November 24, 1992. Airborne concentrations of total chromium, hexa-chromium and nickel were also measured. Most of the local exhaust systems installed in electroplating plants were inadequately designed. Average capture velocities of local exhaust systems in chromium and nickel tanks were 0.45 m/sec and 0.29 m/sec. Average slot velocities in chromium and nickel tanks were 7.30 m/sec and 2.87 m/sec respectively. Both average capture and slot velocities were in noncompliance with the standards recommended by American Conference of Governmental Industrial Hygienists (ACGIH) and National Institute for Occupational Safety and Health (NIOSH). Exhausted air volume was insufficient in all local exhaust systems surveyed. Worker exposure levels to total chromium, hexa-chromium and nickel were 43.0 ㎍/㎥, 1.7 ㎍/㎥ and 9.3 ㎍/㎥, which were below the Korean Standard and U.S. Occupational Health and Safety Administration (OHSA) Permissible Exposure Limit (PEL). However, Worker exposure level to hexa-chromium exceeded the NIOSH Recommended Exposure Limit(REL) of 1 ㎍/㎥. As the result of Scheffee's multiple comparions, worker exposure levels to all metals were significantly different between two groups by the management state of existing local exhaust systems (p$lt;0.05). However, Difference between a group with local exhaust systems which were poorly managed and another group without local exhaust system was satatistically non-significant.

가토에서 CCNU 로 유발된 골수 저형성증의 혈액학적 소견과 골수스캔의 변화에 관한 연구

김승택,이명철,최두혁,고창순,김병국,이문호,박선양,최성재,김노경,최영희 대한내과학회 1986 대한내과학회지 Vol.30 No.1

To understand systematically the hematological changes including the bone marrow changes in chemotherapeutic agent-induced bone marrow hypoplasia and to define the relationship between hematological and bone marrow scan findings and prognosis of the hypoplasia, CCNU (lomustine) was given orally to 44 rabbits to induce hypoplasia of the bone marrow. And serial changes of peripheral blood and bone marrow findings and (111)In Cl(3)((111)In scan)/(99m)Tc tin colloid bone marrow scan((99m)Tc scan) were checked before and after induction of hypoplasia. With assessment of 28 evaluable rabbits, the following results were obtained: 1) Significant hypoplasia of the bone marrow developed around day 4 of CCNU administration and recovered around day 14(cellularity 51,4±13.5% and 24. 5±14.97o before and after CCNU respectively, p<005). Megakaryocyte count was significantly depressed from 95.67,26% to 36.7$gt;31.82%(P$lt;0.005). M: E ratio was decreased from 162±1.19 to 0, 0.5$lt;0. 43(p±0.005). Shift to left(475), maturation a(40%), naked nucleus and degenerated cells(20%), increase of lymphocytes(47%), monocytes and reticulum cells were also found. 2) The uptake ratio of the 99(m)Tc tin colloid bone marrow scan was markedly increased in contrast to the depression of the bone marrow(4.4±2.12 and 14.1±7.06 before and 4 days after CCNU, respectively, p40. 005). Tc scan uptake ratio was inversely related to the cellularity(r=-0.442, p$lt;0.05) and megakaryocyte number of the bone marrow(r= 0.89, p< 0.01) and peripheral blood granulocyte (r = 0. 54. Pg0.01) and platelet count(r=0.40, p$lt;0.05). There was not significant correlation between (111)In scan uptake ratio and hematologic parameters. 3) The amplitude of the change of the (99m)Tc scan uptake ratio was significantly related to the prognosis of the rabbits with experimentally induced hypoplasia of the bone marrow(dead 5.1±2,67, survivors 2,5±0.96, P<0.01). The change of the (111)In scan uptake ratio was not related to the prognosis of these rabbits. In experimentally induced rrow hypoplasia, morphologic changes in addition to the numerical changes of the bone marrow elements were observed. And serial (99)Tc scan of the bone marrow appears to be helpful assessing the severity and predicting the outcome of bone marrow hypoplasia.

독성미만성 갑상선종 환자에서 방사성옥소(131I) 투여후 발생하는 영구적 갑상선기능저하증

이정상,이문호,고창순,이홍규,박선양 대한핵의학회 1977 핵의학 분자영상 Vol.11 No.1

저자들은 방사성옥소투여후에 발생하는 갑상선기능저하증의 발생상황을 알아보기 위하여 1960년부터 1977년까지 서울대학교 의과대학 부속병원 내과 방사성동위원소진료실에서 131I 치료를 받은 독성미만성 갑상선종환자 794명을 대상으로 단회투여군과 다회투여군, 소량투여군과 다량투여군, 그리고 연령군별 및 안구돌출유무에 따른 갑상선기능저하증의 발생빈도를 조사하여 다음과 같은 결과를 얻었다. 1) 631명의 방사성옥소 단회투여군에서는 갑상선기능저하증의 발생빈도가 치료후 1년에 7.4%, 2년에 11.8%, 3년에 16.2%, 4년에 22.1% 그리고 5년에는 25.5%였으며, 163명의 다회투여군에서는 1년에 8.6%, 2년에 10.4%, 3년에 13.3%, 4년에 29.1% 및 5년에는 54.1%로 양군에서 모두 시간이 경과함에 따라 증가하였으며 4년 이후에는 다량투여군에서 그 발생빈도가 급격히 증가하였다. 2) 5mCi 이하의 131I를 1회만 투여받아 평균 4.3±0.6mCi의 131I 치료를 받은 550명의 소량투여군에서의 갑상선기능저하증의 발생빈도는 치료후 1년에 6.8%, 2년에 11.4%, 3년에 15.4%인 반면, 5.5mCi 이상의 131I 투여를 받아 평균 6.3±0.5mCi의 131I 치료를 받은 다량투여군환자 81명에서는 1년에 12.0%, 2년에 15.4% 그리고 3년에 20.4%로 다량투여군에서 발생빈도가 높은 것을 알 수 있었다. 그러나 방사성옥소 치료후 정상 갑상선기능상태로 되는 기간은 소량투여군과 다량투여군에서 각각 평균 5.1±3.6개월 및 4.8±2.8개월로 양군간에 통계학적으로 유의한 차이가 없었다(p$gt;0.1). 3) 방사성옥소 단회소량투여군환자 550명을 대상으로 조사한 연령군별 갑상선기능저하증의 발생빈도는 30세미만의 환자에서는 1년에 4.3%, 2년에 7.7%, 30세에서 49세까지의 환자들에서는 1년에 5.8%, 2년에 11.1% 그리고 50세 이상의 환자들에서는 1년에 11.0%, 2년에 14.4%로 연령이 많을수록 증가하는 경향을 보였다. 4) 역시 방사성옥소 단회소량 투여군환자 300명을 대상으로 조사한 안구돌출유뮤에 따른 갑상선기능저하증의 발생빈도는 치료후 1년과 2년에 각각 안구돌출이 있는 환자들에서는 7.1% 및 12.1%, 그리고 없는 환자에서는 7.3% 및 12.2%로 양군간에 차이가 없었다. 이상에서 저자들은 독성미만성 갑상선종환자에서 방사성옥소 치료후 발생하는 갑상선기능저하증은 과거 국내에서 보고된 것보다 그 발생빈도가 높으며 시간이 경과함에 따라 증가하고, 특히 다회투여군에서는 치료후 4년 이후에 연증가율이 급격에 증가하며, 초회치료로 호전되는 환자에서는 방사성옥소투여량을 줄임으로써 그 발생빈도를 감소시킬 수 있음을 관찰하였다. Radioactive ioine(RAI), principally 131I, effectively controls hyperthyroidism in the majority of patients. The subsequent development of hypothyroidism, however, has been of increasing concern since it was first pointed out by Chapman and Maloof in 1955. And the steady increase of late hypothyroidism during the passage of time was known with its relation with dosage of RAI. The authors have investigated the development of hypothyroidism in 935 patients with diffuse toxic goiter(DTG) who were treated with RAI(131I) at the Seoul National University Hospital from 1960 to 1977 to reveal its relation with the number of RAI treatments, dosage of RAI, age of patients and exophthalmos with the following results. 1)The incidence of hypothyroidism by year after RAI therapy among 631 patients with DTG who were treated with single RAI regimen was 7.4%(1 year), 11.8%(2 year), 16.2%(3 year), 22.1%(4 year) and 25.5%(5 year), and that anong 163 patients given multipie RAI treatments was 8.6%(1 year), 10.4%(2 year), 13.3%(3 year), 29.1%(4 year), and 54.1%(5 year) respectively showing much higher yearly increments from 4 years after RAI treatmenet in comparison with the former. 2) Among 550 patients in the lower dose group treated with single RAI regimen less than 5.0mCi(Mean±S.D.: 4.3±0.6mCi), the incidence of hypothyroidism by year after RAI treatment was 6.8%(1 year), 11.4%(2 year), 15.4%(3 year), while among 81 patients in the higher dose group given single RAI treatment not less than 5.5mCi (Mean±S.D.: 6.3±0.5mCi) it was 12.0%(1 year), 15.4%(2 year) and 20.4%(3 year) respectively. However, the duration till euthyroid state after RAI therapy in the two groups was 5.1±3.6 months and 4.8±2.8 months respectively showing no statistically signficant difference (p$gt;0.1). 3) The incidence of hypothyroidism after RAI treatment in patients younger than 30 years of age was 4.3%(1 year) and 7.7%(2 year); in patients from 30 years to 49 years of age, 5.8%(1 year) and 11.1%(2 year); and in those older than 50 years, 11.0%(1year) and 2 year). The data revealed rising incidence of hypothyroidism with increase of patients' age. 4) Among 116 patients with exophthames the incidence of hypothyroidism by year after RAI treatment was 7.1%(1 year) and 12.15(2 year) while that among 184 patients without exophthalmes was 7.3%(1 year) and 12.2%(2 year) respectively. With the above data the authors could conclude that the hypothyroidism in patients with DTG who were treated by RAI developed more frequently than reported by others in Korea till now, and increased with the passage of time, the yearly increments from 4 years after RAI treatment increasing markedly in the multiple dose group, and the incidence could be reduced by decreasing the administered RAI dose not increasing the duration till euthyroid state after RAI therapy.

당뇨병에서의 혈장 Renin 활성에 관한 연구

이정상,이문호,김성권,최강원,표희정,박정식 대한핵의학회 1979 핵의학 분자영상 Vol.13 No.1

당뇨병에서의 고혈압 및 신합병증에 따른 Renin Angiotensin-Aldosterone계의 동태를 밝히기 위하여 40예의 당뇨병 환자에서 기저 및 furosemide 정주 2시간 후의 PRA를 측정하였다. 1) 40예의 당뇨병 환자는 신합병증과 고혈압의 유무에 따라 4군으로 분류하였으며, 임상적인 합병증이 없는 Ⅰ군에는 15명, 신합병증이 있는 Ⅱ군에는 7명, 신합병증과 고혈압이 같이 있는 Ⅲ군에는 8명, 고혈압만 있는 Ⅳ군에는 10명의 환자가 속하였다. 2) 각 군의 24시간 요중 Na배설량의 평균치 사이에는 유의한 차이가 없었다. 3) 기저 PRA치는 Ⅰ군이 1.53±1.09ng/ml/hr(Mean±S.D), Ⅱ군이 0.63±0.59ng/ml/hr, Ⅲ군이 0.79±0.62ng/ml/hr, Ⅳ군이 1.11±0.80ng/ml/hr로서 Ⅱ군과 Ⅲ군은 Ⅰ군에 비하여 유의하게 저하되어 있으나(P$lt;0.05), 다른 군들 간에는 유의한 차를 볼 수 없었다. 4) furosemide 정주 2시간 후의 PRA치는 Ⅰ군이 2.72±1.96ng/ml/hr, Ⅱ군이 0.92±0.78ng/ml/hr, Ⅲ군은 1.03±0.76ng/ml/hr, Ⅳ군은 1.73±1.39ng/ml/hr로써 Ⅰ군과 Ⅱ군사이에서만 유의한 차이를 보이고(P$lt;0.05), 다른 당뇨병 환자군 사이에서는 유의한 차를 볼 수 없었다. 5) furosemide 정주에 의한 Renin 분필 자극시험에 대한 반응도 Ⅱ군과 Ⅲ군에서는 둔화되어 있는 양상을 보이나, 시험대상도 적고하여 통계적 유의성에는 미치지 못하였다. 이상의 성적에서 신합병증이 있는 당뇨병에서는 혈장 Renin활성이 저하되며 furosemide 정주에 의한 Renin 분필자극시험에 대한 반응도 둔화됨을 알 수 있었다. 또한 당뇨병성 신합병증에 의한 고혈압에서도 혈장 Renin활성은 저하되는 경향을 보여서 이 경우의 고혈압은 Renin이외의 다른 요인이 작용할 것으로 보인다. To evaluate the renin-angiotensin-aldosterone system in diabetes mellitus, basal plasma renin activity(PRA) and its response to intravenous furosemide were determined in 40 diabetic subjects. The diabetics were divided into 4 groups according to the pressence of nephropathy and/or hypertension. Uncomplicated diabetics(Group I) were taken as control group and the results of the other groups were compared to this group. In diabetics viith nephropathy alone(Group Ⅱ), and with nephropathy and hypertension (Group Ⅲ), basal PRA values were 0.63±0.59ng/ml/hr., and 0.79±0.62ng/ml/hr., respectively, both significantly lower than control group. (1.53±1.09ng/ml/hr.). (P$lt;0.05) In both of the above groups, the responses to intravenous furosemide tended to be blunted. On the other hand, in diabetics, with hypertension only (Group Ⅳ), the basal and stimulated PRA were not significantly different from control. Above results suggests that nephropathy may be one of the factors which suppress renin activity in diabetes me.

Tropane Spirohydantoin들의 합성 및 구조분석

정대일,이도훈,송주현,이용균,최순규,박유미,한정태 동아대학교 환경문제연구소 2006 硏究報告 Vol.28 No.1

The tropane ring system is an important substructure in a number of natural products and synthetic compounds of biological and medicinal importance. As a result of the significance of the tropane ring system, the purpose of this study is the synthesis of anticonvulsant compounds of new s tructure anticipated anticonvulsant activity. After we first synthesized the various N-substituted nortropinone derivatives, we prepared new nortropane alkaloids and nortropinone derivatives. Substantially, we tried several experiments to optimize reaction condition. The tropane spirohydantoins 17, 18, 19, 20, 21 were respectively synthesized by the treatment of corresponding N-substituted nortropinone with potassium cyanide and ammonium carbonate.

Bhattacharya법에 의한 혈청 Ca, Zn, Mg, Cu의 정상치

김영기,서진태,박명희,김상인 대한병리학회 1981 Journal of Pathology and Translational Medicine Vol.15 No.3

급성 심근경색증 초기 진단에 latex 응집을 이용한 혈청 myoglobin 측정의 임상적 의의

박영배,서정돈,최윤식,이영우,오병희,손대원,임하진,김유우,박명희 대한내과학회 1987 대한내과학회지 Vol.32 No.2

We evaluated the diagnostic usefulness of latexagglutination test for elevated serum myoglobin as a screening test in the early phase of acute myocardial infarction and 21 patients with chest pain mimicking acute myocardial infarction were included in this study. Result was compared with serum myoglobin level measured by radioimmunoassay (RIA) in every case. The Following results were obtained: 1) When serum myoglobin levels measured by RIA below 85ng/㎖ were regarded as normal, this test showed sensitivity of 82%, specificity of 95%. 2) In latex-agglutionation test for elevated serum myoglobin, test results were interpreted as negative, weakly positive and positive. If we regard weakly positive tests as positive, sensitivity was 93% and specificity was 62%. In contrast, if we regard weakly positive tests as negative specificity rose to 100% while sensitivity reduced to 75%. 3) Agreement rate of both test was k=0.59. It is suggested that latex-agglutination test for elevated serum myoglobin is helpful in ruling out acute myocardial infarction when test result is negative, and that it can be used as a screening test in the early phase of acute myocardial infarction because of its rapidity and simplicity in performing the procedure.

당뇨병유발백서에서 급성패혈증 병발시 적혈구막지질과산화의 변화

박성우,홍성관,유형준,장대영,강승식,유재명,임성희,최문기,노정우,이규만 대한당뇨병학회 1994 Diabetes and Metabolism Journal Vol.18 No.3

소장내용물의 위내역류 및 위내용물 배출시간에 관한 연구

김진호,박승철,이형호,안일민,박영태,김열흥,이창흥 대한내과학회 1986 대한내과학회지 Vol.30 No.2

Radionuclide enterogastric scintigraphy was done with (99m)Tc-DISIDA and (111)In-DTPA in 35cases; control group 5, gastric ulcer group 6, subtotal gastrectomy with Billroth g group 5, and functional gastrointestinal disorder group with or without grossly mixed bile in the gastric juice 19 cases. The results were: 1) Enterogastric reflux was very significantly increased in the subtotal gastrectomy with Billroth II group (p$lt;0, 001), 2) Gastric emptying was significantly delayed in the functional gastrointestinal disorder groups with or without grossly mixed bile (p$lt;0.05, p$lt;0. 001). 3) Enterogastric reflux was not significantly increased in the gastric ulcer group. 4) Enterogastric reflux was not significantly different between the functional gastrointestinal groups with or without grossly mixed bile in the gastric juice. 5) Inverse correlation between the gastric emptying indices and the enterogastric reflux indices was not proved (r=-0.37).

Semi - continuous Culture 방법을 이용한 Condensed Tannin 의 한국재래산양 반추위 섬유소 분해 미생물의 활성에 미치는 영향

배귀석,이상석,최종원,박상엽,장문백,하종규,최일,배희동,김종민 한국낙농학회 1999 韓國酪農學會誌 Vol.21 No.2